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公共服务动机的副作用:文献评述与机制探究
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作者 张书维 张晓会 +1 位作者 秦枭童 尚哲 《公共行政评论》 CSSCI 北大核心 2024年第3期175-194,200,共21页
公共服务动机是公共管理领域长久不衰的重要议题,也是公共部门组织行为研究的持续焦点。公共服务动机常与积极的工作态度和行为相关联,但近年来一些研究发现公共服务动机会正向影响消极满意度、职业倦怠、缺勤等一系列消极的工作态度、... 公共服务动机是公共管理领域长久不衰的重要议题,也是公共部门组织行为研究的持续焦点。公共服务动机常与积极的工作态度和行为相关联,但近年来一些研究发现公共服务动机会正向影响消极满意度、职业倦怠、缺勤等一系列消极的工作态度、心理健康和工作行为。论文利用PRISMA方法对现有讨论公共服务动机负面影响的文献进行全面梳理与总结,并借鉴个体-环境(不)匹配理论和工作需求-资源模型,揭示公共服务动机在作为自变量与调节变量时产生负面结果的机制差异,具体为:“物极必反”效应——个体-环境匹配在公共服务动机与工作投入的关系间发生催化作用;“负正得负”效应——公共服务动机增强个体-环境不匹配与资源损耗间的关系。未来研究可关注上述负面结果的可复制性,挖掘组织层面的负面影响,以及开发缓解公共服务动机负面结果的工具,从理论与实践层面重视公共服务动机的副作用。 展开更多
关键词 公共服务动机 负面结果 个体-环境(不)匹配 工作需求-资源模型 系统综述
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Investigation and Analysis of Nutrition Components of Wild Chives Collected from Hezhang County of Guizhou Province
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作者 Haiping WANG Yang QIU +3 位作者 Fangwei LI Jiangping SONG xiaohui zhang Xixiang LI 《Asian Agricultural Research》 2018年第4期93-98,共6页
Guizhou Province is an important distribution area of wild onion resources,and a large area of wild( Chinese) chives are distributed in Hezhang County. In order to understand and study the distribution of wild chives,... Guizhou Province is an important distribution area of wild onion resources,and a large area of wild( Chinese) chives are distributed in Hezhang County. In order to understand and study the distribution of wild chives,the geographical distribution,habitats and climate of wild chives in Hezhang County were investigated,and the main nutrition components of wild chives were analyzed. The results indicated that there were mainly three kinds of wild chives distributed in Hezhang County, including Allium wallichii Kunth., Allium ovalifolium Hand.-Mazz.( tentatively named),and Allium hookeri Thwaites( tentatively named). Among the 17 kinds of amino acids,except for proline,the content of other amino acids in wild chives was higher than that of the cultivated chives( Allaum tuberosum Rottler ex Spreng.). The sugar content of wild chives was significantly lower than the cultivated chives. Among nine trace elements,the manganese,zinc and iron content of A. ovalifolium Hand.-Mazz. were significantly higher than that of the cultivated chives and other wild chives. Among the four kinds of heavy metals,cadmium content in the three kinds of wild chives exceeded the limitation of the national standard,and cadmium content in A. ovalifolium Hand.-Mazz. was significantly higher than that of the others. Arsenic,mercury and lead content in A. ovalifolium Hand.-Mazz. also exceeded the limitation of the national standard. Vitamin C content in leaves and stalk of A. wallichii Kunth. in the original habits was higher than that of the cultivated chives. The biological characteristics and nutrition components of the wild chives from Hezhang County were significantly different from that of the cultivated chives. The collection and preservation of these resources are of great significance to the enriching of diversity of Chinese chive resources and has great development and utilization value to the improvement of nutritional quality of Chinese chives. 展开更多
关键词 Wild chives Cultivate chives Nutrition component
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电化学合成二苯甲酮的绿色化学实验
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作者 胡良桢 倪黎 +3 位作者 牛子怡 张晓慧 秦波 熊燕 《大学化学》 CAS 2024年第6期350-356,共7页
醇氧化成酮是本科有机化学理论教学内容的重要组成部分。本实验反应产物二苯甲酮在光引发剂与紫外光固化涂料等领域中均具有广泛的应用。以二苯甲酮为骨架的化合物在药物靶向释放领域也有一定的应用。已知制备二苯甲酮的反应涉及反应时... 醇氧化成酮是本科有机化学理论教学内容的重要组成部分。本实验反应产物二苯甲酮在光引发剂与紫外光固化涂料等领域中均具有广泛的应用。以二苯甲酮为骨架的化合物在药物靶向释放领域也有一定的应用。已知制备二苯甲酮的反应涉及反应时间长、使用重金属氧化试剂、脱氢催化剂制备过程复杂等制约因素,使得这些反应在本科实验教学的应用上仍有不足,需要改进。本文利用电化学合成方法,设计了一种绿色环保的合成二苯甲酮的实验方法。该方法用碘化钾作为电解质,乙腈和水的混合溶液作为反应溶剂,直接电解,在不直接添加氧化试剂或者脱氢试剂的情况下将二苯甲醇氧化成二苯甲酮。改进后的方法反应时间较短,产率高,后处理简单,用到的试剂价廉易得,更适用于基础有机实验教学。本实验结合薄层色谱(TLC)、熔点测定、1HNMR以及液质联用仪对反应体系或产物进行分析与结构鉴定,有助于培养学生的实验操作能力与产物鉴定能力。 展开更多
关键词 二苯甲酮 二苯甲醇 电化学氧化
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Importance of V^(4)and optimal acid environment in the hydroxylation of inert benzene via activation of C_(sp2)-H bond
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作者 Peng Dong Yang Xin +6 位作者 Yanwei Li xiaohui zhang Xiaorui Wang Yu Zhao Dongqiang zhang Haowen Ma Guixian Li 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第10期216-226,共11页
