Discussion about Tourism Development of Agricultural Cultural Heritage in Xiajin County of Shandong Province

[Objectives]To discuss the protection and utilization of agricultural cultural heritage in Xiajin County in the context of deep integration of culture and tourism.With the advancement of the process of revitalizing villages through culture and tourism,agricultural cultural heritage has gradually attracted wide attention from all walks of life.This paper is intended to provide new ideas and strategies for the development of local cultural tourism through in-depth analysis of agricultural cultural heritage resources in Xiajin County.[Methods]Using the method of literature research,this paper systematically sorted out the historical background,current situation and value of agricultural cultural heritage in Xiajin County.Besides,the agricultural cultural heritage resources in Xiajin County were comprehensively evaluated using the 3-3-6 evaluation method.On this basis,combined with the theory of industrial convergence and sustainable development,it came up with some specific suggestions on the tourism development of agricultural cultural heritage in Xiajin County.[Results]Through the in-depth evaluation of agricultural cultural heritage resources in Xiajin County,it is found that it has rich historical and cultural heritage and unique tourism value.However,there are still some problems in protection and utilization.In view of the problems,it recommended to attach importance to the inheritance of Xiajin agricultural cultural heritage,develop characteristic heritage tourism and improve relevant supporting facilities.[Conclusions]Deeply excavating the essence of agricultural cultural heritage in Xiajin County and organically combining it with modern tourism is an important way to realize the sustainable development of local cultural tourism.The recommendations are expected to provide reference for the development of agricultural heritage tourism in Xiajin County and other regions,and help to promote the deep integration of culture and tourism,and promote rural revitalization and cultural inheritance.

Overexpression of C-terminal fragment of glutamate receptor 6 prevents neuronal injury in kainate-induced seizure via disassembly of Glu R6-PSD95-MLK3 signaling module

Our previous study showed that when glutamate receptor （GluR）6 C terminus-containing peptide conjugated with the human immunodeficiency virus Tat protein （GluR6）-9c is delivered into hippocampal neurons in a brain ischemic model, the activation of mixed lineage kinase 3 （MLK3） and c-Jun NH2-terminal kinase （JNK） is inhibited via GluR6-postsynaptic density protein 95 （PSD95）. In the present study, we investigated whether the recombinant adenovirus （Ad） carrying GluR6c could suppress the assembly of the GluR6-PSD95-MLK3 signaling module and decrease neuronal cell death induced by kainate in hippocampal CA1 subregion. A seizure model in Sprague-Dawley rats was induced by intraperitoneal injections of kainate. The effect of Ad- Glur6-9c on the phosphorylation of INK, MLK3 and mitogen-activated ldnase kinase 7 （MKK7） was observed with western immunoblots and immunohistochemistry. Our findings revealed that overexpression of GluR6c inhibited the interaction of GluR6 with PSD95 and prevented the kainate-induced activation of INK, MLK3 and MKK7. Furthermore, kainate-mediated neuronal cell death was significantly suppressed by GluR6c. Taken together, GluR6 may play a pivotal role in neuronal cell death.

Biochar-mediated regulation of greenhouse gas emission and toxicity reduction in bioremediation of organophosphorus pesticide-contaminated soils

Organophosphorus pesticides(OPPs) are a set of toxic persistent organic pollutants(POPs) present in the environment. Recently, biochar-mediated bioremediation has exhibited many advantages over conventional methods for the remediation of pesticide-contaminated soil. In the present study, biochar and nitrogen fertilizer(NH_4NO_3)were employed to remediate OPP-contaminated soil and the greenhouse gas(GHG) emission during 90 days of incubation was investigated. After thermal desorption treatment, the content of organophosphorus pesticides reduced from 175.61 μg·kg^(-1) to 62.68 μg·kg^(-1). The addition of NH_4NO_3 in the following bioremediation led to larger reduction(34.35%) of the pesticide concentration than that of biochar(31.90%) for the contaminated soils with thermal desorption treatment, while the simultaneous addition of biochar and NH_4NO_3 led to the largest reduction of pesticide concentration(11.07%) for the soil without thermal desorption treatment. The addition of biochar and NH_4NO_3 only slightly increased the emission rate of GHGs from the soil without thermal treatment,but remarkably increased the emission rate of GHGs from the soil after thermal treatment. In most cases, the addition of NH_4NO_3 is more effective than biochar to promote the degradation of pesticide, but also exhibited higher GHG emission. The microbial community analysis suggests that the enhanced degradation of pesticide is mainly owing to the increased activity of microorganism.

