Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain injury.Behavioral experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain edema.Next,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 cells.Finally,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain edema.Furthermore,YL-0919 effectively combated oxidative stress both in vivo and in vitro.The protective effects of YL-0919 were partially inhibited by BD-1047.These results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist BD-1047.YL-0919 may have potential as a new treatment for traumatic brain injury.

Perpendicularly assembled oriented electrospinning nanofibers based piezoresistive pressure sensor with wide measurement range

With the rapid development of wearable electronics,flexible pressure sensors have attracted wide attention in human–computer interaction and intelligent machines.However,it is a challenge to achieve a sensor with high sensitivity,wide measurement range,and wearing comfortability.Here,we develop an oriented electrospinning thermoplastic polyurethane/polyacrylonitrile(TPU/PAN)nanofibers(OETPN)based piezoresistive pressure sensor(PONPS)in which the active layer and the electrode are assembled perpendicularly.The interdigital electrode is fabricated by spraying silver nanowires(AgNWs)on the OETPN through a mask plate.The active layer is composed of OETPN coated with MXene,encapsulated on the electrode by polyurethane(PU)film.The porous structure of nanofibers membrane broadens the measurement range of the sensor.Employing oriented nanofibers as active layer can improve the sensitivity in low pressure,because oriented nanofibers without interweaving nanofibers are more compressible than disordered nanofibers.Electrode prepared using the spraying method creates nanoscale microstructure and increases sensitivity.The perpendicular assembly has greater response between the active layer and the electrode than the parallel assembly to improve the sensitivity.The sensor exhibits high sensitivity(6.71 kPa^(−1),0.02–2 kPa)and wide measurement range(0.02–700 kPa).The sensor can detect weak signals such as radial artery.A pressure array constructed precisely represents the distribution of pressure.An intelligent throat is created by combining machine learning algorithms with the PONPS.It can detect and recognize subtle throat vibrations while speaking,achieving recognition accuracy up to 100%using support vector machine(SVM)for five words with different syllables.The fabricated sensor shows promising prospects in personal healthcare and intelligent robots.

Flexible wide-range multidimensional force sensors inspired by bones embedded in muscle

Flexible sensors have been widely studied for use in motion monitoring,human‒machine interactions(HMIs),personalized medicine,and soft intelligent robots.However,their practical application is limited by their low output performance,narrow measuring range,and unidirectional force detection.Here,to achieve flexibility and high performance simultaneously,we developed a flexible wide-range multidimensional force sensor(FWMFS)similar to bones embedded in muscle structures.The adjustable magnetic field endows the FWMFS with multidimensional perception for detecting forces in different directions.The multilayer stacked coils significantly improved the output from theμV to the mV level while ensuring FWMFS miniaturization.The optimized FWMFS exhibited a high voltage sensitivity of 0.227 mV/N(0.5–8.4 N)and 0.047 mV/N(8.4–60 N)in response to normal forces ranging from 0.5 N to 60 N and could detect lateral forces ranging from 0.2–1.1 N and voltage sensitivities of 1.039 mV/N(0.2–0.5 N)and 0.194 mV/N(0.5–1.1 N).In terms of normal force measurements,the FWMFS can monitor finger pressure and sliding trajectories in response to finger taps,as well as measure plantar pressure for assessing human movement.The plantar pressure signals of five human movements collected by the FWMFS were analyzed using the k-nearest neighbors classification algorithm,which achieved a recognition accuracy of 92%.Additionally,an artificial intelligence biometric authentication system is being developed that classifies and recognizes user passwords.Based on the lateral force measurement ability of the FWMFS,the direction of ball movement can be distinguished,and communication systems such as Morse Code can be expanded.This research has significant potential in intelligent sensing and personalized spatial recognition.