Hydroxylation of inert benzene through the activation of the C_(sp2)-H bond is a representative reaction about the transformation of C-H bonds to C-O bonds,which has far-reaching guiding significance but remains a cha... Hydroxylation of inert benzene through the activation of the C_(sp2)-H bond is a representative reaction about the transformation of C-H bonds to C-O bonds,which has far-reaching guiding significance but remains a challenging scientific problem.To overcome this problem,a series of VOx-Ga_(2)O_(3)/SiO_(2)-Al_(2)O_(3)were prepared to achieve an efficient and economical hydroxylation path of benzene to phenol.The results showed that the phenol yield was 72.89%(selectivity>98.1%)under the optimum conditions.The reason is that the C-H bond in the benzene ring is activated by heterolysis over a VOx-Ga_(2)O_(3)/SiO_(2)-Al_(2)O_(3)catalyst.Meanwhile,the introduction of aluminum(Al)and gallium(Ga)made a qualitative change in the catalyst,enhancing the electron motion and spin motion of vanadium species,resulting in the increase of V4^(+)/V5^(+)ratio.In addition,the catalyst can provide an optimal acidic environment and a threedimensional cross-linked surface structure that facilitates product diffusion. 展开更多
关键词 C_(sp2)-H activation V4^(+)/V5^(+)ratio Acid microenvironment Catalysis Support Catalyst activation
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Quality-adjusted time without symptoms or toxicity analysis of haploidentical-related donor vs.identical sibling donor hematopoietic stem cell transplantation in acute myeloid leukemia
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作者 Yuewen Wang Xianli Gao +12 位作者 Ting Wang xiaohui zhang Lanping Xu Yu Wang Chenhua Yan Huan Chen Yuhong Chen Wei Han Fengrong Wang Jingzhi Wang Xia Yan Xiaodong Mo Xiaojun Huang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2024年第5期530-544,共15页
Objective:We aimed to compare the quality-adjusted time without symptoms or toxicity(Q-TWiST)in acute myeloid leukemia(AML)patients who received haploidentical-related donor(HID)and identical sibling donor(ISD)hematop... Objective:We aimed to compare the quality-adjusted time without symptoms or toxicity(Q-TWiST)in acute myeloid leukemia(AML)patients who received haploidentical-related donor(HID)and identical sibling donor(ISD)hematopoietic stem cell transplantation(HSCT).Methods:Five clinical health states were defined:toxicity(TOX),acute graft-versus-host disease(GVHD),chronic GVHD(cGVHD),time without symptoms and toxicity(TWiST)and relapse(REL).The equation used in this study was as follows:Q-TWiST=UTOX×TOX+UTWiST×TWiST+UREL×REL+UaGVHD×aGVHD+UcGVHD×cGVHD.Results:A total of 239 AML patients were enrolled.We established a mathematical model,i.e.,Q-TWiST HID HSCT>Q-TWiST ISD HSCT,to explore the range of utility coefficients satisfying the inequality.Based on the raw data,the utility coefficient is equivalent to the following inequality:10.57067UTOX-46.27733UREL+105.9374+3.388078UaGVHD-210.8198UcGVHD>0.The model showed that when UTOX,UREL,and UaGVHD were within the range of 0-1,as well as when UcGVHD was within the range of 0-0.569,the inequality Q-TWiST HID HSCT>Q-TWiST ISD HSCT was valid.According to the results of the ChiCTR1800016972 study,the median coefficients of TOX,acute GVHD(aGVHD),and cGVHD were 0.56(0.41-0.76),0.56(0.47-0.72),and 0.54(0.37-0.79),respectively.We selected a series of specific examples of the coefficients,i.e.,UTOX=0.5,UREL=0.05,UaGVHD-0.5,and UcGVHD-0.5.The Q-TWiST values of ISD and HID HSCT were 896 and 900 d,respectively(P=0.470).Conclusions:We first observed that Q-TWiST was comparable between AML patients receiving HID HSCT and those receiving ISD HSCT. 展开更多
关键词 Quality-adjusted time without symptoms or toxicity acute myeloid leukemia allogeneic hematopoietic stem cell transplantation HAPLOIDENTICAL
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Virtual source approach for maximizing resolution in high-penetration gamma-ray imaging
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作者 Yuchi Wu Shaoyi Wang +14 位作者 Bin Zhu Yonghong Yan Minghai Yu Gang Li xiaohui zhang Yue Yang Fang Tan Feng Lu Bi Bi Xiaoqin Mao Zhonghai Wang Zongqing Zhao Jingqin Su Weimin Zhou Yuqiu Gu 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第3期19-30,共12页
