Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible photodetection.Currently,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered mode.Herein,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays firstly.The as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II heterojunction.Notably,the strain-tunable photodetection performances of device have been demonstrated.Impressively,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible photodetectors.This work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation.This study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying mechanisms.Results showed that B.producta D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis mice.Moreover,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after B.producta D4 intervention.The intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 group.In conclusion,oral administration of B.producta D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota balance.These results are conducive to accelerate the development of B.producta D4 as a functional probiotic for colitis.

Microglial autophagy in neurogenesis:a new player in Alzheimer's disease

While extensive studies have illuminated the impact of Alzheimer's disease(AD) on neuronal survival,there is growing evidence that abnormal postnatal neurogenesis in early AD brains contributes to disease progression.Postnatal neurogenesis serves as a mechanism to replace dead or damaged neurons.New neurons generated from neural stem cells(NSCs) in the subgranular zone(SGZ) of the dentate gyrus integrate into the existing hippocampal circuit.

西藏多龙矿集区铁格隆南铜(金)矿床黄铁矿特征及意义

铁格隆南斑岩-浅成低温热液型铜(金)矿床是班公湖—怒江成矿带上最重要的矿床之一。本文以矿床内发育的黄铁矿为主要研究对象,对其开展微量元素、稀土元素和硫同位素分析。依据产出状态,黄铁矿可以分为黄铁矿-1,黄铁矿-2和黄铁矿-3,其中黄铁矿-2与浅成低温热液型矿化相关,黄铁矿-3与斑岩型矿化相关。黄铁矿-1的Au、Ag、Cu、Pb、Zn、Bi的含量最低,黄铁矿-2的Au、Ag、Cu、Pb、Zn、Bi的含量最高。Cu和Ni、Ag和Cu、Cu和Pb、Ag和Pb、Pb和Zn的相关性可作为黄铁矿-2和黄铁矿-3的辨别标志。黄铁矿-1的δ^(34)S值(1.9‰)最大;黄铁矿-2和黄铁矿-3的δ^(34)S值在–4.5‰~0.3‰之间。黄铁矿富集轻稀土,亏损重稀土,具有“右倾”式稀土配分模式,浅部(200—450 m)黄铁矿的轻重稀土分异程度较大,以正铕异常为主,而深部(700—1000 m)黄铁矿轻重稀土分异相对较小,以负铕异常为主。铁格隆南矿床含硫热液运移方向为横向上从ZK1604向东运移,纵向以ZK1604的230—250 m为中心向深部和侧向运移。黄铁矿中高含量的Cu、Au、Ag以及Ag和Cu、Pb和Zn、Cu和Pb、Ag和Pb的正相关性是指示浅成低温热液型矿化的重要标志,而黄铁矿内Cu和Ni的负相关性是指示斑岩型矿化的标志。

父母情绪社会化行为与青少年同伴社交技能的关系:教养方式的调节作用

采用问卷调查法,考察父母情绪社会化行为对青少年同伴社交技能的独特贡献及父母教养方式在其中的调节作用。结果发现:1) 在控制了教养方式之后,母亲情绪教导能显著正向预测青少年同伴社交技能,表明母亲情绪社会化行为对青少年同伴社交技能有独特贡献。父亲情绪社会化行为对青少年同伴社交技能的预测不显著,说明其在同伴社交技能上不存在独特贡献。2) 父亲温暖支持、自主鼓励调节了父亲情绪谈论、情绪教导与青少年同伴社交技能之间的关系,但母亲教养方式对其情绪社会化行为与青少年同伴社交技能之间的调节作用不明显。

电刺激在视网膜退行性疾病治疗中的研究进展

视网膜病变和视神经损伤导致视觉信息无法正常传递到视觉中枢,对患者的视觉功能以及生活质量产生严重影响。临床工作中常见的眼部疾病如青光眼、外伤性视神经病变、视网膜色素变性等均伴有视网膜神经元和/或视神经的退行性病变,而目前临床上常用的神经保护疗法疗效非常有限。近年研究表明,电刺激对视网膜和视神经具有神经保护和促进再生的作用。本文通过对电刺激在眼科应用的进展进行综述,总结电刺激治疗的相关机制,推动电刺激在眼科疾病研究和应用中的发展。

