Modified Xiaoyao powder for postpartum depression:A systematic review and meta-analysis

Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane Library,and PubMed databases were searched from their inception to April 25,2023.The Cochrane Risk of Bias tool was used to assess the quality of the trials.We applied the risk ratio to present dichotomous data and the mean difference to present continuous data.Data with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using I2.Results:This review included 35 trials involving 2848 participants.The quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;P<.00001),and higher effective rate(relative risk=1.19;95%confidence interval:1.15 to 1.24;P<.00001),When comparing modified Xiaoyao alone with Western medicine,the HAMD depression score remained low,however,the efficacy rate was higher in the modified Xiaoyao group.Regarding adverse events,the modified Xiaoyao group reported weight gain,nausea,and diarrhea,but no severe adverse events were reported.Conclusion:Modified Xiaoyao may help relieve depression in PPD when used alone or in combination with Western medicine,with minor side effects.Therefore,future high-quality,large-sample size RCTs are warranted.

高质量视域下乡村教师学习力提升的基本逻辑、核心内容及实施路径

教育的高质量发展唤起我们对乡村学校教育的再次关注,以期提高乡村学校的育人价值。乡村教育高质量发展牵动我国新时代教育的高质量发展,然而乡村教师队伍的整体素质一直是制约乡村教育高质量发展的主要因素。基于已有研究、理论思辨、田野分析等,尝试构建以经验自觉、知识自觉、思维自觉三大论域,以此实现乡村教师主体自觉。从乡村情境化经验场域、个体化认知基础、学习型结构思维解析乡村教师学习力系统,将其划分为体验式学习力、个性化学习力、交互式学习力的三大学习力类型。鉴于此,挖掘乡村独特学习资源,开发乡村特色教育文化,搭建乡村教师学习组织,最终实现乡村教师主体自觉,以学习力提升推动乡村学校整体进阶,实现特色化、高质量发展。

Photoreduction of CO_(2) in the presence of CH_(4) over g-C_(3)N_(4) modified with TiO_(2) nanoparticles at room temperature

CO_(2)reduction under simulated sunlight over photocatalysts has become an attractive researcher area recently.In this work,carbon nitride compounds modified by TiO_(2)nanoparticles(TNPs)have been used for the photoreduction of CO_(2)in the presence of CH_(4)at room temperature.Briefly,a series of noble-metal-free TNP-graphitic-carbon nitride(g-C_(3)N_(4),also abbreviated CN)photocatalysts with different TNPs loadings and calcination temperatures have been synthesized by a wet-chemical method.The characterization results of XRD,FTIR,SEM,TEM,BET,XPS,CO_(2)Adsorption,UV-vis,and PL demonstrate that the BET surface area and CO_(2)adsorption capacity have been improved after the calcination.Besides,the g-C_(3)N_(4)has been successfully coupled with the TNPs and a heterojunction has formed at their interface.These characters contribute to increase the photocatalytic activity of TNPs-CN toward reducing CO_(2)in the presence of CH_(4),and its'performance is better than bare g-C_(3)N_(4),Titania(P_(25))-CN,MgO-CN,or Cu_(2)O-CN.Orthogonal experiments are then carried out to investigate the sensitivity factors and optimum conditions.The sensitivity results show that the reaction pressure makes little difference on the photocatalysis results,which verifies the photoinduced CO_(2)-CH_(4)reaction has a tiny change in gas volume.In addition,under the optimum conditions,the turnover frequency(TOF)of CO after 4 h reaction can reach 9.98μmol g-cat.^(-1)h^(-1),and traces of ethane and ethylene have been detected during the reactions.In addition,surface acetate and carbonaceous deposit are found on the(20)TNPs-CN/450 surface after continuous 24 h irradiation under the optimum conditions,which resulting in the inactivation of the catalyst.Finally,possible reaction mechanisms have been proposed based on the results.