High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost th... High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray source.In conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung radiation.The size of the gamma-ray source is dependent on the dimensional characteristics of the electron beam.Extensive research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in NDT.In our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial resolution.In this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission area.On the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission angle.Under optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm. 展开更多
关键词 RESOLUTION APPROACH utilizing
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Optimization Conditions of Wheat Mesophyll Protoplast Isolation 被引量:3
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作者 Xingyue Jia xiaohui zhang +1 位作者 Jingming Qu Rong Han 《Agricultural Sciences》 2016年第12期850-858,共10页
The research object of this study is “ML7113” wheat leaf, which is used to isolate protoplast with enzyme hydrolysis method. Three main effectors—the concentration of mannitol, enzymolysis time and centrifugal forc... The research object of this study is “ML7113” wheat leaf, which is used to isolate protoplast with enzyme hydrolysis method. Three main effectors—the concentration of mannitol, enzymolysis time and centrifugal force, affect the production and vitality of protoplast. While the production and vitality of wheat protoplasts were detected by the hemacytometer and the FDA staining respectively. Results showed that, with the increasing concentrations of mannitol during 0.2 M - 0.4 M, protoplast yield increases and when the concentration is 0.4 M, the protoplast vitality can be up to 95%;with the extension of enzymolysis time in 2 h to 8 h, protoplast yield reaches a maximum in 6 h, but its vitality achieves the maximum in 4 h;considering a combination of these two factors impacting on protoplast, we obtain the best time to digest for 4 h;meanwhile, with the increasing of the centrifugal force from 500 rpm - 2000 rpm, its comprehensive effect of protoplast vitality and yield is the highest when the centrifugal force is 1000 rpm for 2 min (replicated three times). So 0.4 M mannitol, 4 h enzymolysis time and 1000 rpm for 2 min centrifugal force are the best separation condition. 展开更多
关键词 WHEAT PROTOPLAST MANNITOL Enzymolysis Time Centrifugal Force
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Study on Diagnosis Weather Process and Flight Impact of Heavy Snowfall in Northeast China “11/2021” 被引量:2
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作者 xiaohui zhang Hengrui Tao Ying Zheng 《Journal of Geoscience and Environment Protection》 2022年第5期170-183,共14页
Based on ERA5 reanalysis data, the characteristics of weather situation, water vapor condition, dynamic uplift condition, energy condition, ice accumulation environment and flight effect of aircraft in the heavy snowf... Based on ERA5 reanalysis data, the characteristics of weather situation, water vapor condition, dynamic uplift condition, energy condition, ice accumulation environment and flight effect of aircraft in the heavy snowfall process in northeast China from November 5 to 12, 2021 are analyzed. The results show that the heavy snowfall process in Northeast China is caused by the combination of Northeast China Cold Vortex, trough, low level frontal cyclone and cold front. Through the analysis of the physical field, it is found that the sufficient water vapor transport is from the south and the southeast, the convergence rising in the lower layer, divergence “pumping” in the upper layer, air flow rising in the vertical plane and a large amount of convection effective potential energy are all contributing to the heavy snowfall. The impact of heavy snowfall on flight mainly includes low visibility and ice accumulation. Water vapor flux, water vapor flux divergence, vertical velocity, potential temperature and convective effective potential energy can all be used as the judging indexes of heavy snowfall forecast. 展开更多
关键词 Heavy Snow Weather Situation Water Vapor Energy Aircraft Icing
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Bioinformatics of Profilin in Wheat 被引量:1
