The Clinical Experience of Prof. Zhang Xiaofeng in the Treatment of Small Follicular, Ovulatory Infertility with Traditional Chinese Medicine

With the popularization of clinical ultrasound technology,small follicular ovulation infertility is gradually being recognized in clinical practice.Low follicle ovulation refers to the phenomenon that the average value of the three diameter lines of the dominant follicle is less than 14mm-18mm under continuous ultrasound monitoring.The dominant follicle ovulates before it develops to maturity,which is a kind of ovulation disorder and one of the leading causes of unexplained infertility[1],accounting for 25%-30%of the total number of patients with infertility[2].At present,Western medicine mostly uses ovulation,stimulating drugs to treat this disease.Still,due to the clinical result of“high ovulation but low pregnancy”,there are certain obstacles in treatment.The purpose of this article is to discuss Zhang Xiaofeng’s understanding of TCM of this disease.The tutor believes that the location of the disease is in the kidney,and the mechanism of the disease is kidney yin deficiency and blood heat.The treatment principle is sequential therapy,nourishing yin and clearing heat,taking into account the protection of the spleen and stomach,and the therapeutic effect is perfect.

Professor Xiaofeng’s Zhang Experience in Treating Postpartum Body Pain

Postpartum physical pain is common in clinic,mostly manifested in pain,numbness or weight,swelling and so on of limbs and joints during puerperium,and some of them fail to heal over the years,becoming stubborn“puerperal fever.”Mr.Zhang has been a doctor for more than 30 years.He has superb medical skills and has unique opinions on postpartum diseases.The author is lucky to follow-up.Now,his experience in syndrome differentiation and treatment of postpartum body pain is analyzed as follows,and the tested case is attached.

Brief Analysis of Treatment of Postpartum Body Pain by Professor Zhang Xiaofeng from the Viewpoint of “Liver Vital Deficiency and Yang Stagnation”

Postpartum body pain is a common gynecological disease in clinical setting.Its symptoms are complex and is difficult to treat.It is often treated in many ways but with poor results,which bring great pain to patients and their families.Professor Zhang Xiaofeng can effectively improve clinical treatment of this disease from the point of view of“liver vital deficiency and yang stagnation”.This paper mainly introduces the professional experience of Professor Zhang Xiaofeng in treating postpartum body pain.A clinical case was attached for reference as proof.

Discussing Professor Zhang Xiaofeng’s clinical experience in the diagnosis and treatment of menorrhagia by “Tongfa”

Through the understanding,identification and treatment of menorrhagia,summarizing professor Zhang Xiaofeng’s clinical experience in the treatment of menorrhagia,focusing on the identification of evidence,using“Tong”as the application,and treating in stages,he prepared Tongjing and Blood Regulating Soup and Tiaoping Tang as the basis for addition and subtraction,to harmonize the organs,qi and blood,Chong Ren and Uterus,in order to restore the balance of yin and yang and the function of Uterus in hiding and diarrhea.

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft

In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.

Application and prospect of the fluid cooling system of solar arrays for probing the Sun

The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,plans to complete the in situ detection of the solar eruption process and observation of the magnetic field structure response.The solar flux received by the satellite ranges from 10^(3) to 10^(6) Wm^(-2),which poses challenges for thermal management of the solar arrays.In this work,the solar array cooling system of the Parker Solar Probe is discussed,the developments of the fluid loop technique are reviewed,and a research plan for a next-generation solar array cooling system is proposed.This paper provides a valuable reference for novel thermal control systems in spacecraft for solar observation.

Nickel-based superalloy architectures with surface mechanical attrition treatment: Compressive properties and collapse behaviour

Surface modifications can introduce natural gradients or structural hierarchy into human-made microlattices,making them simultaneously strong and tough.Herein,we describe our investigations of the mechanical properties and the underlying mechanisms of additively manufactured nickel–chromium superalloy(IN625)microlattices after surface mechanical attrition treatment(SMAT).Our results demonstrated that SMAT increased the yielding strength of these microlattices by more than 64.71%and also triggered a transition in their mechanical behaviour.Two primary failure modes were distinguished:weak global deformation,and layer-by-layer collapse,with the latter enhanced by SMAT.The significantly improved mechanical performance was attributable to the ultrafine and hard graded-nanograin layer induced by SMAT,which effectively leveraged the material and structural effects.These results were further validated by finite element analysis.This work provides insight into collapse behaviour and should facilitate the design of ultralight yet buckling-resistant cellular materials.

