Early identification of scientific breakthroughs through outlier analysis based on research entities

Purpose:To address the“anomalies”that occur when scientific breakthroughs emerge,this study focuses on identifying early signs and nascent stages of breakthrough innovations from the perspective of outliers,aiming to achieve early identification of scientific breakthroughs in papers.Design/methodology/approach:This study utilizes semantic technology to extract research entities from the titles and abstracts of papers to represent each paper’s research content.Outlier detection methods are then employed to measure and analyze the anomalies in breakthrough papers during their early stages.The development and evolution process are traced using literature time tags.Finally,a case study is conducted using the key publications of the 2021 Nobel Prize laureates in Physiology or Medicine.Findings:Through manual analysis of all identified outlier papers,the effectiveness of the proposed method for early identifying potential scientific breakthroughs is verified.Research limitations:The study’s applicability has only been empirically tested in the biomedical field.More data from various fields are needed to validate the robustness and generalizability of the method.Practical implications:This study provides a valuable supplement to current methods for early identification of scientific breakthroughs,effectively supporting technological intelligence decision-making and services.Originality/value:The study introduces a novel approach to early identification of scientific breakthroughs by leveraging outlier analysis of research entities,offering a more sensitive,precise,and fine-grained alternative method compared to traditional citation-based evaluations,which enhances the ability to identify nascent breakthrough innovations.

CT and MRI Findings of Intracranial Cavernous Hemangioma Malformation

Objective:To investigate the computed tomography(CT)and magnetic resonance imaging(MRI)features of cavernous hemangioma malformation(CHM)to enhance diagnostic accuracy.Methods:The CT and MRI findings and clinical information of 23 patients with CHM were retrospectively analyzed.Results:CT examinations were conducted in 7 cases,while MRI was utilized in 23 cases.Additionally,SWI was employed in 5 cases and enhanced imaging techniques were applied in 14 cases.Among the observed lesions,20 cases presented with a singular lesion,whereas 3 cases exhibited multiple lesions.The lesions were located in 8 frontal lobes,6 cerebellums,2 brainstems,6 temporal lobes,1 basal ganglia,3 parieto-occipital lobes,and 2 thalamus regions.The nodules appeared as quasi-circular lesions with clear or well-defined boundaries.They presented as isodense lesions on CT scans,with one lesion showing peritumoral edema.On MRI,T1-weighted imaging(T1WI)demonstrated isointense signals,while T2-weighted imaging(T2WI)showed isointense and hyperintense signals.Additionally,10 lesions exhibited a low signal ring on T2WI.Diffusion-weighted imaging(DWI)revealed nodular or isointense low signals,while susceptibility-weighted imaging(SWI)displayed enlarged areas of low signal.Fourteen lesions underwent contrast-enhanced scanning,with 2 lesions showing no obvious enhancement,1 lesion demonstrating mild to moderate enhancement,and 11 lesions exhibiting significant enhancement.Notably,6 of these enhanced lesions were surrounded by small blood vessels.Conclusion:Cavernous hemangioma malformation is more commonly found in individual cases.CT alone lacks specificity,making it prone to misdiagnosis.A more comprehensive evaluation of cavernous hemangioma malformation can be achieved through a combination of MRI,DWI,SWI,and enhanced examination,providing valuable references for clinical assessment.

Research on the Dilemma and Path of Mental Health Education for College Students from the Perspective of Home-School Cooperation

With the development of society and the advancement of education,the state has increasingly emphasized the importance of mental health education for college students.Mental health education for college students serves as an effective vehicle for psychological education in universities,with family and school education being the two critical fronts.To ensure the smooth implementation of mental health education for college students,it is imperative for schools and families to collaborate and cooperate closely,thus effectively promoting the healthy growth and comprehensive development of students.Given the current challenges such as inadequate awareness of home-school cooperative education,lack of mechanisms for home-school cooperation,and a singular platform for home-school cooperation,we need to comprehensively improve the overall quality of mental health education by unifying the ideology of home-school cooperative education,establishing a sound mechanism for home-school cooperation,innovating the platform for home-school cooperation,and enriching the content of home-school cooperation.

