Traditional email systems can only achieve one-way communication,which means only the receiver is allowed to search for emails on the email server.In this paper,we propose a blockchain-based certificateless bidirectio...Traditional email systems can only achieve one-way communication,which means only the receiver is allowed to search for emails on the email server.In this paper,we propose a blockchain-based certificateless bidirectional authenticated searchable encryption model for a cloud email system named certificateless authenticated bidirectional searchable encryption(CL-BSE)by combining the storage function of cloud server with the communication function of email server.In the new model,not only can the data receiver search for the relevant content by generating its own trapdoor,but the data owner also can retrieve the content in the same way.Meanwhile,there are dual authentication functions in our model.First,during encryption,the data owner uses the private key to authenticate their identity,ensuring that only legal owner can generate the keyword ciphertext.Second,the blockchain verifies the data owner’s identity by the received ciphertext,allowing only authorized members to store their data in the server and avoiding unnecessary storage space consumption.We obtain a formal definition of CL-BSE and formulate a specific scheme from the new system model.Then the security of the scheme is analyzed based on the formalized security model.The results demonstrate that the scheme achieves multikeyword ciphertext indistinguishability andmulti-keyword trapdoor privacy against any adversary simultaneously.In addition,performance evaluation shows that the new scheme has higher computational and communication efficiency by comparing it with some existing ones.展开更多
The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading mar...The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading market.Certificateless signatures are a new cryptographic technology that can address traditional cryptography’s general essential certificate requirements and avoid the problem of crucial escrowbased on identity cryptography.However,most certificateless signatures still suffer fromvarious security flaws.We present a secure and efficient certificateless signing scheme by examining the security of existing certificateless signature schemes.To ensure the integrity and verifiability of electricity carbon quota trading,we propose an electricity carbon quota trading scheme based on a certificateless signature and blockchain.Our scheme utilizes certificateless signatures to ensure the validity and nonrepudiation of transactions and adopts blockchain technology to achieve immutability and traceability in electricity carbon quota transactions.In addition,validating electricity carbon quota transactions does not require time-consuming bilinear pairing operations.The results of the analysis indicate that our scheme meets existential unforgeability under adaptive selective message attacks,offers conditional identity privacy protection,resists replay attacks,and demonstrates high computing and communication performance.展开更多
Recently,a study on a 0.05 T,low-cost,low-power,and computing-driven shielding-free ultra-low-field(ULF)magnetic resonance imaging(MRI)scannerwas published.This work enhances the image quality of MRI and reduces the s...Recently,a study on a 0.05 T,low-cost,low-power,and computing-driven shielding-free ultra-low-field(ULF)magnetic resonance imaging(MRI)scannerwas published.This work enhances the image quality of MRI and reduces the scanning time based on deep learning methods,which is of great significance to enhancing the popularization and availability of MRI[1](https://www.science.org/doi/abs/10.1126/science.adm7168).展开更多
As e-commerce continues to mature,the advantages of live streaming within the industry have become increasingly apparent,offering significant growth opportunities.Social e-commerce platforms,which are user-centered,in...As e-commerce continues to mature,the advantages of live streaming within the industry have become increasingly apparent,offering significant growth opportunities.Social e-commerce platforms,which are user-centered,integrate social networks with e-commerce by leveraging social interactions to drive product sales and enhance the overall consumer shopping experience.This type of e-commerce fosters engagement and promotes products by merging online communities with shopping behavior,creating a more interactive and dynamic marketplace.It not only retains the traditional e-commerce trading and marketing functions but also adds a social dimension,making live stream anchors crucial figures connecting consumers with products.These anchors can attract consumers with their appearance and charm,and use their expertise on live streaming platforms to guide consumers by recommending live content.They can also interact with their audiences and potentially influence them to purchase the recommended goods.It is evident that the attributes of anchors in live streaming rooms significantly impact consumers’online behavior.Therefore,researching how platform contextual factors regulate consumers’online behavior is of great practical significance.This study employs multilevel regression analysis to support its hypotheses using data.The findings indicate that contextual factors of the platform significantly influence online behavior,enhancing the positive relationship between user attachment and online activities.展开更多