Research on fractal characteristics of primary phase morphology in semi-solid A356 alloy

Semi-solid slurry of A356 alloy was prepared by low superheat pouring and slightly electromagnetic stirring, and the fractal characteristics of morphology in semi-solid primary phase was researched. The fractal dimensions of primary phase morphology in the semi-solid A356 alloy were calculated by the program written to calculate the fractal dimensions of box-counting in the image of solid phase morphology in semi-solid metal slurry. The results indicated that the morphology of primary phase in semi-solid A356 prepared by low superheat pouring and slightly electromagnetic stirring is characterized by fractal dimension, and the primary phase morphology obtained by the different processing parameters has different fractal dimensions. The morphology of primary phase at the different position of ingot has different fractal dimensions, which reflected the effect of solidified conditions at different positions in the same ingot on the morphology of semi-solid primary phase. Solidification of semi-solid alloy is a course of change in fractal dimension.

Prelithiation Enhances Cycling Life of Lithium-Ion Batteries:A Mini Review

During the last decade,the rapid development of lithium-ion battery(LIB)energy storage systems has provided significant support for the efficient operation of renewable energy stations.In the coming years,the service life demand of energy storage systems will be further increased to 30 years from the current 20 years on the basis of the equivalent service life of renewable energy stations.However,the life of the present LIB is far from meeting such high demand.Therefore,research on the next-generation LIB with ultra-long service life is imminent.Prelithiation technology has been widely studied as an important means to compensate for the initial coulombic efficiency loss and improve the service life of LIBs.This review systematically summarized the different prelithiation methods from anode and cathode electrodes.Moreover,the large-scale industrialization challenge and the possibility of the existing prelithiation technology are analyzed,based on three key parameters:industry compatibility,prelithiation efficiency,and energy density.Finally,the future trends of improvement in LIB performance by other overlithiated cathode materials are presented,which gives a reference for subsequent research.

The Family of Exponential Attractors and Inertial Manifolds for a Generalized Nonlinear Kirchhoff Equations

In this paper, we study the long-time behavior of a class of generalized nonlinear Kichhoff equation under the condition of n dimension. Firstly, the Lipschitz property and squeezing property of the nonlinear semigroup related to the initial-boundary value problem are proved, and then the existence of its exponential attractor is obtained. By extending the space E0 to Ek, a family of the exponential attractors of the initial-boundary value problem is obtained. In the second part, we consider the long-time behavior for a system of generalized Kirchhoff type with strong damping terms. Using the Hadamard graph transformation method, we obtain the existence of a family of the inertial manifolds while such equations satisfy the spectrum interval condition.

Effect of Dihydrotestosterone on Costimulatory Molecules in a Mouse Model of Graves’ Disease

