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Segment routing for traffic engineering and effective recovery in low-earth orbit satellite constellations
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作者 Shengyu Zhang xiaoqian li Kwan Lawrence Yeung 《Digital Communications and Networks》 SCIE CSCD 2024年第3期706-715,共10页
Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in in... Low-Earth Orbit Satellite Constellations(LEO-SCs)provide global,high-speed,and low latency Internet access services,which bridges the digital divide in the remote areas.As inter-satellite links are not supported in initial deployment(i.e.the Starlink),the communication between satellites is based on ground stations with radio frequency signals.Due to the rapid movement of satellites,this hybrid topology of LEO-SCs and ground stations is time-varying,which imposes a major challenge to uninterrupted service provisioning and network management.In this paper,we focus on solving two notable problems in such a ground station-assisted LEO-SC topology,i.e.,traffic engineering and fast reroute,to guarantee that the packets are forwarded in a balanced and uninterrupted manner.Specifically,we employ segment routing to support the arbitrary path routing in LEO-SCs.To solve the traffic engineering problem,we proposed two source routings with traffic splitting algorithms,Delay-Bounded Traffic Splitting(DBTS)and DBTS+,where DBTS equally splits a flow and DBTS+favors shorter paths.Simu-lation results show that DBTS+can achieve about 30%lower maximum satellite load at the cost of about 10%more delay.To guarantee the fast recovery of failures,two fast reroute mechanisms,Loop-Free Alternate(LFA)and LFA+,are studied,where LFA pre-computes an alternate next-hop as a backup while LFA+finds a 2-segment backup path.We show that LFA+can increase the percentage of protection coverage by about 15%. 展开更多
关键词 Fast reroute Low-earth orbit satellite constellation Segment routing Traffic engineering Traffic splitting
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Incubation temperature induced developmental plasticity of cold responsive physiological phenotypes in Japanese Quails
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作者 Yingxin Kou Rongmiao Zhang +3 位作者 xiaoqian li Na Zhu Yihang Huang Shuping Zhang 《Avian Research》 SCIE CSCD 2024年第3期385-394,共10页
Embryonic development is a critical period for phenotype formation.Environmental variation during embryonic development can induce changes in postnatal phenotypes of animals.The thyroxine secretion and aerobic metabol... Embryonic development is a critical period for phenotype formation.Environmental variation during embryonic development can induce changes in postnatal phenotypes of animals.The thyroxine secretion and aerobic metabolic activity of small birds are important phenotypes closely related to their winter survival.In the context of climate change,it is necessary to determine whether temperature variation during incubation in birds leads to developmental plasticity of these cold responsive phenotypes.We incubated Japanese Quail(Coturnix japonica)eggs at 36.8℃,37.8℃,and 38.8℃,and raised the chicks to 35-day old at 22℃with same raising conditions,then all the quails were exposed to gradually temperature dropping environment(from 15℃to 0℃).After cold treatment,serum T3 level,resting metabolic rate,skeletal muscle and liver metabolomes of the birds were measured.The serum T3 levels were significantly lower in the 38.8℃group and significantly higher in the 36.8℃group compared to the 37.8℃group.The metabolic rate in the 38.8℃group was significantly lower compared to the 37.8℃group.Compared with the 37.8℃group,metabolites involved in the tricarboxylic acid cycle in the liver were significantly lower in the 38.8℃group,and metabolites related to lipid oxidation metabolism and fatty acid biosynthesis were significantly lower in the skeletal muscles in the 38.8℃group but significantly higher in the 36.8℃group.These results indicate that incubation temperature variation can lead to developmental plasticity in cold responsive physiological phenotypes.Higher incubation temperature may impair the capacity of birds coping with cold challenge. 展开更多