<div style="text-align:justify;"> In order to study the transmission characteristics of laser in atmospheric turbulent medium and understand the influence degree of various factors on amplitude fluctua...<div style="text-align:justify;"> In order to study the transmission characteristics of laser in atmospheric turbulent medium and understand the influence degree of various factors on amplitude fluctuation, by means of smooth perturbation method, this paper establishes a theory model of amplitude fluctuation of laser propagation in turbulent medium by using the smooth perturbation method and reflects the amplitude fluctuation degree, carries out specific discussion on each influence factor. The results show that the larger the wavelength, the more stable the amplitude fluctuation. With the increase of laser section radius, the amplitude fluctuates sharply and then decreases slowly after reaching the peak. Transmission distance is the main influence factor of amplitude fluctuation. With the increase of transmission distance, the amplitude fluctuation will become more obvious. The amplitude acquisition can be comprehensively modulated in a specific transmission distance by wavelength and section ra-dius, so as to ensure the stability of the received laser and provide a theoretical basis for the interferometry technology. </div>展开更多
Soil microorganisms and physicochemical properties are considered the two most influencing factors for maintaining plant diversity.However,the operational mechanisms and which factor is the most influential manipulato...Soil microorganisms and physicochemical properties are considered the two most influencing factors for maintaining plant diversity.However,the operational mechanisms and which factor is the most influential manipulator remain poorly understood.In this study,we examine the collaborative influences of soil physicochemical properties(i.e.,soil water,soil organic matter(SOM),salinity,total phosphorus and nitrogen,pH,soil bulk density and fine root biomass)and soil microorganisms(fungi and bacteria)on plant diversity across two types of tree patches dominated by big and small trees(big trees:height≥7 m and DBH≥60 cm;small trees:height≤4.5 m and DBH≤20 cm)in an arid desert region.Tree patch is consists of a single tree or group of trees and their accompanying shrubs and herbs.It was hypothesized that soil physicochemical properties and microorganisms affect plant diversity but their influence differ.The results show that plant and soil microbial diversity increased with increasing distances from big trees.SOM,salinity,fine root biomass,soil water,total phosphorus and total nitrogen contents decreased with increasing distance from big trees,while pH and soil bulk density did not change.Plant and soil microbial diversity were higher in areas close to big trees compared with small trees,whereas soil physicochemical properties were opposite.The average contribution of soil physicochemical properties(12.2%-13.5%)to plant diversity was higher than microbial diversity(4.8%-6.7%).Salinity had the largest negative affect on plant diversity(24.7%-27.4%).This study suggests that soil fungi constrain plant diversity while bacteria improve it in tree patches.Soil physicochemical properties are the most important factor modulating plant diversity in arid desert tree patches.展开更多
The mathematical modeling of a rotating tapered Timoshenko beam with preset and pre-twist angles is constructed. The partial differential equations governing the six degrees, i.e., three displacements in the axial, fl...The mathematical modeling of a rotating tapered Timoshenko beam with preset and pre-twist angles is constructed. The partial differential equations governing the six degrees, i.e., three displacements in the axial, flapwise, and edgewise directions and three cross-sectional angles of torsion, flapwise bending, and edgewise bending, are obtained by the Euler angle descriptions. The power series method is then used to inves- tigate the natural frequencies and the corresponding complex mode functions. It is found that all the natural frequencies are increased by the centrifugal stiffening except the twist frequency, which is slightly decreased. The tapering ratio increases the first transverse, torsional, and axial frequencies, while decreases the second transverse frequency. Because of the pre-twist, all the directions are gyroscopically coupled with the phase differences among the six degrees.展开更多