PlaqueNet:deep learning enabled coronary artery plaque segmentation from coronary computed tomography angiography

Cardiovascular disease,primarily caused by atherosclerotic plaque formation,is a significant health concern.The early detection of these plaques is crucial for targeted therapies and reducing the risk of cardiovascular diseases.This study presents PlaqueNet,a solution for segmenting coronary artery plaques from coronary computed tomography angiography(CCTA)images.For feature extraction,the advanced residual net module was utilized,which integrates a deepwise residual optimization module into network branches,enhances feature extraction capabilities,avoiding information loss,and addresses gradient issues during training.To improve segmentation accuracy,a depthwise atrous spatial pyramid pooling based on bicubic efficient channel attention(DASPP-BICECA)module is introduced.The BICECA component amplifies the local feature sensitivity,whereas the DASPP component expands the network’s information-gathering scope,resulting in elevated segmentation accuracy.Additionally,BINet,a module for joint network loss evaluation,is proposed.It optimizes the segmentation model without affecting the segmentation results.When combined with the DASPP-BICECA module,BINet enhances overall efficiency.The CCTA segmentation algorithm proposed in this study outperformed the other three comparative algorithms,achieving an intersection over Union of 87.37%,Dice of 93.26%,accuracy of 93.12%,mean intersection over Union of 93.68%,mean Dice of 96.63%,and mean pixel accuracy value of 96.55%.

母猪妊娠后期肥胖将加重其围产期代谢紊乱,影响仔猪生产性能和肠道健康

研究探讨了妊娠后期母猪肥胖对其围产期代谢状况及仔猪生产性能、肠道健康和免疫系统的影响。选用经产长白×大白母猪60头,将妊娠109日龄母猪按背膘厚度分为两组(正常背膘厚度组=17 mm;背膘过厚组,≥21 mm)。试验结果表明,母猪妊娠后期背膘厚度过大,降低了活产仔猪总数和窝重。与正常背膘厚度母猪相比,背膘厚度过大会使母猪血糖、白介素6(IL-6)和肿瘤坏死因子-α(TNF-α)水平和稳态模型胰岛素评价抵抗值升高。过厚的背膘还降低了围产期母猪血浆中总超氧化物歧化酶的含量,增加了硫代巴比妥酸活性物质的含量。此外,过厚背膘母猪的粪便中TNF-α水平升高,而白介素10(IL-10)水平下降。最终结论是母猪妊娠后期肥胖加重了围产期母猪的代谢紊乱,降低了活产仔猪的数量,对母猪及其后代的肠道健康产生了不利影响。

选择性动脉介入术治疗妊娠滋养细胞肿瘤临床分析

目的:探讨选择性动脉栓塞(selective arterial embolization,SAE)术和动脉灌注化疗栓塞术在妊娠滋养细胞肿瘤(gestational trophoblastic neoplasia,GTN)治疗中的应用价值。方法:回顾性分析2010年7月至2020年1月27例于首都医科大学附属北京妇产医院行SAE治疗的GTN患者临床资料,分为动脉灌注化疗栓塞组(n=14)和单纯动脉栓塞组(n=13),所有患者行SAE治疗联合静脉化疗。超声检查子宫病灶大小改变、检测血清人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-HCG)下降水平及保留生育功能情况。结果:患者平均年龄为35.37(19~51)岁,17例活动性出血患者行SAE治疗后出血均得到有效控制,患者行静脉化疗的总疗程中位数为4个疗程,治疗过程中行子宫切除为6例。两组患者行SAE联合静脉化疗1个疗程,超声检查评定治疗有效率为51.8%(14/27),两组间比较差异无统计学意义(P=0.413);血清β-HCG平均下降(2.07±0.91)个对数,两组间比较差异无统计学意义(P=0.987)。结论:SAE治疗用于预防或控制高危GTN病灶出血效果肯定,动脉灌注化疗未明显提高动脉栓塞联合静脉化疗的疗效。

利用CRISPR/Cas9系统构建FGF21基因敲除小鼠模型

成纤维细胞生长因子(fibroblast growth factors,FGFs)是细胞间的多功能信号分子,调节生物体的多种生理功能。FGF21作为一种重要的调控因子,对毛囊发育及生长周期具有重要作用。为研究FGF21基因对毛囊发育及生长周期的影响及作用机制,本研究通过构建靶向敲除FGF21基因的载体,体外将Cas9 m RNA和g RNA显微注射到FVB小鼠受精卵中,在小鼠FGF21基因的第1外显子上造成移码突变,从而获得FGF21基因敲除(knock out,KO)小鼠。通过测序鉴定F0代小鼠基因型,共获得3只FGF21等位基因敲除小鼠(Fgf21^(-/-));q RT-PCR和Western blotting结果表明,在Fgf21^(-/-)小鼠中未检测到FGF21 m RNA表达和FGF21蛋白表达;经脱毛再生及皮肤组织H&E染色发现,与野生型(wild type,WT)小鼠相比,Fgf21^(-/-)小鼠体重降低、器官组织未出现异常变化、毛发生长速度减慢、毛囊的直径和毛发的密度均减小。本研究利用CRISPR/Cas9技术成功构建了Fgf21^(-/-)小鼠模型,为后续研究FGF21基因在毛囊发育及生长周期中的功能提供了更好的动物模型。