温度与加载应力对双轴取向聚甲基丙烯酸甲酯蠕变行为的影响

考察了不同试验温度下YB-DM-11航空有机玻璃的拉伸性能,基于拉伸性能研究结果,在加载应力不超过对应温度下有机玻璃屈服强度的情况下,研究了蠕变温度和加载应力对有机玻璃蠕变行为的影响。结果表明,温度从25℃升至115℃,有机玻璃的屈服强度从85.69 MPa下降到9.89 MPa,降幅达88%。有机玻璃蠕变行为是温度、应力耦合作用的结果,升高温度或增加加载应力均能较大地提高有机玻璃的蠕变速率;通过降低蠕变温度或减小加载应力能有效地将有机玻璃蠕变过程控制在前2个阶段。采用广义蠕变方程和有效时间理论的蠕变模型对YB-DM-11航空有机玻璃前2个阶段的蠕变曲线进行拟合,所得拟合曲线与实验结果具有较高的重合度。

Understanding the promotional effects of trace doped Zn in Co/NC for efficient one-pot catalytic conversion of furfural to 2-methyl-tetrahydrofuran

2-methyl-tetrahydrofuran(2-MTHF)is a promising biofuel or fuel additive with excellent burning property,a versatile new-style solvent in organic synthesis,and an important medical intermediate.In this work,a one-pot selective conversion of furfural(FA)into 2-MTHF was carried out over Zn doped Co/NC catalysts.The Zn-Co/NC-1 catalyst with trace Zn dopant(0.38 wt%)exhibited the best performance(yield of 2-MTHF:93.8%).According to the characterizations,it was found that the Zn not only incorporates into the carbon support but also partially dopes into Co nanoparticles.Subsequently,theoretical calculations demonstrated that the doping of Zn in carbon support can effectively enhance the electron transfer from the support to the metallic Co particle,leading to the electron-rich Co surface.The presence of Zn was found to promote the dissociation of hydrogen and to lower the diffusion barrier of hydrogen atom,in favor of the hydrogenation/hydrodeoxygenation processes.Furthermore,the Zn doped models exhibit much lower barrier in breaking C–OH bond of FOL,resulting in higher activity for hydrodeoxygenation of FOL.These theoretical results are consistent with the in situ FT-IR analysis of adsorption substrates and intermediates over Zn doped catalyst.This work reveals the mechanism of dopant Zn tailoring the electronic structure and catalytic performance of active sites,providing a deep insight into the design of economical and high-performance catalysts for hydrogenation/hydrodeoxygenation of biomass feedstocks.

Regulating ethane and ethylene synthesis by proton corridor microenvironment for CO_(2) electrolysis

Electrocatalytic reduction of carbon dioxide is one of the most effective strategies to achieve carbon neutrality and energy sustainability.Although high-value multi-carbon products have been widely studied,limited electrocatalysts have been reported for the selective conversion of ethane.More importantly,the factors tuning the selectivity between ethane and ethylene have not been clarified.Here,Zn@Cu nanowire arrays(Zn@Cu-NWAs) catalyst is proposed to stimulate the maintenance of efficient CO_(2)-to-C_(2)H_(6) conversion at high current densities.Meanwhile,in order to investigate the factors affecting the interconversion between ethane and ethylene,the counterpart catalyst that facilitates C–C coupling to ethylene was also synthesized.Time-of-flight secondary-ion mass spectroscopy(TOF-SIMS),in-situ Raman spectroscopy,and simulation results show that Zn@Cu-NWAs can provide a localized proton corridor environment for the formation of ethane,accelerating the further proton-coupled CO_(2) reduction reaction(CO_(2)RR)kinetics.Hence,this catalyst delivered an ethane Faraday efficiency of over 65% at-1.14 V vs.RHE with a total current density of 142.3 mA/cm^(2).This work provides a new perspective on regulating the local microenvironment to modify the selectivity of multi-carbon products.

The activity and kinetic properties of cellulases in substrates containing metal ions and acid radicals

The effects of various metal ions (Na+, K+, Ca2+, Mg2+, Al3+, Co2+) and anions (Cl–, SO2-4 and CH3COO–) on two cellulases were investigated. Fitting of the data to Michaelis-Menten kinetics showed that Al3+ noncom-petitively inhibited cellulase (Km = 22.68 g/L;Vmax = 0.269 mg/min at 5.0 mmol/L AlCl3) and Mg2+ competitively inhibited cellulase (Km = 50.0 g/L;Vmax = 0.434 mg/min at 10.0 mmol/L MgCl2) Different metal ions increased or decreased inhibition of cellulase activity slightly below 1 mmol/L and strongly over 10 mmol/L. The results indicated that filter paper activeity (FPA) was suitable for analysis of enzymatic saccharification with various lignocellulosic substrates whereas crude cellulase was suitable for applications in the biomass industry. Some metal ions were proved to inhibit cellulase reversibly.