Objective Graves’disease is the most common autoimmune thyroid disease and its prevalence and clinical manifestations are disparate between females and males.Costimulatory molecules play an essential role in regulating autoimmune responses.The objective of this study was to determine if expression of inhibitory molecules was correlated with treatment by dihydrotestosterone(DHT)in an in vivo BALB/c mouse model of experimental autoimmune Graves’disease.Methods Female BALB/c mice were immunized three times with thyroid stimulating hormone receptor A-subunit encoded by adenovirus to establish a Graves’disease model.Three different doses of DHT or a matching placebo were administered by implantation of slow-release pellets a week before the first immunization.Four weeks after the third immunization,the mice were euthanatized,and then the spleen and thymus were removed.Total thyroxine and free thyroxine levels in serum of mice were detected using a radioimmunoassay kit.Real-time polymerase chain reaction was performed to estimate the expression of costimulatory molecules in lymphocytes from the spleen and thymus.Flow cytometry was used to analyze the percentage of CD4^+T cells in splenic lymphocytes.Quantitative data were compared with unpaired t-tests.Correlation between two variables was analyzed using Analysis of Variance.Results Treatment with DHT can dramatically reduce total thyroxine and free thyroxine levels.Higher expression of programmed death-1 was found in the spleen of Graves’disease mice receiving 5 mg of DHT treatment(0.635±0.296 vs.0.327±0.212;t=2.714,P=0.014),similarly,T-cell immunoglobulin domain and mucin domain 3(TIM-3)in both the spleen(1.004±0.338 vs.0.646±0.314;t=2.205,P=0.022)and the thymus(0.263±0.127 vs.0.120±0.076;t=3.221,P=0.004)also increased after 5 mg of DHT treatment compared with the parallel placebo model mice.Moreover,the percentage of CD4^+T cells declined in the splenic lymphocytes of Graves’disease mice treated with 5 mg of DHT(19.90%±3.985%vs.24.05%±2.587%;t=2.804,P=0.012).A significant negative association was observed between expression of TIM-3 in the spleen and serum levels of total thyroxine(r=-0.7106,P=0.014)as well as free thyroxine(r=-0.6542,P=0.029).Conclusion This study demonstrates that DHT can ameliorate experimental autoimmune Graves’disease,which may occur by up-regulating expression of programmed death-1 and TIM-3 and inhibiting development of CD4^+T cells.

Effect of reinforced fiber on morphology of Si phases in Al_2O_3/AI-Si alloy composite

Alumina/aluminum-silicon alloy composite is manufactured by squeeze casting. The effect of the reinforcementon the morphology of the silicon phase in aluminum-silicon alloy is studied. The results indicate that an alumina fiber canserve as propitious sites for the heterogeneous nucleation of the silicon phase, and the primary silicon in the compositecan nucleate on the surface of the fiber. The fiber in the composite can trigger twin during the coupled growth of thealuminum-silicon eutectic and lead to modification of the eutectic silicon near the fiber.

Development of Yimeng Red Tourism Resources from the Perspective of Tourist Perception

In this paper,the connotation of red tourism is explained from a new perspective firstly.On the basis of summarizing and evaluating the red tourism resources in Yimeng,combined with the current development status of red tourism in Yimeng region,based on the subjective evaluation of tourists on the development of red tourism in Yimeng region,several targeted suggestions for the development of red tourism in Yimeng are proposed.

Exploration on the Value and Path of Red Tourism Integrated into Ideological and Political Courses in Colleges and Universities

The state has issued a series of policy documents to vigorously promote the construction and development of ideological and political courses in colleges and universities.Red tourism provides a broader vision and deeper meaning for deepening the educational function of ideological and political courses.Using research methods such as literature research and case analysis,the restrictive factors that affect the effect of ideological and political education are discussed,and new ideas and new ways are put forward,such as promoting the synchronous construction of the first classroom and the second classroom of ideological and political courses,and integrating the small classroom of ideological and political education into the large classroom of society.The research could provide useful reference for the deepening development of red tourism in the new era and the multi-dimensional expansion of ideological and political courses in colleges and universities.