MRI Findings and Diagnostic Significance of Soft Tissue Schwannomas in the Extremities

Objective:To analyze the MRI features and rare manifestations of schwannomas of the extremities to improve diagnosis.Methods:Retrospective analysis of 23 cases of schwannomas in the extremities confirmed by surgical pathology,summarizing its signs,signal characteristics and MRI enhancement.Results:Among the 23 cases,20 were single lesions,and 3 were multiple lesions,resulting in a total of 28 lesions.The distribution of these lesions included 7 in the thigh,9 in the calves,4 in the armpits,3 in the hips,and 4 each in the upper arms and forearms.Additionally,there was one lesion located in the groin.On T1-weighted imaging(T1WI),the lesions showed iso-intensity or hypo-intensity.On T2-weighted imaging(T2WI),they appeared slightly hyperintense or hyper-intense.Some lesions exhibited multiple small vesicle-like higher signals,cystic changes,and fiber spacing on T2WI.Furthermore,one lesion showed a liquid-liquid plane.The“target sign”was observed in 18 lesions(64.3%)and“neuropathic signs”were present in six lesions(21.4%).Finally,it was noted that on MRI enhancement,the lesions demonstrated uniform or uneven enhancement.The lesions were uniformly or unevenly enhanced on MRI enhancement.Conclusions:The MRI findings of schwannoma in the extremities exhibit specific characteristics.The cystic changes on T2WI also display distinct features.Recognition of rare MRI findings,such as cystic changes,liquid-liquid plane and septum,should be emphasized to enhance the accuracy of pre-diagnosing schwannomas.

Analysis of the Risk of Basilar Aneurysm Rupture Based on CTA Morphological Parameters

Objective:To investigate morphological risk factors of basilar aneurysm rupture based on computer tomography angiography(CTA)parameters.Materials and methods:The clinical and CTA data of 43 patients with basilar aneurysm admitted to Shaanxi Provincial People's Hospital from January 2015 to July 2023 were analyzed.The patients were divided into“ruptured group”and“unruptured group,”and the morphological parameters of aneurysms were measured.The general data and morphological parameters between the two groups were statistically analyzed.Logistic regression was used to analyzed statistically significant parameters,and the receiver operating characteristic curve was drawn to evaluate its diagnostic effectiveness.Results:Irregular aneurysms were more likely to rupture than regular aneurysms(χ^(2)=13.971,P<0.05).The maximum diameter(4.92[3.37-6.94]mm),length-width ratio(1.31[1.14-1.55]),height(4.08[2.71-5.34]mm),aspect ratio(0.99[0.84-1.45]),and inflow angle(133.63±11.21°)of aneurysms in the ruptured group were larger than the unruptured group,and the differences were statistically significant(P<0.05).Binary logistic regression showed that aneurysm shape(OR=39.347,P=0.021),length-width ratio(OR=313.062,P=0.033),and inflow angle(OR=1.156,P=0.004)were independent risk factors for rupture.The area under the curve were 0.809,0.842.and 0.894,respectively.Conclusion:Aneurysm shape,aspect ratio,and blood flow incidence angle are independent risk factors for basilar aneurysm rupture,which means that they can be used to predict the risk of rupture to a certain extent.

Collision Neoplasms of the Vermiform Appendix

Neoplasms of the vermiform appendix represent 1% of all gastrointestinal tumors, with epithelial and neuroendocrine histological subtypes being the most frequent. When two or more neoplasms with different components originate synchronically in the appendix with clear margin between them, it is called a collision tumor, with exceptional cases being reported in literature. The purpose is to present two new cases of collision tumors of the appendix and perform a review of the published literature. Two cases of an 82-year-old female and a 41-year-old male with collision tumors of the vermiform appendix are presented, with clinical presentation, radiological evaluation and surgical treatment exposed. Our results are compared with other published reports. In accordance with the other reported cases, both patients presented with low-grade appendiceal mucinous neoplasm (LAMN). Female patient with synchronous goblet cell carcinoma managed with a completion right colectomy and Hyperthermic intraperitoneal chemotherapy (HIPEC) and the other patient with well-differentiated neuroendocrine (NET) tumor managed with laparoscopic appendectomy without adjuvant treatment. Since very few cases have been reported, no diagnostic and therapeutic consensus and guidelines exist up to date. We agree that local, regional, and systemic therapies should be chosen according to the tumor that represents the worst prognosis.