关键词 Cold response Developmental plasticity Incubation temperature Metabolic rate Metabolomes Precocial bird THYROXIN
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Internal electric field modulation by copper vacancy concentration of cuprous sulfide nanosheets for enhanced selective CO_(2) photoreduction
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作者 Xian Shi Weidong Dai +4 位作者 xiaoqian li Yang Bai Qin Ren Yao Lei Xing'an Dong 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第4期324-330,共7页
Although the internal electric field(IEF)of photocatalysts is acknowledged as a potent driving force for photocharge separation,modulating the IEF intensity to achieve enhanced photocatalytic performances remains a ch... Although the internal electric field(IEF)of photocatalysts is acknowledged as a potent driving force for photocharge separation,modulating the IEF intensity to achieve enhanced photocatalytic performances remains a challenge.Herein,cuprous sulfide nanosheets with different Cu vacancy concentration were employed to study IEF modulation and corresponding direct charge transfer.Among the samples,Cu_(1.8)S nanosheets possessed intensified IEF intensity compared with those of Cu_(2)S and Cu_(1.95)S nanosheets,suggesting that an enhanced IEF intensity could be achieved by introducing more Cu vacancies.This intensified IEF of Cu_(1.8)S nanosheets induced numerous photogenerated electrons to migrate to its surface,and the dissociative electrons were then captured by Cu vacancies,resulting in efficient charge separation spatially.In addition,the Cu vacancies on Cu_(1.8)S nanosheets accumulated electrons as active sites to lower the energy barrier of rate-determining step of CO_(2)photoreduction,leading to the selective conversion of CO_(2)to CO.Herein,the manipulation of IEF intensity through Cu vacancy concentration regulation of cuprous sulfide photocatalysts for efficient charge separation has been discussed,providing a scientific strategy to rationally improve photocata lytic performances for solar energy conversion. 展开更多
关键词 Internal electric field intensity Cuprous sulfide photocatalysts Cu vacancies Charge separation Selective CO_(2) photoreduction
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An intelligent task offloading algorithm(iTOA)for UAV edge computing network 被引量:8
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作者 Jienan Chen Siyu Chen +3 位作者 Siyu Luo Qi Wang Bin Cao xiaoqian li 《Digital Communications and Networks》 SCIE 2020年第4期433-443,共11页
Unmanned Aerial Vehicle(UAV)has emerged as a promising technology for the support of human activities,such as target tracking,disaster rescue,and surveillance.However,these tasks require a large computation load of im... Unmanned Aerial Vehicle(UAV)has emerged as a promising technology for the support of human activities,such as target tracking,disaster rescue,and surveillance.However,these tasks require a large computation load of image or video processing,which imposes enormous pressure on the UAV computation platform.To solve this issue,in this work,we propose an intelligent Task Offloading Algorithm(iTOA)for UAV edge computing network.Compared with existing methods,iTOA is able to perceive the network’s environment intelligently to decide the offloading action based on deep Monte Calor Tree Search(MCTS),the core algorithm of Alpha Go.MCTS will simulate the offloading decision trajectories to acquire the best decision by maximizing the reward,such as lowest latency or power consumption.To accelerate the search convergence of MCTS,we also proposed a splitting Deep Neural Network(sDNN)to supply the prior probability for MCTS.The sDNN is trained by a self-supervised learning manager.Here,the training data set is obtained from iTOA itself as its own teacher.Compared with game theory and greedy search-based methods,the proposed iTOA improves service latency performance by 33%and 60%,respectively. 展开更多