VLC-Based Indoor Positioning Algorithm Combined with OFDM and Particle Filter

Visible light communications(VLC) have recently attracted a growing interest and can be a potential solution to realize indoor positioning,however,the performance of existing indoor positioning system is limited by multipath distortion inside a room.In order to combat the effect of multipath distortion,this paper proposes an LED-based indoor positioning algorithm combined with hybrid OFDM(HOFDM),in which asymmetrically clipped optical OFDM(ACOOFDM) is transmitted on the odd subcarriers while using pulse amplitude modulated discrete multitone(PAM-DMT) to modulate the imaginary part of each even subcarrier.In this scheme,we take a combined approach where a received-signal-strength(RSS) technique is employed to determine the location of the receiver and realize the 3-D positioning by Trust-region-based positioning.Moreover,a particle filter is used to further improve the positioning accuracy.Results confirm that this proposed positioning algorithm can achieve high accuracy even with multipath distortion,and the algorithm has better performance when combined with particle filter.

Mechanisms underlying attenuation of apoptosis of cortical neurons in the hypoxic brain by flavonoids from the stems and leaves of Scutellaria baicalensis Georgi

Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi, an antioxidant, markedly improve memory impairments and neuronal injuries. In the present study, primary cortical neurons of rats were exposed to potassium cyanide to establish a model of in vitro neural cell apoptosis. Inhibition of apoptosis by flavonoids from the stems and leaves of Scutellaria baical- ensis Georgi at concentrations of 18.98, 37.36, and 75.92 gg/mL was detected using this model. These flavonoids dramatically increased cell survival, inhibited cell apoptosis and excessive pro- duction of malondialdehyde, and increased the activities of superoxide dismutase, glutathione peroxidase, and Na＋-K＊-ATPase in primary cortical neurons exposed to potassium cyanide. The flavonoids from the stems and leaves of Scutellaria baicalensis Georgi were originally found to have a polyhydric structure and to protect against cerebral hypoxia in in vitro and in vivo models, including hypoxia induced by potassium cyanide or cerebral ischemia. The present study suggests that flavonoids from the stems and leaves of Scutellaria baicalensis Georgi exert neuroprotective effects via modulation of oxidative stress, such as malondialdehyde, superoxide dismutase, glutathione peroxidase and Na＋-K＋-ATPase disorders induced by potassium cyanide.

The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite

The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.

Robust Dataset Classification Approach Based on Neighbor Searching and Kernel Fuzzy C-Means

Dataset classification is an essential fundament of computational intelligence in cyber-physical systems (CPS). Due to the complexity of CPS dataset classification and the uncertainty of clustering number, this paper focuses on clarifying the dynamic behavior of acceleration dataset which is achieved from micro electro mechanical systems (MEMS) and complex image segmentation. To reduce the impact of parameters uncertainties with dataset classification, a novel robust dataset classification approach is proposed based on neighbor searching and kernel fuzzy c-means (NSKFCM) methods. Some optimized strategies, including neighbor searching, controlling clustering shape and adaptive distance kernel function, are employed to solve the issues of number of clusters, the stability and consistency of classification, respectively. Numerical experiments finally demonstrate the feasibility and robustness of the proposed method. © 2014 Chinese Association of Automation.