Synergistic piezoelectricity enhanced BaTiO_(3)/polyacrylonitrile elastomer-based highly sensitive pressure sensor for intelligent sensing and posture recognition applications

Designing stretchable and skin-conformal self-powered sensors for intelligent sensing and posture recognition is challenging.Here,based on a multi-force mixing and vulcanization process,as well as synergistically piezoelectricity of BaTiO_(3)and polyacrylonitrile,an all-in-one,stretchable,and self-powered elastomer-based piezo-pressure sensor(ASPS)with high sensitivity is reported.The ASPS presents excellent sensitivity(0.93 V/104 Pa of voltage and 4.92 nA/104 Pa of current at a pressure of 10-200 kPa)and high durability(over 10,000 cycles).Moreover,the ASPS exhibits a wide measurement range,good linearity,rapid response time,and stable frequency response.All components were fabricated using silicone,affording satisfactory skinconformality for sensing postures.Through cooperation with a homemade circuit and artificial intelligence algorithm,an information processing strategy was proposed to realize intelligent sensing and recognition.The home-made circuit achieves the acquisition and wireless transmission of ASPS signals(transmission distance up to 50 m),and the algorithm realizes the classification and identification of ASPS signals(accuracy up to 99.5%).This study proposes not only a novel fabrication method for developing self-powered sensors,but also a new information processing strategy for intelligent sensing and recognition,which offers significant application potential in human-machine interaction,physiological analysis,and medical research.

Flexible PDMS-based triboelectric nanogenerator for instantaneous force sensing and human joint movement monitoring

Flexible wearable sensors with excellent electric response and self-powered capability have become an appealing hotspot for personal healthcare and human-machine interfaces.Here,based on triboelectric nanogenerator(TENG),a flexible self-powered tactile sensor composed of micro-frustum-arrays-structured polydimethylsiloxane(PDMS)film/copper(Cu)electrodes,and poly(vinylidenefluoride-trifluoroethylene)(P(VDF-TrFE))nanofibers has been demonstrated.The TENG-based self-powered tactile sensor can generate electrical signals through the contact-separation process of two triboelectric layers under external mechanical stimuli.Due to the uniform and controllable micro-frustum-arrays structure fabricated by micro-electro-mechanical system(MEMS)process and the P(VDF-TrFE)nanofibers fabricated by electrostatic spinning,the flexible PDMS-based sensor presents high sensitivity of 2.97 V kPa^-1,stability of 40,000 cycles(no significant decay),response time of 60 ms at 1 Hz,low detection pressure of a water drop(~4 Pa,35 mg)and good linearity of 0.99231 in low pressure region.Since the PDMS film presents ultra-flexibility and excellent-biocompatibility,the sensor can be comfortably attached on human body.Furthermore,the tactile sensor can recognize various types of human body movements by the corresponding electrical signals.Therefore,the as-prepared TENGs are potential on the prospects of gesture detection,health assessment,human-machine interfaces and so on.

Ultralong-life and high-rate web-like Li4Ti5O12 anode for high-performance flexible lithium-ion batteries

Flexible lithium ion batteries （LIBs） have recently attracted increasing attention as they show unique promising advantages, such as flexibility, shape diversity, and light weight. Similar to conventional LIBs, flexible LIBs with long cycle life and high-rate performance are very important for applications of high performance flexible electronics. Herein, we report a three-dimensional （3D） web-like binderfree Li4Ti5O12 （LTO） anode assembled from numerous 1D nanowires exhibiting excellent cycling performance with high capacities of 153 and 115 mA·h·g^-1 after 5,000 cycles at 2 C and 20 C, respectively, and excellent rate property with a capacity of 103 mA·h·g^-1 even at a very high current rate of 80 C. Surprisingly, a flexible full battery assembled from the web-like LTO nanostructure and LiMn2O4 （LMO） nanorods exhibited a high capacity of 125 mA·h·g^-1 at high current rate of 20 C, and showed excellent flexibility with little performance degradation even in seriously bent states.

Advanced rechargeable lithium-ion batteries based on bendable ZnCo2O4-urchins-on-carbon-fibers electrodes

A novel class of ZnCo2O4-urchins-on-carbon-fibers matrix has been designed, characterized, and used to fabricate high-performance energy storage devices. We obtained a reversible lithium storage capacity of 1180 mA＇h/g even after 100 cycles, demonstrating the highreversible capacity and excellent cycle life of the as-prepared samples. Tested as fast-charging batteries, these electrodes exhibited a considerable capacity of 750 mA＇h/g at an exceptionally high rate of 20 C （18 A/g）, with an excellent cycle life （as long as 100 cycles）, which are the best high-rate results reported at such a high charge^discharge current density for ZnCo2O4-based anode materials in lithium rechargeable batteries. Such attractive properties may be attributed to the unique structure of the binder-free ZnCo2O4-urchins-on-carbon-fibers matrix. Full batteries were also developed by combining the ZnCo2O4 anodes with commercial LiCoO2 cathodes, which showed flexible/wearable and stable features for use as very promising future energy storage units.