关键词 Unmanned aerial vehicles(UAVs) Mobile edge computing(MEC) Intelligent task offloading algorithm(iTOA) Monte Carlo tree search(MCTS) Deep reinforcement learning Splitting deep neural network(sDNN)
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Global Solution of a Nonlinear Conservation Law with Weak Discontinuous Flux in the Half Space
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作者 xiaoqian li Jing Zhang 《American Journal of Computational Mathematics》 2018年第4期326-342,共17页
This paper is concerned with the initial-boundary value problem of a nonlinear conservation law in the half space R+= {x |x > 0} where a>0 , u(x,t) is an unknown function of x ∈ R+ and t>0 , u ± , um ar... This paper is concerned with the initial-boundary value problem of a nonlinear conservation law in the half space R+= {x |x > 0} where a>0 , u(x,t) is an unknown function of x ∈ R+ and t>0 , u ± , um are three given constants satisfying um=u+≠u- or um=u-≠u+ , and the flux function f is a given continuous function with a weak discontinuous point ud. The main purpose of our present manuscript is devoted to studying the structure of the global weak entropy solution for the above initial-boundary value problem under the condition of f '-(ud) > f '+(ud). By the characteristic method and the truncation method, we construct the global weak entropy solution of this initial-boundary value problem, and investigate the interaction of elementary waves with the boundary and the boundary behavior of the weak entropy solution. 展开更多
关键词 NONLINEAR Conservation Laws with WEAK Discontinuous Flux Initial-Boundary Value Problem Shock WAVE RAREFACTION WAVE Contact Discontinuity Interaction Structure of Global WEAK Entropy Solution
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Function-reversible facets enabling SrTiO_(3)nanocrystals for improved photocatalytic hydrogen evolution
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作者 Bin WANG Bei AN +1 位作者 xiaoqian li Shaohua SHEN 《Frontiers in Energy》 SCIE EI CSCD 2024年第1期101-109,共9页
It has been widely reported that,for faceted nanocrystals,the two adjacent facets with different band levels contribute to promoted charge separation,and provide active sites for photocatalytic reduction and oxidation... It has been widely reported that,for faceted nanocrystals,the two adjacent facets with different band levels contribute to promoted charge separation,and provide active sites for photocatalytic reduction and oxidation reaction,respectively.In such cases,only one family of facets can be used for photocatalytic hydrogen evolution.Herein,by using SrTiO_(3)nanocrystals enclosed by{023}and{001}facets as a model photocatalyst,this paper proposed a strategy to achieve the full-facets-utilization of the nanocrystals for photocatalytic hydrogen via chemically depositing Pt nanoparticles on all facets.The photo-deposition experiment of CdS provided direct evidence to demonstrate that the{023}facets which were responsible for photooxidation reaction can be function-reversed for photocatalytic hydrogen evolution after depositing Pt nanoparticles,together with the{001}facets.Thus,the full-facets-utilization led to a much-improved activity for photocatalytic hydrogen,in contrast to those SrTiO_(3)nanocrystals with only{001}facets deposited by Pt nanoparticles via a photo-deposition method. 展开更多
关键词 SrTiO_(3)nanocrystals crystal facets PHOTOCATALYSIS hydrogen evolution
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下颌牙列缺失固定种植修复的(牙合)学研究 被引量:11
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作者 于文倩 李晓茜 +2 位作者 马丽 马晓妮 徐欣 《华西口腔医学杂志》 CAS CSCD 北大核心 2020年第1期30-36,共7页