左心室血管肉瘤超声误诊为左心室血栓回顾分析

目的探讨左心室血管肉瘤发病机制及其左心室血管肉瘤误诊为左心室血栓的原因、超声表现。方法对误诊为左心室血栓1例的临床资料进行回顾性分析。结果患者因胸痛、胸闷4年余于饮酒时突发胸痛,胸闷,考虑为"急性广泛前壁心肌梗死",在我院予行左冠PTCA及支架植入术。再次就诊我院,完善相关检查。心电图提示急性下壁心梗,CDFI:其内未见明显血流信号,超声提示:左室壁节段性运动减弱;左室轻度扩大;左室心尖部低回声团;左室收缩及舒张功能减退。结论临床罕见、惯性思维诊断及鉴别诊断不足,导致本例误诊的主要原因。加强对该病认识、综合全面分析病情,尽早检查螺旋CT、PETCT和MRI,为临床手术治疗提供可靠依据,延长患者生命。

A Micro Perspective of Research Dynamics Through“Citations of Citations”Topic Analysis

Purpose:Research dynamics have long been a research interest.It is a macro perspective tool for discovering temporal research trends of a certain discipline or subject.A micro perspective of research dynamics,however,concerning a single researcher or a highly cited paper in terms of their citations and“citations of citations”(forward chaining)remains unexplored.Design/methodology/approach:In this paper,we use a cross-collection topic model to reveal the research dynamics of topic disappearance topic inheritance,and topic innovation in each generation of forward chaining.Findings:For highly cited work,scientific influence exists in indirect citations.Topic modeling can reveal how long this influence exists in forward chaining,as well as its influence.Research limitations:This paper measures scientific influence and indirect scientific influence only if the relevant words or phrases are borrowed or used in direct or indirect citations.Paraphrasing or semantically similar concept may be neglected in this research.Practical implications:This paper demonstrates that a scientific influence exists in indirect citations through its analysis of forward chaining.This can serve as an inspiration on how to adequately evaluate research influence.Originality:The main contributions of this paper are the following three aspects.First,besides research dynamics of topic inheritance and topic innovation,we model topic disappearance by using a cross-collection topic model.Second,we explore the length and character of the research impact through“citations of citations”content analysis.Finally,we analyze the research dynamics of artificial intelligence researcher Geoffrey Hinton’s publications and the topic dynamics of forward chaining.

SOME ENDPOINT ESTIMATES FOR COMMUTATORS OF θ-TYPE CALDERóN-ZYGMUND OPERATORS

In this note, the authors prove that the commutator Tb, generated by θ-type Calderon-Zygmund operator T and a Lipschitz function b is bounded from LP（R^n） intoLip（β_n/p）（R^n） and also maps from Ln/β （R^n） into BMO（R^n）.

Bibliometric Analysis of Patient Navigation Model Applied in Colorectal Cancer Care Based on Web of Science