Effectiveness of Rain Classroom Intelligent Teaching Design : A Case Study of the Course of Spring Water Tourism Resources

[Objectives]To evaluate the effectiveness of Rain Classroom intelligent teaching in the course of Spring Water Tourism Resources.[Methods]The course of Spring Water Tourism Resources in the course of Overview of Tourism Resources was taken as an example,the pre-class preparation,in-class teaching,and after-class evaluation links were designed separately through the Rain Classroom platform.Then,a questionnaire survey was carried out for the students of Spring Water Tourism Resources.[Results]About 58.3%of the students believed that the greatest advantage of using the Rain Classroom teaching platform is that the learning method is flexible and can improve the ability of independent learning;61.78%of students stated that playing 3D animation in the classroom has the best effect for learning different tourism resources;with the aid of the Rain Classroom platform,the communication between teachers and students becomes more timely,and the students' ability to deal with practical problems can be practiced.[Conclusions]This study is intended to build an intelligent classroom model suitable for tourism management department based on the Rain Classroom platform.It is recommended to promote and apply this model in the teaching of tourism management.

Teaching Design of Tourism Management Based on Information-based Teaching Method:A Case Study of Selection of Hotel Construction Site

Taking the knowledge points of hotel construction site selection as an example,this paper integrated the information-based teaching method with traditional classrooms.With the aid of virtual reality(VR)technology,the information-based teaching can turn the abstract knowledge into vivid knowledge.Using the Rain Classroom platform,teachers can communicate with students in a better manner.Combined with the powerful spatial data analysis function of geographic information system(GIS)software,it is intended to provide new ideas and perspectives for the effective integration of traditional teaching classrooms and information technology,and effectively apply them to the practical teaching process.

Research on Evaluation and Development of Industrial Heritage Tourism Resources in Textile Valley

This paper selects Qingdao Textile Valley as the research object,establishes the evaluation system of industrial heritage tourism resources,and analyzes the evaluation factors of industrial heritage tourism resources,such as resource element value,market location value,and environmental factors.Then this paper puts forward some effective suggestions to promote the development of industrial heritage tourism in Textile Valley.The results show that the measures put forward,such as fully tapping the value of resource elements,improving the surrounding traffic environment,perfecting tourism signs,perfecting local traffic routes,improving the complementarity of tourism resources,and expanding the tourist market,can scientifically and effectively protect urban industrial heritage,improve the development level of urban tourism,and speed up the transformation of new and old energy in Qingdao.

Effect of Nursing Intervention Based on Caprini Risk Assessment Scale for Venous Thromboembolism in Perioperative Patients with Liver Cancer

Objective:To explore the effect of nursing intervention based on Caprini risk assessment scale for venous thromboembolism(VTE)in perioperative patients with liver cancer.Methods:A total of 128 hepatocellular cancer(HCC)patients who were hospitalized in our department from January 2021 to March 2022 and met the research criteria were selected.According to odd and even numbers in the order of inclusion,64 cases were divided into two groups:a control group and an observation group.The control group received routine nursing intervention during perioperative period,while the observation group received nursing intervention based on Caprini risk assessment scale for VTE.The incidence of VTE and complications were compared between the two groups.Results:The incidence of VTE and postoperative complications in the observation group were lower than those in the control group(P<0.05).Conclusion:Nursing intervention based on Caprini risk assessment scale for VTE can reduce the incidence of perioperative deep vein thrombosis and complications in patients with liver cancer;thus,it is worthy of clinical application.

Do They Pose a Danger:Evaluation of the Recidivism Characteristics in China’s Community Corrections?

The modern criminal justice system includes community corrections,which play a preventive role in lowering recidivism among offenders.However,some offenders continue to commit crimes during community corrections.This research focuses on community corrections in Chinese community policing practice,particularly offender recidivism.The study collected a total of 500 questionnaires from offenders in the provincial administrative regions of northern China,which included first offense status,psychological status,and recidivism behavior.The study found that most recidivists are usually arrested for“drunk driving”,which may be related to their ability to exercise self-restraint,and that alcohol may contribute to their deviant behavior.Another important finding relates to young recidivists,who may have difficulty securing employment during community corrections and thus use crime again to gain income.In general,this study explores the offender population in Chinese community corrections practice and discusses the factors within it that influence offender recidivism.This may support law enforcement agencies in further evaluating the effectiveness of community corrections,and may provide new information for understanding community corrections in China.

