A considerable efficiency gap exists between large-area perovskite solar modules and small-area perovskite solar cells.The control of forming uniform and large-area film and perovskite crystallization is still the mai...A considerable efficiency gap exists between large-area perovskite solar modules and small-area perovskite solar cells.The control of forming uniform and large-area film and perovskite crystallization is still the main obstacle restricting the efficiency of PSMs.In this work,we adopted a solid-liquid two-step film formation technique,which involved the evaporation of a lead iodide film and blade coating of an organic ammonium halide solution to prepare perovskite films.This method possesses the advantages of integrating vapor deposition and solution methods,which could apply to substrates with different roughness and avoid using toxic solvents to achieve a more uniform,large-area perovskite film.Furthermore,modification of the NiO_(x)/perovskite buried interface and introduction of Urea additives were utilized to reduce interface recombination and regulate perovskite crystallization.As a result,a large-area perovskite film possessing larger grains,fewer pinholes,and reduced defects could be achieved.The inverted PSM with an active area of 61.56 cm^(2)(10×10 cm^(2)substrate)achieved a champion power conversion efficiency of 20.56%and significantly improved stability.This method suggests an innovative approach to resolving the uniformity issue associated with large-area film fabrication.展开更多
The seismic performance of medical systems is crucial for the seismic resilience of communities.The report summarizes the observed damage to twelve hospital buildings in the area affected by the MW 7.8 and MW 7.5 eart...The seismic performance of medical systems is crucial for the seismic resilience of communities.The report summarizes the observed damage to twelve hospital buildings in the area affected by the MW 7.8 and MW 7.5 earthquakes on February 6,2023 in Turkey.They include five base-isolated buildings and seven fixed-base buildings in southcentral Turkey's seven most heavily affected provinces.By relating the post-quake occupancy statuses of the hospitals with the estimated seismic demands during the earthquake doublet,the report offers the following observations:(1)the base-isolated hospital buildings on friction pendulum bearings generally exhibited superior performance of achieving the goal of immediate occupancy and provided better protection for nonstructural elements than fixed-base counterparts did;(2)the fixed-base hospital buildings of reinforced concrete structures constructed after 2001 successfully achieved the goal of collapse prevention even under very high seismic demands;(3)some fixed-base hospitals also remained operational even if they were very close to the fault rupture and were subjected to higher-than-design-level earthquake ground motions.展开更多
Background:In China,Rhizoma atractylodis macrocephalae-Paeonia lactiflora Pall(Biazhu-Baishao,BZBS)is a classic herb pair used to treat intestinal stress syndrome,ulcerative colitis and other diseases.However,the mech...Background:In China,Rhizoma atractylodis macrocephalae-Paeonia lactiflora Pall(Biazhu-Baishao,BZBS)is a classic herb pair used to treat intestinal stress syndrome,ulcerative colitis and other diseases.However,the mechanism of BZBS in the treatment of functional constipation(FC)has been little studied and remains unclear.In this study,a behavioral investigation,colon tissue morphology,enzyme-linked immunosorbent assay(Elisa)and intestinal microflora analysis have been used to illuminate the potential mechanism of the effects of BZBS on FC in a rat model.Methods:A FC rat model was constructed and BZBS was given as treatment.Observations and recordings were made of the fecal moisture content,the defecation time of the first black stool,and the rate of intestinal propulsion.Elisa was used to detect the expression levels of substance P(SP),vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT)in the colon.To ascertain the composition of the microbial community,a high throughput 16S ribosomal RNA(16S r RNA)gene sequencing technique was employed.Results:Oral administration of BZBS significantly ameliorated several key excretion parameters,including the time to first black stool defecation,stool water content,and the propulsion rate in the small intestine in FC rats.It increased the expression of SP,VIP and 5-HT in the colon.16S r RNA gene sequencing results showed that BZBS changed the microbial community structure,decreased the Bacteroidetes/Firmicutes ratio,increased the relative abundance of Blautia and Fusicatenibacter,and decreased the relative abundance of Ruminococcus and Roseburia.Conclusions:BZBS effectively alleviates FC and improves dysbacteriosis.展开更多
Myeloblastosis(MYB)类转录因子是高等植物中最大的转录因子家族之一,在植物发育及防御反应过程中发挥重要作用,还参与植物对干旱等非生物胁迫的响应。谷子(Setaria italica L.)起源于中国,具有抗旱、耐瘠薄的特性,是研究单子叶作物非...Myeloblastosis(MYB)类转录因子是高等植物中最大的转录因子家族之一,在植物发育及防御反应过程中发挥重要作用,还参与植物对干旱等非生物胁迫的响应。谷子(Setaria italica L.)起源于中国,具有抗旱、耐瘠薄的特性,是研究单子叶作物非生物胁迫抗性的理想材料。本研究对耐低氮胁迫谷子品种郑204经低氮处理后进行转录组分析,鉴定出一个在低氮胁迫条件下明显上调的MYB类转录因子SiMYB42。系统发育树结果表明,SiMYB42属于R2R3-MYB亚族,具有2个MYB保守域;表达模式分析显示,SiMYB42在低氮、高盐、干旱和ABA胁迫条件下表达量显著上调;亚细胞定位、quantitative real-time PCR及转录激活活性分析结果表明,SiMYB42蛋白定位于植物的细胞核和细胞膜中,主要在谷子的叶部或根部表达,具有转录激活活性;基因功能分析结果表明,在正常条件下,转SiMYB42基因拟南芥与野生型Columbia-0拟南芥(WT)无明显差异,但在低氮条件下,转SiMYB42基因拟南芥的主根长、根系表面积及鲜重均显著高于WT,结果证明SiMYB42基因可以提高转基因植物对低氮胁迫的耐性;下游基因表达分析结果显示,在转SiMYB42基因拟南芥中,参与植物氮素转运的硝酸盐转运基因NRT2.1、NRT2.4和NRT2.5的表达水平均高于WT,启动子分析结果显示NRT2.1、NRT2.4和NRT2.5基因启动子序列中均具有MYB结合位点。以上结果证明,SiMYB42可以通过调控下游硝酸盐转运体基因的表达提高植物在低氮条件下的耐性。本研究揭示了SiMYB42基因在低氮胁迫反应途径中的作用,为进一步了解谷子低氮胁迫响应的调控网络奠定了基础。展开更多