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作者 Jingming Qu xiaohui zhang +1 位作者 Xingyue Jia Rong Han 《Open Journal of Immunology》 2016年第4期181-188,共8页
Profilin is a small actin-binding protein that is essential in all organisms. While the wheat genome sequence database is not currently available, the exploration of bioinformatics is very important. Therefore, this a... Profilin is a small actin-binding protein that is essential in all organisms. While the wheat genome sequence database is not currently available, the exploration of bioinformatics is very important. Therefore, this article predicted the structure and function of profilin in wheat by bioinformatics methods. The amino acid sequence of profilin was searched in GeneBack. While its signal peptides were analyzed through CBS prediction server, the hydrophobicities were analyzed by bioedit software, we used EMBnet server and DNAstar to analyse the transmembrane domains and the B-cell epitopes of the profilin respectively. Finally, the tertiary structure of the protein was predicted through Swiss-Model. This information will help develop rational strategies to improve the component-resolving diagnosis and immunotherapy of profilin allergy. 展开更多
关键词 WHEAT Profilin Allergic BIOINFORMATICS
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中性粒细胞胞外诱捕网在弥漫性大B细胞淋巴瘤中的研究进展 被引量:2
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作者 姚倩 张小慧 +4 位作者 胡耀嘉 金建君 刘淑媚 张燕(综述) 席亚明(审校) 《中国肿瘤临床》 CAS CSCD 北大核心 2022年第4期210-213,共4页
中性粒细胞作为血液循环中的一种静态细胞,在受到微生物侵袭时发挥吞噬及杀菌作用,中性粒细胞激活后形成一种特殊的网状结构-中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)。NETs是一把双刃剑。正常情况下,NETs发挥清除... 中性粒细胞作为血液循环中的一种静态细胞,在受到微生物侵袭时发挥吞噬及杀菌作用,中性粒细胞激活后形成一种特殊的网状结构-中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)。NETs是一把双刃剑。正常情况下,NETs发挥清除病原微生物的作用,但NETs产生过量时,其则参与多种疾病的发展过程,如自身免疫性疾病、糖尿病、动脉粥样硬化、血管炎等疾病。此外,NETs还与多种恶性肿瘤的增殖、转移、预后等密切相关。本文将从NETs的形成及其对弥漫性大细胞淋巴瘤的影响进行综述。 展开更多
关键词 中性粒细胞 中性粒细胞胞外诱捕网 弥漫性大B细胞淋巴瘤 预后
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Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation 被引量:8
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作者 Yifei Cheng Yuhong Chen +11 位作者 Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu xiaohui zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang 《Engineering》 SCIE EI 2019年第1期150-155,共6页
Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after ... Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. 展开更多
关键词 Donor-derived CD19-targeted T CELL INFUSION Hematopoietic stem CELL transplantation B CELL acute lymphoblastic leukemia Minimal residual disease
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Modeling and analysis of Schistosoma Argonaute protein molecular spatial conformation 被引量:4
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作者 Jianhua zhang Zhigang Shang +1 位作者 xiaohui zhang Yuntao zhang 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第4期275-278,共4页
Objective:To analyze the amino acid sequence composition,secondary structure,the spatial conformation of its domain and other characteristics of Argonaute protein.Methods:Bioinformatics tools and the internet server w... Objective:To analyze the amino acid sequence composition,secondary structure,the spatial conformation of its domain and other characteristics of Argonaute protein.Methods:Bioinformatics tools and the internet server were used.Firstly,the amino acid sequence composition features of the Argonaute protein were analyzed,and the phylogenetic tree was constructed.Secondly,Argonaute protein's distribution of secondary structure and its physicochemical properties were predicted.Lastly,the protein functional expression form of the domain group was established through the Phyre-based analysis on the spatial conformation of Argonaute protein domains.Results:593 amino acids were encoded by Argonaute protein,the phylogenetic tree was constructed,and Argonaute protein's distribution of secondary structure and its physicochemical properties were obtained through analysis.In addition,the functional expression form which comprised the N-terminal PAZ domain and C-terminal Piwi domain for the Argonaute protein was obtained with Phyre.Conclusions:The information relationship between the structure and function of the Argonaute protein can be initially established with bioinformatics tools and the internet server,and this provides the theoretical basis for further clarifying the function of Schistosoma Argonaute protein. 展开更多
