Objective: To compare the clinical efficacy of artificial femoral head replacement and Proximal femoral nail antirotation (PFNA) in the treatment of unstable femoral intertrochanteric fractures in the elderly. Methods...Objective: To compare the clinical efficacy of artificial femoral head replacement and Proximal femoral nail antirotation (PFNA) in the treatment of unstable femoral intertrochanteric fractures in the elderly. Methods: This study retrospectively analyzed 60 elderly patients with unstable intertrochanteric fractures treated with PFNA and artificial femoral head replacement from 2015.06 to 2018.06, of which 34 were in the PFNA group (Group A) and 26 in the artificial femoral head replacement group (Group B). Statistical analysis of relevant surgical indicators such as surgical time, intraoperative blood loss, postoperative blood transfusion, postoperative time to landing, postoperative infection rate, hospital stay, number of secondary operations, postoperative VAS score, and postoperative Hip function score comparison. Results: All 60 patients were followed up for 1 - 24 months. Compared with the artificial femoral head replacement group, the operation time of PFNA group was shorter, the blood loss during operation was less, and the difference was statistically significant (P 0.05). Conclusion: The hip joint function and pain scores of the artificial femoral head replacement group in the early and follow-up periods are better than those of the PFNA group. The artificial femoral head replacement is more suitable for the treatment of elderly unstable intertrochanteric fractures.展开更多
目的评价复苏性主动脉球囊阻断术(resuscitative endovascular balloon occlusion of the aorta,REBOA)治疗不可压迫性躯干出血的效果,探讨哪些研究领域可能是进一步推进REBOA应用的关键。方法使用“复苏性主动脉球囊阻断术(REBOA)”、...目的评价复苏性主动脉球囊阻断术(resuscitative endovascular balloon occlusion of the aorta,REBOA)治疗不可压迫性躯干出血的效果,探讨哪些研究领域可能是进一步推进REBOA应用的关键。方法使用“复苏性主动脉球囊阻断术(REBOA)”、“复苏性主动脉血管内球囊闭塞(resuscitation intravascular balloon occlusion of the aorta)”、“球囊闭塞(balloon occlusion)”、“部分主动脉球囊闭塞(partial resuscitative endovascular balloon occlusion of the aorta)”、“部分复苏性主动脉球囊阻断术(partial resuscitation of aortic balloon blockade)”、“部分球囊闭塞(part of the balloon is occluded)”等关键词在PubMed、Embase、Cochrane等数据库中对文献进行回顾。纳入临床研究文献,排除数据集重叠、缺少2个以上变量的文章,分为院前和院内环境下两组。采用SPSS 20.0统计软件进行分析。结果16篇临床文献表明,院前环境下进行REBOA手术共47例(存活率为87.2%),穿透伤19例(40.4%),钝性损伤28例(59.6%),接受REBOAⅠ区治疗26例(55.3%),Ⅲ区治疗21例(44.7%),球囊扩张时间为36.8min。院内环境进行REBOA手术共705例(存活率为41%),穿透伤138例(19.6%),钝性损伤549例(77.9%),其他损伤18例(2.6%),接受REBOAⅠ区治疗493例(74.3%),Ⅱ区治疗16例(2.4%),Ⅲ区治疗155例(23.3%),球囊扩张时间36min。院前组军事环境下此手术者共31例(存活率为96.8%),民用环境下此手术者共16例(存活率为68.8%),在院前环境、穿透伤和区域(Zone)分区为I区患者接受REBOA紧急止血后的存活率明显升高。结论REBOA具有微创、操作相对简单的优点,非常适合军事战争或灾害救援等特定条件下创伤急救的需求。但病情诊断困难与插管时间限制了院前REBOA的使用,因此该技术距离真正走向实际应用,还需要对最适宜的对象、优化的阻断技术和阻断持续的时间等问题进行进一步的研究。展开更多
Bifenthrin(BF) is an important type I synthetic fluorinated pyrethroid insecticide and acaricide.Previous investigations have indicated that the metabolisms of BF in human cells were through oxidative processes,and cy...Bifenthrin(BF) is an important type I synthetic fluorinated pyrethroid insecticide and acaricide.Previous investigations have indicated that the metabolisms of BF in human cells were through oxidative processes,and cytotoxicity was induced by the oxidative stress.In this study,the protective effects of EGCG,which is a major individual of green tea polyphenols,on the human embryonic lung fibroblast cell line HFL-I exposed to BF were investigated.The results showed that BF could induce oxidative stress leading to cytotoxicity in HFL-I cells.The pretreatment of EGCG at low concentrations significantly recovered the cell viability and morphology,inhibited excess generation of ROS,enhanced antioxidant enzyme activities and avoided loss of mitochondrial membrane potential.The results suggested that EGCG might eliminate the BF-induced damage in HFL-I cells.展开更多