Dynamic QoS Mapping and Adaptive Semi-Persistent Scheduling in 5G-TSN Integrated Networks

The ubiquitous and deterministic communication systems are becoming indispensable for future vertical applications such as industrial automation systems and smart grids.5G-TSN(Time-Sensitive Networking)integrated networks with the 5G system(5GS)as a TSN bridge are promising to provide the required communication service.To guarantee the endto-end(E2E)QoS(Quality of Service)performance of traffic is a great challenge in 5G-TSN integrated networks.A dynamic QoS mapping method is proposed in this paper.It is based on the improved K-means clustering algorithm and the rough set theory(IKCRQM).The IKC-RQM designs a dynamic and loadaware QoS mapping algorithm to improve its flexibility.An adaptive semi-persistent scheduling(ASPS)mechanism is proposed to solve the challenging deterministic scheduling in 5GS.It includes two parts:one part is the persistent resource allocation for timesensitive flows,and the other part is the dynamic resource allocation based on the max-min fair share algorithm.Simulation results show that the proposed IKC-RQM algorithm achieves flexible and appropriate QoS mapping,and the ASPS performs corresponding resource allocations to guarantee the deterministic transmissions of time-sensitive flows in 5G-TSN integrated networks.

KH型剪切调控蛋白:星形胶质细胞炎性细胞因子生成检测点

中枢神经系统(CNS)慢性炎性反应是许多神经退行性疾病和自身免疫性疾病的主要病理特点之一。作为免疫活性细胞,星形胶质细胞(Ast)在CNS炎性反应过程中发挥了重要作用。它可表达许多细胞因子,如肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)等,这些细胞因子可直接或通过募集免疫细胞等途径间接促进炎性反应。检测点的存在可保证这些细胞因子的生成受到严密控制。细胞因子mRNA3’-非翻译区的腺苷酸/尿苷酸富含元件(ARE)由于可调节mRNA稳定性和翻译效率而扮演着主要检测点的角色。KH型剪切调控蛋白(KSRP)是一种RNA结合蛋白,可通过与ARE结合降低mRNA的稳定性。本研究检测了KSRP对Ast细胞因子表达和旁分泌表型的影响。笔者发现了一个包括TNF-α和L-1β在内的炎性介质网络。与同窝出生的对照小鼠相比,KSRP-/-小鼠Ast上述炎性介质的表达在RNA水平增高了2～4倍。而这种KSRP-/-小鼠Ast激活后产生的TNF-α和IL-1β甚至能达到对照组的15倍以上。离体情况下,KSRP-/-Ast条件性培养液有趋化作用且能诱导神经元死亡。令人惊讶的是,笔者发现仅通过特定途径激活Ast后才能观察到部分mRNA半衰期延长。荧光素酶报告系统研究显示KSRP可在转录水平和转录后水平调节细胞因子基因的表达。本研究提示KSRP在促炎介质的调控方面发挥重要作用,因此在CNS炎性和自身免疫性疾病中有广泛意义。

Geochronology and zircon geochemistry of auriferous intrusions in the Bumo deposit,Hainan Province,China

Intrusion-related gold deposits(IRGS)are a lowgrade,large-tonnage exploration target.Recently,auriferous magmatic rocks were found in the Bumo deposit of the Gezhen shear zone in Hainan Province,China.However,the geochronology and geochemical characteristics of the intrusions,as well as the mineralization potential,are still unclear.Field and petrographic work show that the sulfidebearing intrusions can be divided into diorite porphyrites,quartz monzodiorites and monzodiorites.Zircon LA–ICP–MS U–Pb dating demonstrates that diorite porphyrites,quartz monzodiorites and monzodiorites were formed at104±1,114±1,114±1 Ma,respectively.In addition,sulfides in Yanshanian intrusion-related gold mineralization haveδ;S values of 0.2–4.4%,lower than those in Hercynian-Indosinian(1.9–9.8%)orogenic deposits(ca.219–378 Ma)in the Gezhen shear zone.In addition,all these intrusions display close correlations between Eu/EuN*with Th/U,consistent with the differentiation of amphibole,apatite and titanite from a hydrous melt.Moreover,zircon Eu/EuN*in the intrusions are higher than0.4,demonstrating that the magmatic rocks have high water contents and oxygen fugacity values,favorable for gold mineralization.Consequently,the Yanshanian magmatic rocks can be a new potential gold exploration target in the Gezhen shear zone.