Proton exchange membrane fuel cells suffer from the sluggish kinetics of the oxygen reduction reaction(ORR)and the high cost of Pt catalysts.In the present work,a high‐performance ORR catalystbased on Fe,N,S‐doped p...Proton exchange membrane fuel cells suffer from the sluggish kinetics of the oxygen reduction reaction(ORR)and the high cost of Pt catalysts.In the present work,a high‐performance ORR catalystbased on Fe,N,S‐doped porous carbon(FeNS‐PC)was synthesized using melamine formaldehyderesin as C and N precursors,Fe(SCN)3as Fe and S precursors,and CaCl2as a template via a two‐stepheat treatment without a harsh template removal step.The results show that the catalyst treated at900℃(FeNS‐PC‐900)had a high surface area of775m2/g,a high mass activity of10.2A/g in anacidic medium,and excellent durability;the half‐wave potential decreased by only20mV after10000potential cycles.The FeNS‐PC‐900catalyst was used as the cathode in a proton exchangemembrane fuel cell and delivered a peak power density of0.49W/cm2.FeNS‐PC‐900therefore hasgood potential for use in practical applications.展开更多
A novel metamaterial plate with subwavelength lever-type resonators is proposed to obtain low frequency broadband band gaps and good sound insulation performance.The band structure is theoretically derived,and the val...A novel metamaterial plate with subwavelength lever-type resonators is proposed to obtain low frequency broadband band gaps and good sound insulation performance.The band structure is theoretically derived,and the validity of the theoretical method is verified by the finite element method.The formation mechanisms of the band gaps are illustrated by the analysis of the effective dynamic mass density and group velocity.The effect of the lever ratio on the band gaps is analyzed.The results indicate that as the lever ratio increases,the first band gap shifts to lower frequencies,while the bandwidth is widened.Moreover,the sound insulation performance of the proposed metamaterial plate is evaluated via examining the sound transmission loss(STL).Compared with the metamaterial plates without lever accessories,the proposed metamaterial plates with a suitable lever ratio have better sound insulation performance at low frequencies.展开更多
Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with MDD.Aims We investigated inflammatory markers,such as interleukin(IL...Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with MDD.Aims We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate prognosis.Methods The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ClinicalTrials.gov,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating Scale.Blood levels.of TNF-α,IL-6 and hsCRP were assessed using antibody array analysis.Results Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after adjustment.In patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe pain.However,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week follow-up.Conclusions This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression subtypes.Further studies on the immunoinflammatory mechanism underlying different subtypes of depression are expected for improved individualised therapy.展开更多
Cultivated chrysanthemum(Chrysanthemum morifolium Ramat.)is an economically important ornamental plant species grown worldwide.However,the origin of the genus Chrysanthemum remains unclear.This study was conducted in ...Cultivated chrysanthemum(Chrysanthemum morifolium Ramat.)is an economically important ornamental plant species grown worldwide.However,the origin of the genus Chrysanthemum remains unclear.This study was conducted in the Hengduan Mountains,Yunnan Province.We took advantage of a special geographic region where the southernmost species of Ajania and the highest altitude population of Chrysanthemum indicum coexist to investigate their evolutionary origins.Diversity analysis of 9 populations of 5 species that came from 3 genera was carried out based on morphological traits and SRAP markers.Furthermore,topographical and ecological analyses and surveys of the vegetation communities in the plots were carried out for correlation analysis,and past data were used to reconstruct the ancient topography and vegetation to estimate the migration path and divergence time.We found that Chrysanthemum and Ajania were closely related based on the smooth transition states among marginal female florets and their common pollination system.The genetic relationship between Phaeostigma and Chrysanthemum was relatively distant,and Ajania was between them.Low light intensity and relatively humid habitats may be driving the elongation and evolution of marginal female florets.We found that Chrysanthemum and related genera were largely restricted to stony topographies at an altitude of~3000 m.a.s.l.and in specialized alpine coniferous(Pinus)and broadleaved(Quercus)mixed forest marginal communities.These stony topographies have become ecological islands of refuge for these species in the current interglacial period.The Hengduan Mountains play a key role in the evolution,divergence,and survival of Chrysanthemum and its allies.展开更多