Coupling of ultrasmall and small CoxP nanoparticles confined in porous SiO2 matrix for a robust oxygen evolution reaction

Rational design of electrocatalysts is important for a sustainable oxygen evolution reaction(OER).It is still a huge challenge to engineer active sites in multi-sizes and multi-components simultaneously.Here,a series of CoxP nanoparticles(NPs)confined in an SiO2matrix(SiO2/CoxP)is designed and synthesized as OER electrocatalysts.The phosphorization of the hydrolyzed Co-phyllosilicate promotes the formation of ultrasmall and small Co2P and CoP.These are firmly confined in the SiO2matrix.The coupling of multi-size and multi-component CoxP catalysts can regulate reaction kinetics and electron transfer ability,enrich the active sites,and eventually promote the intrinsic OER activity.The SiO2matrix provides abundant porous structure and oxygen vacancies,and these facilitate the exposure of active sites and improve conductivity.Because of the synergy and interplay of multisized/component CoxP NPs and the porous SiO2matrix,the unique SiO2/CoxP heterostructure exhibits low overpotential(293 m V@10 mA cm-2),and robust stability(decay 12 mV after 5000 CV cycles,97.4%of initial current after 100 h chronoamperometric)for the OER process,exceeding many advanced metal phosphide electrocatalysts.This work provides a novel tactic to design low-cost,simple,and highly efficient OER electrocatalysts.

Experimental Research on Structural Behaviors of Glulam I-Beam with a Special-Shaped Section

In order to enhance the bearing capacity of structural components,save materials,and reduce cost,a glued laminated timber(glulam)I-beam that is theoretically suitable for engineering application was proposed.In this study,18 glulam specimens were fabricated using larch dimension lumber and resorcinol-formaldehyde resin.Four-point bending tests were carried out to compare the ultimate bearing capacity,strain,and deflection of various specimens.The results showed that:(1)The typical failure mode at bending is the web shear failure parallel to grain.Before the failure,cracks and sounds appear at the beam web,which represent the sudden brittle failure.(2)The cross-sectional strain of glulam beam changed linearly with the beam height,indicating that the plane section assumption was basically established.(3)Stiffener could improve the initial flexural stiffness of glulam beam,which experiences an increase of 28.21%.Larger the shear span ratio,smaller the initial flexural stiffness.The initial flexural stiffness improves by 10-23.5%with the increase in the thickness of the lower flange.(4)The effects of stiffener and shear-span ratio on shear strength are relatively significant.After the stiffeners are set at the support and the loading point in pairs,the shear strength of the glulam beam increases by 15.05%averagely.With the increase in the shear-span ratio,the shearing strength of the glulam I-beam gradually reduces.The equation of the shearing strength with the shear span ratio is obtained,which is shown by high fitting precision.(5)The shear strength correlation,as proposed by Soltis and Rammer,is suitable not only for rectangular beams,but also for glulam I-beams.

Structural characteristics,anticoagulant and antithrombotic mechanism of a novel polysaccharide from Rosa Chinensis Flos

This is the first report on a polysaccharide(RCJ2-Ib)isolated from Rosa Chinensis Flos.RCJ2-Ib was obtained through the extraction with water,precipitation with ethanol,separation with DEAE-52 column and purification with DEAE-Sepharose Fast Flow column and Sephadex G100 column.GC,FT-IR and NMR analyses revealed that RCJ2-Ib(3.3 k Da)was a 1,4-linked polymannuronic acid containing substantialβ-Danomers units.The anticoagulant effect of RCJ2-Ib evaluated by using rabbit ear venous blood and an acute blood stasis rat model showed that RCJ2-Ib had obvious anticoagulant activity in regulating endogenous and exogenous coagulation pathways and reducing serum thromboxane B2 and endothelin-1.In addition,RCJ2-Ib could also increase the number of Lactobacillus and Escherichia coli.As a result,RCJ2-Ib has the potential to inhibit thrombosis and maintain the intestinal environment.

Correlation of obstructive sleep apnea hypopnea syndrome with metabolic syndrome in snorers

Though obstructive sleep apnea hypopnea syndrome（OSAHS） and metabolic syndrome（MS） are correlated;the contributing factors for the occurrence of MS in Chinese snorers remain largely undefined.We aimed to investigate the associated pathogenesis of coexistence of OSAHS and MS in Chinese snorers.A total of 144 Chinese habitual snorers were divided into 3 groups,the control group（simple snorers）（n = 36）,the mild OSAHS group（n= 52）and the moderate-to-severe OSAHS group（n = 56）.The incidence of MS in the moderate-to-severe OSAHS group（26.8%） was significantly higher than that in the control group（8.3%）,the mild OSAHS group（11.1%） and all the OSAHS patients（19.45%）（all P 〈 0.05）.Homeostatic model assessment（HOMA） index and proinsulin（PI） were negatively correlated with nocturnal meanSpO2 and miniSpO2.Meanwhile,nocturnal SpO2 were negatively correlated with body mass index,waist and neck circumferences and diastolic blood pressure,but positively correlated with total cholesterol and high-density lipoprotein cholesterol.The study indicated that in Chinese snorers,moderate-to-severe OSAHS was closely associated with MS via nocturnal hypoxemia.