Application Effect of Medium-Length Peripheral Catheter in Critically Ill Patients Undergoing Hepatobiliary Surgery

Objective:To investigate the effect of using peripheral medium-length catheters in critically ill patients undergoing hepatobiliary surgery.Methods:A retrospective analysis of the nursing experience and effect of using medium-length catheters for infusion in 102 critically ill patients undergoing hepatobiliary surgery from March 2021 to April 2022 was conducted.Results:All 102 patients had successful catheter placement with no catheter-associated infections,blockage,decannulation,or breakage.However,four cases had blood oozing from the puncture site,but it resolved after changing the dressing.Conclusion:Medium-length catheters are superior to traditional infusion tools in terms of benefit;thus,they deserve to be widely promoted in clinical practice.

基于信息化老年综合评估的多学科管理护理模式在脑梗死患者中的应用效果

目的探讨基于信息化老年综合评估的多学科管理护理模式在脑梗死患者中的应用效果。方法选取江苏省南通市通州区人民医院神经内科2022年6月至2023年6月住院的老年脑梗死患者为研究对象,分别在本院神经内科病区1和神经内科病区2随机抽取干预组和对照组患者各63例。对照组给予常规的护理干预措施,包括入院后的健康宣教、病情观察、治疗护理以及出院前指导等内容。干预组给予基于信息化的老年综合评估的多学科管理护理干预。采用χ^(2)检验比较2组患者住院期间的并发症发生率,采用t检验比较干预前后的肢体简化Fugl-Meyer运动功能和平衡功能评分、日常生活能力Barthel评分、焦虑抑郁水平HAMD/HAMA评分以及生活质量量表评分等指标的变化。结果(1)干预组患者住院期间的并发症总发生率为3.17%,低于对照组的12.70%,差异具有统计学意义(χ^(2)=3.682,P=0.024)。(2)干预后,2组患者的上下肢简化Fugl-Meyer运动功能评分和平衡功能评分均高于干预前,且干预组的上下肢简化Fugl-Meyer运动功能评分[上肢:(49.64±10.12)分 vs(43.88±9.33)分;下肢:(52.90±11.81)分 vs(45.21±10.75)分]以及简化Fugl-Meyer平衡功能评分[上肢:(9.17±0.98)分 vs(12.45±1.19)分;下肢:(12.45±1.19)分 vs(8.91±1.11)分]均比对照组高,差异均具有统计学意义(t=3.255,P=0.041;t=3.493,P=0.036;t=3.670,P=0.032;t=3.945,P=0.027)。(3)干预后2组患者的Barthel评分均高于干预前,同时干预组Barthel评分[(92.70±19.15)分]较对照组[(77.57±18.47)分]更高,差异具有统计学意义(t=3.369,P=0.031)。(4)干预后干预组的HAMD与HAMA评分均低于干预前,同时也低于对照组[(36.57±4.61)分 vs(49.24±5.42)分;(37.44±3.72)分 vs(51.74±4.32)分],差异具有统计学意义(t=5.324,P=0.007;t=4.845,P=0.012)。(5)干预前2组患者的独立性、生理功能、社会关系、环境、精神、心理状态6项生活质量量表评分比较,差异均无统计学意义(P均>0.05)。干预后干预组的6项生活质量量表评分比均要高于干预前,也高于对照组,差异均具有统计学意义(P均<0.05)。结论基于信息化老年综合评估的多学科管理护理模式能够降低脑梗死患者住院期间的并发症发生率,提升患者的肢体功能状态和日常生活能力,同时还能减少患者焦虑与抑郁等不良情绪,最终加速患者的康复,提高其生活质量。