目的探讨下颌牙列缺失固定种植修复的咬合及肌电特点,为无牙颌固定种植修复的治疗提供参考。方法选取60例下颌牙列缺失固定种植修复的患者,其中A组上颌为固定种植修复,B组上颌为天然牙列,C组上颌为可摘局部义齿,每组20例患者。使用T-sca... 目的探讨下颌牙列缺失固定种植修复的咬合及肌电特点,为无牙颌固定种植修复的治疗提供参考。方法选取60例下颌牙列缺失固定种植修复的患者,其中A组上颌为固定种植修复,B组上颌为天然牙列,C组上颌为可摘局部义齿,每组20例患者。使用T-scan记录4种颌位的咬合特点,采用肌电仪记录静息状态及牙尖交错位最大紧咬时颞肌前束和咬肌的电位变化,探讨咬合与肌电之间的联系。结果咬合分析结果:C组的咬合接触时间、最大咬合力时左右侧咬合力平衡度及咬合力中心左右向偏移度、咬合力中心位移、前伸颌及侧方颌的咬合分离时间均大于A、B两组(P<0.05),3组最大咬合力时咬合力中心前后向偏移度及前牙区咬合力百分比的差异均无统计学意义(P>0.05)。肌电分析结果:C组的静息状态下肌电幅值、牙尖交错位最大紧咬时咀嚼肌不对称指数大于A、B两组(P<0.05),A、B组的牙尖交错位最大紧咬时肌电幅值大于C组(P<0.05)。结论在下颌牙列缺失固定种植修复中,当上颌为可摘局部义齿时,咬合不稳定程度及咬合力中心偏移大于上颌为固定种植修复和天然牙列的患者。咬合与肌电息息相关,上颌可摘局部义齿可造成肌电活动增加,降低咀嚼肌的潜力,双侧肌电的不对称与咬合不平衡有关。 展开更多
关键词 无牙颌患者 固定种植修复 咬合分析系统 T-scan 肌电仪
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奥沙利铂过敏反应临床特征的研究 被引量:10
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作者 李小倩 杨全良 +3 位作者 何光照 毕延智 张程亮 马剑 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第24期1268-1271,共4页
目的:通过分析结直肠癌患者使用含奥沙利铂方案化疗前常规行地塞米松5 mg预处理后过敏反应发生的临床特征,为降低奥沙利铂过敏风险提供参考依据。方法:回顾性分析2014年1月至2017年10月苏州大学附属常州肿瘤医院收治的242例含奥沙利铂... 目的:通过分析结直肠癌患者使用含奥沙利铂方案化疗前常规行地塞米松5 mg预处理后过敏反应发生的临床特征,为降低奥沙利铂过敏风险提供参考依据。方法:回顾性分析2014年1月至2017年10月苏州大学附属常州肿瘤医院收治的242例含奥沙利铂方案化疗的结直肠癌患者临床资料,统计过敏反应发生率,对多项因素与过敏反应关系进行单因素分析,采用Logistic多因素回归模型分析影响过敏反应发生的独立因素,并探讨奥沙利铂过敏患者再次使用奥沙利铂治疗的结局。结果:242例结直肠癌患者使用含奥沙利铂方案化疗前行地塞米松5 mg静推,发生过敏反应12例(4.9%),均为Ⅰ型过敏反应,中位发生时间6(5.5~10.5)个周期,中位累积剂量895(716.5~1 075.0)mg。多因素分析提示存在无奥沙利铂间隔期为过敏反应的独立预测因素(P=0.04)。其中3例奥沙利铂过敏患者接受药物预处理后再次使用奥沙利铂,1例(33.3%)成功完成治疗。结论:奥沙利铂使用前常规行小剂量地塞米松预处理,过敏反应发生率低于文献报道,安全性高,无奥沙利铂间隔期患者再次使用该药过敏反应发生率明显提高,奥沙利铂过敏患者再次使用需谨慎。 展开更多
关键词 结直肠癌 奥沙利铂 过敏反应
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Exposure to environmental bisphenol A inhibits HTR-8/SVneo cell migration and invasion 被引量:1
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作者 Pu Wei Dongqing Ru +5 位作者 xiaoqian li Dongyan Shi Mingshun Zhang Qing Xu Hong Zhou Shuang Wen 《The Journal of Biomedical Research》 CAS CSCD 2020年第5期369-378,I0007,共11页
Environmental pollutants,such as bisphenol A(BPA) have recently been implicated in the development of adverse birth outcomes.However,the underlying teratogenic mechanisms remain unclear.We investigated the effects of ... Environmental pollutants,such as bisphenol A(BPA) have recently been implicated in the development of adverse birth outcomes.However,the underlying teratogenic mechanisms remain unclear.We investigated the effects of BPA on the migration and invasion of human primary extravillous trophoblast HTR-8/SVneo cells.Our results indicated that BPA reduced cell migration and invasion.Moreover,it altered the ratio of matrix metalloproteinases(MMPs) and tissue inhibitors of MMPs(TIMPs) by downregulating MMP-2 and MMP-9,and upregulating TIMP-1 and TIMP-2.Furthermore,BPA suppressed integrin β1,integrin α5,and vimentin.Interestingly,BPA-induced invasion was partially restored by G15,a membrane G-protein-coupled estrogen receptor 30 antagonist.We further revealed that 42 proteins were differentially expressed by mass spectrometry analysis,which could be divided into three categories based on gene ontology including biological process,cellular component,and molecular function.These results suggest that BPA reduces HTR-8/SVneo cell migration and invasion by downregulating MMP-2 and MMP-9,up-regulating TIMP-1 and TIMP-2,and suppressing adhesion molecules. 展开更多
关键词 bisphenol A HTR8/SVneo cells cell invasion INTEGRINΒ1
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A generalizable strategy based on the rule of“like dissolves like”to construct porous liquids with low viscosity for CO_(2)capture 被引量:1
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作者 Yangyang Xin Hailong Ning +8 位作者 Dechao Wang(✉) xiaoqian li Wendi Fan xiaoqian Ju Hongni Wang Yichi Zhang Zhiyuan Yang Dongdong Yao Yaping Zheng 《Nano Research》 SCIE EI CSCD 2023年第7期10369-10380,共12页
