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中药复方九味汤化学成分鉴定及质谱裂解规律研究
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作者 赵佳宇 吕悦广 +5 位作者 辛通 郭倩倩 张文赢 李金鸿 薛宏宇 马强 《质谱学报》 北大核心 2025年第1期11-25,共15页
基于超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-Q/Orbitrap HRMS)技术,建立了中药复方九味汤中化学成分的鉴定方法。在样品处理过程中,采用超声/微波辅助萃取技术提取九味汤中的有效成分。提取液经Waters ACQUITY UPLC BEH ... 基于超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-Q/Orbitrap HRMS)技术,建立了中药复方九味汤中化学成分的鉴定方法。在样品处理过程中,采用超声/微波辅助萃取技术提取九味汤中的有效成分。提取液经Waters ACQUITY UPLC BEH C18色谱柱(150 mm×2.1 mm,1.7μm)分离,在电喷雾正、负离子模式下电离,四极杆/静电场轨道阱高分辨质谱仪检测。采用全扫描-数据依赖型二级质谱扫描(Full MS/dd-MS2)模式采集数据,Xcalibur 4.1软件对数据进行色谱峰对齐和提取,随后将母离子和碎片离子的精确质量数信息与中药成分高分辨质谱数据库(OTCML)及自建数据库进行匹配,共鉴定出黄酮类、生物碱类、萜类、苯丙素类、氨基酸类、有机酸类、甾体类等144种化合物,并对代表性化合物的质谱裂解规律进行解析。本研究可为进一步揭示九味汤的药理作用提供科学依据。 展开更多
关键词 九味汤 超声/微波辅助萃取(UMAE) 超高效液相色谱-四极杆/静电场轨道阱高分辨质谱(UHPLC-Q/Orbitrap HRMS) 裂解规律
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两种油管钢在模拟油田高温高压O_(2)-CO_(2)地层水环境中的腐蚀行为
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作者 宋文文 谢俊峰 +7 位作者 赵密锋 袁军涛 冯文昊 谭凤玲 李轩鹏 辛通 张慧慧 付安庆 《腐蚀与防护》 CAS CSCD 北大核心 2024年第7期14-23,共10页
氧气与二氧化碳共存环境的腐蚀已成为油田注入井况中金属材料损伤的主要诱因。采用高温高压釜模拟了西部某油田注入井工况(O_(2)-CO_(2)共存环境),通过腐蚀失重试验、点蚀三维形貌分析、腐蚀产物显微分析等方法研究了P110和3Cr两种油管... 氧气与二氧化碳共存环境的腐蚀已成为油田注入井况中金属材料损伤的主要诱因。采用高温高压釜模拟了西部某油田注入井工况(O_(2)-CO_(2)共存环境),通过腐蚀失重试验、点蚀三维形貌分析、腐蚀产物显微分析等方法研究了P110和3Cr两种油管钢在高温高压、O_(2)-CO_(2)共存的高矿化度地层水环境中的腐蚀行为。结果表明:两种油管钢在O_(2)-CO_(2)共存环境中遭受了严重的均匀腐蚀和局部腐蚀;在90~150℃内,两种材料的腐蚀随温度升高而加剧,均匀腐蚀速率增幅达79.7%,最大点蚀速率的增幅达143.4%;O_(2)与CO_(2)共存时,阴极反应显著加快,加速了保护性较差的铁氧化物的形成,导致严重的均匀腐蚀和局部腐蚀,而低Cr钢中的Cr不足以改善腐蚀产物膜的保护性,使该钢不能适应O_(2)-CO_(2)共存环境。 展开更多
关键词 注入井 O_(2)-CO_(2)共存 腐蚀 油管钢 局部腐蚀
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砂型铸造Mg-9Gd-3Y-0.5Zr合金的线收缩
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作者 蒋锐 吴国华 +6 位作者 谢赫 童鑫 张亮 戚方舟 刘文才 耿莹晶 任广笑 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第5期1441-1455,共15页
研究铸件几何特征对砂型铸造Mg-9Gd-3Y-0.5Zr(VW93)合金线收缩的影响。利用3D扫描仪精确提取自由收缩和受阻收缩砂铸件的尺寸,并用于计算收缩系数。引入砂芯体积与铸件包络体积之比(γ)量化砂芯对铸件收缩的约束程度。通过分析自由收缩... 研究铸件几何特征对砂型铸造Mg-9Gd-3Y-0.5Zr(VW93)合金线收缩的影响。利用3D扫描仪精确提取自由收缩和受阻收缩砂铸件的尺寸,并用于计算收缩系数。引入砂芯体积与铸件包络体积之比(γ)量化砂芯对铸件收缩的约束程度。通过分析自由收缩系数的统计分布和受阻收缩系数随γ的变化规律发现,VW93合金的自由收缩系数为1.96%,受阻收缩系数随γ的增大而线性减小,此关系为根据铸件几何结构预测VW93合金收缩率提供支持。 展开更多
关键词 自由收缩 受阻收缩 砂型铸造 Mg-9Gd-3Y-0.5Zr合金
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Effect of addition temperature on dispersion behavior and grain refinement efficiency of MgO introduced into Mg alloy
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作者 Le ZAI xin tong +1 位作者 Yun WANG Xiao-huai XUE 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第8期2491-2506,共16页
The effect of addition temperature of MgO particles(MgOp)on their dispersion behavior and the efficiency of grain refinement in AZ31 Mg alloy was investigated.In addition,the grain refinement mechanism was systematica... The effect of addition temperature of MgO particles(MgOp)on their dispersion behavior and the efficiency of grain refinement in AZ31 Mg alloy was investigated.In addition,the grain refinement mechanism was systematically studied by microstructure characterization,thermodynamic calculation,and analysis of solidification curves.The results show that the