地质领域实体关系抽取是构建地质知识图谱的基础,对地质领域文本信息抽取与知识库构建具有重要的作用。针对地质领域实体关系复杂、缺少人工标注语料库等特点,提出了面向地质领域实体关系联合抽取模型,着重对多地质文本中存在的复杂重...地质领域实体关系抽取是构建地质知识图谱的基础,对地质领域文本信息抽取与知识库构建具有重要的作用。针对地质领域实体关系复杂、缺少人工标注语料库等特点,提出了面向地质领域实体关系联合抽取模型,着重对多地质文本中存在的复杂重叠关系进行识别,避免传统流水线模型中由于实体识别错误造成级联误差。文章构建了高质量地质领域实体关系语料库,提出了基于预训练语言模型BERT(Bidirectional Encoder Representations from Transformers)和双向门控循环单元BiGRU(Bidirectional Gated Recurrent Units)与条件随机场CRF(Conditional Random Field)的序列标注模型,实现对实体关系的联合抽取。在构建数据集上进行了实验,结果表明,本文提出的联合抽取模型在实体关系抽取上的F1值达到0.671,验证了本文模型在地质实体关系抽取的有效性。展开更多
Background:Liqi Huoxue dripping pill(LQHXDP),a traditional Chinese drug for coronary heart disease,has a protective effect on the heart of rats with myocardial ischemia-reperfusion injury(MIRI)in previous studies;howe...Background:Liqi Huoxue dripping pill(LQHXDP),a traditional Chinese drug for coronary heart disease,has a protective effect on the heart of rats with myocardial ischemia-reperfusion injury(MIRI)in previous studies;however,its mechanism of action remains unclear.The purpose of this study was to investigate the protective mechanism of LQHXDP on MIRI in rats and its relationship with the PI3K/Akt signaling pathway.Methods:In this study,Sprague-Dawley rats were pre-infused with LQHXDP(175 mg/kg/d)for 10 days.PI3K inhibitor LY294002(0.3 mg/kg)was intravenously injected 15 minutes before ischemia.The rat model of MIRI was established by ligating the left anterior descending coronary artery.Subsequently,cardiac hemodynamics,serum myocardial injury markers,inflammatory factors,myocardial infarct size,antioxidant indexes,myocardial histopathology,and phosphorylation levels of key proteins of PI3K/Akt signaling pathway were assessed in rats.Results:LQHXDP was found to improve cardiac hemodynamic indexes,reduce serum creatine kinase MB isoenzyme activity and cardiac troponin and heart-type fatty acid binding protein levels,lower serum interleukin-1 beta,interleukin-6 and tumour necrosis factorαlevels,reduce the myocardial infarct size and enhance the antioxidant capacity of myocardial tissue in MIRI rats.Pathological analysis revealed that LQHXDP attenuated the extent of myocardial injury and protected mitochondria from damage in MIRI rats.Immunoblot analysis revealed that LQHXDP increased the expression levels of p-Akt and p-GSK-3βin MIRI rat cardiomyocytes.PI3K inhibitor LY294002 could impair these effects of LQHXDP.Conclusion:LQHXDP attenuated myocardial injury,attenuated oxidative stress injury and reduced inflammatory response in MIRI rats,and its protective effects were mediated by activating of PI3K/Akt/GSK-3βsignaling pathway.展开更多
文摘地质领域实体关系抽取是构建地质知识图谱的基础,对地质领域文本信息抽取与知识库构建具有重要的作用。针对地质领域实体关系复杂、缺少人工标注语料库等特点,提出了面向地质领域实体关系联合抽取模型,着重对多地质文本中存在的复杂重叠关系进行识别,避免传统流水线模型中由于实体识别错误造成级联误差。文章构建了高质量地质领域实体关系语料库,提出了基于预训练语言模型BERT(Bidirectional Encoder Representations from Transformers)和双向门控循环单元BiGRU(Bidirectional Gated Recurrent Units)与条件随机场CRF(Conditional Random Field)的序列标注模型,实现对实体关系的联合抽取。在构建数据集上进行了实验,结果表明,本文提出的联合抽取模型在实体关系抽取上的F1值达到0.671,验证了本文模型在地质实体关系抽取的有效性。
基金supported by National Natural Science Foundation of China(Grant No.81860873 and 81960864)the Scientific and Technological Projects of Guizhou Province(Qian Kehe Jichu(2016)1401)High-level Talents Project of Guizhou Province(GUTCM(ZQ2018005)).
文摘Background:Liqi Huoxue dripping pill(LQHXDP),a traditional Chinese drug for coronary heart disease,has a protective effect on the heart of rats with myocardial ischemia-reperfusion injury(MIRI)in previous studies;however,its mechanism of action remains unclear.The purpose of this study was to investigate the protective mechanism of LQHXDP on MIRI in rats and its relationship with the PI3K/Akt signaling pathway.Methods:In this study,Sprague-Dawley rats were pre-infused with LQHXDP(175 mg/kg/d)for 10 days.PI3K inhibitor LY294002(0.3 mg/kg)was intravenously injected 15 minutes before ischemia.The rat model of MIRI was established by ligating the left anterior descending coronary artery.Subsequently,cardiac hemodynamics,serum myocardial injury markers,inflammatory factors,myocardial infarct size,antioxidant indexes,myocardial histopathology,and phosphorylation levels of key proteins of PI3K/Akt signaling pathway were assessed in rats.Results:LQHXDP was found to improve cardiac hemodynamic indexes,reduce serum creatine kinase MB isoenzyme activity and cardiac troponin and heart-type fatty acid binding protein levels,lower serum interleukin-1 beta,interleukin-6 and tumour necrosis factorαlevels,reduce the myocardial infarct size and enhance the antioxidant capacity of myocardial tissue in MIRI rats.Pathological analysis revealed that LQHXDP attenuated the extent of myocardial injury and protected mitochondria from damage in MIRI rats.Immunoblot analysis revealed that LQHXDP increased the expression levels of p-Akt and p-GSK-3βin MIRI rat cardiomyocytes.PI3K inhibitor LY294002 could impair these effects of LQHXDP.Conclusion:LQHXDP attenuated myocardial injury,attenuated oxidative stress injury and reduced inflammatory response in MIRI rats,and its protective effects were mediated by activating of PI3K/Akt/GSK-3βsignaling pathway.