Background:We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz.(AMK)and Paeonia lactiflora Pall.(PLP).Methods:The main active ingredients of AMK and PLP were...Background:We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz.(AMK)and Paeonia lactiflora Pall.(PLP).Methods:The main active ingredients of AMK and PLP were screened by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.A database of functional constipation targets was established by GeneCard and OMIM.An“ingredient-target”network map was constructed with Cytoscape software(version 3.7.1),and molecular docking analysis was performed on the components and genes with the highest scores.The rats in the normal group were given saline,and those in the other groups were given 10 mg/kg diphenoxylate once a day for 14 days.The serum and intestinal tissue levels of adenosine monophosphate(cAMP),protein kinase A(PKA),and adenylyl cyclase(AC)of the rats and aquaporin(AQP)1,AQP3,and AQP8 were measured.Results:AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.After treatment with AMK,PLP,or mosapride,the serum and intestinal tissue levels of AC,cAMP,and PKA were significantly downregulated.Groups receiving AMK and PLP or mosapride exhibited a reduction in the level of AQP1,AQP3,and AQP8 to varying degrees.Conclusion:Molecular docking analysis revealed that AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.Studies have confirmed that AMK and PLP can also affect AC,cAMP,and PKA.AC,cAMP,and PKA in model rats were significantly downregulated.AQP expression is closely related to AC,cAMP,and PKA.AMK and PLP can reduce the expression of AQP1,AQP3,and AQP9 in the colon of constipated rats.展开更多
Objective To investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.Methods This is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care U...Objective To investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.Methods This is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care Unit.We enrolled 545 septic patients who needed vasopressors on at least the first day of ICU admission.The general characteristics,blood lactate level,mean arterial pressure(MAP),central venous pressure(CVP)and saturation of central venous oxygen(ScvO2)at admission and 6,24 hours after admission were collected.The parameters at different time points were compared.Lactate clearance rate and in-hospital mortality were analyzed.Results The 6-hour lactate clearance rate was 21.6%(IQR,8.6%-39.0%),and in-hospital mortality was 9.4%.For patients with low CVP values(<8 mm Hg,1 mm Hg=0.133 kPa)at admission,CVP increased significantly at 6 hours after admission(5.4±1.6 mm Hg vs.7.7±2.6 mm Hg,P<0.001).For patients with low MAP(<75 mm Hg)at admission,the MAP values increased significantly at 6 hours(64.2±7.1 mm Hg vs.82.2±13.1 mm Hg,P<0.001).For patients with low ScvO2 value(<70%)at admission,the ScvO2 value increased significantly at 6 hours(61.9%±7.0%vs.71.9%±7.8%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours after admission.For patients with high CVP values(≥8 mm Hg)at admission,CVP decreased significantly at 6 hours(11.3±4.0 mm Hg vs.10.3±2.9 mm Hg,P<0.001).For patients with high MAP(≥75 mm Hg)at admission,the MAP values decreased significantly at 6 hours(94.2±13.9 mm Hg vs.89.4±11.4 mm Hg,P<0.001).For patients with high ScvO2 value(≥70%)at admission,the ScvO2 values decreased significantly at 6 hours(76.8%±4.2%vs.72.9%±7.3%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours.Conclusions This study suggested that in the resuscitation of sepsis and septic shock patients in the ICU,the target values did not need to be within the“normal range”recommended by early-goal directed therapy.The“target-and-endpoint”protocol,which aimed for personalized goals,deserves more consideration.展开更多
Objective Focused cardiac ultrasound(FCU)and lung ultrasound(LU)are increasingly being used in critically ill patients.This study aimed to investigate the effect of FCU in combination with LU on these patients and to ...Objective Focused cardiac ultrasound(FCU)and lung ultrasound(LU)are increasingly being used in critically ill patients.This study aimed to investigate the effect of FCU in combination with LU on these patients and to determine if the timing of ultrasound examination was associated with treatment change.Methods This is a multicenter cross-sectional observational study.Consecutive patients admitted to the intensive care unit(ICU)were screened for enrollment.FCU and LU were performed within the first 24 h,and treatment change was proposed by the performer based on the ultrasound results and other clinical conditions.Results Among the 992 patients included,502 were examined within 6 h of ICU admission(early phase group),and 490 were examined after 6 h of admission(later phase group).The early phase group and the later phase group had similar proportions of treatment change(48.8%vs.49.0%,χ^(2)=0.003,P=0.956).In the multivariable analysis,admission for respiratory failure was an independent variable associated with treatment change,with an odds ratio(OR)of 2.357[95%confidence interval(CI):1.284-4.326,P=0.006];the timing of examination was not associated with treatment change(OR=0.725,95%CI:0.407-1.291,P=0.275).Conclusions FCU in combination with LU,whether performed during the early phase or later phase,had a significant impact on the treatment of critically ill patients.Patients with respiratory failure were more likely to experience treatment change after the ultrasound examination.展开更多
Objective This study aimed to determine which parameters in transthoracic echocardiography(TTE)are more likely to be affected when applied in a critical care setting with mechanical ventilation.Methods Ninety mechanic...Objective This study aimed to determine which parameters in transthoracic echocardiography(TTE)are more likely to be affected when applied in a critical care setting with mechanical ventilation.Methods Ninety mechanically ventilated ICU patients were enrolled into the study group.The control group consisted of 90 patients who underwent interventional therapy.All patients had bedside TTE for parametric measurements including the right ventricular size,septal kinetics and left ventricular ejection fraction(LVEF)by eyeballing(visual assessment),the tricuspid annular plane systolic excursion(TAPSE),mitral annular plane systolic excursion(MAPSE)by M-mode sonography,the right ventricular outflow tract velocity-time integral(RVOT VTI)and left ventricular outflow tract velocity-time integral(LVOT VTI)by pulse-Doppler,the right ventricular fraction of area change(FAC)and left ventricular ejection fraction(LVEF Simpson)by endocardium tracing.We compared the differences in the frequency of optimal image acquisition in assessments of these parameters between the two groups,as well as the differences in acquisition rates of parameter measurements in ventilated ICU patients.Results