grain size of AZ31 Mg alloy initially decreases and then increases as the MgOp addition temperature is increased from 720 to 810℃,exhibiting a minimum value of 136μm at 780℃.The improved grain refinement efficiency with increasing MgOp addition temperature can be attributed to the reduced Mg melt viscosity and enhanced wettability between MgOp and Mg melt.Furthermore,a corresponding physical model describing the solidification behavior and grain refinement mechanism was proposed. 展开更多
关键词 grain refinement MgO nucleation particles AZ31 alloy addition temperature dispersion behavior
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Role of alloying and heat treatment on microstructure and mechanical properties of cast Al-Li alloys:A review
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作者 Guo-hua Wu You-jie Guo +4 位作者 Fang-zhou Qi Shen Zhang Yi-xiao Wang xin tong Liang Zhang 《China Foundry》 SCIE EI CAS CSCD 2024年第5期445-460,共16页
Due to the prominent advantages of low density,high elastic modulus,high specific strength and specific stiffness,cast Al-Li alloys are suitable metallic materials for manufacturing complex large-sized components and ... Due to the prominent advantages of low density,high elastic modulus,high specific strength and specific stiffness,cast Al-Li alloys are suitable metallic materials for manufacturing complex large-sized components and are ideal structural materials for aerospace,defense and military industries.On the basis of the microstructural characteristics of cast Al-Li alloys,exploring the role of alloying and micro-alloying can stabilize their dominant position and further expand their application scope.In this review,the development progress of cast Al-Li alloys was summarized comprehensively.According to the latest research highlights,the influence of alloying and heat treatment on the microstructure and mechanical properties was systematically analyzed.The potential methods to improve the alloy performance were concluded.In response to the practical engineering requirements of cast Al-Li alloys,the scientific challenges and future research directions were discussed and prospected. 展开更多
关键词 cast Al-Li alloy ALLOYING microstructure mechanical properties heat treatment
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High-Resolution Recognition of Orbital Angular Momentum Modes in Asymmetric Bessel Beams Assisted by Deep Learning
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作者 徐鹏飞 童鑫 +2 位作者 曾子帅 刘书悉 赵道木 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第7期27-35,共9页
Fractional orbital angular momentum(OAM) vortex beams present a promising way to increase the data throughput in optical communication systems. Nevertheless, high-precision recognition of fractional OAM with different... Fractional orbital angular momentum(OAM) vortex beams present a promising way to increase the data throughput in optical communication systems. Nevertheless, high-precision recognition of fractional OAM with different propagation distances remains a significant challenge. We develop a convolutional neural network(CNN)method to realize high-resolution recognition of OAM modalities, leveraging asymmetric Bessel beams imbued with fractional OAM. Experimental results prove that our method achieves a recognition accuracy exceeding 94.3% for OAM modes, with an interval of 0.05, and maintains a high recognition accuracy above 92% across varying propagation distances. The findings of our research will be poised to significantly contribute to the deployment of fractional OAM beams within the domain of optical communications. 展开更多