A multi-degree-of-freedom device is proposed,which can achieve efficient vibration reduction as the main objective and energy harvesting as the secondary purpose.The device comprises a multiscale nonlinear vibration a...A multi-degree-of-freedom device is proposed,which can achieve efficient vibration reduction as the main objective and energy harvesting as the secondary purpose.The device comprises a multiscale nonlinear vibration absorber(NVA)and piezoelectric components.Energy conversion and energy measurement methods are used to evaluate the device performance from multiple perspectives.Research has shown that this device can efficiently transfer transient energy from the main structure and convert a portion of transient energy into electrical energy.Main resonance and higher-order resonance are the main reasons for efficient energy transfer.The device can maintain high vibration reduction performance even when the excitation amplitude changes over a large range.Compared with the single structures with and without precompression,the multiscale NVA-piezoelectric device offers significant vibration reduction advantages.In addition,there are significant differences in the parameter settings of the two substructures for vibration reduction and energy harvesting.展开更多
Deployable/retractable damped cantilever beams are a class of time-varying parametric structures which have attracted considerable research interest due to their many potential applications in the intelligent robot fi...Deployable/retractable damped cantilever beams are a class of time-varying parametric structures which have attracted considerable research interest due to their many potential applications in the intelligent robot field and aerospace.In the present work,the dynamic characteristics of a deployable/retractable damped cantilever beam are investigated experimentally and theoretically.The time-varying damping,as a function of the beam length,is obtained by both the enveloped fitting method and the period decrement method.Furthermore,the governing equation of the deployable/retractable damped cantilever beam is derived by introducing the time-varying damping parameter,and the corresponding closed-form solution and vibration principles are investigated based on the averaged method.The theoretical predictions for transient dynamic responses are in good agreement with the experimental results.The dynamic mechanism analysis on time-varying damping offers flexible technology in mechanical and aerospace fields.展开更多
The conventional microwell-based platform for construction of organoid models exhibits limitations in precision oncology applications because of low-speed growth and high variability. Here, we established organoid mod...The conventional microwell-based platform for construction of organoid models exhibits limitations in precision oncology applications because of low-speed growth and high variability. Here, we established organoid models on a nested array chip for fast and reproducible drug testing using 50% matrigel. First, we constructed mouse small intestinal and colonic organoid models. Compared with the conventional microwell-based platform, the mouse organoids on the chip showed accelerated growth and improved reproducibility due to the nested design of the chip. The design of the chip provides miniaturized and uniform shaping of the matrigel that allows the organoid to grow in a concentrated and controlled manner. Next, a patient-derived organoid(PDO) model from colorectal cancer tissues was successfully generated and characterized on the chip. Finally, the PDO models on the chip, from three patients, were implemented for high-throughput drug screening using nine treatment regimens. The drug sensitivity testing on the PDO models showed good quality control with a coefficient of variation under 10% and a Z’ factor of more than 0.7. More importantly, the drug responses on the chip recapitulate the heterogeneous response of individual patients, as well as showing a potential correlation with clinical outcomes. Therefore,the organoid model coupled with the nested array chip platform provides a fast and reproducible means for predicting drug responses to accelerate precise oncology.展开更多
Based on the observation data of CHAMP satellite from 2006 to 2009, a 2D crustal magnetic anomaly model in China is established to study the distribution characteristics of crustal magnetic anomaly. In this paper, the...Based on the observation data of CHAMP satellite from 2006 to 2009, a 2D crustal magnetic anomaly model in China is established to study the distribution characteristics of crustal magnetic anomaly. In this paper, the 2D anomaly model is derived from the Legendre polynomial expansion of harmonic term N =6-50. The result shows that many elaborate structures reflected in magnetic anomaly map well correspond to the geologic structures in China and its adjacent area. The magnetic anomaly at low satellite height behaves complexly, which is mainly caused by the magnetic disturbance of shallow rocks.In contrast, the magnetic field isolines at high satellite height are relatively sparse and only magnetic anomalies of deep crust are reflected. This fact implies that the 2D model of crustal magnetic anomaly provides an important method of the space prolongation of geomagnetic field, and is of theoretical and practice importance in geologic structure analysis and geophysical prospecting.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62172337,62241207)Key Project of GansuNatural Science Foundation(No.23JRRA685).