There were significantly fewer patients in the study group than in the control group who had optimal images acquisitions for parameter assessments with M-mode method,pulse Doppler method and endocardiumtracing method(P<0.05);no significant difference was obsered in the number of patients with optimal images for RV eyeballing and LVEF eyeballing between the two groups.In the study group,significantly fewer optimal images were acquired for FAC than forTAPSE(22.2%vs、72.2%,χ2=45.139,P<0.001)and RVOT VTI(22.2%vs.71.1%,χ2=43.214,P<0.001);there were also fewer optimal images acquired for LVEF Simpson than for MAPSE(37.8%ys.84.4%,χ2=41.236,P<0.001)and LVOT VTI(37.8%vs.85.6%,/=43.455,P<0.001).Conclusions Images acquisition of optimal TTE images tend to be difRcult in mechanically ventilated ICU patients,but eyeballing method for functional evaluation could be an alternative method.For quantitative parameters measurements,M-mode based longitudinal function evaluation and pulse Doppler-based VTI were superior to the endocardium-tracing based parameter assessments.展开更多
Quantum image processing has long been a fascinating field,but establishing the existence of quantum speedup for all images remains challenging.In this study,we aim to identify a subset of images for which a quantum a...Quantum image processing has long been a fascinating field,but establishing the existence of quantum speedup for all images remains challenging.In this study,we aim to identify a subset of images for which a quantum algorithm can be developed with a guaranteed advantage.Specifically,we present a quantum image filtering algorithm that exhibits an exponential speedup for efficiently encoded images with a lower-bounded signal-to-noise ratio.Our approach relies on a fixed-point Grover's search to emulate the effect of Hadamard multiplication with the filtering function.To demonstrate its effectiveness,we apply our method to three typical filtering problems.Additionally,we emphasize the significance of the efficient-encoding assumption by illustrating that the quantum speedup may diminish for images lacking efficient encoding.Our work underscores the importance of exploring image types and features to realize potential quantum advantages in image processing.展开更多
To the Editor:Given the high rates of pre-diseases and various initiating causes,critical illnesses have become the most heterogeneous group in clinical practice,which multiplies treatment challenges.Despite different...To the Editor:Given the high rates of pre-diseases and various initiating causes,critical illnesses have become the most heterogeneous group in clinical practice,which multiplies treatment challenges.Despite different types of injurious“hit,”this response to various acute critical conditions is relatively homogenous and may eventually progress to a critical illness.展开更多
Different from the concept of universal computation,the universality of a quantum neural network focuses on the ability to approximate arbitrary functions and is an important guarantee for effectiveness.However,conven...Different from the concept of universal computation,the universality of a quantum neural network focuses on the ability to approximate arbitrary functions and is an important guarantee for effectiveness.However,conventional approaches of constructing a universal quantum neural network may result in a huge quantum register that is challenging to implement due to noise on a near-term device.To address this,we propose a simple design of a duplication-free quantum neural network whose universality can be rigorously proven.Specifically,instead of using multiple duplicates of the quantum register,our method relies on a single quantum register combined with multiple activation functions to create nonlinearity and achieve universality.Accordingly,our proposal requires significantly fewer qubits with shallower circuits,and hence substantially reduces the resource overhead and the noise effect.In addition,simulations demonstrate that our universality design is able to achieve a better learning accuracy in the presence of noise,illustrating a great potential in solving larger-scale learning problems on near-term devices.展开更多
Airline passenger volume is an important reference for the implementation of aviation capacity and route adjustment plans.This paper explores the determinants of airline passenger volume and proposes a comprehensive p...Airline passenger volume is an important reference for the implementation of aviation capacity and route adjustment plans.This paper explores the determinants of airline passenger volume and proposes a comprehensive panel data model for predicting volume.First,potential factors influencing airline passenger volume are analyzed from Geo-economic and service-related aspects.Second,the principal component analysis(PCA)is applied to identify key factors that impact the airline passenger volume of city pairs.Then the panel data model is estimated using 120 sets of data,which are a collection of observations for multiple subjects at multiple instances.Finally,the airline data from Chongqing to Shanghai,from 2003 to 2012,was used as a test case to verify the validity of the prediction model.Results show that railway and highway transportation assumed a certain proportion of passenger volumes,and total retail sales of consumer goods in the departure and arrival cities are significantly associated with airline passenger volume.According to the validity test results,the prediction accuracies of the model for 10 sets of data are all greater than 90%.The model performs better than a multivariate regression model,thus assisting airport operators decide which routes to adjust and which new routes to introduce.展开更多
Van der Waals (vdW) heterojunctions are equipped to avert dangling bonds due to weak, inter-layer vdW force, and ensure strong in-plane covalent bonding for two-dimensional layered structures. We fabricated four het...Van der Waals (vdW) heterojunctions are equipped to avert dangling bonds due to weak, inter-layer vdW force, and ensure strong in-plane covalent bonding for two-dimensional layered structures. We fabricated four heterojunctions devices of different layers based on p-type distorted 1T-MX2 ReSe2 and n-type hexagonal MoS2 nanoflakes, and measured their electronic and optoelectronic properties. The device showed a high rectification coefficient of 500 for the diode, a high ON/OFF ratio and higher electron mobility for the field-effect transistor (FET) compared with the individual components, and a high current responsivity (Rλ) and external quantum efficiency (EQE) of 6.75 A/W and 1,266%, respectively, for the photodetector.展开更多