关键词 BESSEL FRACTIONAL ORBITAL
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Progress in manipulating spin polarization for solar hydrogen production
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作者 Qian Yang xin tong Zhiming Wang 《Materials Reports(Energy)》 EI 2024年第1期43-57,共15页
Photocatalytic and photoelectrochemical water splitting using semiconductor materials are effective approaches for converting solar energy into hydrogen fuel.In the past few years,a series of photocatalysts/photoelect... Photocatalytic and photoelectrochemical water splitting using semiconductor materials are effective approaches for converting solar energy into hydrogen fuel.In the past few years,a series of photocatalysts/photoelectrocatalysts have been developed and optimized to achieve efficient solar hydrogen production.Among various optimization strategies,the regulation of spin polarization can tailor the intrinsic optoelectronic properties for retarding charge recombination and enhancing surface reactions,thus improving the solar-to-hydrogen(STH)efficiency.This review presents recent advances in the regulation of spin polarization to enhance spin polarized-dependent solar hydrogen evolution activity.Specifically,spin polarization manipulation strategies of several typical photocatalysts/photoelectrocatalysts(e.g.,metallic oxides,metallic sulfides,non-metallic semiconductors,ferroelectric materials,and chiral molecules)are described.In the end,the critical challenges and perspectives of spin polarization regulation towards future solar energy conversion are briefly provided. 展开更多
关键词 Spin polarization Solar energy conversion Photocatalytic hydrogen production Photoelectrochemical water splitting
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WiCount:一种基于WiFi-CSI的人数识别方法 被引量:6
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作者 丁亚三 郭斌 +3 位作者 辛通 王沛 王柱 於志文 《计算机科学》 CSCD 北大核心 2019年第11期297-303,共7页
人数识别即是对一定区域内活动人数的监测计数,在人群控制、流量监管等方面有着重要应用。例如,在百货商场或者机场中,对排队人数或者服务区休息人数进行估计可以为提升服务质量做出贡献。目前,研究人员已提出了一些基于摄像头和可穿戴... 人数识别即是对一定区域内活动人数的监测计数,在人群控制、流量监管等方面有着重要应用。例如,在百货商场或者机场中,对排队人数或者服务区休息人数进行估计可以为提升服务质量做出贡献。目前,研究人员已提出了一些基于摄像头和可穿戴设备的人数识别方法,但是这些方案均存在一些不足,例如摄像头只能提供可视范围内的监控,可穿戴设备需要被监控对象有意识地穿戴。也有一些学者利用雷达相关技术实现了穿墙式感知识别,但是这类系统设计复杂,应用成本较高,多用于军事领域。文中提出了一种基于WiFi信号的室内人数识别方案WiCount,其利用信道状态信息(Channel State Information,CSI)的幅值波动来刻画室内人数的变化,利用机器学习算法实现对人的计数。WiCount旨在进行更细粒度的室内人数识别,即人在室内任意位置时该方法均能准确识别人数。它根据室内人数与CSI幅值变化的关系,提取了有效的数学特征,减弱了相同人数在室内不同位置所产生的CSI幅值波动差异,然后通过训练3种分类器(SVM、KNN、BP神经网络)来识别监测区域内的人数。在实验室和会议室分别部署了验证系统,结果显示,在人数规模较小的情况下,所提方法的识别效果良好。其中,实验室环境下,不超过4人时,系统的识别率达90%;会议室环境下,不超过2人,在监测区域内任意位置活动时,系统的识别率可达89.58%。 展开更多
关键词 人数识别 信道状态信息 无线感知 WiFi感知 机器学习
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拟用于可穿戴气敏传感器的二氧化钛/纳米纤维素复合膜制备及表征 被引量:4
