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免疫治疗在胃癌中的应用研究进展
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作者 熊德君 丁晓凌 周晓荣 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第7期359-365,共7页
胃癌是全球最常见的恶性肿瘤之一,由于胃癌筛查率低和早期症状轻微,多数患者在晚期才被确诊,影响预后。近年来,随着研究深入,胃癌的免疫治疗取得显著进展,尤其对不可切除和转移性病例效果显著,使其成为继手术、化疗、放疗和靶向治疗后... 胃癌是全球最常见的恶性肿瘤之一,由于胃癌筛查率低和早期症状轻微,多数患者在晚期才被确诊,影响预后。近年来,随着研究深入,胃癌的免疫治疗取得显著进展,尤其对不可切除和转移性病例效果显著,使其成为继手术、化疗、放疗和靶向治疗后的有效治疗方法。免疫治疗通过人为调控免疫系统生效,包括过继细胞疗法、免疫检查点抑制剂和肿瘤疫苗等。目前,免疫治疗虽然前景广阔,但在临床应用中仍面临诸多挑战和问题。本文就胃癌免疫治疗的临床应用以及存在的问题进行综述。 展开更多
关键词 胃癌 免疫治疗 过继细胞疗法 免疫检查点抑制剂 肿瘤疫苗
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Integrated Active Suspension and Anti-Lock Braking Control for Four-Wheel-Independent-Drive Electric Vehicles
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作者 Ze Zhao Lei Zhang +3 位作者 xiaoling ding Zhiqiang Zhang Shaohua Li Liang Gu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第1期87-98,共12页
This paper presents an integrated control scheme for enhancing the ride comfort and handling performance of a four-wheel-independent-drive electric vehicle through the coordination of active suspension system(ASS)and ... This paper presents an integrated control scheme for enhancing the ride comfort and handling performance of a four-wheel-independent-drive electric vehicle through the coordination of active suspension system(ASS)and anti-lock braking system(ABS).First,a longitudinal-vertical coupled vehicle dynamics model is established by integrating a road input model.Then the coupling mechanisms between longitudinal and vertical vehicle dynamics are analyzed.An ASS-ABS integrated control system is proposed,utilizing an H∞controller for ASS to optimize load transfer effect and a neural network sliding mode control for ABS implementation.Finally,the effectiveness of the proposed control scheme is evaluated through comprehensive tests conducted on a hardware-in-loop(HIL)test platform.The HIL test results demonstrate that the proposed control scheme can significantly improve the braking performance and ride comfort compared to conventional ABS control methods. 展开更多
关键词 Four-wheel-independent-drive electric vehicles Active suspension system(ASS) Anti-lock braking system(ABS) Vertical-longitudinal vehicle dynamics
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母猪饲喂关键营养技术 被引量:3
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作者 丁小玲 苗文萍 +2 位作者 张琳琨 刘国桢 张宇昕 《猪业科学》 2021年第5期42-45,共4页
母猪的生产性能影响整个猪场的效益,营养调控是改善母猪生产性能的重要途径。文章结合国内外母猪营养研究的最新报道,概述了母猪后备期、妊娠期和泌乳期的关键营养技术,为养猪生产中的营养调控提供参考。
关键词 母猪 营养技术 生产性能 阶段营养
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间充质干细胞及其外泌体对肿瘤影响的研究进展 被引量:3
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作者 崔舒悦 汤帅 +1 位作者 丁晓玲 丁刚 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第5期351-357,共7页
在我国,无论城市还是农村,恶性肿瘤都是我国居民死亡的主要原因。间充质干细胞(mesenchymal stem cells,MSCs)具有多向分化潜能、自我更新能力和良好的免疫调节特性。而外泌体作为MSCs旁分泌的重要物质,在肿瘤微环境中介导细胞间的信息... 在我国,无论城市还是农村,恶性肿瘤都是我国居民死亡的主要原因。间充质干细胞(mesenchymal stem cells,MSCs)具有多向分化潜能、自我更新能力和良好的免疫调节特性。而外泌体作为MSCs旁分泌的重要物质,在肿瘤微环境中介导细胞间的信息交流与传递,影响肿瘤的发生发展。有研究报道了MSCs及其来源的外泌体对肿瘤的影响具有相互矛盾的发现,一方面MSCs及其外泌体具有肿瘤趋向性,能够靶向特定部位抑制肿瘤生长;另一方面也有证据表明MSCs具有致瘤性,作为肿瘤微环境的一部分影响肿瘤的生长和迁移。本文将综述MSCs及其外泌体与肿瘤发生发展的关系以及MSCs及其外泌体如何在肿瘤发生发展中扮演不同角色,以期为肿瘤的诊断、预后和精准治疗提供有益的帮助。 展开更多
关键词 间充质干细胞 外泌体 肿瘤 癌症
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Enhanced photocatalytic hydrogen evolution along with byproducts suppressing over Z-scheme CdxZn1-xS/Au/g-C3N4 photocatalysts under visible light 被引量:12
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作者 He Zhao xiaoling ding +2 位作者 Bing Zhang Yingxuan Li Chuanyi Wang 《Science Bulletin》 SCIE EI CAS CSCD 2017年第9期602-609,共8页
Inspired by natural photosynthesis, a new series of Z-scheme Cd_xZn_(1-x)S/Au/g-C_3N_4 photocatalysts were synthesized via depositing Au particles on g-C_3N_4, followed by anchoring CdxZn_(1-x)S solid solution on the ... Inspired by natural photosynthesis, a new series of Z-scheme Cd_xZn_(1-x)S/Au/g-C_3N_4 photocatalysts were synthesized via depositing Au particles on g-C_3N_4, followed by anchoring CdxZn_(1-x)S solid solution on the pre-formed Au/g-C_3N_4 for photocatalytic hydrogen evolution. Their structure, morphology and optical property were investigated in detail. Photocatalytic activities of the developed photocatalysts for water splitting were evaluated under visible-light irradiation(k > 420 nm) using glucose as electron donor.The highest hydrogen evolution rate of 123 lmol g^(-1)h^(-1)is achieved by Cd_(0.8Z)n_(0.2)S/Au/g-C_3N_4, which is 52.2 and 8.63 times higher than that of Au/g-C_3N_4 and Cd S/Au/g-C_3N_4, respectively. The results of photoluminescence spectra, photoelectrochemical and time-resolved photoluminescence spectra indicate that the improved photocatalytic activities for Cd_xZn_(1-x)S/Au/g-C_3N_4 are due to the efficient separation of photogenerated carriers. In addition, it is noteworthy that the undesired byproducts CO and CO_2 are greatly reduced by introducing CdxZn_(1-x)S over Au/g-C_3N_4 surface. In the photocatalytic process, gluconic acid originated from the reaction of photogenerated hydroxyl radical with glucose plays a vital role on suppressing the formation of the gas byproducts. The present work will provide a new strategy to design Z-scheme photocatalysts with enhanced efficiency for water splitting along with suppressing the byproducts. 展开更多
关键词 Hydrogen evolution CdxZn1-xS/Au/g-C3N4 BYPRODUCTS Z-scheme Visible light
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