A retrospective study of 2228 cases with eyelid tumors

AIM： To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS： In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin： epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS： Most eyelid tumors were epidermal in origin（1080, 48.5%）, followed by miscellaneous（885, 39.7%） and adnexal tumors（263, 11.8%）. Among all the tumors, 292（13.1%） were malignant lesions, 1910（85.7%） benign and 26（1.1%） premalignant lesions. Most malignant tumors originated from epidermal cells（60.0%）, followed by adnexal cells（34.6%）. The most common malignant tumors were basal cell carcinomas（56.5%） followed by sebaceous carcinoma（34.6%）, squamous cell carcinomas（3.8%） and lymphoma/plasmocytoma（1.7%）. The benign and premalignant eyelid lesions mostly originated from epidermal cells（46.4%） followed by miscellaneous cell sources（45.2%）, including melanocytic nevus（33.8%）, seborrheic keratosis（13.7%）, squamous cell papilloma（13.0%） and epidermal cysts（11.5%）. CONCLUSION： Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.

Effect of the posterior corneal surface on total corneal astigmatism in patients with age-related cataract

AIM： To explore the effect of the posterior astigmatism on total corneal astigmatism and evaluate the error caused by substituting the corneal astigmatism of the simulated keratometriy （simulated K） for the total corneal astigmatism in age-related cataract patients. METHODS： A total of 211 eyes with age-related cataract from 164 patients （mean age： 66.8±9.0y, range： 45-83y） were examined using a multi-colored spot reflection topographer, and the total corneal astigmatism was measured. The power vector components J0 and J45 were analyzed. Correlations between the magnitude difference of the simulated K and total cornea astigmatism （magnitude differenceSimK-Tca）, anterior J0, and absolute meridian difference （AMD） between the anterior and posterior astigmatisms were calculated. To compare the astigmatism of the simulated K and total cornea both in magnitude and axial orientation, we drew double-angle plots and calculated the vector difference between the two measures using vector analysis. A corrective regression formula was used to adjust the magnitude of the simulated K astigmatism to approach that of the total cornea. RESULTS： The magnitude differenceSimK-Tca was positively correlated with the anterior corneal J0 （Spearman’s rho= 0.539; P〈0.001） and negatively correlated with the AMDR （Spearman’s rho=-0.875, P〈0.001）. When the anterior J0 value was larger than 1.3 D or smaller than -0.8 D, the errors caused by determining the total corneal astigmatism with the karatometric calculation tended to be greater than 0.25 D. An underestimation by 16% was observed for against the rule （ATR） astigmatism and an overestimation by 9% was observed for with the rule （WTR） astigmatism when ignoring the posterior measurements. CONCLUSION： Posterior corneal astigmatism should be valued for more precise corneal astigmatism management, especially for higher ATR astigmatism of the anterior corneal surface. We suggest a 9% reduction in the magnitude of the simulated K in eyes with WTR astigmatism, and a 16% addition of the magnitude of the simulated K in eyes with ATR astigmatism.

A Brief Summary of Current Therapeutic Strategies for Spinal Cord Injury

Spinal cord injury(SCI)is a tremendous disaster in a person’s life.It interrupts the brain-body neuronal circuits,resulting in functional deficits.Pathogenesis of SCI is a progressive and comprehensive event.In clinical trials,attempts to promote nerve regeneration and functional recovery after SCI have met with failures.Recently,with the development of transcriptome sequencing and biomaterials,researchers have struggled to explore novel efficient therapeutic treatments for SCI.Here,we summarize the recent pro-gress that has been made in SCI repair based on the lesion microenvironment,neural circuits,and bioma-terial scaffolds.We also propose several important directions for future research,including targeted-microRNA therapy,blood vessel interventions,and multiple treatment combinations.In short,we hope this review will enlighten researchers in the field and pave the way for SCI therapy.

The interaction mechanism and the functionality of yeast protein with hydrophilic and hydrophobic bioactive molecules

Yeast protein is a kind of yeast-source high-quality complete protein.The coexistence of bioactive molecules with yeast protein may influence its physicochemical property.This study discussed the interaction mechanism of yeast protein with two bioactive molecules,the hydrophobic curcumin and the hydrophilic epigallocatechin gallate(EGCG).Results indicated that curcumin and EGCG could interact with yeast protein with different binding stoichiometric numbers(0.8109±0.0695 and 2.7248±0.2422)and binding constants((3.8152±0.0078)×10^(4) and(1.1875±0.0440)×10^(5)),respectively.Both EGCG and curcumin decreased theα-helix content while increased theβ-sheet proportion,and co-binding remarkably reduced theα-helix proportion relative to the single ligand binding.The co-binding of these two compounds decreased the association extent of the yeast protein,which in turn reduced the diameter of yeast protein-EGCG-curcumin complex.The binding of EGCG with yeast protein improved the thermal stability of curcumin.Moreover,the co-binding improved the emulsification stability of yeast protein,and curcumin exhibited a more remarkable effect in improving the foamability.This work provides a theoretical basis for clarifying the interaction mechanisms of hydrophobic/hydrophilic molecules with yeast protein,and extends the potential applications of the novel fungus protein sources for food function enhancement and bioactive molecule stabilization.