Porous liquids(PLs),an emerging porous material with permanent cavities,have attracted extensive attention in recent years.However,the current construction methods are complicated and resulting PLs possess high viscos... Porous liquids(PLs),an emerging porous material with permanent cavities,have attracted extensive attention in recent years.However,the current construction methods are complicated and resulting PLs possess high viscosity values,which cannot meet the requirements of practical industrial applications.Herein,we demonstrate a generalizable and simple strategy to prepare type III PLs with low viscosity based on the rule of“like dissolves like”.Specifically,the monoglycidyl ether terminated polydimethylsiloxane(denoted by E-PDMS)is attached to the surface of Universitetet i Oslo(UiO)-66-NH_(2)via covalent linkage,constructing the pore generator(UiO-66-NH_(2)-E-PDMS,denoted by P-UiO-66).Then,P-UiO-66 is dispersed into different types and amounts of sterically hindered solvents(PDMS400 or PDMS6000),obtaining a series of type III PLs(denoted by P-UiO-66-PLs)with permanent cavities and low viscosities.The gas sorption-desorption test shows that P-UiO-66-PLs have an enormous potential for CO_(2)/N_(2) selective separation.Besides,the porosity of P-UiO-66-PLs and the CO_(2)sorption mechanism are demonstrated by molecular simulation.Furthermore,the generality of the synthesis strategy is confirmed by the successful construction of PLs using two other amino-metal-organic frameworks(MOFs)(MIL-53(Al)-NH_(2)and MIL-88B(Fe)-NH_(2)).Importantly,it’s worth noting that the strategy based on the rule of“like dissolves like”sheds light on the preparation of other types of PLs for task-specific applications. 展开更多
关键词 porous liquids like dissolves like CO_(2)capture low viscosity
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Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma
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作者 Meiting Chen Zhao Wang +10 位作者 Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan xiaoqian li Zhiming li Qingqing Cai He Huang Tongyu lin 《Cancer Biology & Medicine》 SCIE CAS CSCD 2021年第3期833-840,共8页
Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123... Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center.We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle cytarabine.Forty-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based chemotherapy.Seventy-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC regimens.Results:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,respectively.Major grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,respectively.We observed 4 cases(3.3%)of septic shock after chemotherapy.Two treatment-related deaths occurred from severe infection.Conclusions:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens. 展开更多
关键词 Sporadic Burkitt lymphoma modified chemotherapy toxicity R-CODOX-M/IVAC adults
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A novel vanadium complex VO(p-dmada)inhibits neuroinflammation induced by lipopolysaccharide
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作者 Zhijun He xiaoqian li +8 位作者 Huajie Zhang Xin liu Shuangxue Han Anwar Abdurahman liming Shen Xiubo Du Nan li Xiaoda Yang Qiong liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第10期209-214,共6页
Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of ... Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of nerve injury. In this paper, a novel vanadium complex, vanadyl N-(p-N,Ndimethylaminophenylcarbamoylmethyl)iminodiacetate(VO(p-dmada)), was synthesized from vanadyl sulfate and N,N-dimethyl-p-phenylenediamine, which was structurally characterized by Fourier transform infrared spectrum and ESI-MS analysis. The effect of VO(p-dmada) on neuroinflammation was investigated by using the models of lipopolysaccharide(LPS)-induced BV2 microglial cells and BALB/c mice.Our data demonstrated that VO(p-dmada) significantly suppressed microglial activation by downregulating inflammatory mediators and associated proteins, and inactivating nuclear factor-κ B(NF-κ B) signaling pathway. VO(p-dmada) also upregulated peroxisome proliferator activated receptor gamma(PPARγ) by reducing transglutaminase 2 and heat shock protein 60 expression. Co-treatment with PPARγ antagonist GW9662 significantly impeded the inhibitory effect of VO(p-dmada) on LPS-induced neuroinflammation.These cumulative findings demonstrated that VO(p-dmada) is a potential new drug for the treatment of neuroinflammation-related neurodegenerative diseases. 展开更多
关键词 Vanadium Vanadyl N-(p-N Ndimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)) NEUROINFLAMMATION MICROGLIA Proteomics Peroxisome proliferator activated receptor gamma(PPARγ)
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DC Traction Power Supply System Based on Modular Multilevel Converter Suitable for Energy Feeding and De-icing 被引量:1
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作者 lingxi Hou Shuqing Zhang +4 位作者 Yingdong Wei xiaoqian li Qirong Jiang Mingrui li Weirui li 《CSEE Journal of Power and Energy Systems》 SCIE EI CSCD 2024年第2期649-659,共11页
A novel DC traction power supply system suitable for energy feeding and de-icing is proposed in this paper for an urban rail transit catenary on the basis of the full bridge submodule (FBSM) modular multilevel convert... A novel DC traction power supply system suitable for energy feeding and de-icing is proposed in this paper for an urban rail transit catenary on the basis of the full bridge submodule (FBSM) modular multilevel converter (MMC). The FBSM-MMC is a novel type of voltage source converter (VSC) and can directly control the output DC voltage and conduct bipolar currents, thus flexibly controlling the power flow of the urban rail transit catenary. The proposed topology can overcome the inherent disadvantages of the output voltage drop in the diode rectifier units, increase the power supply distance and reduce the number of traction substations. The flexible DC technology can coordinate multiple FBSM-MMCs in a wide area and jointly complete the bidirectional control of catenary power flow during the operation of the electric locomotive, so as to realize the local consumption and optimal utilization of the recovered braking energy of the train. In addition, the FBSM-MMCs can also adjust the output current when the locomotive is out of service to prevent the catenary from icing in winter. The working modes of the proposed topology are illustrated in detail and the control strategy is specially designed for normal locomotive operations and catenary de-icing. Simulation cases conducted by PSCAD/EMTDC validate the proposed topology and its control strategy. 展开更多
关键词 DC traction power supply system de-icing for catenary energy feeding modular multilevel converter based on full-bridge submodules(FBSM-MMC) urban rail transit
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Chaperone-and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
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作者 Fenghao Geng Jianhui Chen +13 位作者 Bin Song Zhicheng Tang xiaoqian li Shuaijun Zhang Tingyi Yang Yulan liu Wei Mo Yining Zhang Chuntang Sun Lei Tan Wenling Tu Daojiang Yu Jianping Cao Shuyu Zhang 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2024年第8期856-872,共17页