Background: The mortality rate of colorectal cancer in China is on the rise, which has exceeded the global average rate, thus making the care of colorectal cancer widely concerned. As a comprehensive nursing model, the patient navigation model has shown its effectiveness in improving the quality of life among patients with chronic diseases and reducing the shortage of current healthcare resources in some area. This study aims to identify the current status and dilemma of the patient navigation model applied in colorectal cancer care in China. Methods: Bibliometric method was used to analyze published articles regarding the application of patient navigation model in colorectal cancer care retrieved from the Web of Science database. Statistics were presented using visualization method processed by the Bibliographic Items Co-occurrence Matrix Builder (BICOMB) software. Results: 124 articles, from 2006 to 2018, covering 14 countries, involving 931 researchers, 356 institutions and 60 publications were obtained;American research papers are the largest components of the aforementioned articles;only one of them is written by Chinese authors. The 3 leading institutions in this domain are University OF Rochester, Ohio State University, Icahn School of Medicine at Mount Sinai, yet the distribution of authors is relatively decentralized. “Cancer” is the main journal that publishes the researches in this domain. Research hotspots are on “cancer prevention and screening”, “health disparities”, “economic evaluation”, “patient navigators”, and “ethnicity”. Conclusion: In China, the research on the patient navigation is still in its infancy. Therefore, the Chinese government should provide more endorsement to this particular area and encourage the cooperation with other countries. China, having a long way to go, should further explore patient navigation on colorectal cancer care and establish a model that matches its cultural backgrounds.

Arctic summer sea ice phenology including ponding from 1982 to 2017

Information on the Arctic sea ice climate indicators is crucial to business strategic planning and climate monitoring.Data on the evolvement of the Arctic sea ice and decadal trends of phenology factors during melt season are necessary for climate prediction under global warming.Previous studies on Arctic sea ice phenology did not involve melt ponds that dramatically lower the ice surface albedo and tremendously affect the process of sea ice surface melt.Temporal means and trends of the Arctic sea ice phenology from 1982 to 2017 were examined based on satellite-derived sea ice concentration and albedo measurements.Moreover,the timing of ice ponding and two periods corresponding to it were newly proposed as key stages in the melt season.Therefore,four timings,i.e.,date of snow and ice surface melt onset(MO),date of pond onset(PO),date of sea ice opening(DOO),and date of sea ice retreat(DOR);and three durations,i.e.,melt pond formation period(MPFP,i.e.,MO–PO),melt pond extension period(MPEP,i.e.,PO–DOR),and seasonal loss of ice period(SLIP,i.e.,DOO–DOR),were used.PO ranged from late April in the peripheral seas to late June in the central Arctic Ocean in Bootstrap results,whereas the pan-Arctic was observed nearly 4 days later in NASA Team results.Significant negative trends were presented in the MPEP in the Hudson Bay,the Baffin Bay,the Greenland Sea,the Kara and Barents seas in both results,indicating that the Arctic sea ice undergoes a quick transition from ice to open water,thereby extending the melt season year to year.The high correlation coefficient between MO and PO,MPFP illustrated that MO predominates the process of pond formation.

Two Weighted BMO Estimates for the Maximal Bochner-Riesz Commutator

In this note, the author prove that maximal Bocher-Riesz commutator Bδ,＊^b generated by operator Bδ,＊ and function b∈ BMO（ω） is a bounded operator from L^p（μ） into L^p（ν）, where w∈ （μν^- 1）^1/p,μ,v ∈ Ap for 1 〈 p 〈 ∞. The proof relies heavily on the pointwise estimates for the sharp maximal function of the commutator Bδ,＊^b.

Advances in Measures of Reducing Chemical Pesticides to Control Plant Diseases

In order to provide the technological support for further implementing measures of reducing chemical pesticide to control plant diseases,the research progress on non-chemical pesticide measures to control plant diseases are reviewed from the aspects of agricultural control,botanical pesticide control and microbial pesticide control,and the development prospects are proposed,including accelerating innovative research on botani-cal pesticide control such as Chinese herb extracts,and screening microbial pesticides from valuable bio-control bacteria or plant endophyte metabolites for commercial production and utilization.

Nonlocal Dynamics for Non-Gaussian Systems Arising in Biophysical Modeling

The aim of this article is to review our recent work on nonlocal dynamics of non-Gaussian systems arising in a gene regulatory network.We have used the mean exit time,escape probability and maximal likely trajectory to quantify dynamical behaviors of a stochastic diferential system with non-Gaussianα-stable Lévy motions,to examine how the nonGaussianity index and noise intensity afect the gene transcription processes.