关键词 ARGONAUTE protein Distribution of SECONDARY structure Phyre Domain SCHISTOSOMA SPATIAL CONFORMATION AMINO acid sequence
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An ultra-robust fingerprinting method for quality assessment of traditional Chinese medicine using multiple reaction monitoring mass spectrometry 被引量:4
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作者 Zhenhao Li xiaohui zhang +2 位作者 Jie Liao xiaohui Fan Yiyu Cheng 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第1期88-95,共8页
Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine.However,this pattern-oriented approach still has some weak points i... Chromatographic fingerprinting has been perceived as an essential tool for assessing quality and chemical equivalence of traditional Chinese medicine.However,this pattern-oriented approach still has some weak points in terms of chemical coverage and robustness.In this work,we proposed a multiple reaction monitoring(MRM)-based fingerprinting method in which approximately 100 constituents were simultaneously detected for quality assessment.The derivative MRM approach was employed to rapidly design MRM transitions independent of chemical standards,based on which the large-scale fingerprinting method was efficiently established.This approach was exemplified on QiShenYiQi Pill(QSYQ),a traditional Chinese medicine-derived drug product,and its robustness was systematically evaluated by four indices:clustering analysis by principal component analysis,similarity analysis by the congruence coefficient,the number of separated peaks,and the peak area proportion of separated peaks.Compared with conventional ultraviolet-based fingerprints,the MRM fingerprints provided not only better discriminatory capacity for the tested normal/abnormal QSYQ samples,but also higher robustness under different chromatographic conditions(i.e.,flow rate,apparent pH,column temperature,and column).The result also showed for such large-scale fingerprints including a large number of peaks,the angle cosine measure after min-max normalization was more suitable for setting a decision criterion than the unnormalized algorithm.This proof-of-concept application gives evidence that combining MRM technique with proper similarity analysis metrices can provide a highly sensitive,robust and comprehensive analytical approach for quality assessment of traditional Chinese medicine. 展开更多
关键词 Multiple reaction monitoring Mass spectrometry-based fingerprinting Quality assessment Traditional Chinese medicine Robustness evaluation
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Design and platform testing of the compact torus central fueling device for the EAST tokamak 被引量:2
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作者 孔德峰 庄革 +15 位作者 兰涛 张寿彪 叶扬 董期龙 陈晨 吴捷 张森 赵志豪 孟凡卫 张小辉 黄艳清 文斐 訾鹏飞 李磊 胡广海 宋云涛 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第6期95-102,共8页
Compact torus(CT)injection is a highly promising technique for the central fueling of future reactor-grade fusion devices since it features extremely high injection velocity and relatively high plasma mass.Recently,a ... Compact torus(CT)injection is a highly promising technique for the central fueling of future reactor-grade fusion devices since it features extremely high injection velocity and relatively high plasma mass.Recently,a CT injector for the EAST tokamak,EAST-CTI,was developed and platform-tested.In the first round of experiments conducted with low parameter settings,the maximum velocity and mass of the CT plasma were 150 km·s^(-1)and 90μg,respectively.However,the parameters obtained by EAST-CTI were still very low and were far from the requirements of a device such as EAST that has a strong magnetic field.In future,we plan to solve the spark problem that EAST-CTI currently encounters(that mainly hinders the further development of experiments)through engineering methods,and use greater power to obtain a more stable and suitable CT plasma for EAST. 展开更多
关键词 compact torus(CT) central fueling EAST-CTI EAST tokamak
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Investigation of the compact torus plasma motion in the KTX-CTI device based on circuit analyses 被引量:2