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics,but the underlying mechanism remains poorly understood.Here,we revealed that the transcriptional activa... The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics,but the underlying mechanism remains poorly understood.Here,we revealed that the transcriptional activation of interferon regulatory factor 1(IRF1)in response to ionizing radiation,cytotoxic chemicals and SARS-CoV-2 viral infection determines the fate of structural cells and regulates communication between structural and immune cells.Radiation-induced leakage of mtDNA initiates the nuclear translocation of IRF1,enabling it to regulate the transcription of inflammation-and cell death-related genes.Novel posttranslational modification(PTM)sites in the nuclear localization sequence(NLS)of IRF1 were identified.Functional analysis revealed that mutation of the acetylation site and the phosphorylation sites in the NLS blocked the transcriptional activation of IRF1 and reduced cell death in response to ionizing radiation.Mechanistically,reciprocal regulation between the single-stranded DNA sensors SSBP1 and IRF1,which restrains radiation-induced and STING/p300-mediated PTMs of IRF1,was revealed.In addition,genetic deletion or pharmacological inhibition of IRF1 tempered radiation-induced inflammatory cell death,and radiation mitigators also suppressed SARS-CoV-2 NSP-10-mediated activation of IRF1.Thus,we revealed a novel cytoplasm-oriented mechanism of IRF1 activation in structural cells that promotes inflammation and highlighted the potential effectiveness of IRF1 inhibitors against immune disorders. 展开更多
关键词 Interferon regulatory factor 1(IRF1) Ionizing radiation Nuclear translocation Posttranslational modification(PTM) Transcription regulation
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羽毛球女子单打运动员陈雨菲、安洗莹、戴资颖的技术对比研究
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作者 李传升 李晓倩 徐志华 《体育科学进展》 2024年第2期362-372,共11页
羽毛球体育运动是一种隔网竞技体育运动,已受到了全球民众的广泛青睐。本文选取世界顶尖女子单打选手陈雨菲、安洗莹以及戴资颖之间的6场(15局)的大型比赛,运用文献资料、录像观察和数理统计等方法,对陈雨菲、安洗莹、戴资颖在比赛中不... 羽毛球体育运动是一种隔网竞技体育运动,已受到了全球民众的广泛青睐。本文选取世界顶尖女子单打选手陈雨菲、安洗莹以及戴资颖之间的6场(15局)的大型比赛,运用文献资料、录像观察和数理统计等方法,对陈雨菲、安洗莹、戴资颖在比赛中不同前场技术的运用以及发接发的特点的技术进行了比对研究。并将先进的技战术特点应用到实践的教学与训练中,同时也有利于我国女单专业及业余羽毛球爱好者的学习。 展开更多
关键词 羽毛球 陈雨菲 安洗莹 戴资颖 女子单打 技战术
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Characteristics and health risks of population exposure to phthalates via the use of face towels 被引量:1
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作者 Wenhui Zhang Na Zheng +7 位作者 Sujing Wang Siyu Sun Qirui An xiaoqian li Zimeng li Yining Ji Yunyang li Jiamin Pan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第8期1-13,共13页
The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expos... The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations of<MDL–2388 ng/g,with a median of 173.2 ng/g,which was a lower contamination level compared with other textiles.PAE contents in used face towels were significantly higher than in new face towels.The concentrations of PAEs in coral velvet were significantly higher than those in cotton.Water washing removed some PAEs,while detergent washing increased the PAE content on face towels.Gender,weight,use time,and material were the main factors affecting EDI.The HQ and HIwere less than 1,which proved PAEs had no significant non-carcinogenic health risks.Among the five target PAEs studied,DEHPwas the only carcinogenic PAE andmay cause potential health risks after long-term exposure.Therefore,we should pay more attention to DEHP. 展开更多
关键词 Face towels PHTHALATES Dermal exposure Estimated daily intake Risk assessment
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分化型甲状腺癌患者^(131)I治疗后唾液腺损伤的相关因素分析
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作者 李晓倩 仝慧敏 +5 位作者 黄楠 岳荣丽 方菊 秦卓琦 陆克义 程艳 《国际放射医学核医学杂志》 2023年第7期406-412,共7页
目的 探讨分化型甲状腺癌(DTC)患者^(131)I治疗后唾液腺损伤的危险因素.方法 回顾性分析2019年1月至2022年7月于山西医科大学第一医院行^(131)I治疗的107例DTC患者的临床资料,其中男性35例、女性72例,年龄(42.8±1.0)岁.比较唾液腺... 目的 探讨分化型甲状腺癌(DTC)患者^(131)I治疗后唾液腺损伤的危险因素.方法 回顾性分析2019年1月至2022年7月于山西医科大学第一医院行^(131)I治疗的107例DTC患者的临床资料,其中男性35例、女性72例,年龄(42.8±1.0)岁.比较唾液腺损伤患者与唾液腺正常患者年龄、身体质量指数、收缩压、舒张压、原发肿瘤的组织病理学分型及分期、是否有淋巴结转移、是否并发糖尿病、^(131)I治疗前促甲状腺素(TSH)水平、停用左甲状腺素钠片(L-T4)时间、^(131)I治疗剂量、^(131)I全身显像(WBS)等临床资料的差异.符合正态分布的计量资料的组间比较采用单因素方差分析(ANOVA),计数资料的组间比较采用X^(2)检验,期望频数<5时采用Fisher确切概率法.通过单因素分析和多因素Logistic回归分析明确唾液腺损伤的相关因素.结果 107例DTC患者中,37例患者发生唾液腺损伤,唾液腺损伤的发生率为34.6%.单因素分析结果显示,唾液腺损伤患者的年龄、收缩压大于唾液腺正常患者[(45.84±2.10)岁对(41.11±0.97)岁,(127.59±3.10)mm Hg 对(119.86±1.84)mmHg],唾液腺损伤患者^(131)I 治疗前TSH水平低于唾液腺正常患者[(99.82±8.46)mIU/L对(122.59±4.03)mIU/L],且差异有统计学意义(F=5.457、5.210、6.288,均P<0.05).多因素Logistic回归分析结果显示,年龄、^(131)I治疗前TSH水平、收缩压是唾液腺功能损伤的非独立危险因素(OR=1.017、0.989、1.023,均P>0.05).结论 年龄较大、^(131)I治疗前TSH水平较低及收缩压较高是DTC患者行^(131)I治疗出现唾液腺损伤的相关因素. 展开更多