Fluid resuscitation is an essential intervention in critically ill patients,and its ultimate goal is to restore tissue perfusion.Critical illnesses are often accompanied by glycocalyx degradation caused by inflammator...Fluid resuscitation is an essential intervention in critically ill patients,and its ultimate goal is to restore tissue perfusion.Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions,hypoperfusion,shock,and so forth,leading to disturbed microcirculatory perfusion and organ dysfunction.Therefore,maintaining or even restoring the glycocalyx integrity may be of high priority in the therapeutic strategy.Like drugs,however,different resuscitation fluids may have beneficial or harmful effects on the integrity of the glycocalyx.The purpose of this article is to review the effects of different resuscitation fluids on the glycocalyx.Many animal studies have shown that normal saline might be associated with glycocalyx degradation,but clinical studies have not confirmed this finding.Hydroxyethyl starch(HES),rather than other synthetic colloids,may restore the glycocalyx.However,the use of HES also leads to serious adverse events such as acute kidney injury and bleeding tendencies.Some studies have suggested that albumin may restore the glycocalyx,whereas others have suggested that balanced crystalloids might aggravate glycocalyx degradation.Notably,most studies did not correct the effects of the infusion rate or fluid volume;therefore,the results of using balanced crystalloids remain unclear.Moreover,mainly animal studies have suggested that plasma may protect and restore glycocalyx integrity,and this still requires confirmation by high-quality clinical studies.展开更多
Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COV...Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020).展开更多
The current study analyzes the contribution of 10 water quality parameters(including pH,turbidity,conductivity,total dissolved solids(TDS),hardness,total organic carbon(TOC),alkalinity,calcium ions,chlorides and sulfa...The current study analyzes the contribution of 10 water quality parameters(including pH,turbidity,conductivity,total dissolved solids(TDS),hardness,total organic carbon(TOC),alkalinity,calcium ions,chlorides and sulfates) to corrosion extent of stainless steel valves taken from different locations in a reverse osmosis system of a reclaimed water plant.The valves were in service for 5 years.Raman spectroscopy and X-ray photoelectron spectroscopy analyses are conducted to quantify corrosion products on different valves under various water quality conditions.On that basis,bivariate and multivariate regression analyses between the 10 water quality parameters and the corrosion extent of valve specimens(represented by metal loss percentage(MLP) values) are carried out to check the contribution of those water quality parameters to MLP.The results indicate that the proportions of metal oxides as corrosion products vary according to the corrosion extent of the valves.Although no linear correlation is founds all 10 water quality parameters except for pH show a significant positive correlation with the MLP values of the valve specimens.Moreover,results of multivariate regression suggest that the variation of MLP can be explained by turbidity,TDS,TOC and sulfates.A positive contribution of turbidity,TDS and TOC to MLP is observed,whereas the contribution of sulfates is negative.The results from the current work help to identify the reasons for water quality-induced failure of stainless steel equipment in RO systems.展开更多
The optical and optoelectronic characteristics of SnS nanosheets with strong anisotropic crystal structure are researched.Transmission electron microscopy and polarized Raman spectra are used to determine the crystal ...The optical and optoelectronic characteristics of SnS nanosheets with strong anisotropic crystal structure are researched.Transmission electron microscopy and polarized Raman spectra are used to determine the crystal orientation of SnS nanosheets.The photodetector based on SnS nanosheets exhibits the carrier mobility of 37.75 cm^(2)/V·s,photoresponsivity of 310.5 A/W and external quantum efficiency of 8.56×10^(4)%at 450 nm.Optical absorption around the absorption edge presents obvious polarization sensitivity with the highest optical absorption dichroic ratio of 3.06 at 862 nm.Due to anisotropic optical absorption,the polarized photocurrent appears as the periodic change affected by the polarized direction of the incident light at 808 nm.Overall,SnS nanosheets show good potential in the future application of the polarized photodetectors for specific wavelength.展开更多
Critical care ultrasonography(CCUS)is essential in the evaluation of shock,respiratory failure,and to guide central venous access.[1] Nurses also use ultrasound for nursing practice such as thrombosis screening,ultras...Critical care ultrasonography(CCUS)is essential in the evaluation of shock,respiratory failure,and to guide central venous access.[1] Nurses also use ultrasound for nursing practice such as thrombosis screening,ultrasound-guided vascular puncture,feeding tube placement,and lung physical therapy.[2]CCUS strengths are lack of radiation,portability,and low costs.Therefore,CCUS has considerable clinical use in critical care.展开更多
基金the financial support from Shanxi Province Science and Technology Department(20201101012,202101060301016)the support from the APRC Grant of the City University of Hong Kong(9380086)+5 种基金the TCFS Grant(GHP/018/20SZ)MRP Grant(MRP/040/21X)from the Innovation and Technology Commission of Hong Kongthe Green Tech Fund(202020164)from the Environment and Ecology Bureau of Hong Kongthe GRF grants(11307621,11316422)from the Research Grants Council of Hong KongGuangdong Major Project of Basic and Applied Basic Research(2019B030302007)Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials(2019B121205002).