文摘Traditional email systems can only achieve one-way communication,which means only the receiver is allowed to search for emails on the email server.In this paper,we propose a blockchain-based certificateless bidirectional authenticated searchable encryption model for a cloud email system named certificateless authenticated bidirectional searchable encryption(CL-BSE)by combining the storage function of cloud server with the communication function of email server.In the new model,not only can the data receiver search for the relevant content by generating its own trapdoor,but the data owner also can retrieve the content in the same way.Meanwhile,there are dual authentication functions in our model.First,during encryption,the data owner uses the private key to authenticate their identity,ensuring that only legal owner can generate the keyword ciphertext.Second,the blockchain verifies the data owner’s identity by the received ciphertext,allowing only authorized members to store their data in the server and avoiding unnecessary storage space consumption.We obtain a formal definition of CL-BSE and formulate a specific scheme from the new system model.Then the security of the scheme is analyzed based on the formalized security model.The results demonstrate that the scheme achieves multikeyword ciphertext indistinguishability andmulti-keyword trapdoor privacy against any adversary simultaneously.In addition,performance evaluation shows that the new scheme has higher computational and communication efficiency by comparing it with some existing ones.
基金the National Fund Project No.62172337National Natural Science Foundation of China(No.61662069)China Postdoctoral Science Foundation(No.2017M610817).
文摘The carbon tradingmarket can promote“carbon peaking”and“carbon neutrality”at low cost,but carbon emission quotas face attacks such as data forgery,tampering,counterfeiting,and replay in the electricity trading market.Certificateless signatures are a new cryptographic technology that can address traditional cryptography’s general essential certificate requirements and avoid the problem of crucial escrowbased on identity cryptography.However,most certificateless signatures still suffer fromvarious security flaws.We present a secure and efficient certificateless signing scheme by examining the security of existing certificateless signature schemes.To ensure the integrity and verifiability of electricity carbon quota trading,we propose an electricity carbon quota trading scheme based on a certificateless signature and blockchain.Our scheme utilizes certificateless signatures to ensure the validity and nonrepudiation of transactions and adopts blockchain technology to achieve immutability and traceability in electricity carbon quota transactions.In addition,validating electricity carbon quota transactions does not require time-consuming bilinear pairing operations.The results of the analysis indicate that our scheme meets existential unforgeability under adaptive selective message attacks,offers conditional identity privacy protection,resists replay attacks,and demonstrates high computing and communication performance.
文摘Recently,a study on a 0.05 T,low-cost,low-power,and computing-driven shielding-free ultra-low-field(ULF)magnetic resonance imaging(MRI)scannerwas published.This work enhances the image quality of MRI and reduces the scanning time based on deep learning methods,which is of great significance to enhancing the popularization and availability of MRI[1](https://www.science.org/doi/abs/10.1126/science.adm7168).
文摘As e-commerce continues to mature,the advantages of live streaming within the industry have become increasingly apparent,offering significant growth opportunities.Social e-commerce platforms,which are user-centered,integrate social networks with e-commerce by leveraging social interactions to drive product sales and enhance the overall consumer shopping experience.This type of e-commerce fosters engagement and promotes products by merging online communities with shopping behavior,creating a more interactive and dynamic marketplace.It not only retains the traditional e-commerce trading and marketing functions but also adds a social dimension,making live stream anchors crucial figures connecting consumers with products.These anchors can attract consumers with their appearance and charm,and use their expertise on live streaming platforms to guide consumers by recommending live content.They can also interact with their audiences and potentially influence them to purchase the recommended goods.It is evident that the attributes of anchors in live streaming rooms significantly impact consumers’online behavior.Therefore,researching how platform contextual factors regulate consumers’online behavior is of great practical significance.This study employs multilevel regression analysis to support its hypotheses using data.The findings indicate that contextual factors of the platform significantly influence online behavior,enhancing the positive relationship between user attachment and online activities.