Switchable terahertz polarization converter based on VO_(2)metamaterial

A switchable terahertz(THz)polarization converter based on vanadium dioxide(VO_(2)) metamaterial is proposed.It is a 5-layer structure which containing metal split-ring-resonator(SRR),the first polyimide(PI)spacer,VO_(2) film,the second PI spacer,and metal grating.It is an array structure and the period in x and y directions is 100μm.The performance is simulated by using finite integration technology.The simulation results show that,when the VO_(2) is in insulating state,the device is a transmission polarization converter.The cross-linear polarization conversion can be realized in a broadband of0.70 THz,and the polarization conversion rate(PCR)is higher than 99%.Under thermal stimulus,the VO_(2) changes from insulating state to metallic state,and the device is a reflective polarization converter.The linear-to-circular polarization conversion can be successfully realized in a broadband of 0.50 THz,and the PCR is higher than 88%.

Characterization of a broad substrates specificity acyl-CoA:diacylglycerol acyltransferase 1 from the green tide alga Ulva prolifera

Triacylglycerols(triglycerides,TAGs)are the major carbon and energy storage forms in various organisms,and important components of cellular membranes and signaling molecules;they have essential functions in multiple physiological processes and stress regulation.Acyl-CoA:diacylglycerol acyltransferase(DGAT)catalyzes the final and only committed acylation step in the synthesis of TAGs in eukaryotes.The present work identified and isolated a novel gene,UpDGAT1,from the green tide alga Ulva prolifera.The activity of UpDGAT1 was confirmed by heterologous expression in a Saccharomyces cerevisiae TAG-deficient quadruple mutant.Results of thin-layer chromatography and BODIPY staining indicated that UpDGAT1 was able to restore TAG synthesis and lipid body formation in the yeast.Lipid analysis of yeast cells revealed that UpDGAT1 showed broad substrate specificity,accepting saturated as well as mono-and polyunsaturated acyl-CoAs as substrates.High salinity and high temperature stresses increased UpDGAT1 expression and TAG accumulation in U.prolifera.The present study provides clues to the functions of UpDGAT1 in TAG accumulation in,and stress adaptation of,U.prolifera.

Identification of genes under positive selection reveals evolutionary adaptation of Ulva mutabilis

Ulvophytes are attractive model systems for understanding the evolution of growth,development,and environmental stress responses.They are untapped resources for food,fuel,and high-value compounds.The rapid and abundant growth of Ulva species makes them key contributors to coastal biogeochemical cycles,which can cause significant environmental problems in the form of green tides and biofouling.Until now,the Ulva mutabilis genome is the only Ulva genome to have been sequenced.To obtain further insights into the evolutionary forces driving divergence in Ulva species,we analyzed 3905 single copy ortholog family from U.mutabilis,Chlamydomonas reinhardtii and Volvox carteri to identify genes under positive selection(GUPS)in U.mutabilis.We detected 63 orthologs in U.mutabilis that were considered to be under positive selection.Functional analyses revealed that several adaptive modifications in photosynthesis,amino acid and protein synthesis,signal transduction and stress-related processes might explain why this alga has evolved the ability to grow very rapidly and cope with the variable coastal ecosystem environments.