文摘A considerable efficiency gap exists between large-area perovskite solar modules and small-area perovskite solar cells.The control of forming uniform and large-area film and perovskite crystallization is still the main obstacle restricting the efficiency of PSMs.In this work,we adopted a solid-liquid two-step film formation technique,which involved the evaporation of a lead iodide film and blade coating of an organic ammonium halide solution to prepare perovskite films.This method possesses the advantages of integrating vapor deposition and solution methods,which could apply to substrates with different roughness and avoid using toxic solvents to achieve a more uniform,large-area perovskite film.Furthermore,modification of the NiO_(x)/perovskite buried interface and introduction of Urea additives were utilized to reduce interface recombination and regulate perovskite crystallization.As a result,a large-area perovskite film possessing larger grains,fewer pinholes,and reduced defects could be achieved.The inverted PSM with an active area of 61.56 cm^(2)(10×10 cm^(2)substrate)achieved a champion power conversion efficiency of 20.56%and significantly improved stability.This method suggests an innovative approach to resolving the uniformity issue associated with large-area film fabrication.
基金jointly sponsored by the Institute of Engineering Mechanicsthe Natural Science Foundation of China(No.52122811)。
文摘The seismic performance of medical systems is crucial for the seismic resilience of communities.The report summarizes the observed damage to twelve hospital buildings in the area affected by the MW 7.8 and MW 7.5 earthquakes on February 6,2023 in Turkey.They include five base-isolated buildings and seven fixed-base buildings in southcentral Turkey's seven most heavily affected provinces.By relating the post-quake occupancy statuses of the hospitals with the estimated seismic demands during the earthquake doublet,the report offers the following observations:(1)the base-isolated hospital buildings on friction pendulum bearings generally exhibited superior performance of achieving the goal of immediate occupancy and provided better protection for nonstructural elements than fixed-base counterparts did;(2)the fixed-base hospital buildings of reinforced concrete structures constructed after 2001 successfully achieved the goal of collapse prevention even under very high seismic demands;(3)some fixed-base hospitals also remained operational even if they were very close to the fault rupture and were subjected to higher-than-design-level earthquake ground motions.
基金Natural Science Foundation of Zhejiang Province,Grant/Award Number:Y19H280022。
文摘Background:In China,Rhizoma atractylodis macrocephalae-Paeonia lactiflora Pall(Biazhu-Baishao,BZBS)is a classic herb pair used to treat intestinal stress syndrome,ulcerative colitis and other diseases.However,the mechanism of BZBS in the treatment of functional constipation(FC)has been little studied and remains unclear.In this study,a behavioral investigation,colon tissue morphology,enzyme-linked immunosorbent assay(Elisa)and intestinal microflora analysis have been used to illuminate the potential mechanism of the effects of BZBS on FC in a rat model.Methods:A FC rat model was constructed and BZBS was given as treatment.Observations and recordings were made of the fecal moisture content,the defecation time of the first black stool,and the rate of intestinal propulsion.Elisa was used to detect the expression levels of substance P(SP),vasoactive intestinal peptide(VIP),5-hydroxytryptamine(5-HT)in the colon.To ascertain the composition of the microbial community,a high throughput 16S ribosomal RNA(16S r RNA)gene sequencing technique was employed.Results:Oral administration of BZBS significantly ameliorated several key excretion parameters,including the time to first black stool defecation,stool water content,and the propulsion rate in the small intestine in FC rats.It increased the expression of SP,VIP and 5-HT in the colon.16S r RNA gene sequencing results showed that BZBS changed the microbial community structure,decreased the Bacteroidetes/Firmicutes ratio,increased the relative abundance of Blautia and Fusicatenibacter,and decreased the relative abundance of Ruminococcus and Roseburia.Conclusions:BZBS effectively alleviates FC and improves dysbacteriosis.