文摘Objective: To compare the clinical efficacy of artificial femoral head replacement and Proximal femoral nail antirotation (PFNA) in the treatment of unstable femoral intertrochanteric fractures in the elderly. Methods: This study retrospectively analyzed 60 elderly patients with unstable intertrochanteric fractures treated with PFNA and artificial femoral head replacement from 2015.06 to 2018.06, of which 34 were in the PFNA group (Group A) and 26 in the artificial femoral head replacement group (Group B). Statistical analysis of relevant surgical indicators such as surgical time, intraoperative blood loss, postoperative blood transfusion, postoperative time to landing, postoperative infection rate, hospital stay, number of secondary operations, postoperative VAS score, and postoperative Hip function score comparison. Results: All 60 patients were followed up for 1 - 24 months. Compared with the artificial femoral head replacement group, the operation time of PFNA group was shorter, the blood loss during operation was less, and the difference was statistically significant (P 0.05). Conclusion: The hip joint function and pain scores of the artificial femoral head replacement group in the early and follow-up periods are better than those of the PFNA group. The artificial femoral head replacement is more suitable for the treatment of elderly unstable intertrochanteric fractures.
文摘目的评价复苏性主动脉球囊阻断术(resuscitative endovascular balloon occlusion of the aorta,REBOA)治疗不可压迫性躯干出血的效果,探讨哪些研究领域可能是进一步推进REBOA应用的关键。方法使用“复苏性主动脉球囊阻断术(REBOA)”、“复苏性主动脉血管内球囊闭塞(resuscitation intravascular balloon occlusion of the aorta)”、“球囊闭塞(balloon occlusion)”、“部分主动脉球囊闭塞(partial resuscitative endovascular balloon occlusion of the aorta)”、“部分复苏性主动脉球囊阻断术(partial resuscitation of aortic balloon blockade)”、“部分球囊闭塞(part of the balloon is occluded)”等关键词在PubMed、Embase、Cochrane等数据库中对文献进行回顾。纳入临床研究文献,排除数据集重叠、缺少2个以上变量的文章,分为院前和院内环境下两组。采用SPSS 20.0统计软件进行分析。结果16篇临床文献表明,院前环境下进行REBOA手术共47例(存活率为87.2%),穿透伤19例(40.4%),钝性损伤28例(59.6%),接受REBOAⅠ区治疗26例(55.3%),Ⅲ区治疗21例(44.7%),球囊扩张时间为36.8min。院内环境进行REBOA手术共705例(存活率为41%),穿透伤138例(19.6%),钝性损伤549例(77.9%),其他损伤18例(2.6%),接受REBOAⅠ区治疗493例(74.3%),Ⅱ区治疗16例(2.4%),Ⅲ区治疗155例(23.3%),球囊扩张时间36min。院前组军事环境下此手术者共31例(存活率为96.8%),民用环境下此手术者共16例(存活率为68.8%),在院前环境、穿透伤和区域(Zone)分区为I区患者接受REBOA紧急止血后的存活率明显升高。结论REBOA具有微创、操作相对简单的优点,非常适合军事战争或灾害救援等特定条件下创伤急救的需求。但病情诊断困难与插管时间限制了院前REBOA的使用,因此该技术距离真正走向实际应用,还需要对最适宜的对象、优化的阻断技术和阻断持续的时间等问题进行进一步的研究。
文摘Bifenthrin(BF) is an important type I synthetic fluorinated pyrethroid insecticide and acaricide.Previous investigations have indicated that the metabolisms of BF in human cells were through oxidative processes,and cytotoxicity was induced by the oxidative stress.In this study,the protective effects of EGCG,which is a major individual of green tea polyphenols,on the human embryonic lung fibroblast cell line HFL-I exposed to BF were investigated.The results showed that BF could induce oxidative stress leading to cytotoxicity in HFL-I cells.The pretreatment of EGCG at low concentrations significantly recovered the cell viability and morphology,inhibited excess generation of ROS,enhanced antioxidant enzyme activities and avoided loss of mitochondrial membrane potential.The results suggested that EGCG might eliminate the BF-induced damage in HFL-I cells.
