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Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease
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作者 Dandan Chu Mengyang Zhao +8 位作者 Shisong Rong Wonho Jhe xiaolu cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第6期439-457,共19页
Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Alt... Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases. 展开更多
关键词 Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome NANOMEDICINE
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Intelligent Vascularized 3D/4D/5D/6D‑Printed Tissue Scaffolds 被引量:1
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作者 Xiaoyu Han Qimanguli Saiding +7 位作者 xiaolu cai Yi Xiao Peng Wang Zhengwei cai Xuan Gong Weiming Gong Xingcai Zhang Wenguo Cui 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第12期376-418,共43页
Blood vessels are essential for nutrient and oxygen delivery and waste removal.Scaffold-repairing materials with functional vascular networks are widely used in bone tissue engineering.Additive manufacturing is a manu... Blood vessels are essential for nutrient and oxygen delivery and waste removal.Scaffold-repairing materials with functional vascular networks are widely used in bone tissue engineering.Additive manufacturing is a manufacturing technology that creates three-dimensional solids by stacking substances layer by layer,mainly including but not limited to 3D printing,but also 4D printing,5D printing and 6D printing.It can be effectively combined with vascularization to meet the needs of vascularized tissue scaffolds by precisely tuning the mechanical structure and biological properties of smart vascular scaffolds.Herein,the development of neovascularization to vascularization to bone tissue engineering is systematically discussed in terms of the importance of vascularization to the tissue.Additionally,the research progress and future prospects of vascularized 3D printed scaffold materials are highlighted and presented in four categories:functional vascularized 3D printed scaffolds,cell-based vascularized 3D printed scaffolds,vascularized 3D printed scaffolds loaded with specific carriers and bionic vascularized 3D printed scaffolds.Finally,a brief review of vascularized additive manufacturing-tissue scaffolds in related tissues such as the vascular tissue engineering,cardiovascular system,skeletal muscle,soft tissue and a discussion of the challenges and development efforts leading to significant advances in intelligent vascularized tissue regeneration is presented. 展开更多
关键词 INTELLIGENT Additive manufacturing Tissue engineering VASCULARIZATION OSTEOGENESIS
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Computational Investigation of the Interaction Between Hydrogen Atoms and an Intense Circularly Polarized Laser Field
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作者 Lifeng Yang Wang Xu +9 位作者 Qiren Zhang Wen Luo Qiangyan Pan xiaolu cai Gongtao Fan Yongjiang Li Benji Xu Zhe Yan Guangwei Fan Zhendong An 《Communications in Computational Physics》 SCIE 2012年第3期756-774,共19页
The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a se... The study of interactions between a high-power laser and atoms has been one of the fundamental and interesting topics in strong field physics for decades.Based on a nonperturbativemodel,ten years ago,we developed a set of programs to facilitate the study of interactions between a circularly polarized laser and atomic hydrogen.These programs included only contribution from the bound states of the hydrogen atom.However,as the laser intensity increases,contribution from continuum states to the excitation and ionization processes becomes larger and can no longer be neglected.Furthermore,because the original code is not able to add this contribution directly due to its many disadvantages,a major upgrade of the code is required before including the contribution from continuum states in future.In this paper,first we deduce some important formulas for contribution of continuum states and present modifications and tests for the upgraded code in detail.Second we show some comparisons among new results,old results from the original codes and the available experimental data.Overall the new result agrees with experimental data well.Last we present our calculation of above-threshold ionization(ATI)rate and compare it with a pertubative calculation.The comparison shows that our nonperturbative calculation can also produce ATI peak suppression. 展开更多
关键词 Hydrogen atoms high-power laser nonperturbative PHOTOIONIZATION
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