文摘Myeloblastosis(MYB)类转录因子是高等植物中最大的转录因子家族之一,在植物发育及防御反应过程中发挥重要作用,还参与植物对干旱等非生物胁迫的响应。谷子(Setaria italica L.)起源于中国,具有抗旱、耐瘠薄的特性,是研究单子叶作物非生物胁迫抗性的理想材料。本研究对耐低氮胁迫谷子品种郑204经低氮处理后进行转录组分析,鉴定出一个在低氮胁迫条件下明显上调的MYB类转录因子SiMYB42。系统发育树结果表明,SiMYB42属于R2R3-MYB亚族,具有2个MYB保守域;表达模式分析显示,SiMYB42在低氮、高盐、干旱和ABA胁迫条件下表达量显著上调;亚细胞定位、quantitative real-time PCR及转录激活活性分析结果表明,SiMYB42蛋白定位于植物的细胞核和细胞膜中,主要在谷子的叶部或根部表达,具有转录激活活性;基因功能分析结果表明,在正常条件下,转SiMYB42基因拟南芥与野生型Columbia-0拟南芥(WT)无明显差异,但在低氮条件下,转SiMYB42基因拟南芥的主根长、根系表面积及鲜重均显著高于WT,结果证明SiMYB42基因可以提高转基因植物对低氮胁迫的耐性;下游基因表达分析结果显示,在转SiMYB42基因拟南芥中,参与植物氮素转运的硝酸盐转运基因NRT2.1、NRT2.4和NRT2.5的表达水平均高于WT,启动子分析结果显示NRT2.1、NRT2.4和NRT2.5基因启动子序列中均具有MYB结合位点。以上结果证明,SiMYB42可以通过调控下游硝酸盐转运体基因的表达提高植物在低氮条件下的耐性。本研究揭示了SiMYB42基因在低氮胁迫反应途径中的作用,为进一步了解谷子低氮胁迫响应的调控网络奠定了基础。
基金supported by the Project of Zhejiang Natural Science Foundation(LY19H280004)the Exploration Project of Zhejiang Natural Science Foundation(LQ21H270002)。
文摘Background:We aimed to reveal the mechanism of functional constipation in the treatment of Atractylodes macrocephala Koidz.(AMK)and Paeonia lactiflora Pall.(PLP).Methods:The main active ingredients of AMK and PLP were screened by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.A database of functional constipation targets was established by GeneCard and OMIM.An“ingredient-target”network map was constructed with Cytoscape software(version 3.7.1),and molecular docking analysis was performed on the components and genes with the highest scores.The rats in the normal group were given saline,and those in the other groups were given 10 mg/kg diphenoxylate once a day for 14 days.The serum and intestinal tissue levels of adenosine monophosphate(cAMP),protein kinase A(PKA),and adenylyl cyclase(AC)of the rats and aquaporin(AQP)1,AQP3,and AQP8 were measured.Results:AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.After treatment with AMK,PLP,or mosapride,the serum and intestinal tissue levels of AC,cAMP,and PKA were significantly downregulated.Groups receiving AMK and PLP or mosapride exhibited a reduction in the level of AQP1,AQP3,and AQP8 to varying degrees.Conclusion:Molecular docking analysis revealed that AMK and PLP had a significant role in the regulation of targets in the treatment of functional constipation.Studies have confirmed that AMK and PLP can also affect AC,cAMP,and PKA.AC,cAMP,and PKA in model rats were significantly downregulated.AQP expression is closely related to AC,cAMP,and PKA.AMK and PLP can reduce the expression of AQP1,AQP3,and AQP9 in the colon of constipated rats.
文摘Objective To investigate the effect of target-and-endpoint protocol on the resuscitation of septic patients.Methods This is a retrospective study performed at the Peking Union Medical College Hospital Intensive Care Unit.We enrolled 545 septic patients who needed vasopressors on at least the first day of ICU admission.The general characteristics,blood lactate level,mean arterial pressure(MAP),central venous pressure(CVP)and saturation of central venous oxygen(ScvO2)at admission and 6,24 hours after admission were collected.The parameters at different time points were compared.Lactate clearance rate and in-hospital mortality were analyzed.Results The 6-hour lactate clearance rate was 21.6%(IQR,8.6%-39.0%),and in-hospital mortality was 9.4%.For patients with low CVP values(<8 mm Hg,1 mm Hg=0.133 kPa)at admission,CVP increased significantly at 6 hours after admission(5.4±1.6 mm Hg vs.7.7±2.6 mm Hg,P<0.001).For patients with low MAP(<75 mm Hg)at admission,the MAP values increased significantly at 6 hours(64.2±7.1 mm Hg vs.82.2±13.1 mm Hg,P<0.001).For patients with low ScvO2 value(<70%)at admission,the ScvO2 value increased significantly at 6 hours(61.9%±7.0%vs.71.9%±7.8%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours after admission.For patients with high CVP values(≥8 mm Hg)at admission,CVP decreased significantly at 6 hours(11.3±4.0 mm Hg vs.10.3±2.9 mm Hg,P<0.001).For patients with high MAP(≥75 mm Hg)at admission,the MAP values decreased significantly at 6 hours(94.2±13.9 mm Hg vs.89.4±11.4 mm Hg,P<0.001).For patients with high ScvO2 value(≥70%)at admission,the ScvO2 values decreased significantly at 6 hours(76.8%±4.2%vs.72.9%±7.3%,P<0.001).No difference was found between the values at 6 hours and the corresponding values at 24 hours.Conclusions This study suggested that in the resuscitation of sepsis and septic shock patients in the ICU,the target values did not need to be within the“normal range”recommended by early-goal directed therapy.The“target-and-endpoint”protocol,which aimed for personalized goals,deserves more consideration.
文摘Objective Focused cardiac ultrasound(FCU)and lung ultrasound(LU)are increasingly being used in critically ill patients.This study aimed to investigate the effect of FCU in combination with LU on these patients and to determine if the timing of ultrasound examination was associated with treatment change.Methods This is a multicenter cross-sectional observational study.Consecutive patients admitted to the intensive care unit(ICU)were screened for enrollment.FCU and LU were performed within the first 24 h,and treatment change was proposed by the performer based on the ultrasound results and other clinical conditions.Results Among the 992 patients included,502 were examined within 6 h of ICU admission(early phase group),and 490 were examined after 6 h of admission(later phase group).The early phase group and the later phase group had similar proportions of treatment change(48.8%vs.49.0%,χ^(2)=0.003,P=0.956).In the multivariable analysis,admission for respiratory failure was an independent variable associated with treatment change,with an odds ratio(OR)of 2.357[95%confidence interval(CI):1.284-4.326,P=0.006];the timing of examination was not associated with treatment change(OR=0.725,95%CI:0.407-1.291,P=0.275).Conclusions FCU in combination with LU,whether performed during the early phase or later phase,had a significant impact on the treatment of critically ill patients.Patients with respiratory failure were more likely to experience treatment change after the ultrasound examination.