An ultra-sensitive and wide measuring range pressure sensor with paper-based CNT film/interdigitated structure

Flexible pressure sensors have attracted great attention due to their potential in the wearable devices market and in particular in human-machine interactive interfaces.Pressure sensors with high sensitivity,wide measurement range,and low-cost are now highly desired for such practical applications.In the present investigation,an ultrasensitive pressure sensor with wide measurement range has been successfully fabricated.Carbon nanotubes(CNTs)(uniformly sprayed on the surface of paper)comprise the sensitivity material,while lithographed interdigital electrodes comprise the substrate.Due to the synergistic effects of CNT’s high specific surface area,paper’s porous structure,interdigital electrodes’efficient contact with CNT,our pressure sensor realizes a wide measurement range from 0 to 140 kPa and exhibits excellent stability through 15,000 cycles of testing.For the paper-based CNT film/interdigitated structure(PCI)pressure sensor,the connection area between the sensitive material and interdigital electrodes dominates in the lowpressure region,while internal change within the sensitive materials plays the leading role in the high-pressure region.Additionally,the PCI pressure sensor not only displays a high sensitivity of 2.72 kPa–1(up to 35 kPa)but also can detect low pressures,such as that exerted by a resting mung bean(about 8 Pa).When attached to the surface of a human body,the pressure sensor can monitor physiological signals,such as wrist movement,pulse beats,or movement of throat muscles.Furthermore,the pressure sensor array can identify the spatial pressure distribution,with promising applications in humanmachine interactive interfaces.

A high-performance, single-electrode and stretchable piezotriboelectric hybrid patch for omnidirectional biomechanical energy harvesting and motion monitoring

Triboelectric nanogenerators(TENGs)have recently drawn much attention in the field of biomechanical energy harvesting and motion monitoring.However,the electrode stretchability and contact-separation model induced complicated packed structure remain a problem that heavily affects output performance during various human movements and requires to be urgently addressed.Here,a single-electrode piezotriboelectric hybrid nanogenerator(SEP-TENG)integrated with stretchable liquid-metal metal electrodes is reported,which simultaneously achieves outstanding energy harvesting performance and skincomfort human motion monitoring.A polarized piezoelectric BaTiO_(3)/silicon rubber(SR)composites film is served as the effective negative tribomaterial,benefiting from the improved dielectric constant and piezoelectric charge transfer,the optimized SEP-TENG generates a high peak power density of 5.7 W/m^(2) while contacted with human skin.Besides,owing to the ultralow Young's modulus of the SR encapsulation layer and tribo-piezoelectric hybrid layer,the homogeneous integrated multilayer composite serves no break till a 745%elongation,promoting that the SEP-TENG could effectively harvest biomechanical energy and realize stable power supplying for wearable electronics even under large deformation state.Furthermore,the SEP-TENG could comfortably attach to the finger joints and collect bending energy.This work provides a novel design methodology for a single-electrode TENG to realize omnidirectional biomechanical energy harvesting and motion monitoring.

Stretchable and skin-conformal piezo-triboelectric pressure sensor for human joint bending motion monitoring

Stretchable,skin-conformal,and self-powered wearable pressure sensors have garnered significant attention for use in human joint bending motion monitoring.Here,a piezo-triboelectric pressure sensor(P-TPS)based on triboelectric nanogenerator and piezoelectric nanogenerator is demonstrated.The P-TPS can generate an enhanced electrical output by coupling the dual-mode triboelectrification and piezoelectric effect.The P-TPS shows high sensitivity(voltage=0.3 V/kPa;current=4.3 nA/kPa;pres-sure range=0-200 kPa),high linearity,and good stability.Furthermore,it demonstrates a wide mea-surement range(0-800 kPa),table frequency response,and fast response time.Additionally,all components of the P-TPS are fabricated using flexible and stretchable materials,affording satisfactory stretchability and excellent skin conformality.Owing to their ability to self-power,they can be attached to the outside of joints to monitor human joint bending movements in real time.Hence,this study provides a novel method of using a stretchable and skin-conformal piezo-triboelectric nanogenerator with high electrical performance as a self-powered pressure sensor,which offers significant potential in personalized recognition,medical research,and human machine interface.