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作者 Qilong DONG Defeng KONG +19 位作者 Xiaohe WU Yang YE Kun YANG Tao LAN Chen CHEN Jie WU Sen zhang Wenzhe MAO Zhihao ZHAO Fanwei MENG xiaohui zhang Yanqing HUANG Wei BAI Dezheng YANG Fei WEN Pengfei ZI Lei LI Guanghai HU Shoubiao zhang Ge ZHUANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第2期36-44,共9页
Compact torus(CT)injection is one of the most promising methods for the central fuelling of next-generation reactor-grade fusion devices due to its high density,high velocity,and selfcontained magnetised structure.A n... Compact torus(CT)injection is one of the most promising methods for the central fuelling of next-generation reactor-grade fusion devices due to its high density,high velocity,and selfcontained magnetised structure.A newly compact torus injector(CTI)device in Keda Torus e Xperiment(KTX),named KTX-CTI,was successfully developed and tested at the University of Science and Technology in China.In this study,first,we briefly introduce the basic principles and structure of KTX-CTI,and then,present an accurate circuit model that relies on nonlinear regression analysis(NRA)for studying the current waveform of the formation region.The current waveform,displacement,and velocity of CT plasma in the acceleration region are calculated using this NRA-based one-dimensional point model.The model results were in good agreement with the experiments.The next-step upgrading reference scheme of the KTX-CTI device is preliminarily investigated using this NRA-based point model.This research can provide insights for the development of experiments and future upgrades of the device. 展开更多
关键词 compact torus(CT) circuit modelling nonlinear regression analysis(NRA) point model
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Large-scale population structure and genetic architecture of agronomic traits of garlic 被引量:2
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作者 Huixia Jia Qing Zhao +5 位作者 Jiangping Song xiaohui zhang Wenlong Yang Zhenzhen Du Yue Zhu Haiping Wang 《Horticulture Research》 SCIE CSCD 2023年第4期187-199,共13页
Garlic,an asexually propagated crop,is the second important bulb crop after the onion and is used as a vegetable and medicinal plant.Abundant and diverse garlic resources have been formed over thousands of years of cu... Garlic,an asexually propagated crop,is the second important bulb crop after the onion and is used as a vegetable and medicinal plant.Abundant and diverse garlic resources have been formed over thousands of years of cultivation.However,genome variation,population structure and genetic architecture of garlic agronomic traits were still not well elucidated.Here,1100258 single nucleotide polymorphisms(SNPs)were identified using genotyping-by-sequencing in 606 garlic accessions collected from43 countries.Population structure,principal component and phylogenetic analysis showed that these accessions were divided into five subpopulations.Twenty agronomic traits,including above-ground growth traits,bulb-related and bolt-related traits in two consecutive years were implemented in a genome-wide association study.In total,542 SNPs were associated with these agronomic traits,among which 188 SNPs were repeatedly associated with more than two traits.One SNP(chr6:1896135972)was repeatedly associated with ten traits.These associated SNPs were located within or near 858 genes,56 of which were transcription factors.Interestingly,one non-synonymous SNP(Chr4:166524085)in ribosomal protein S5 was repeatedly associated with above-ground growth and bulb-related traits.Additionally,gene ontology enrichment analysis of candidate genes for genomic selection regions between complete-bolting and non-bolting accessions showed that these genes were significantly enriched in‘vegetative to reproductive phase transition of meristem’,‘shoot system development’,‘reproductive process’,etc.These results provide valuable information for the reliable and efficient selection of candidate genes to achieve garlic genetic improvement and superior varieties. 展开更多
关键词 AGRONOMIC TRAITS repeatedly
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Influence of High-Velocity Blood Flow on Right-to-Left Shunt in Patients with Patent Foramen Ovale during the Valsalva Maneuver 被引量:2
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作者 xiaohui zhang Baomin Liu 《Journal of Biosciences and Medicines》 2019年第1期13-22,共10页