Accumulation Characteristics and Safety Evaluation of Heavy Metals in Four Kinds of Aquatic Products from Lake Taihu

In order to investigate the current status of heavy metals pollution and food safety of aquatic products from Lake Taihu,atomic absorption spectrophotometry( AAS) was used to determine the contents of Pb,Cd,Cu,and Zn in the head,muscle and viscera of farmed and wild aquatic products. The results showed that the distribution patterns of heavy metals in different parts of aquatic products were quite different. Heavy metals were mainly distributed in the head and viscera of all investigated aquatic products except wild Carassius auratus. The contents of heavy metals in each part of aquatic products generally decreased in the following order: Zn > Cu > Pb > Cd. The levels of heavy metals pollution in the muscle tissue of farmed and wild aquatic products were different,with higher levels being found in the muscle tissue of wild aquatic products. Furthermore,the content of each heavy metal in muscle tissue was also different among different kinds of aquatic products,with both farmed and wild Metapenaeus ensis having the strongest Cu accumulation capacity while wild C. auratus having the strongest Zn accumulation capacity. The heavy metals pollution in the muscle tissue of aquatic products from Lake Taihu was generally at unpolluted to minor pollution level,and only a few of them were seriously polluted with heavy metals. The main pollution factors were Pb and Zn.

全球变暖加剧青藏高原湖泊效应

Lake-effect snowfall(LES)occurs when cold air moves across open lakes.LES is expected to occur more frequently over the TP,due to the intensified lake expansion caused by intensified global warming.Thus,there is an urgent need to comprehensively assess the LES over the TP.Here,we revealed that the LES is triggered by westerly southward shift leading to the drop in air temperature and is positively correlated with lake area,wind speed and longitude across 12 large lakes(>300 km^(2))based on satellite observations and reanalysis data.Using a sensitivity model simulation,we determined that large lakes in the southern TP contributed to more than 50%of the snowfall in the downwind area in 2013.Projections indicate that the westerly-triggered LES will increase under the future RCP4.5 climate warming scenario,highlighting the importance of developing adaptive policies to address the growing risks associated with future LES.

Growth of Noncentrosymmetric Two-Dimensional Single Crystals

Among the various two-dimensional(2D)materials,more than 99%of them are noncentrosymmetric.However,since the commonly used substrates are generally centrosymmetric,antiparallel islands are usually inevitable in the growth of noncentrosymmetric 2D materials because of the energetic equivalency of these two kinds of antiparallel islands on centrosymmetric substrates.Therefore,achieving the growth of noncentrosymmetric 2D single crystals has long been a great challenge compared with the centrosymmetric ones like graphene.In this review,we presented the remarkable efforts and progress in the past decade,through precise chemical processes.We first discussed the great challenge and possible strategies in the growth of noncentrosymmetric 2D single crystals.Then,we focused on the advancements made in producing representative noncentrosymmetric 2D single crystals,including hexagonal boron nitride(hBN),transition metal dichalcogenides(TMDs),and other noncentrosymmetric 2D materials.At last,we summarized and looked forward to future research on the growth of layer-,stacking-,and twist-controlled noncentrosymmetric 2D single crystals and their heterostructures.

绝缘衬底上二维单晶材料制备研究进展

二维材料因其原子级的厚度而展现出优异的电学、光学、磁学和热学性质,在电子、光电和能源等领域具有广阔的应用前景.随着传统硅基器件逼近物理极限,摩尔定律的延续面临着巨大挑战,二维材料被寄望于超越硅基材料以实现新一代电子器件的构建.可控制备大尺寸单晶二维薄膜是实现其高性能和大规模应用的关键.过去十几年来,研究人员在二维单晶的材料生长方面付出了大量努力,典型的二维导体石墨烯、半导体过渡金属硫族化合物和绝缘体六方氮化硼的生长尺寸已经由微米级扩展到晶圆级.然而,二维材料薄膜通常需要覆盖在绝缘衬底上才能充分发挥性能,因此在绝缘衬底直接生长二维单晶材料是实现高性能电子和光电子器件的终极目标.本文从绝缘衬底上不同种类二维单晶材料的生长行为展开探讨,回顾了近十年来过渡金属硫族化合物、石墨烯和氮化硼在绝缘衬底上的生长策略以及机理,对绝缘衬底上制备高质量二维单晶材料面临的挑战和未来发展进行了总结和展望.