Inhibition of corneal neovascularization by topical application of nintedanib in rabbit models

AIM:To evaluate the potential efficacy and mechanisms of nintedanib in corneal neovascularization(NV)in rabbit models.METHODS:Corneal NV was induced using 1 mol/L Na OH.Rabbits(n=21)were randomized to 3 groups:Group 1 were treated with 0.9%NaCl,Group 2 with Avastin(5 mg/mL),and Group 3 with nintedanib(1 mg/mL).All treatments star ted 1 d af ter alkaline burns and were topically performed 3 times a day for 2 wk.Photographs were taken on a slit lamp microscope on day 7 and 14.The NV area,the length of the vascularization and angiogenesis index(AI)were used to evaluate the corneal NV.On day 14,the immunohistochemical(IHC)studies of the cornea were examined.Western blot was performed to test the expression levels of vascular endothelial growth factor(VEGF),Akt,p-Akt,P38,p-P38,MMP-2 and MMP-9.RESULTS:The corneal NV area,vessel length and AI in Group 3 were significantly lower than Group 2,with both being lower than Group 1.IHC staining showed that VEGF was significantly overexpressed in the epithelium and stroma of cornea following alkaline burns.In contrast,the level of VEGF was significantly suppressed in both Group 2 and Group 3.Western blot results further confirmed that,compared with Group 1,Group 3 had significantly reduced expressions of VEGF,Akt,p-Akt,p-P38,MMP-2,and MMP-9 in corneal tissues.Trends of lower levels of MMP-2,AKT,and p-AKT in Group 3 than Group 2 were identified.CONCLUSION:Nintedanib and Avastin can effectively inhibit corneal NV,with P38 MAPK and AKT signaling pathways being possibly involved.Nintedanib seems more effective than Avastin and has the potential to be a novel therapy for preventing corneal NV.

Correlation between photoreceptor injury-regeneration and behavior in a zebrafish model

Direct exposure to intensive visible light can lead to solar retinopathy, including macular injury. The signs and symptoms include central scotoma, metamorphopsia, and decreased vision. However, there have been few studies examining retinal injury due to intensive light stimulation at the cellular level. Neural network arrangements and gene expression patterns in zebrafish photoreceptors are similar to those observed in humans, and photoreceptor injury in zebrafish can induce stem cell-based cellular regeneration. Therefore, the zebrafish retina is considered a useful model for studying photoreceptor injury in humans. In the current study, the central retinal photoreceptors of zebrafish were selectively ablated by stimulation with high-intensity light. Retinal injury, cell proliferation and regeneration of cones and rods were assessed at 1, 3 and 7 days post lesion with immunohistochemistry and in situ hybridization. Additionally, a light/dark box test was used to assess zebrafish behavior. The results revealed that photoreceptors were regenerated by 7 days after the light-induced injury. However, the regenerated cells showed a disrupted arrangement at the lesion site. During the injury-regeneration process, the zebrafish exhibited reduced locomotor capacity, weakened phototaxis and increased movement angular velocity. These behaviors matched the morphological changes of retinal injury and regeneration in a number of ways. This study demonstrates that the zebrafish retina has a robust capacity for regeneration. Visual impairment and stress responses following high-intensity light stimulation appear to contribute to the alteration of behaviors.

Comparison of pseudophakic retinal straylight in spherical/aspherical and hydrophobic/hydrophilic intraocular lens

AIM: To study the potential reasons of increased straylight in pseudophakic eyes. METHODS: Cross -sectional study. Seventy patients diagnosed as bilateral age-related cataract and implanted with Tecnis ZA9003, Sensar AR40e, SA6OAT, XLSTABI ZO or Akeros AO intraocular lens (IOL) were enrolled in this research. Straylight was measured by a C -Quant straylight meter three to four weeks postoperatively. Five different modalities of IOL, including spherical/aspherical optics and hydrophobic/hydrophilic material were tested in this study. Normal as well as dilated pupils were used. The main outcome variable for straylight measurement was the logarithmic straylight parameter, log(s). RESULTS: The straylight parameter increased significantly after pupil dilation (P<0.05). Straylight of aspherical IOL was significantly higher after pupil dilation (P<0.06) compared to spherical IOL. In normal pupil, straylight of hydrophobic IOL was significant higher when compared with hydrophilic IOL (P<0.05). CONCLUSION: Straylight and visual acuity stand for the different aspects of visual function. Several factors including pupil diameter, optic material, aspherical design of IOL influence intraocular light scattering in pseudophakic eyes. Further investigation was needed to study the impact of optic material and optic surface design on pseudophakic straylight.

Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice

Differentialiy expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results showed that 21 peptides were down-regulated, with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9, demonstrating the most significant decreases. These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease.

Feasibility of establishing cerebral ischemia models by using aerocyst-blocking bilateral ascending pharyngeal artery of piglets Imaging assessment

BACKGROUND： The cerebral ischemia and ischemia/reperfusion animal models are used to simulate the human cerebrovascular diseases is one of the popular topics of neurological science recently. To study the pathophysiology, pathogenesis, prophylaxis and treatment of ischemic cerebrovascular diseases and to establish the ideal animal model that is the most similar to the human cerebral ischemia, are the topics that the people generally cared about. OBJECTIVE： To evaluate the effects of aerocyst-blocking bilateral ascending pharyngeal artery on the establishment of cerebral ischemia models by using digital subtraction angiography （DSA）, magnetic resonance diffusion-weighted imaging （DWI） and magnetic resonance perfusion-weighted imaging （PWI）. DESIGN： Repetitive measure animal experiment. SETTING： Zhongshan Hospital Affiliated to Dalian University. MATERIALS： The experiment was carried out in the Animal Laboratory （Provincial Laboratory）, Zhongshan Hospital of Dalian Univeristy from January to May 2006. A total of 14 domestic piglets, of 6 months old, weighing 12-15 kg, of either gender, were selected from Animal Experimental Center, Dalian University. Multistar T.O.P digital subtraction angiography machine was provided by Siemens Company, German. METHODS： Aerocyst-blocking bilateral ascending pharyngeal artery was used to establish cerebral ischemia models. And then, Multistar T.O.P. DSA was used for imaging of cerebral vessels before blocking, during blocking and at 0.5 and 2 hours after ischemia perfusion. GE Signa 1.5 T supraconduction magnetic resonance imaging was used for DWI examination; in addition, PWI was used based on focal sites and areas. Otherwise, magnetic resonance imaging （MRI） was used to detect signal changes of T1WI and T2WI in ischemic areas. MAIN OUTCOME MEASURES： Analytic results of DSA, DWI, PWI and MRI. RESULTS： All 14 experimental piglets were involved in the final analysis. ① DSA： The blood flow of bilateral ascending pharyngeal arteries and its branch were blocked at blocking phase, which restored 0.5 and 2 hours after reperfusion. ② DWI and PWI： There were no observable abnormalities in PWI and DWI at pre-blocking. Abnormal increased signals were found on both DWI and PWI at during and post-blocking. There were reduction in ADC and rCBF and delay in rTTP at all time points except pre-blocking. ③ MRI： There were no abnormal signals observable at any time of pre- and post-blocking in T1WI and T2WI. CONCLUSION： It is feasible to establish this kind of animal experimental models, and it can simulate the ischemic state; meanwhile, the existence and extent can be showed directly by DSA, DWI, and PWI.

Long-term results of clear lens extraction combined with piggyback intraocular lens implantation to correct high hyperopia

AIM:To assess the refractive outcome of clear lensectomy combined with piggyback intraocular lens implantation in highly hyperopic patients.METHODS:This case review included 19 eyes of 10 patients with high hyperopia and axial length less than 21mm.Intraocular lens power was calculated for emmetropia using the Holladay II formula in 17 eyes,and SRK/T formula in 2 eyes following clear lens extraction and piggyback intraocular lens implantation.Patients were examined periodically over 24 months for visual acuity and spherical equivalent(SE).RESULTS:The mean postoperative SE at 24 months was 0.20±1.39D(range,-3.00 to 2.50D),better than preoperative 9.81±2.62D(range,+6.00 to +14.50D)(P【0.001).Five eyes had SE within±0.5D of emmetropia and 11 eyes within±1.00D at postoperative 24 months.The mean postoperative uncorrected visual acuity(UCVA) at 24 months was 0.60±0.36,significantly improved compared to preoperative 1.39±0.33(P【0.001).The mean best-corrected visual acuity(BCVA) at 24 months was 0.49±0.35,not statistically different compared to preoperative 0.38±0.30(P=0.34).Twelve eyes maintained and 1 gained 1 or more Snellen line of BCVA,4 eyes lost 1 line,and 2 eyes lost 2 lines at 24 postoperative months.Twelve eyes best-corrected near visual acuity (BCNVA) achieved J1 at postoperative 24 months compared to preoperative 7 eyes and the other 7 eyes better than J3.CONCLUSION:Clearlensextractioncombinedpiggyback intraocular lens implantation appears to be an effective procedure to correct high hyperopia but mild overcorrection and intralenticular opacification may require secondary procedure.