Invariance in the Seasonal Median Dates for Mono-Modal Monsoonal Rainfall Distribution over the Semi-Arid Ecotone of Sub-Saharan West Africa

Seasonal distribution of mono-modal, monsoonal rainfall across the semi-arid ecotone of sub-Saharan of West Africa is highly variable and unpredictable. The ever-present risk of drought and crop failure in this environment often results in food shortages that are met by emergency food aid. Humanitarian assistance planners would be better prepared for such interventions in a timely manner if they have reliable indicators that forewarn the impending failure of the rains. A good indicator would be a characteristic of the seasonal rainfall distribution that can be shown to be reasonably invariant over time and space. The objective of this study is to investigate whether such invariance existed for the seasonal median date (meaning the date when 50% of the seasonal total occurs). Such invariance is expected since the sun’s cyclic declination forces the advance and retreat of the Inter-tropical Front over West Africa. We examined the statistical properties of the seasonal median date for 1349 station-years of rainfall records for 30 rainfall stations in Burkina Faso and Niger with coordinates ranging from 9.88° to 18.5° north latitude and -4.77° to 13.2° longitude. The results showed that the median date was quite narrowly distributed over years with rather weak dependence on geographical coordinates. It can therefore be used as a reasonable ex-ante indicator of the success or failure of the rains as the rainy season progress.

Fibrovascular proliferation of retinopathy of prematurity in zone Ⅱ after initial ranibizumab treatment

This study was designed to explore the prevalence of fibrovascular proliferation not regressed in zone Ⅱ stage 3 retinopathy of prematurity(ROP)after initial intravitreal ranibizumab(IVR)injections and to explore the possible influence factors.Fifty-seven patients(108 eyes)with ROP who underwent intravitreal injection of ranibizumab between January 2013 and July 2014 participated in the retrospective study.Based on regress of fibrovascular tissue or not after initial injections of ranibizumab,eligible eyes were divided into two groups.Data was collected and analyzed with SPSS 16.0.In the study,108 eyes of 57 patients(18 females,39 males)underwent initial intravitreal injection.The mean birth weight was 1,440.0±357.7 g and the mean gestational age was 30.5±2.0 weeks.Eight of 57(14.0%)patients showed unfavorable fibrovascular proliferation after initial ranibizumab treatment within 2 weeks.Among them,11 eyes were controlled by further laser treatment and 3 eyes underwent vitrectomy.The difference of occurrence rate in hemorrhage between the two groups was significant(P<0.030),and the unfavorable group required more laser treatment(P<0.001).The incidence of unfavorable fibrovascular proliferation was relatively high,and intraocular hemorrhage was possibly associated with the progress in zone Ⅱ stage 3 ROP after initial IVR injection.

Spatial-Temporal Event Detection Method with Multivariate Water Quality Data

With the rapid development of the society,water contamination events cause great loss if the accidents happen in the water supply system.A large number of sensor nodes of water quality are deployed in the water supply network to detect and warn the contamination events to prevent pollution from speading.If all of sensor nodes detect and transmit the water quality data when the contamination occurs,it results in the heavy communication overhead.To reduce the communication overhead,the Connected Dominated Set construction algorithm-Rule K,is adopted to select a part fo sensor nodes.Moreover,in order to improve the detection accuracy,a Spatial-Temporal Abnormal Event Detection Algorithm with Multivariate water quality data(M-STAEDA)was proposed.In M-STAEDA,first,Back Propagation neural network models are adopted to analyze the multiple water quality parameters and calculate the possible outliers.Then,M-STAEDA algorithm determines the potential contamination events through Bayesian sequential analysis to estimate the probability of a contamination event.Third,it can make decision based on the multiple event probabilities fusion.Finally,a spatial correlation model is applied to determine the spatial-temporal contamination event in the water supply networks.The experimental results indicate that the proposed M-STAEDA algorithm can obtain more accuracy with BP neural network model and improve the rate of detection and the false alarm rate,compared with the temporal event detection of Single Variate Temporal Abnormal Event Detection Algorithm(M-STAEDA).

