Bladder cancer(BC)is the tenth most prevalent malignancy globally,presenting significant clinical and societal challenges because of its high incidence,rapid progression,and frequent recurrence.Presently,cystoscopy an...Bladder cancer(BC)is the tenth most prevalent malignancy globally,presenting significant clinical and societal challenges because of its high incidence,rapid progression,and frequent recurrence.Presently,cystoscopy and urine cytology serve as the established diagnostic methods for BC.However,their efficacy is limited by their invasive nature and low sensitivity.Therefore,the development of highly specific biomarkers and effective noninvasive detection strategies is imperative for achieving a precise and timely diagnosis of BC,as well as for facilitating an optimal tumor treatment and an improved prognosis.microRNAs(miRNAs),short noncoding RNA molecules spanning around 20–25 nucleotides,are implicated in the regulation of diverse carcinogenic pathways.Substantially altered miRNAs form robust functional regulatory networks that exert a notable influence on the tumorigenesis and progression of BC.Investigations into aberrant miRNAs derived from blood,urine,or extracellular vesicles indicate their potential roles as diagnostic biomarkers and prognostic indicators in BC,enabling miRNAs to monitor the progression and predict the recurrence of the disease.Simultaneously,the investigation centered on miRNA as a potential therapeutic agent presents a novel approach for the treatment of BC.This review comprehensively analyzes biological roles of miRNAs in tumorigenesis and progression,and systematically summarizes their potential as diagnostic and prognostic biomarkers,as well as therapeutic targets for BC.Additionally,we evaluate the progress made in laboratory techniques within this field and discuss the prospects.展开更多
In this paper, a tracking system with space virtual feedback （SVF） is presented. The whole tracking system is closed by the space virtual feedback line that is the line of sight （LOS）, but the parts in the system,...In this paper, a tracking system with space virtual feedback （SVF） is presented. The whole tracking system is closed by the space virtual feedback line that is the line of sight （LOS）, but the parts in the system, such as the tracking subsystem and the servo subsystem, are in the state of open-loop. Because the SVF tracking model is used, the correcting loops can be removed in this system architecture. So the tracking speed and accuracy of the system are greatly improved.展开更多
基金supported by the China Postdoctoral Science Foundation(Grant No.2022M721404)the Natural Science Foundation of Jiangsu Province(Grant No.BK20220737)+1 种基金the Social Development Foundation of Clinical Frontier Technology of Jiangsu Province(Grant No.BE2017763)the Medical Research Project of Jiangsu Province Health Committee(Grant No.K2019020).
文摘Bladder cancer(BC)is the tenth most prevalent malignancy globally,presenting significant clinical and societal challenges because of its high incidence,rapid progression,and frequent recurrence.Presently,cystoscopy and urine cytology serve as the established diagnostic methods for BC.However,their efficacy is limited by their invasive nature and low sensitivity.Therefore,the development of highly specific biomarkers and effective noninvasive detection strategies is imperative for achieving a precise and timely diagnosis of BC,as well as for facilitating an optimal tumor treatment and an improved prognosis.microRNAs(miRNAs),short noncoding RNA molecules spanning around 20–25 nucleotides,are implicated in the regulation of diverse carcinogenic pathways.Substantially altered miRNAs form robust functional regulatory networks that exert a notable influence on the tumorigenesis and progression of BC.Investigations into aberrant miRNAs derived from blood,urine,or extracellular vesicles indicate their potential roles as diagnostic biomarkers and prognostic indicators in BC,enabling miRNAs to monitor the progression and predict the recurrence of the disease.Simultaneously,the investigation centered on miRNA as a potential therapeutic agent presents a novel approach for the treatment of BC.This review comprehensively analyzes biological roles of miRNAs in tumorigenesis and progression,and systematically summarizes their potential as diagnostic and prognostic biomarkers,as well as therapeutic targets for BC.Additionally,we evaluate the progress made in laboratory techniques within this field and discuss the prospects.
文摘In this paper, a tracking system with space virtual feedback （SVF） is presented. The whole tracking system is closed by the space virtual feedback line that is the line of sight （LOS）, but the parts in the system, such as the tracking subsystem and the servo subsystem, are in the state of open-loop. Because the SVF tracking model is used, the correcting loops can be removed in this system architecture. So the tracking speed and accuracy of the system are greatly improved.