Increasingπ-electron availability in benzene ring incorporated graphitic carbon nitride for increased photocatalytic hydrogen generation

Increasing the availability ofπ-electron in graphitic carbon nitride(g-C_(3)N_(4))can reduce the band gap and thus enhance the photocatalytic hydrogen(H_(2))generation activity upon exposure to visible light,However,such strategy has not yet been largely applied to increase the H_(2)generation of g-C_(3)N_(4).Herein,we succes s fully increased the amount ofπ-electron in g-C_(3)N_(4)by incorporatingπ-electron-rich benzene rings through copolymerization of melamine and trimesic acid in air.The incorporation of benzene rings not only extends the light absorption of g-C_(3)N_(4)to 650 nm,but also improves the electrical conductivity due to delocalization ofπelectrons in benzene rings.As a result,a 3.4 times enhancement of photocatalytic H_(2)generation was achieved from the g-C_(3)N_(4)with benzene ring incorporation in comparing with that of pristine g-C_(3)N_(4).More interestingly,H_(2)generation still occurs under irradiation of the light ofλ≥490 nm,above the absorption edge of pristine g-C_(3)N_(4)(~460 nm),illustrating the positive effectiveness of incorporated benzene rings on enhancing the H_(2)generation capacity of g-C_(3)N_(4).The present work manifests the advantages of increasingπ-conjugated electrons on designing highly active g-C_(3)N_(4)photocatalysts.

Enhanced energy storage properties and temperature stability of fatigue-free La-modified PbZrO3 films under low electric fields

Electrostatic energy^-storage capacitors,with their ultrahigh storage density and high temperature stability,have been receiving increasing attention of late for their ability to meet the critical requirements of pulsed power devices in low^-consumption systems.In such a context,this work reports on the successful production of anti^-ferroelectric(AFE)thin films with excellent energy storage performance under a relatively low electric field.In particular,La^-doped Pb Zr O3 thin films were fabricated using a sol^-gel method,yielding a recoverable energy storage density of 34.87 J cm^-3 with an efficiency of 59.23%at room temperature under the electric field of^800 k V cm^-1.The temperature dependence of the energy storage property was demonstrated from room temperature to 210°C,indicating a stable density variation between 34.87 and 27.98 J cm^-3.The films also exhibited excellent anti^-fatigue property(endurance of up to 3×10^9cycles and the recoverable energy storage density varied from 39.78 to 29.32 J cm^-3 combined with an efficiency of 61.03%–44.95%under the test frequencies from 10 to 5000 Hz).All results were obtained using compact films with a high polarization(Pmax)of approximately 103.7μC cm^-2 and low remnant polarization(Pr^7μC cm^-2),which was owing to the combination of La Ni O3 buffer layers and vacancies at Pb sites.These results illustrate the great potential of pulsed power devices in low^-consumption systems operating in a wide range of temperatures and long^-term operations.

A Cyclometalated Iridium（Ⅲ） Complex Serves as a Phosphorescent Probe for Specific Mitochondrial Imaging in Living Cells

A new cyclometalated iridium（Ⅲ） complex [Ir（2-pq）2（HPIP）]C1 （lrl, 2-pq=3-phenylisoquinoline, HPIP= 2-（2-hydroxyphenyl）imidazo[4,5-f] 1,10-phenanthroline） was synthesized and applied to image mitochondria in living cells. Irl displayed excellent ability to selectively accumulate in mitochondria of live cells with no requirement of replacement of the culture medium. Due to Irl exhibiting better photostability than the commercially available mitochondrial trackers, this complex could be applicable for the imaging and tracking of the mitochondrial mor- phological changes over long periods of time. In addition, in vitro cytotoxicity investigation revealed that it! showed negligible cytotoxicity at the concentrations employed. Based on these, Irl is suitable for organelle-selective imaging in living cells.