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PD-1/PD-L1抑制剂治疗NSCLC脑转移的免疫机制与临床研究进展 被引量:4
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作者 盛佳敏 俞晓晴 +1 位作者 李晖(综述) 范云(审校) 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第11期976-982,共7页
脑转移是非小细胞肺癌(non-small cell lung cancer, NSCLC)的常见并发症,预后较差。近年来,免疫检查点抑制剂将恶性肿瘤的治疗带入新纪元。程序性死亡因子-1(programmed death-1, PD-1)/程序性死亡因子配体-1(programmed death ligand ... 脑转移是非小细胞肺癌(non-small cell lung cancer, NSCLC)的常见并发症,预后较差。近年来,免疫检查点抑制剂将恶性肿瘤的治疗带入新纪元。程序性死亡因子-1(programmed death-1, PD-1)/程序性死亡因子配体-1(programmed death ligand 1, PD-L1)抑制剂通过激活自身免疫系统,产生抗肿瘤效应。PD-1/PD-L1抑制剂在NSCLC脑转移治疗中初露锋芒,但其确切疗效及最佳治疗模式仍有待进一步研究。本文针对NSCLC脑转移灶的免疫微环境,PD-1/PD-L1抑制剂在颅内的作用机制及其临床研究现状进行综述。 展开更多
关键词 肺肿瘤 脑转移 免疫治疗 PD-1/PD-L1
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The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis 被引量:2
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作者 Changhui Du Zhenjie Li +9 位作者 Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun xiaoqing yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen 《Food Science and Human Wellness》 SCIE CSCD 2023年第4期1212-1223,共12页
Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we in... Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans. 展开更多
关键词 Carnosic acid Inflammatory bowel diseases COLITIS Gut microbiota METABOLITES
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Engineering particles towards 3D supraballs-based passive cooling via grafting CDs onto colloidal photonic crystals
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作者 Jie Wu xiaoqing yu +1 位作者 Guoxing Li Su Chen 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第4期457-463,共7页
Particle engineering has opened the floodgates to material science in both fundamental and application field. However, covalent interactions have not yet been adequately designed in the particle engineering for functi... Particle engineering has opened the floodgates to material science in both fundamental and application field. However, covalent interactions have not yet been adequately designed in the particle engineering for functional colloidal photonic crystals(CPCs). Herein, we achieved covalent coupling between carboxylrich poly(styrene-acrylic acid)(P(St-AA)) monodispersed colloidal particles and amine-rich carbon dots(CDs) based on an feasible and universal particle engineering strategy. The designed CDs-grafted P(St-AA)monodispersed colloidal particles initiate a hydrogen bond-driven assembly mode and ensure the construction of large-scale crack-free CPCs. Moreover, the CDs equipped with selective broad-band absorption capacity could improve the saturation of structural colors for high-visibility CPCs. Furthermore, an injectable photonic hydrogel(IPH) is developed to design CPC supraball hydrogel via integrating the CDsgrafted P(St-AA) CPC supraballs with supramolecular hydrogel. Combining superior flexibility, sufficient self-healing capacity of supramolecular hydrogel with visual optical information of our CPC supraballs, a cyclically reversible coding and decoding system was developed. Meanwhile, we firstly demonstrated the novel strategy of 3D supraballs-based passive cooling. The designed 3D CPC supraball hydrogel presents nearly full observation angle reflections behavior and excellent water evaporation capacity and achieves3.6 ℃ temperature drops, showing the application advantages in 3D thermal management. This work not only provides a new insight for manipulating optical properties of CPCs, but also demonstrates an easyto-perform platform, as well as indicates the direction for the promising application of CPCs. 展开更多
关键词 Particle engineering Carbon dots Colloidal photonic crystals Passive cooling Digital coding
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Optimal Designs for Genomic Selection in Hybrid Crops 被引量:6
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作者 Tingting Guo xiaoqing yu +8 位作者 Xianran Li Haozhe Zhang Chengsong Zhu Sherry Flint-Garcia Michael D.McMullen James B.Holland Stephen J.Szalma Randall J.Wisser Jianming yu 《Molecular Plant》 SCIE CAS CSCD 2019年第3期390-401,共12页
Improved capacity of genomics and biotechnology has greatly enhanced genetic studies in different areas. Genomic selection exploits the geno type-to-phe no type relationship at the whole-ge nome level and is being imp... Improved capacity of genomics and biotechnology has greatly enhanced genetic studies in different areas. Genomic selection exploits the geno type-to-phe no type relationship at the whole-ge nome level and is being implemented in many crops? Here we show that design-thinking and data-mining techniques can be leveraged to optimize genomic prediction of hybrid performance? We phenotyped a set of 276 maize hybrids generated by crossing founder inbreds of nested association mapping populations for flowering time, ear height, and grain yield? With 10 296 310 SNPs available from the parental inbreds, we explored the pat? terns of genomic relati on ships and phenotypic variation to establish training samples based on clustering, graphic n etwork analysis, and genetic mating scheme ? Our analysis showed that training set desig ns outperformed random sampling and earlier methods that either minimize the mean of prediction error variance or maximize the mean of generalized coefficient of determination. Additional analyses of 2556 wheat hybrids from an early-stage hybrid breeding system and 1439 rice hybrids from an established hybrid breeding system validated the approaches. Together, we dem on strated that effective genomic predicti on models can be established with a training set 2%-13% of the size of the whole set, enabling an efficient exploration of enormous inf ere nee space of gen etic combi nations. 展开更多
关键词 data MINING MOLECULAR BREEDING GENOMIC RELATIONSHIP GENOMIC selection optimal design
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Structural and functional variations of phytoplankton communities in the face of multiple disturbances 被引量:3
