Objective： The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation （HSCT） for acute leukemia （AL） and analyze the factors affecting the prognosis of these pati...Objective： The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation （HSCT） for acute leukemia （AL） and analyze the factors affecting the prognosis of these patients. Methods： The clinical and follow-up data of 93 AL patients （median age, 30 years） undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results： Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease （aGvHD） and extensive chronic GvHD （cGvHD） were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality （TRM） and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival （OS） and disease-free survival （DFS） of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse （all P〈0.05）. Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis （all P〈0.05）. Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes （all P〈0.05）. Conclusions： Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis.展开更多
Mixed-valence metallic compounds are a class of functional materials with peculiar electrochemical properties.Exploring the correlation between defects and corrosion resistance of mixed-valence metallic compounds is a...Mixed-valence metallic compounds are a class of functional materials with peculiar electrochemical properties.Exploring the correlation between defects and corrosion resistance of mixed-valence metallic compounds is a novel and interesting subject.Through an intelligently designed synergistic process of reduction and directed assembly,not only the directional generation of oxygen vacancies along the normal direction of the(010)crystal plane was achieved,but also the W_(18)O_(49)mixed-valence metal oxide(MVMO)with a single crystalline phase and an assembled ordered three-dimensional cluster structure of nanorods was obtained.Three attractive effects of oriented oxygen vacancies in W_(18)O_(49)MVMO were discovered.First,the oxygen vacancy channels realized the directional concentrated transport of oxygen atoms to form dense oxide passivation film.Second,the directional concentrated oxygen vacancies as active centers effectively solved the problem of difficult photoelectron leap and separation of pure-phase semiconductors,realizing photogenerated cathodic protection.Third,the high-energy vacancies endowed the material with antibacterial function,which contributed to the stable existence of the anti-corrosion system.The resistance value of W_(18)O_(49)MVMO as an anti-corrosion functional material was increased to more than 4.00 times that of the original metal protection layer.The experimental results obtained in this research were of great reference value for revealing the intrinsic mechanism of correlation between oxygen defect orientation of MVMOs and electrochemistry.展开更多
文摘Objective： The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation （HSCT） for acute leukemia （AL） and analyze the factors affecting the prognosis of these patients. Methods： The clinical and follow-up data of 93 AL patients （median age, 30 years） undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results： Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease （aGvHD） and extensive chronic GvHD （cGvHD） were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality （TRM） and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival （OS） and disease-free survival （DFS） of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse （all P〈0.05）. Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis （all P〈0.05）. Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes （all P〈0.05）. Conclusions： Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis.
基金This work was supported by the National Natural Science Foundation of China(No.21878090)Opening Project of Material Corrosion and Protection Key Laboratory of Sichuan Province(No.2020CL04).
文摘Mixed-valence metallic compounds are a class of functional materials with peculiar electrochemical properties.Exploring the correlation between defects and corrosion resistance of mixed-valence metallic compounds is a novel and interesting subject.Through an intelligently designed synergistic process of reduction and directed assembly,not only the directional generation of oxygen vacancies along the normal direction of the(010)crystal plane was achieved,but also the W_(18)O_(49)mixed-valence metal oxide(MVMO)with a single crystalline phase and an assembled ordered three-dimensional cluster structure of nanorods was obtained.Three attractive effects of oriented oxygen vacancies in W_(18)O_(49)MVMO were discovered.First,the oxygen vacancy channels realized the directional concentrated transport of oxygen atoms to form dense oxide passivation film.Second,the directional concentrated oxygen vacancies as active centers effectively solved the problem of difficult photoelectron leap and separation of pure-phase semiconductors,realizing photogenerated cathodic protection.Third,the high-energy vacancies endowed the material with antibacterial function,which contributed to the stable existence of the anti-corrosion system.The resistance value of W_(18)O_(49)MVMO as an anti-corrosion functional material was increased to more than 4.00 times that of the original metal protection layer.The experimental results obtained in this research were of great reference value for revealing the intrinsic mechanism of correlation between oxygen defect orientation of MVMOs and electrochemistry.
