Turbo Message Passing Based Burst Interference Cancellation for Data Detection in Massive MIMO-OFDM Systems

This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.

神经母细胞瘤CCCG-NB-2015共识多中心应用总结

目的:对中国多中心应用CCCG-NB-2015共识方案诊治的儿童神经母细胞瘤(neuroblastoma,NB)病例进行回顾性分析总结,以期为改进NB诊疗工作提供有力依据。方法:回顾性分析2013年3月至2020年7月经统一规范的CCCG-NB-2015共识方案诊治的全国多中心500例NB患儿的临床和预后资料,通过Cox单因素和多因素回归分析明确影响NB预后的关键因素;分别绘制神经元特异性烯醇化酶(neuron-specific enolase,NSE)和乳酸脱氢酶(lactate dehydrogenase,LDH)在预测骨髓转移和复发的ROC曲线,明确NSE和LDH的临床价值;比对分析NB两种不同分期系统和危险度分组系统下患儿的预后差异,着重分析中危组人群的队列特征和预后结局。结果:通过单因素分析共确定10个潜在的预后因子,分别为年龄、肿瘤原发部位、INPC分类、骨髓转移、MYCN状态、INSS分期、INRGSS分期、诊断时NSE、LDH水平和影像学定义的危险因素(image-defined risk factors,IDRFs),均P<0.05。Cox多因素分析结果显示与无事件生存率(event-free survival,EFS)密切相关的独立预后因子为INPC分类、骨髓转移、诊断时NSE、LDH水平,与OS密切相关的独立预后因子为NSE、LDH水平及INRGSS分期(均P<0.05);NSE和LDH可以较好地预测NB骨髓转移、复发等事件发生(均P<0.05);INSS分期中非4期和4期的3年EFS分别为93.8%和52.6%;转换为INRGSS分期后,L1、L2、MS和M期的3年EFS分别为94.4%、87.2%、87.5%和53.6%。低危组、中危组和高危组3年和5年的EFS分别为97.1%和97.1%、90.0%和87.3%、53.9%和47.3%;其中INSS分期中3期且伴有INPC为UH型的患儿在CCCG-NB-2015共识方案中被归入高危组,其预后差,5年EFS为65.7%(P<0.05),但却在INRG危险度分组中被列入中危组。结论:NSE和LDH水平在预测NB患儿骨髓是否转移以及预后评价方面具有重要价值。INRGSS分期为预后的独立影响因子,其较INSS分期在对患儿预后评估方面更具有临床意义,推荐使用INRGSS分期系统;CCCG-NB-2015共识方案各危险度分组治疗下低中危组预后较好,高危组预后较差,建议将来可降低低危组的治疗强度,而对于基于INRG危险度分组治疗的前提下,中危组的治疗建议继续延用CCCG-NB-2015共识中危组方案。

RIS-Aided Constant-Envelope Beamforming for Multiuser Wireless Power Transfer:A Max-Min Approach

As a revolutionary hardware technology that can reconfigure the propagation environment,reconfigurable intelligent surfaces(RISs)have been regarded as a promising solution to enhance wireless networks.In this paper,we consider a multiuser multiple-input single-output(MISO)wireless power transfer(WPT)system,which is assisted by several RISs.In order to improve energy efficiency and reduce hardware cost,we consider that the energy transmitter(ET)in the WPT system is equipped with a constant-envelope analog beamformer,instead of a digital beamformer.Focusing on user fairness,we study a minimum received power maximization problem by jointly optimizing the ET beamforming and the RIS phase shifts,subject to the constant-envelope constraints.We iteratively solve this non-convex maxmin problem by leveraging both the successive convex approximation(SCA)method and the alternating direction method of multipliers(ADMM)algorithm.Numerical results demonstrate the effectiveness of the proposed algorithm and show attractive performance gain brought by RISs.

The BHLH Transcriptional Factor PIF4 Competes with the R2R3-MYB Transcriptional Factor MYB75 to Fine-Tune Seeds Germination under High Glucose Stress

It is known that the high level of sugar including glucose suppresses seed germination through ABA signal.ABI5 is an essential component to mediate ABA-dependent seed germination inhibition,but underlying mechanism needs more investigation.Previous study demonstrated the PIF4 activated the expression of ABI5 to suppress seed germination in darkness.Here we reported that PIF4 also mediated the seed germination inhibition through ABI5 under high concentration of glucose treatment.Furthermore,we found that PIF4 interacted with PAP1,the central factor to control anthocyanin biosynthesis.Such interaction was confirmed in vitro and in planta.Biochemical and physiological analysis revealed that PAP1 bond the promoter of ABI5 to suppress its expression,thus enhanced seed germination under high concentration of glucose treatment.Specially,PAP1 competed with PIF4 to antagonize the activation of PIF4 on ABI5 expression,thus promoted seed germination under high glucose treatment.Given these,we uncover a novel role for PIF4 and PAP1 in controlling seed germination under high glucose treatment,and reveal their antagonistic mechanism by which coordinates ABI5 expression to control seed germination in response to the glucose signal.

Treatment results of childhood extracranial malignant germ cell tumors and the salvage approach for recurrent and refractory cases: a single-center report

Objective The aim of this study is to report the treatment result of childhood excranial malignant germ cell tumors and discuss the experience for recurrent and refractory cases treatment from our center.Methods We have retrospectively analyzed 58 extracranial malignant germ cell tumor patients treated with surgery and chemotherapy from our center over a 9-year period.Another 14 recurrent and refractory cases referred from other centers were added to the study for salvage approach.We evaluated the treatment results for primary cases and relapsed cases with a median follow-up of 61.5 months.Several factors were analysed to evaluate their power to the outcome of these cases.Results The 5-year event-free and overall survival for primary cases were 74.1±5.7%and 86.2±4.5%,respectively.25 recurrent or refractory cases entered the salvage approach study,and 17 patients were alive till the end of follow-up.We demonstrated superior survival outcome for those with successful local control through pre-operative and post-operative radiotherapy,second-look surgery and multi-drug secondline chemotherapies.Conclusion The outcome for childhood extracranial malignant germ cell tumors is generally favorable.For recurrent and refractory cases,multi-modality treatment approaches including radiotherapy,salvage chemotherapy and secondlook surgery are important for better local control.