文摘<div style="text-align:justify;"> In order to study the transmission characteristics of laser in atmospheric turbulent medium and understand the influence degree of various factors on amplitude fluctuation, by means of smooth perturbation method, this paper establishes a theory model of amplitude fluctuation of laser propagation in turbulent medium by using the smooth perturbation method and reflects the amplitude fluctuation degree, carries out specific discussion on each influence factor. The results show that the larger the wavelength, the more stable the amplitude fluctuation. With the increase of laser section radius, the amplitude fluctuates sharply and then decreases slowly after reaching the peak. Transmission distance is the main influence factor of amplitude fluctuation. With the increase of transmission distance, the amplitude fluctuation will become more obvious. The amplitude acquisition can be comprehensively modulated in a specific transmission distance by wavelength and section ra-dius, so as to ensure the stability of the received laser and provide a theoretical basis for the interferometry technology. </div>
基金This work was supported fi nancially by National Natural Science Foundation of China(Grant Nos.and 41,871,031 and 31,860,111)Natural Science Foundation of Xinjiang(Grant No.2017D01C080).
文摘Soil microorganisms and physicochemical properties are considered the two most influencing factors for maintaining plant diversity.However,the operational mechanisms and which factor is the most influential manipulator remain poorly understood.In this study,we examine the collaborative influences of soil physicochemical properties(i.e.,soil water,soil organic matter(SOM),salinity,total phosphorus and nitrogen,pH,soil bulk density and fine root biomass)and soil microorganisms(fungi and bacteria)on plant diversity across two types of tree patches dominated by big and small trees(big trees:height≥7 m and DBH≥60 cm;small trees:height≤4.5 m and DBH≤20 cm)in an arid desert region.Tree patch is consists of a single tree or group of trees and their accompanying shrubs and herbs.It was hypothesized that soil physicochemical properties and microorganisms affect plant diversity but their influence differ.The results show that plant and soil microbial diversity increased with increasing distances from big trees.SOM,salinity,fine root biomass,soil water,total phosphorus and total nitrogen contents decreased with increasing distance from big trees,while pH and soil bulk density did not change.Plant and soil microbial diversity were higher in areas close to big trees compared with small trees,whereas soil physicochemical properties were opposite.The average contribution of soil physicochemical properties(12.2%-13.5%)to plant diversity was higher than microbial diversity(4.8%-6.7%).Salinity had the largest negative affect on plant diversity(24.7%-27.4%).This study suggests that soil fungi constrain plant diversity while bacteria improve it in tree patches.Soil physicochemical properties are the most important factor modulating plant diversity in arid desert tree patches.
基金Project supported by the National Natural Science Foundation of China(Nos.11672007,11402028,11322214,and 11290152)the Beijing Natural Science Foundation(No.3172003)the Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of Education,Northeastern University(No.VCAME201601)
文摘The mathematical modeling of a rotating tapered Timoshenko beam with preset and pre-twist angles is constructed. The partial differential equations governing the six degrees, i.e., three displacements in the axial, flapwise, and edgewise directions and three cross-sectional angles of torsion, flapwise bending, and edgewise bending, are obtained by the Euler angle descriptions. The power series method is then used to inves- tigate the natural frequencies and the corresponding complex mode functions. It is found that all the natural frequencies are increased by the centrifugal stiffening except the twist frequency, which is slightly decreased. The tapering ratio increases the first transverse, torsional, and axial frequencies, while decreases the second transverse frequency. Because of the pre-twist, all the directions are gyroscopically coupled with the phase differences among the six degrees.
基金supported by the National Basic Research Program of China (973 Program,2015CB932303)the National Natural Science Founda-tion of China (21373175,21621091)~~
文摘Proton exchange membrane fuel cells suffer from the sluggish kinetics of the oxygen reduction reaction(ORR)and the high cost of Pt catalysts.In the present work,a high‐performance ORR catalystbased on Fe,N,S‐doped porous carbon(FeNS‐PC)was synthesized using melamine formaldehyderesin as C and N precursors,Fe(SCN)3as Fe and S precursors,and CaCl2as a template via a two‐stepheat treatment without a harsh template removal step.The results show that the catalyst treated at900℃(FeNS‐PC‐900)had a high surface area of775m2/g,a high mass activity of10.2A/g in anacidic medium,and excellent durability;the half‐wave potential decreased by only20mV after10000potential cycles.The FeNS‐PC‐900catalyst was used as the cathode in a proton exchangemembrane fuel cell and delivered a peak power density of0.49W/cm2.FeNS‐PC‐900therefore hasgood potential for use in practical applications.