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作者 Jun R.Yang xiaoqing yu +2 位作者 Huihuang Chen Yi-Ming Kuo Jun Yang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第2期287-297,共11页
The global decline of freshwater biodiversity caused by climate change and human activities are supposed to disrupt ecosystem services related to water quality and alter the structure and function of aquatic communiti... The global decline of freshwater biodiversity caused by climate change and human activities are supposed to disrupt ecosystem services related to water quality and alter the structure and function of aquatic communities across space and time,yet the effects of the combination of these factors on plankton community ecosystem has received relatively little attention.This study aimed to explore the impacts of disturbances(e.g.human activity,temperature,precipitation,and water level)on phytoplankton community structure(i.e.community evenness and community composition)and function(i.e.resource use efficiency)in four subtropical reservoirs over 7 years from 2010 to 2016.Our results showed that community turnover(measured as community dissimilarity)was positively related to disturbance frequency,but no significant correlation was found between phytoplankton biodiversity(i.e.evenness)and disturbance frequency.Phytoplankton resource use efficiency(RUE=phytoplankton biomass/total phosphorus)was increased with a higher frequency of disturbance with an exception of cyanobacteria.The RUE of Cyanobacteria and diatoms showed significantly negative correlations with their community evenness,while the RUE of Chlorophyta exhibited a positive correlation with their community turnover.We suggest that multiple environmental disturbances may play crucial roles in shaping the structure and functioning of plankton communities in subtropical reservoirs,and mechanism of this process can provide key information for freshwater uses,management and conservation. 展开更多
关键词 ALGAE BIODIVERSITY Community ecology PLANKTON Resource use efficiency Subtropical reservoir
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Theoretical study on the formation mechanism of polychlorinated dibenzothiophenes/thianthrenes from 2-chlorothiophenol molecules 被引量:1
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作者 xiaoqing yu Jiamin Chang +2 位作者 Xian Liu Wenxiao Pan Aiqian Zhang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2018年第4期318-327,共10页
Homogeneous formation of polychlorinated dibenzothiophenes/thianthrenes(PCDT/TAs),sulfurated compounds analogous to polychlorinated dibenzo-p-dioxin/dibenzofurans(PCDD/Fs), has been well-documented to occur via ra... Homogeneous formation of polychlorinated dibenzothiophenes/thianthrenes(PCDT/TAs),sulfurated compounds analogous to polychlorinated dibenzo-p-dioxin/dibenzofurans(PCDD/Fs), has been well-documented to occur via radical–radical coupling reactions from chlorinated thiophenol precursors. However, the current understanding of the formation mechanism of PCDT/TAs is exclusively limited to the inherent point of view that chlorothiophenoxy radicals act as the only required intermediates for PCDT/TAs. This study investigates reaction pathways for the formation of PCDT/TAs involving two new types of radical species, i.e., substituted phenyl radicals and substituted thiophenoxyl diradicals. Taking 2-chlorothiophenol(2-CTP) as a model compound for chlorothiophenols,we found that apart from the mostly discussed chlorothiophenoxy radicals, substituted phenyl radicals and substituted thiophenoxyl diradicals could also be readily formed via the reaction of 2-CTP with H radicals. Furthermore, direct self-and cross-coupling of these radicals can result in the formation of PCDT/TAs, including 1-monochlorothianthrene(1-MCTA), 1,6-dichlorothianthrene(1,6-DCTA), 4,6-dichlorodibenzothiophene(4,6-DCDT)and 1,6-dichlorodibenzothiophene(1,6-DCDT). The pathways proposed in this work are proven to be both thermodynamically and kinetically favorable. Particularly, comparisons were made between the formation mechanisms of sulfurated and oxygenated dioxin systems from an energetic point view, showing that replacing oxygen with sulfur atoms greatly reduces the activation barriers of the rate-controlling steps involved in the PCDT/TA formation processes compared with those involved for PCDD/Fs. The calculated results in this work may improve our understanding of the formation mechanism of PCDT/TAs from chlorothiophenol precursors and should be informative to environmental scientists. 展开更多
关键词 Polychlorinated dibenzothiophenes/thianthrenes Formation mechanism Phenyl radicals Thiophenoxyl diradicals Density functional theory study
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Improving Approximate Bayesian Computation with Pre-judgment Rule
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作者 Yanbo Wang xiaoqing yu +2 位作者 Pinle Qin Rui Chai Gangzhu Qiao 《国际计算机前沿大会会议论文集》 2020年第1期230-246,共17页
Approximate Bayesian Computation(ABC)is a popular approach for Bayesian modeling,when these models exhibit an intractable likelihood.However,during each proposal of ABC,a great number of simulators are required and ea... Approximate Bayesian Computation(ABC)is a popular approach for Bayesian modeling,when these models exhibit an intractable likelihood.However,during each proposal of ABC,a great number of simulators are required and each simulation is always time-consuming.The overall goal of this work is to avoid inefficient computational cost of ABC.A pre-judgment rule(PJR)is proposed,which mainly aims to judge the acceptance condition using a small fraction of simulators instead of the whole simulators,thus achieving less computational complexity.In addition,it provided a theoretical study of the error bounded caused by PJR Strategy.Finally,the methodology was illustrated with various examples.The empirical results show both the effectiveness and efficiency of PJR compared with the previous methods. 展开更多
关键词 Approximate Bayesian Computation Bayesian inference Markov Chain Monte Carlo Pre-judgment rule
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