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作者 周静 童欣 沈文浩 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2020年第3期149-157,共9页
使用纤维素酶和木聚糖酶(酶活比9:1)组成总酶活为10U/mL的复合酶液,以桉木浆为原料在50℃水解12h,获得平均长度约625nm、平均直径50nm的棒状纳米晶纤维素(NCC)。以所制备的NCC为原料,采用真空抽滤法获得了透明柔性NCC膜,其弹性模量为817... 使用纤维素酶和木聚糖酶(酶活比9:1)组成总酶活为10U/mL的复合酶液,以桉木浆为原料在50℃水解12h,获得平均长度约625nm、平均直径50nm的棒状纳米晶纤维素(NCC)。以所制备的NCC为原料,采用真空抽滤法获得了透明柔性NCC膜,其弹性模量为8178MPa,抗张强度为33MPa,透光度为90.86%,裂断应变为99%,表明NCC膜具有良好的力学性能和透光性,可用作柔性器件的基底材料。然后,进一步在NCC中加入气敏材料纳米二氧化钛(TiO2)胶体,采用真空抽滤法获得了TiO2/NCC复合膜。研究结果表明,添加少量TiO2(1%、2%、4%)的TiO2/NCC复合膜依然具有良好的透光度(90%以上)与物理性能(弹性模量4906MPa、抗张强度37MPa、裂断应变45%)。在室温下,TiO2/NCC复合膜对氨气具有气敏响应,以及良好的选择性和稳定性。这些研究结果为制备高性能的TiO2/NCC可穿戴气敏传感器的进一步研究奠定了良好基础。 展开更多
关键词 复合酶解法 纳米晶纤维素膜 二氧化钛 物理性能
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镁合金不同黑色防腐-吸光一体化涂层的性能研究 被引量:3
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作者 辛童 白力静 +3 位作者 董博轩 吴俊楠 陈桂涛 王志虎 《兵器材料科学与工程》 CAS CSCD 北大核心 2019年第5期64-69,共6页
通过紫外人工加速方法研究挤压AZ31镁基体上环氧涂层和微弧氧化陶瓷层的吸光及防腐性能。结果表明:两种黑色涂层均为高吸收涂层,经1 250 h的紫外辐照后吸光率仍保持稳定,但有机涂层阻抗值下降3个数量级,黑色陶瓷层阻抗值保持稳定;环氧... 通过紫外人工加速方法研究挤压AZ31镁基体上环氧涂层和微弧氧化陶瓷层的吸光及防腐性能。结果表明:两种黑色涂层均为高吸收涂层,经1 250 h的紫外辐照后吸光率仍保持稳定,但有机涂层阻抗值下降3个数量级,黑色陶瓷层阻抗值保持稳定;环氧涂层的异丙基和亚甲基基团在紫外辐照下易发生光氧化降解,破坏涂层结构,降低腐蚀性能;陶瓷层是以Cu固溶于MgO基的MgxCu1-xO陶瓷相,其吸光及防腐性能持久性好,更适宜于紫外辐照强的环境。 展开更多
关键词 镁合金 黑色涂层 紫外辐照 吸光 腐蚀
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以弥漫性肺囊性病变伴咯血为表现的干燥综合征1例报告及文献复习 被引量:1
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作者 辛桐 王琦 +2 位作者 陈默 李伟 高鹏 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2018年第6期1303-1306,共4页
目的:探讨1例干燥综合征(SS)患者的诊疗过程并结合相关文献复习,分析SS患者的临床特征,提高临床医生对SS罕见临床症状影像学特征的认识。方法:患者,女性,23岁,因呼吸困难伴咳嗽、咳痰1个月,咯血3d就诊,查体显示睑结膜苍白,无其他明显阳... 目的:探讨1例干燥综合征(SS)患者的诊疗过程并结合相关文献复习,分析SS患者的临床特征,提高临床医生对SS罕见临床症状影像学特征的认识。方法:患者,女性,23岁,因呼吸困难伴咳嗽、咳痰1个月,咯血3d就诊,查体显示睑结膜苍白,无其他明显阳性体征。胸部CT显示双肺多发囊样改变,行支气管镜活检、唇腺活检及风湿系列等其他相关检查,并给予相关治疗。结果:患者最初考虑诊断为淋巴管平滑肌瘤病(LAM)。通过相关检查最终确诊为SS,并给予口服糖皮质激素及免疫抑制剂治疗。患者经过治疗,病情好转,呼吸困难减轻,无咯血,肺弥散功能明显好转,2个月后复查患者胸部CT较治疗前无明显变化。结论:SS患者中伴有双肺多发囊样病变者罕见。SS多发生于育龄期妇女,应与LAM相鉴别。 展开更多
关键词 干燥综合征 淋巴管平滑肌瘤病 弥漫性肺囊样病变 咯血 病例报告
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固相缩聚法制备半芳香族聚酰胺纳米复合材料 被引量:1
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作者 黄佳 童心 +2 位作者 龙盛如 杨杰 王孝军 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2020年第8期51-57,共7页
以原位固相缩聚法合成出具有高相对分子质量的聚对苯二甲酰己二胺(PA6T)-co-聚己内酰胺(PA6)/有机蒙脱土(OMMT)纳米复合材料,分别对PA6T/OMMT的黏度、结构、形貌、热稳定性能以及力学性能进行了表征。结果表明,固相缩聚能够显著提高溶... 以原位固相缩聚法合成出具有高相对分子质量的聚对苯二甲酰己二胺(PA6T)-co-聚己内酰胺(PA6)/有机蒙脱土(OMMT)纳米复合材料,分别对PA6T/OMMT的黏度、结构、形貌、热稳定性能以及力学性能进行了表征。结果表明,固相缩聚能够显著提高溶液缩聚产物的黏度;少量OMMT的加入可以改善基体的热稳定性,当OMMT质量分数为0.5%时,热稳定性能最佳;OMMT的加入使材料的力学性能得到改善,当OMMT质量分数为1%时,拉伸强度从纯样的84.3 MPa提高到114.4 MPa;X射线衍射分析和电镜结果表明形成了插层型纳米复合材料。 展开更多
关键词 聚酰胺 蒙脱土 拉伸强度 插层结构
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PTBP1与肿瘤发展和治疗关系的研究进展 被引量:3
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作者 辛彤 孙悦 胡晶 《肿瘤防治研究》 CAS CSCD 2022年第7期715-720,共6页
多聚嘧啶区结合蛋白1(PTBP1,也被称为hnRNP I)是一种研究广泛的RNA结合蛋白,参与调控mRNA剪接、翻译、稳定性和定位。PTBP1可参与多种非编码RNA的作用过程,影响肿瘤的发生与发展。在肿瘤治疗方面,PTBP1可能作为关键因子影响靶向药物作... 多聚嘧啶区结合蛋白1(PTBP1,也被称为hnRNP I)是一种研究广泛的RNA结合蛋白,参与调控mRNA剪接、翻译、稳定性和定位。PTBP1可参与多种非编码RNA的作用过程,影响肿瘤的发生与发展。在肿瘤治疗方面,PTBP1可能作为关键因子影响靶向药物作用靶点以及肿瘤耐药性。本文就PTBP1在肿瘤中的作用及其在肿瘤治疗中的研究进展作一综述。 展开更多