Titanium Dioxide Nanoparticles Promote Root Growth by Interfering with Auxin Pathways in Arabidopsis thaliana

TiO_(2) nanoparticles(nano-TiO_(2))are widely used in the world,and a considerable amount of nano-TiO_(2) is released into the environment,with toxic effects on organisms.In the various species of higher plants,growth,including seed germination,root elongation,and biomass accumulation,is affected by nano-TiO_(2).However,the underlying molecular mechanisms remain to be elucidated.In this study,we observed that nano-TiO_(2) promoted root elongation in a dose-dependent manner.Furthermore,we found that nano-TiO_(2) elevated auxin accumulation in the root tips of the auxin marker lines DII-VENUS and DR5::GUS,and,correspondingly,quantitative real-time PCR analysis revealed that nano-TiO_(2) increased the expression levels of auxin biosynthesis-and transport-related genes.GFP fluorescence observation using transgenic PIN2-GFP indicated that nano-TiO_(2) promoted root growth by inducing PIN2 accumulation.Thus,we propose that nano-TiO_(2) promote root growth in Arabidopsis thaliana by altering the expression levels of auxin biosynthesis-and transport-related genes.

Utility of Urban Public Facilities of Haikou City Based on Behavioral Theory

From functions,ornament and art,on the basis of the behavioral theory,the utility of urban public facilities was surveyed and studied with Longhua District of Haikou City as an example.It summed up the basis for designing urban public facilities behind behavior habits of residents,in the hope of making future urban construction and management more humanized.Accordingly,it is expected to set up appropriate concept of public facilities,and play especially important role in creating favorable urban living environment.

Dynamic Performance Analysis of Steel Frame Structure under Seismic Action

In order to find out the dynamic characteristics of a steel frame structure project in the 8 degree (0.3g) area, the artificial wave, Taft wave and El Centro wave were input by using the finite element analysis software ANSYS. The dynamic time-history analysis of the structure shows the dynamic performance of the structure under the frequent earthquakes and rare earthquakes.

Observed Tidal Currents in Prydz Bay and Their Contribution to the Amery Ice Shelf Basal Melting

Tides play a key role in regulating the circulation and water properties around Antarctica,yet tidal currents and the corresponding influences in Prydz Bay have not been quantified with observational datasets.This study focuses on the observed characteristics of tidal currents and quantifies the tidal contribution to the basal melting of the Amery Ice Shelf(AIS).Long-term hydrography observations are provided by 10 moorings over the continental shelf and 6 borehole sites drilled through the AIS.Based on the mooring observations,we analyze the observed tidal currents,and evident seasonality in the mixed diurnal–semidiurnal tidal currents is identified.Barotropic tides dominate the tidal currents at the AIS front,except at the western corner where the seabed is abruptly deeper.The spatially and temporally averaged magnitude of tidal currents for all the current meter records is only~3 cm s^(−1).However,an observed maximum tidal velocity of~11 cm s^(−1) occurs at the AIS front,and the maximal time-averaged tidal kinetic energy reaches~31%of the total kinetic energy over the outer continental shelf.Based on the borehole observations,tide-like pulsing is identified in the ocean layer adjacent to the AIS basal surface.The maximal tidal contribution of the AIS basal melting is estimated at 69%based on a simple model.Due to the paucity of long-term velocity observations in the sub-ice-shelf cavity,the uncertainties of the estimated tide-induced melting in this study could be attributed to the simulated velocity.

Challenges and opportunities for managing pediatric central nervous system tumors in China

Central nervous system(CNS)tumors represent the most deadly cancer in pediatric age group.In China,thousands of children are diagnosed with CNS tumors every year.Despite the improving socioeconomic status and availability of medical expertise within the country,unique challenges remain for the delivery of pediatric neuro-oncology service.In this review,we discuss the existing hurdles for improving the outcome of children with CNS tumors in China.Need for precise disease burden estimation,lack of intra-and inter-hospital collaborative networks,high probability of treatment abandonment,along with financial toxicities from treatment represent the key challenges that Chinese healthcare providers encounter.The tremendous opportunities for advancing the status of pediatric neuro-oncology care in and beyond the country are explored.

Reconfigurable Intelligent Surface Assisted D2D Underlay Communications:A Two-Timescale Optimization Design

The performance of a device-to-device(D2D)underlay communication system is limited by the co-channel interference between cellular users(CUs)and D2D devices.To address this challenge,a reconfigurable intelligent surface(RIS)aided D2D underlay system is studied in this paper.A two-timescale optimization scheme is proposed to reduce the required channel training and feedback overhead,where transmit beamforming at the base station(BS)and power control at the D2D transmitters are adapted to instantaneous effective channel state information(CSI);and the RIS phase shifts are adapted to slow-varying channel mean.Based on the two-timescale optimization scheme,we aim to maximize the D2D ergodic weighted sum-rate(WSR)subject to a given outage probability constrained signal-to-interference-plus-noise ratio(SINR)target for each CU.The two-timescale problem is decoupled into two sub-problems,and the two sub-problems are solved iteratively.Numerical results verified that the two-timescale based optimization performs better than two baselines,and also demonstrated a favourable trade-off between system performance and CSI overhead.