关键词 甲状腺肿瘤 碘放射性同位素 涎腺炎 危险因素
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Influence of cadmium and copper mixtures to rhizosphere bacterial communities
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作者 Qirui An Yunyang li +7 位作者 Na Zheng Jincai Ma Shengnan Hou Siyu Sun Sujing Wang Pengyang li xiaoqian li Chunmei Zhao 《Soil Ecology Letters》 CAS CSCD 2023年第1期94-107,共14页
To study the effects of combined Cd and Cu pollution on rhizosphere bacterial community.High-throughput sequencing was used to examine the response of rhizosphere bacterial communities to heavy-metal stress under sing... To study the effects of combined Cd and Cu pollution on rhizosphere bacterial community.High-throughput sequencing was used to examine the response of rhizosphere bacterial communities to heavy-metal stress under single and mixed pollution of cadmium(Cd)and copper(Cu).With additions of Cd and Cu,the mean diversity index of rhizosphere bacterial community was in the order Cu alone>Cd-Cu mixtures>Cd alone.In all Cd and Cu treatments,the dominant phyla were Proteobacteria,Actinobacteria,Chloroflexi and Acidobacteria.In the additions with different concentrations of Cd-Cu mixtures,LEfSe indicated that there were differences in the predominant species of rhizosphere bacterial communities.Some genera such as Streptomyces and Microbacterium belonging to Actinobacteria as biomarkers were significantly enriched in both control and treatments,while some genera such as Pseudoxanthomonas and Rhodopseudomonas belonging to Proteobacteria as biomarkers were observed to be enriched in the additions with single and mixture of Cd and Cu.According to the Nonmetric multidimensional scaling(NMDS)analysis,the structure of rhizosphere bacterial community was different between treatments and the CK.Principal Component Analysis(PCA)and permutational multivariate analysis of variance(PERMANOVA)showed that there were significant differences among treatments(p<0.01),and that the addition of Cu might be the primary factor affecting the composition of rhizosphere bacterial communities. 展开更多
关键词 CADMIUM COPPER High-throughput sequencing Bacterial community structure
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环境空气质量基准和标准制定方法及其对我国的启示 被引量:4
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作者 王永越 张芷宁 +10 位作者 罗震宇 何廷堃 刘欢 段雷 陆克定 刘诚 李晓倩 吴丰昌 张远航 刘文清 贺克斌 《科学通报》 EI CAS CSCD 北大核心 2022年第27期3324-3339,共16页
我国已经在大气污染治理方面取得了显著成效,空气质量明显改善,积累了先进的空气污染治理经验.现阶段,我国应逐步开启对环境空气质量基准的研究.本文详细介绍了国际上主要的三大类环境空气质量基准和标准的制定原则与方法,分别基于人体... 我国已经在大气污染治理方面取得了显著成效,空气质量明显改善,积累了先进的空气污染治理经验.现阶段,我国应逐步开启对环境空气质量基准的研究.本文详细介绍了国际上主要的三大类环境空气质量基准和标准的制定原则与方法,分别基于人体健康、植被暴露以及土壤/水体生态系统化学指标;汇总比较了国际上较常采用的一系列评价指标.在此基础上,对我国上述三方面的本土化基础研究进行综述,分析了我国开展环境空气质量基准研究的原则性路径,包括工作初期和完善体系的预期架构,指出工作初期制定基准的工作可以适当从简,但在工作基础逐渐丰富后,应当逐步细化的工作原则.此外,本文还对国内外环境空气标准的制定策略中采纳基准的情况进行了简要的比较和梳理,结合我国环境空气达标现状、管理体系和工作基础,面向“美丽中国”和“健康中国”的宏伟目标,提出在科学构建环境空气质量评估体系的过程中,既要考虑我国本土人群健康与生态独特的安全红线,又要注意基准向标准转化过程可能带来的管理难点,从而确保环境空气污染防治攻坚战稳步推进并取得胜利. 展开更多
关键词 环境空气质量 基准制定 人体健康 植被暴露 土壤/水体生态系统化学指标
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多孔液体在气体捕集与分离领域的应用 被引量:4
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作者 王德超 辛洋洋 +2 位作者 李晓倩 姚东东 郑亚萍 《化学进展》 SCIE CAS CSCD 北大核心 2021年第10期1874-1886,共13页
多孔液体是指具有永久性孔隙的液体材料,其将多孔固体的有序规整孔道和液体的流动性等诸多优点相结合,在气体捕集与分离领域表现出巨大的应用潜力,成为新的研究热点。本文首先简单阐述了多孔液体的概念及分类,并总结了多孔液体形成的必... 多孔液体是指具有永久性孔隙的液体材料,其将多孔固体的有序规整孔道和液体的流动性等诸多优点相结合,在气体捕集与分离领域表现出巨大的应用潜力,成为新的研究热点。本文首先简单阐述了多孔液体的概念及分类,并总结了多孔液体形成的必要条件;然后分别详细综述了三类多孔液体的合成进展,并阐述了多孔液体在气体捕集与分离方面的应用,着重介绍了近五年的研究进展;最后对其现存的挑战及未来展望进行了总结。 展开更多
关键词 多孔液体 多孔空腔 位阻溶剂 气体捕集 分离
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