基金Project supported by the National Natural Science Foundation of China(No.11972050)。
文摘A novel metamaterial plate with subwavelength lever-type resonators is proposed to obtain low frequency broadband band gaps and good sound insulation performance.The band structure is theoretically derived,and the validity of the theoretical method is verified by the finite element method.The formation mechanisms of the band gaps are illustrated by the analysis of the effective dynamic mass density and group velocity.The effect of the lever ratio on the band gaps is analyzed.The results indicate that as the lever ratio increases,the first band gap shifts to lower frequencies,while the bandwidth is widened.Moreover,the sound insulation performance of the proposed metamaterial plate is evaluated via examining the sound transmission loss(STL).Compared with the metamaterial plates without lever accessories,the proposed metamaterial plates with a suitable lever ratio have better sound insulation performance at low frequencies.
基金Key Projects of Clinical Research Center of Shanghai Mental Health Center(grant number CRC2018ZD02)key supporting projects of Clinical Research Center of Shanghai Mental Health Center(grant number SHDC 2020CR6023)+2 种基金Research and DevelopmentProgramof China(grant number 2016YFC1307100)Shanghai Key Project of Science and Technology(grant number 2018SHZDZX05)Natural Science Foundation of China(grant number 81771465,81801338 and 81930033).
文摘Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with MDD.Aims We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate prognosis.Methods The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ClinicalTrials.gov,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).Subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating Scale.Blood levels.of TNF-α,IL-6 and hsCRP were assessed using antibody array analysis.Results Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after adjustment.In patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe pain.However,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week follow-up.Conclusions This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression subtypes.Further studies on the immunoinflammatory mechanism underlying different subtypes of depression are expected for improved individualised therapy.
基金funded by the National Key Research and Development Program of China(2019YFD1001501)the National Natural Science Foundation of China(31730081,31870306)+1 种基金the Youth Program of Science and Technology Department of Yunnan Province(2016FD070)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institution.
文摘Cultivated chrysanthemum(Chrysanthemum morifolium Ramat.)is an economically important ornamental plant species grown worldwide.However,the origin of the genus Chrysanthemum remains unclear.This study was conducted in the Hengduan Mountains,Yunnan Province.We took advantage of a special geographic region where the southernmost species of Ajania and the highest altitude population of Chrysanthemum indicum coexist to investigate their evolutionary origins.Diversity analysis of 9 populations of 5 species that came from 3 genera was carried out based on morphological traits and SRAP markers.Furthermore,topographical and ecological analyses and surveys of the vegetation communities in the plots were carried out for correlation analysis,and past data were used to reconstruct the ancient topography and vegetation to estimate the migration path and divergence time.We found that Chrysanthemum and Ajania were closely related based on the smooth transition states among marginal female florets and their common pollination system.The genetic relationship between Phaeostigma and Chrysanthemum was relatively distant,and Ajania was between them.Low light intensity and relatively humid habitats may be driving the elongation and evolution of marginal female florets.We found that Chrysanthemum and related genera were largely restricted to stony topographies at an altitude of~3000 m.a.s.l.and in specialized alpine coniferous(Pinus)and broadleaved(Quercus)mixed forest marginal communities.These stony topographies have become ecological islands of refuge for these species in the current interglacial period.The Hengduan Mountains play a key role in the evolution,divergence,and survival of Chrysanthemum and its allies.
基金Project supported by the National Natural Science Foundation of China(Nos.11972050 and 12332001)。
文摘A multi-degree-of-freedom device is proposed,which can achieve efficient vibration reduction as the main objective and energy harvesting as the secondary purpose.The device comprises a multiscale nonlinear vibration absorber(NVA)and piezoelectric components.Energy conversion and energy measurement methods are used to evaluate the device performance from multiple perspectives.Research has shown that this device can efficiently transfer transient energy from the main structure and convert a portion of transient energy into electrical energy.Main resonance and higher-order resonance are the main reasons for efficient energy transfer.The device can maintain high vibration reduction performance even when the excitation amplitude changes over a large range.Compared with the single structures with and without precompression,the multiscale NVA-piezoelectric device offers significant vibration reduction advantages.In addition,there are significant differences in the parameter settings of the two substructures for vibration reduction and energy harvesting.