2007-2018年浙江省义乌市新生儿出生体重变化趋势比较分析

目的分析2007-2018年浙江省义乌市新生儿出生体重变化趋势,并与不同标准进行比较,制订和更新适合目标人群的新生儿出生体重曲线。方法利用义乌市妇幼保健信息平台的数据,提取2007年1月至2018年6月记录的新生儿出生体重,分析出生体重变化趋势以及低出生体重儿和巨大儿发生率变化情况。采用LMS方法计算出胎龄别出生体重百分位数参考值,运用GAMLSS模型绘制出生体重曲线;将本研究的胎龄别出生体重百分位数参考值与国内外研究进行对比。结果本研究共纳入了68 358名新生儿,其中男、女婴的平均出生体重分别为3 373 g和3 257 g。男、女婴早产的比例分别为6.01%和5.04%,男婴早产比例显著高于女婴。低出生体重儿和巨大儿分别占3.84%和7.43%。出生胎龄33~41周的男婴出生体重均显著大于女婴出生体重。随着出生胎龄的增长,出生体重也相应增加。男婴出生胎龄为37~41周的胎龄别出生体重均大于2015年全国标准;33~41周的胎龄别出生体重均大于INTERGROWTH-21st的百分位数参考值。女婴出生胎龄为38~41周的胎龄别出生体重均大于2015年全国标准;33、35~41周的胎龄别出生体重均大于INTERGROWTH-21st的百分位数参考值。结论 2007-2018年义乌市男婴出生体重呈逐年下降趋势,女婴出生体重随年份变化趋势不显著。本次研究提出了义乌市新生儿胎龄别出生体重参考值,分性别绘制了出生体重曲线参考。

茶树嫩枝扦插的高效方法

茶(Camellia sinensis)是世界上最重要的饮料作物之一,随着种植面积的扩大,茶苗的需求量也日益增加。传统的扦插育苗方式存在着生根难、周期长和取材难等问题,因此优化扦插生根的方法十分重要。该研究以较易获得、但传统方法难以生根的绿色嫩枝为扦插材料,首先对培养介质进行改良。与土培和水培相比,利用海绵培养可以使茶树幼嫩插穗在1个月之内快速生根,生根率达32.2%。其次,对海绵培方法做进一步优化,确定一芽一叶的幼嫩短穗生根潜力更佳;同时,添加生根粉能够促进茶树茎部愈伤组织与根系的形成,其中1.25g·L–1生根粉处理48小时对茶树扦插快速生根最有效,生根率达42.0%。综上,通过优化培养介质和扦插材料以及适当添加生根粉等措施,建立了一种茶树高效嫩枝扦插生根的方法。该方法能够显著缩短嫩枝插穗的生根时间,突破了扦插材料的限制,有效降低了扦插成本,具有重要的应用前景。

Vertical response of microbial community and degrading genes to petroleum hydrocarbon contamination in saline alkaline soil

A column microcosm was conducted by amending crude oil into Dagang Oilfield soil to simulate the bioremediation process. The dynamic change of microbial communities and metabolic genes in vertical depth soil from 0 to 80 cm were characterized to evaluate the petroleum degradation potential of indigenous microorganism. The influence of environmental variables on the microbial responds to petroleum contamination were analyzed. Degradation extent of 42.45% of n-alkanes(C8–C40) and 34.61% of 16ΣPAH were reached after 22 weeks. Relative abundance of alkB, nah, and phe gene showed about 10-fold increment in different depth of soil layers. Result of HTS profiles demonstrated that Pseudomonas, Marinobacter and Lactococcus were the major petroleum-degrading bacteria in0–30 and 30–60 cm depth of soils. Fusarium and Aspergillus were the dominant oil-degrading fungi in the 0–60 cm depth of soils. In 60–80 cm deep soil, anaerobic bacteria such as Bacteroidetes, Lactococcus, and Alcanivorax played important roles in petroleum degradation.Redundancy analysis(RDA) and correlation analysis demonstrated that petroleum hydrocarbons(PHs) as well as soil salinity, clay content, and anaerobic conditions were the dominant effect factors on microbial community compositions in 0–30, 30–60, and 60–80 cm depth of soils, respectively.