In this study, we investigated the changes in the right-to-left shunt (RLS) of the patent foramen ovale (PFO) at different phases of the Valsalva maneuver and analyzed the possible mechanisms. The study population con... In this study, we investigated the changes in the right-to-left shunt (RLS) of the patent foramen ovale (PFO) at different phases of the Valsalva maneuver and analyzed the possible mechanisms. The study population consisted of 57 patients with symptoms highly suggestive of a PFO. These patients had been diagnosed with apsychia, migraine with aura, cerebral infarction, transient ischemic attack (TIA), and cerebral ischemia with unknown cause. Routine echocardiography was performed in all patients to rule out a cardiac malformation. Contrast-transcranial Doppler (c-TCD) and contrast-enhanced transthoracic echocardiography (c-TTE) were used to visualize and quantify the RLS. The standard apical four chamber view was used to observe the changes of E peak, A peak, and velocity-time integral (VTI) ratio of tricuspid blood flow during the strain phase and release phase of the Valsalva maneuver. Paired t-test was used to compare E peak, A peak, and VTI ratio of tricuspid blood flow during the different phases. The right-to-left shunt across the PFO (PFO-RLS) was graded in the two phases and compared by Kruskal-Wallis test. Compared with the strain phase of the Valsalva maneuver, the parameters of E, A, and VTI in diastolic period in patients with PFO-RLS at the release phase were significantly increased [54.30 ± 13.65 cm/s vs 100.35 ± 21.11 cm/s, 42.21 ± 12.32 cm/s vs 57.30 ± 18.88 cm/s, 10.34 ± 3.27 cm/s vs 19.58 ± 4.56 cm/s, respectively], and the difference was statistically significant. The positive consequence of PFO-RLS, as diagnosed by c-TTE with the Valsalva maneuver at the release phase of the Valsalva maneuver, was significantly higher than that at the strain phase of the Valsalva maneuver. At the beginning of release phase of the Valsalva maneuver, decreased intrathoracic pressure led to increased venous backflow into the right atrium. Thus, high-velocity blood flow rapidly pushed the PFO open, which resulted in a significant increase in the PFO-RLS. Therefore, the increase of the PFO-RLS during the Valsalva maneuver is caused by the impact of high-velocity blood flow the PFO. 展开更多
关键词 PATENT Foramen Ovale Right to Left SHUNT VALSALVA MANEUVER HIGH-VELOCITY Blood Flow
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TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling 被引量:1
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作者 Li Ma Chunhua She +13 位作者 Qian Shi Qiang Yin Xinxin Ji Yongrong Wang Yulong Fan Xinyao Kong Peng Li Zengfeng Sun xiaohui zhang Zhen zhang Jian Wang Tong Wang Yuanfu Xu Wenliang Li 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第3期606-617,共12页
Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma patients.The mechanism behind this type of... Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma patients.The mechanism behind this type of primary resistance is not well understood.The aim of this study was to investigate gefitinib resistance in glioblastoma, and explore ways to circumvent this significant clinical problem.Methods: MTT method was used to test the cell viability after EGFR-positive glioblastoma cells were treated with indicated drugs;real-time quantitative PCR method was included to detect the TNFα mRNA levels in glioma tissues and cell lines.ELISA was introduced to measure the TNFα protein levels in cell culture supernatant of glioblastoma cells treated with gefitinib.Western blot was used to detect the activity change of intracellular kinases in drug-treated glioblastoma cells.Two mouse xenograft tumor models were carried out to evaluate the in vivo effects of a combination of EGFR and TNFα inhibitors.Results: We found that glioblastoma resistance to gefitinib may be mediated by an adaptive pro-survival TNFα-JNK-Axl signaling axis, and that high TNFα levels in the glioblastoma microenvironment may further intensify primary resistance.A combination of the TNFα-specific small-molecule inhibitor C87 and gefitinib significantly enhanced the sensitivity of glioblastoma cells to gefitinib in vitro and in vivo.Conclusions: Our findings provide a possible explanation for the primary resistance of glioblastoma to EGFR inhibitors and suggest that dual blockade of TNFα and EGFR may be a viable therapeutic strategy for the treatment of patients with chemotherapy-refractory advanced glioblastoma. 展开更多