基金Project supported by the National Natural Science Foundation of China(Nos.11672007 and 11832002)the Graduate Technological Innovation Project of Beijing Institute of Technology(No.2017CX10037)。
文摘Deployable/retractable damped cantilever beams are a class of time-varying parametric structures which have attracted considerable research interest due to their many potential applications in the intelligent robot field and aerospace.In the present work,the dynamic characteristics of a deployable/retractable damped cantilever beam are investigated experimentally and theoretically.The time-varying damping,as a function of the beam length,is obtained by both the enveloped fitting method and the period decrement method.Furthermore,the governing equation of the deployable/retractable damped cantilever beam is derived by introducing the time-varying damping parameter,and the corresponding closed-form solution and vibration principles are investigated based on the averaged method.The theoretical predictions for transient dynamic responses are in good agreement with the experimental results.The dynamic mechanism analysis on time-varying damping offers flexible technology in mechanical and aerospace fields.
基金supported by grants from the National Natural Science Foundation of China (No.82174086)the Beijing Natural Science Foundation (No.7222273)+3 种基金the Beijing Xisike Clinical Oncology Research Foundation (Nos.Y-xsk2021-0004 and Y-XD202001-0172)the Youth Talents Promotion Project of China Association of Chinese Medicine (No.2020-QNRC2-08)the Clinical Medicine Plus X-Young Scholars Project of Peking University (No.BMU2021MX009)the Peking University People’s Hospital Research and Development Funds (No.RDY2020-18)。
文摘The conventional microwell-based platform for construction of organoid models exhibits limitations in precision oncology applications because of low-speed growth and high variability. Here, we established organoid models on a nested array chip for fast and reproducible drug testing using 50% matrigel. First, we constructed mouse small intestinal and colonic organoid models. Compared with the conventional microwell-based platform, the mouse organoids on the chip showed accelerated growth and improved reproducibility due to the nested design of the chip. The design of the chip provides miniaturized and uniform shaping of the matrigel that allows the organoid to grow in a concentrated and controlled manner. Next, a patient-derived organoid(PDO) model from colorectal cancer tissues was successfully generated and characterized on the chip. Finally, the PDO models on the chip, from three patients, were implemented for high-throughput drug screening using nine treatment regimens. The drug sensitivity testing on the PDO models showed good quality control with a coefficient of variation under 10% and a Z’ factor of more than 0.7. More importantly, the drug responses on the chip recapitulate the heterogeneous response of individual patients, as well as showing a potential correlation with clinical outcomes. Therefore,the organoid model coupled with the nested array chip platform provides a fast and reproducible means for predicting drug responses to accelerate precise oncology.
基金supported by the National Natural Science Foundation of China (No.41274079,41074048,41374076)National High Technology Research and Development Program of China (863 Program) (2012AA061403,2012AA09A201)
文摘Based on the observation data of CHAMP satellite from 2006 to 2009, a 2D crustal magnetic anomaly model in China is established to study the distribution characteristics of crustal magnetic anomaly. In this paper, the 2D anomaly model is derived from the Legendre polynomial expansion of harmonic term N =6-50. The result shows that many elaborate structures reflected in magnetic anomaly map well correspond to the geologic structures in China and its adjacent area. The magnetic anomaly at low satellite height behaves complexly, which is mainly caused by the magnetic disturbance of shallow rocks.In contrast, the magnetic field isolines at high satellite height are relatively sparse and only magnetic anomalies of deep crust are reflected. This fact implies that the 2D model of crustal magnetic anomaly provides an important method of the space prolongation of geomagnetic field, and is of theoretical and practice importance in geologic structure analysis and geophysical prospecting.