文摘Objective This study aimed to determine which parameters in transthoracic echocardiography(TTE)are more likely to be affected when applied in a critical care setting with mechanical ventilation.Methods Ninety mechanically ventilated ICU patients were enrolled into the study group.The control group consisted of 90 patients who underwent interventional therapy.All patients had bedside TTE for parametric measurements including the right ventricular size,septal kinetics and left ventricular ejection fraction(LVEF)by eyeballing(visual assessment),the tricuspid annular plane systolic excursion(TAPSE),mitral annular plane systolic excursion(MAPSE)by M-mode sonography,the right ventricular outflow tract velocity-time integral(RVOT VTI)and left ventricular outflow tract velocity-time integral(LVOT VTI)by pulse-Doppler,the right ventricular fraction of area change(FAC)and left ventricular ejection fraction(LVEF Simpson)by endocardium tracing.We compared the differences in the frequency of optimal image acquisition in assessments of these parameters between the two groups,as well as the differences in acquisition rates of parameter measurements in ventilated ICU patients.Results There were significantly fewer patients in the study group than in the control group who had optimal images acquisitions for parameter assessments with M-mode method,pulse Doppler method and endocardiumtracing method(P<0.05);no significant difference was obsered in the number of patients with optimal images for RV eyeballing and LVEF eyeballing between the two groups.In the study group,significantly fewer optimal images were acquired for FAC than forTAPSE(22.2%vs、72.2%,χ2=45.139,P<0.001)and RVOT VTI(22.2%vs.71.1%,χ2=43.214,P<0.001);there were also fewer optimal images acquired for LVEF Simpson than for MAPSE(37.8%ys.84.4%,χ2=41.236,P<0.001)and LVOT VTI(37.8%vs.85.6%,/=43.455,P<0.001).Conclusions Images acquisition of optimal TTE images tend to be difRcult in mechanically ventilated ICU patients,but eyeballing method for functional evaluation could be an alternative method.For quantitative parameters measurements,M-mode based longitudinal function evaluation and pulse Doppler-based VTI were superior to the endocardium-tracing based parameter assessments.
基金supported by the National Natural Science Foundation of China(Grant No.92265208)the National Key R&D Program of China(Grant No.2018YFA0306703)startup funding supported by the University of Massachusetts,Boston。
文摘Quantum image processing has long been a fascinating field,but establishing the existence of quantum speedup for all images remains challenging.In this study,we aim to identify a subset of images for which a quantum algorithm can be developed with a guaranteed advantage.Specifically,we present a quantum image filtering algorithm that exhibits an exponential speedup for efficiently encoded images with a lower-bounded signal-to-noise ratio.Our approach relies on a fixed-point Grover's search to emulate the effect of Hadamard multiplication with the filtering function.To demonstrate its effectiveness,we apply our method to three typical filtering problems.Additionally,we emphasize the significance of the efficient-encoding assumption by illustrating that the quantum speedup may diminish for images lacking efficient encoding.Our work underscores the importance of exploring image types and features to realize potential quantum advantages in image processing.
基金Key Project of Central Health Care Scientific Research(No.2020ZD08)
文摘To the Editor:Given the high rates of pre-diseases and various initiating causes,critical illnesses have become the most heterogeneous group in clinical practice,which multiplies treatment challenges.Despite different types of injurious“hit,”this response to various acute critical conditions is relatively homogenous and may eventually progress to a critical illness.
基金supported by the National Key R&D Program of China(Grant No.2018YFA0306703)the National Natural Science Foundation of China(Grant No.92265208)。
文摘Different from the concept of universal computation,the universality of a quantum neural network focuses on the ability to approximate arbitrary functions and is an important guarantee for effectiveness.However,conventional approaches of constructing a universal quantum neural network may result in a huge quantum register that is challenging to implement due to noise on a near-term device.To address this,we propose a simple design of a duplication-free quantum neural network whose universality can be rigorously proven.Specifically,instead of using multiple duplicates of the quantum register,our method relies on a single quantum register combined with multiple activation functions to create nonlinearity and achieve universality.Accordingly,our proposal requires significantly fewer qubits with shallower circuits,and hence substantially reduces the resource overhead and the noise effect.In addition,simulations demonstrate that our universality design is able to achieve a better learning accuracy in the presence of noise,illustrating a great potential in solving larger-scale learning problems on near-term devices.
基金The National Natural Science Fund of China(No.U1564201 and No.U51675235).
文摘Airline passenger volume is an important reference for the implementation of aviation capacity and route adjustment plans.This paper explores the determinants of airline passenger volume and proposes a comprehensive panel data model for predicting volume.First,potential factors influencing airline passenger volume are analyzed from Geo-economic and service-related aspects.Second,the principal component analysis(PCA)is applied to identify key factors that impact the airline passenger volume of city pairs.Then the panel data model is estimated using 120 sets of data,which are a collection of observations for multiple subjects at multiple instances.Finally,the airline data from Chongqing to Shanghai,from 2003 to 2012,was used as a test case to verify the validity of the prediction model.Results show that railway and highway transportation assumed a certain proportion of passenger volumes,and total retail sales of consumer goods in the departure and arrival cities are significantly associated with airline passenger volume.According to the validity test results,the prediction accuracies of the model for 10 sets of data are all greater than 90%.The model performs better than a multivariate regression model,thus assisting airport operators decide which routes to adjust and which new routes to introduce.
基金This work was supported by the "Hundred Talents Program" of Chinese Academy of Sciences (CAS),the National Natural Science Foundation of China (No. 91233120), and the CAS/SAFEA International Partnership Program for Creative Research Teams.