关键词 GLIOBLASTOMA EGFR TNFΑ INHIBITOR drug resistance
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Contamination and human health risk assessment of heavy metal(loid)s in topsoil and groundwater around mining and dressing factories in Chifeng,North China 被引量:1
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作者 Di Zhao Qiang Wu +9 位作者 Yifan Zeng Juan zhang Aoshuang Mei xiaohui zhang Shuai Gao Hanyuan Wang Honglei Liu Yong zhang Shuai Qi Xu Jia 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第1期33-47,共15页
Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk asse... Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk assessment of heavy metal(loid)s driven by the wide distribution of metal ore processing,mining,and smelting factories in Hexigten Banner and Bairin Left Banner.We conducted surveys to assess the levels of heavy metal(loid)s(Cr,As,Pb,Cd,and Hg)in the topsoil and groundwater of the areas.The results indicated that the concentrations of As,Cd,and Pb in partial soil samples exceeded the environmental quality standards of Grade II.Based on contamination assessments,such as geoaccumulation indices and pollution indices,we inferred that Cd,Pb,and As were primary pollutants in topsoil.Potential ecological risks when considered as part of the average risk indices(RI)are up to 1626.40 and 2818.76,respectively,in the two areas.Comparative analysis revealed that Cd posed a very high potential ecological risk,followed by As.Moreover,the evaluation showed that the three exposure pathways of carcinogenic and non-carcinogenic risk followed a descending order:inhalation>ingestion>dermal contact,except for Pb.Arsenic in topsoil posed a potential non-carcinogenic risk to human health,while there were no adverse efects of As in groundwater.In addition,the average total carcinogenic risk for As in the two areas,as well as the risk of Pb in the topsoil of Bairin Left Banner and all the fve heavy metal(loid)s in groundwater,exceeded human tolerance.Pb–Zn mines caused higher human health risks.In addition,the tandem contamination of heavy metal(loid)s in soil and groundwater was not obvious.This research study provides a basis for pollution remediation to control heavy industry-induced ecological and health risks of heavy metal(loid)s. 展开更多
关键词 Heavy metal(loid)s Contamination indices Ecological risks Human health risks Chifeng
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Rock borehole shear tests in dam foundation of Xiangjiaba hydropower station 被引量:2
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作者 Yufei Zhao Xiaogang Wang +3 位作者 xiaohui zhang Zhixin Jia Xiangxi Zeng Hongtao zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE 2012年第4期360-366,共7页
Xiangjiaba hydropowcr station is one of the complicated geological conditions of its dam foundation, parameters of rock masses are very important issues. To cascade power stations on the Jinsha River, China. Due to th... Xiangjiaba hydropowcr station is one of the complicated geological conditions of its dam foundation, parameters of rock masses are very important issues. To cascade power stations on the Jinsha River, China. Due to the evaluating the rock mass quality and determining the mechanical address these issues, several groups of rock borehole shear tests (RBSTs) were conducted on the black mudstone in the dam foundation of Xiangjiaba hydropower station in the second construction phase. Forty three groups of shear strengths of black mudstone samples were obtained from RBSTs, and the shear strength parameters (c and f) were calculated using the least squares method. In addition, the limitations and merits of RBST employed in the Xiangjiaba hydropower station were discussed. Test results indicate that the shear strength parameters obtained from RBST have a good correlation with the results from sotmd wave test in borehole. It is believed that RBST has a good adaptability and applicability in geotechnical engineering. 展开更多
关键词 rock mass: field investigation: rock borehole shear test (RBST) shear strength parameters
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