Repeatability of Ophtha Top topography and comparison with IOL-Master and Lenstar LS900 in cataract patients

AIM：To determine the repeatability of Ophtha Top topography and assess the consistency with intraocular lens（IOL）-Master and Lenstar LS900（Lenstar）in measuring corneal parameters among cataract patients.METHODS：Totally 125 eyes were enrolled.Corneas were successively measured with Ophtha Top,IOL-Master and Lenstar at least three times.The flattest meridian power（Kf）,the steepest meridian power（Ks）,mean power（Km）,J0 and J45 were recorded.Intra-class correlation coefficients（ICCs）,the coefficient of variance（COV）,within subject standard deviation（Sw）,and test-retest repeatability（2.77Sw）were adopted to determine the repeatability.The 95%limit of agreement（95%LOA）and Bland-Altman plots were used to assess comparability.RESULTS：Repeatability of Ophtha Top topography for measuring corneal parameters showed the ICCs were all above 0.93,2.77Sw was lower than 0.31,and the COV of the Kf and Ks was lower than 0.25.The keratometric readings with Ophtha Top topography were flatter than with the IOLMaster and Lenstar devices,while the Pearson correlation coefficients were over 0.97.The J0 and J45 with Ophtha Top topography were smaller compared with Lenstar and IOL-Master,while was comparable between Lenstar and IOL-Master.CONCLUSION：Ophtha Top topography shows excellent repeatability for measuring corneal parameters.However,differences between the Ophtha TOP topography and Lenstar,IOL-Master both in cornea curvature and the astigmatism should be noted clinically.

The Function of GABA in Plant Cell Growth, Development and Stress Response

Gamma-aminobutyric acid(GABA)is a ubiquitous four-carbon non-protein amino acid that is involved in various physiological processes of plant growth and development,such as root architecture,stem elongation,leaf senescence,pollen tube growth,fruit ripening,and seed germination.GABA is also related to plant stress responses,such as drought,salt,cold,and heat stresses.Regulation of GABA in plant stress responses is complex and involves multiple signaling pathways,including calcium and hormone signaling.This paper systematically reviews the synthesis,metabolic pathways and regulatory role of GABA in plants,which will provide new insights into the understanding of plant growth and stress responses and offer novel strategies for improving crop productivity and stress.

西藏尼玛县文部乡地质灾害危险性及场镇适宜性综合评估

文部乡位于尼玛县南部,距离尼玛县政府驻地尼玛镇约81公里,人口集中,场镇总体地势开阔,场镇后山泥石流地质灾害集中发育,对文部北村居民及场镇建筑物等威胁较大。为此,选择文部场镇作为重点场镇开展地质灾害综合调查,通过分析场镇地形地貌、地层岩性等地质条件、并结合工程测绘、钻探等手段对场镇地质灾害、地质环境等进行调查研究,对场镇规划范围地质灾害分布特征和危险性进行评估,在此基础上,对场镇规划范围建设用地适宜性做出分区评估。

Manufacturing process and microstructure of copper-coated aluminum wires

Copper-coated aluminum wires exhibit good electrical conductivity, high thermal conductivity, low contact resistance of copper and low density, and provide economic advantages over aluminum. However, there are some problems in the manufacring processes of hot-dip copper-coated aluminum wires, such as the difficulties in controlling coating process. In this work, the hot-dip copper-coating method of aluminum wires was investigated for producing copper-coated aluminum wire composites. The interface microstructure between the aluminum wire and the copper coating layer was analyzed by scanning electron microscopy （SEM） and energy-dispersive X-ray spec- trometry （EDS）. Five different fluxing agents were tested. Experimental results show that appropriate conditions for the hot-dip process are determined as the liquid copper temperature of 1085℃ and the treatment time less than 1 s. A success in hot-dip copper-coated aluminum wires is achieved by hot-dipping a low-melting-point metal into a high-melting-point metal liquid, which is significant for the further devel- opment and application of copper-coated aluminum wire composites.