文摘Van der Waals (vdW) heterojunctions are equipped to avert dangling bonds due to weak, inter-layer vdW force, and ensure strong in-plane covalent bonding for two-dimensional layered structures. We fabricated four heterojunctions devices of different layers based on p-type distorted 1T-MX2 ReSe2 and n-type hexagonal MoS2 nanoflakes, and measured their electronic and optoelectronic properties. The device showed a high rectification coefficient of 500 for the diode, a high ON/OFF ratio and higher electron mobility for the field-effect transistor (FET) compared with the individual components, and a high current responsivity (Rλ) and external quantum efficiency (EQE) of 6.75 A/W and 1,266%, respectively, for the photodetector.
文摘Fluid resuscitation is an essential intervention in critically ill patients,and its ultimate goal is to restore tissue perfusion.Critical illnesses are often accompanied by glycocalyx degradation caused by inflammatory reactions,hypoperfusion,shock,and so forth,leading to disturbed microcirculatory perfusion and organ dysfunction.Therefore,maintaining or even restoring the glycocalyx integrity may be of high priority in the therapeutic strategy.Like drugs,however,different resuscitation fluids may have beneficial or harmful effects on the integrity of the glycocalyx.The purpose of this article is to review the effects of different resuscitation fluids on the glycocalyx.Many animal studies have shown that normal saline might be associated with glycocalyx degradation,but clinical studies have not confirmed this finding.Hydroxyethyl starch(HES),rather than other synthetic colloids,may restore the glycocalyx.However,the use of HES also leads to serious adverse events such as acute kidney injury and bleeding tendencies.Some studies have suggested that albumin may restore the glycocalyx,whereas others have suggested that balanced crystalloids might aggravate glycocalyx degradation.Notably,most studies did not correct the effects of the infusion rate or fluid volume;therefore,the results of using balanced crystalloids remain unclear.Moreover,mainly animal studies have suggested that plasma may protect and restore glycocalyx integrity,and this still requires confirmation by high-quality clinical studies.
基金This work was supported in part by the National Natural Science Foundation of China(61872216 and 81630103 to JZ,31900862 to DZ,31871443 to PL)the National Key R&D Program(2019YFA0508403 to PL,2020YFA0803300 to HL)the Turing Al Institute of Nanjing and the Zhongguancun Haihua Institute for Frontier Information Technology.
文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020).
基金supported by the China Postdoctoral Science Foundation (No.2018M631495)the National Natural Science Foundation of China (Nos.51808312,51879139)the National Key Research and Development Program of China for International Science & Innovation Cooperation Major Project between Governments (No.2016YFE0118800).
文摘The current study analyzes the contribution of 10 water quality parameters(including pH,turbidity,conductivity,total dissolved solids(TDS),hardness,total organic carbon(TOC),alkalinity,calcium ions,chlorides and sulfates) to corrosion extent of stainless steel valves taken from different locations in a reverse osmosis system of a reclaimed water plant.The valves were in service for 5 years.Raman spectroscopy and X-ray photoelectron spectroscopy analyses are conducted to quantify corrosion products on different valves under various water quality conditions.On that basis,bivariate and multivariate regression analyses between the 10 water quality parameters and the corrosion extent of valve specimens(represented by metal loss percentage(MLP) values) are carried out to check the contribution of those water quality parameters to MLP.The results indicate that the proportions of metal oxides as corrosion products vary according to the corrosion extent of the valves.Although no linear correlation is founds all 10 water quality parameters except for pH show a significant positive correlation with the MLP values of the valve specimens.Moreover,results of multivariate regression suggest that the variation of MLP can be explained by turbidity,TDS,TOC and sulfates.A positive contribution of turbidity,TDS and TOC to MLP is observed,whereas the contribution of sulfates is negative.The results from the current work help to identify the reasons for water quality-induced failure of stainless steel equipment in RO systems.
基金This work was financially supported by the National Natural Science Foundation of China(Grant Nos.62004193 and 81900912)the National Key Research and Development Program of China(Grant No.2017YFA0207500)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB43000000)Beijing National Laboratory for Molecular Sciences(BNLMS201908).
文摘The optical and optoelectronic characteristics of SnS nanosheets with strong anisotropic crystal structure are researched.Transmission electron microscopy and polarized Raman spectra are used to determine the crystal orientation of SnS nanosheets.The photodetector based on SnS nanosheets exhibits the carrier mobility of 37.75 cm^(2)/V·s,photoresponsivity of 310.5 A/W and external quantum efficiency of 8.56×10^(4)%at 450 nm.Optical absorption around the absorption edge presents obvious polarization sensitivity with the highest optical absorption dichroic ratio of 3.06 at 862 nm.Due to anisotropic optical absorption,the polarized photocurrent appears as the periodic change affected by the polarized direction of the incident light at 808 nm.Overall,SnS nanosheets show good potential in the future application of the polarized photodetectors for specific wavelength.
基金Key Project of Central Health Care Scientific Research(No. 2020ZD08)Beijing Municipal Science and Technology Commission(No. Z201100005520038)+1 种基金Fundamental Research Funds for the Central Universities(No. 3332021018)Nursing Scientific Research Fund Project of Peking Union Medical College Hospital(No. XHHLKY201903)。
文摘Critical care ultrasonography(CCUS)is essential in the evaluation of shock,respiratory failure,and to guide central venous access.[1] Nurses also use ultrasound for nursing practice such as thrombosis screening,ultrasound-guided vascular puncture,feeding tube placement,and lung physical therapy.[2]CCUS strengths are lack of radiation,portability,and low costs.Therefore,CCUS has considerable clinical use in critical care.