Special library services for regional economic development(SRED)—Practice of the NSLC

Purpose: By case studies of the service for regional economic development(SRED) carried out by the National Science Library of the Chinese Academy of Sciences(NSLC), this article tries to describe basic directions of special libraries in the SRED.Design/methodology/approach: By comparing the aims and service forms of the SRED provided by domestic and foreign libraries and information service institutions, the authors examined the basic services provided by special libraries. Through a summary of the SRED exploration carried out by the NSLC, the authors introduce its main content, service methods, products, and service mechanisms. By analyzing the information needs of SRED users and summarizing users’ practical experiences of services, the authors propose a design for the SRED framework of the NSLC. In addition, the authors mention key points to be noticed during the process of service implementation, illustrating them with a number of selected SRED cases. The authors suggest that the SRED network and joint service mechanism are effective ways to implement SRED services. Findings: Based on information resource and expert networks, special libraries like the NSLC can carry out SRED to meet user requirements. The NSLC has not only constructed its own SRED framework, but has also expanded the patron service to the industrial intelligence service area. By setting up a nationwide S&T;(science and technology) novelty search network and a literature and information service alliance, the NSLC provides a variety of information training services. This enriches the content of the knowledge service of special libraries and enlarges the library service of the NSLC.Research limitations: The SRED of Chinese libraries is still in the exploratory stage. Questions as how to scientifically design service content and service modes, and how to establish a sustainable regional service system based on user needs are still being researchedand discussed. Furthermore, we need to pay more attention to the construction of the service network and respond more quickly to feedback while creating the SRED.Practical implications: The SRED experience of the NSLC has shown that special libraries can implement a knowledge service for economic development, and the SRED is an important direction of knowledge services for special libraries.Originality/value: Through describing a practical SRED, this paper provides a valuable reference for libraries in the transformation process from library service to knowledge service. The experimental SRED of the NSLC has verified the rationality of our service framework in support of regional economic development.

Highly sensitive fluorescent sensing and photocatalytic degradation performance of two-dimensional Tb-organic network

A novel tetra-nuclear Tb-organic network,named as [Tb_(4)(2-pyia)_(6)(HAc)_(0.5)(2,2'-bipy)(H_(2)O)_(4.5)]·2,2'-bipy·H_(2)O(1),was synthesized hydrothermally based on 5-(pyridin-2-ylmethoxy) isophthalic acid(H_(2)pyia) and 2,2'-bipyridine(2,2'-bipy) ligands,and characterized by single crystal X-ray diffraction,thermogravimetric(TG) analyses,powder X-ray diffraction(PXRD) and infrared(IR) technology.1 possesses a two-dimensional network based on the tetra-nuclear inorganic building units,and the π-πstacking interactions between the pyia^(2-) ligands and the guest 2,2'-bipy molecules play an important role in the forming of 3D supramolecular structure.1 exhibits excellent fluorescent sensing performance for Fe^(3+)(1.26×10^(-8) mol/L),Cr_(2)O_(7)^(2-)(8.1×10^(-7) mol/L),2,4,6-trinitrophenol(TNP)(2.71×10^(-8) mol/L)and tetracycline(TCT)(2.76×10^(-7) mol/L) in aqueous solution with lower detection concentrations.The sensing mechanisms of 1 were investigated by density functional theory(DFT) calculations,ultraviolet-visible(UV-Vis) diffuse reflectance spectroscopy,PXRD and fluorescent lifetime analyses.The activated product of 1 was prepared by heating at 255℃ under constant pressure and used to photo-catalytically degrade TCT.Both 1 and the activated one have good photocatalytic degradation performance for TCT with degradation rates of 84.29% and 96.07%,respectively.The photocatalytic mechanisms were discovered by UV-Vis diffuse reflectance spectroscopy and radical trap experiments.The Tb-organic framework might be an excellent multifunctional fluorescent sensor and a good photocatalytic agent for TCT degradation in the future.