Towards growth of pure AB-stacked bilayer graphene single crystals

Given its intriguing band structure and unique tunable bandgap,AB-stacked bilayer graphene has great potentials in the applications of high-end electronics,optoelectronics and semiconductors.The epitaxial growth of AB-stacked single-crystal bilayer graphene films requires a strict AB-stacked lattice,identical orientations and seamless stitching of bilayer graphene islands.However,the particles inevitably present on the metal surface that produced during high temperature growth would induce random orientations,twisted stacking islands,and uncontrollable multilayers,which is a great challenge to overcome.Here,we propose a heat-resisting-box assisted strategy to produce nearly pure AB-stacked bilayer graphene single-crystal films on Cu/Ni(111)foils.With our technique,the particles on the Cu/Ni(111)surface are effectively eliminated,which greatly minimizes the occurrence of randomly twisted islands and uncontrollable multilayers.The as-grown AB-stacked bilayer graphene films show>99%alignment and>99%AB stacking order.Our work provides a promising method towards the growth of pure AB-stacked bilayer graphene single crystals and would accelerate its device applications.

黏土矿物对病毒生物地球化学作用的影响探讨与展望

作为自然界丰度最高的生命体,病毒活跃于海洋、土壤、冰川等各类生态系统.通过侵染细菌、古菌及真核微生物,病毒在调控微生物群落和元素生物地球化学循环过程中扮演着关键角色.在自然环境中,病毒与无机或有机颗粒存在广泛的相互作用.黏土矿物是广泛分布于陆地和海洋环境的无机颗粒,陆地生态系统中的黏土矿物可在大气、河流和冰川的作用下搬运至海洋,并在水体中沉降形成深海沉积物.黏土矿物对病毒具有高度亲和力,影响着环境中病毒的丰度、活性和感染能力.因此,黏土矿物对病毒介导的生物地球化学循环过程有着重要的影响.本文从各类生境中病毒的生态功能、病毒的生物地球化学作用模型和黏土矿物对病毒的吸附作用3个方面进行了概述,并讨论了陆地和海洋生态系统中黏土矿物的吸附作用对病毒功能和生物地球化学作用的潜在影响,提出黏土矿物是影响病毒驱动的生物地球化学循环不可忽视的因素,未来应将黏土矿物作为评估病毒生物地球化学作用的参数之一.

"镂空法"在胸腔镜食管癌根治术中清扫喉返神经旁淋巴结的应用价值

目的探讨在胸腔镜食管癌根治术中采用"镂空法"行喉返神经旁淋巴结清扫的临床应用价值。方法回顾性队列研究。纳入2017年1月—2020年6月厦门大学附属第一医院胸外科178例T1~T3期食管癌患者临床资料,其中男105例、女73例,年龄41~78岁。178例患者均采用微创McKeown食管癌切除术治疗,根据术中喉返神经淋巴结的清扫方式不同分为两组:采用传统方法100例纳入传统组,采用"镂空法"78例纳入镂空组。比较两组患者术中出血量、手术时间、喉返神经旁淋巴结清扫数、术后喉返神经损伤发生率及损伤程度、术后胸腔引流量、食管吻合口瘘及肺部相关并发症。结果两组患者年龄、性别、肿瘤病灶部位及临床分期等基线资料比较,差异均无统计学意义(P值均>0.05)。镂空组喉返神经旁淋巴结清扫数目左侧为(5.28±1.77)枚、右侧为(3.33±1.36)枚,传统组喉返神经旁淋巴结清扫数目左侧为(1.79±0.96)枚、右侧为(1.05±0.88)枚;同侧组间比较,镂空组均多于传统组,差异均有统计学意义(t=15.710、12.841,P值均<0.01)。镂空组78例中,喉返神经损伤共3例(3.85%),其中轻度损伤2例(2.56%)、中度损伤1例(1.28%);传统组100例中,喉返神经损伤12例(12.00%),其中轻度损伤8例(8.00%)、中度损伤4例(4.00%);镂空组喉返神经损伤的发生率及损伤程度低于传统组,但组间比较差异均无统计学意义(χ^(2)=3.775,Z=-1.936,P值均>0.05)。镂空组肺部感染7例(8.97%)、传统组为20例(20.00%),差异有统计学意义(χ^(2)=4.140,P<0.05)。两组术中出血量、手术时间、术后胸腔引流量及食管吻合口瘘发生率比较,差异均无统计学差异(P值均>0.05)。结论在胸腔镜食管癌切除术中采用"镂空法"清扫喉返神经旁淋巴结是安全、可行的,在增加喉返神经旁淋巴结清扫数目的同时不增加喉返神经损伤的发生率。