关键词 PTBP1 分子机制 非编码RNA 耐药
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中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗 被引量:9
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作者 Ming Zhou Xiaoyuan Chen +14 位作者 Hong Zhang Lin Xia xin tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang 《癌症》 SCIE CAS CSCD 2019年第12期517-527,共11页
背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSC... 背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 展开更多
关键词 晚期非小细胞肺癌 安罗替尼 抗血管生成 表皮生长因子受体 间变性淋巴瘤激酶 药物不良反应
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Effect of grain refinement induced by wire and arc additive manufacture (WAAM) on the corrosion behaviors of AZ31 magnesium alloy in NaCl solution 被引量:8
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作者 Jianwei LI Youmin QIU +9 位作者 Junjie YANG Yinying SHENG Yanliang YI Xun ZENG Lianxi CHEN Fengliang YIN Jiangzhou SU Tiejun ZHANG xin tong Bin GUO 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第1期217-229,共13页
Additive manufacturing(AM)of Mg alloys has become a promising strategy for producing complex structures,but the corrosion performance of AM Mg components remains unexploited.In this study,wire and arc additive manufac... Additive manufacturing(AM)of Mg alloys has become a promising strategy for producing complex structures,but the corrosion performance of AM Mg components remains unexploited.In this study,wire and arc additive manufacturing(WAAM)was employed to produce single AZ31 layer.The results revealed that the WAAM AZ31 was characterized by significant grain refinement with non-textured crystallographic orientation,similar phase composition and stabilized corrosion performance comparing to the cast AZ31.These varied corrosion behaviors were principally ascribed to the size of grain,where cast AZ31 and WAAM AZ31 were featured by micro galvanic corrosion and intergranular corrosion,respectively. 展开更多
关键词 AZ31 magnesium alloy Wire and arc additive manufacturing(WAAM) Grain refinement Microstructure Intergranular corrosion
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A Bandwidth-Link Resources Cooperative Allocation Strategy of Data Communication in Intelligent Transportation Systems 被引量:5
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作者 Xiaoming Jiang Kangfei Li +2 位作者 Haobin Jiang Na Zhu xin tong 《China Communications》 SCIE CSCD 2019年第4期234-249,共16页
The bandwidth resources allocation strategies of the existing Internet of Vehicles(IoV) are mainly base on the communication architecture of the traditional 802.11 x in the wireless local area network(WLAN). The tradi... The bandwidth resources allocation strategies of the existing Internet of Vehicles(IoV) are mainly base on the communication architecture of the traditional 802.11 x in the wireless local area network(WLAN). The traditional communication architecture of IoV will easily cause significant delay and low Packet Delivery Ratio(PDR) for disseminating critical security beacons under the condition of high-speed movement, distance-varying communication, and mixed traffic. This paper proposes a novel bandwidth-link resources cooperative allocation strategy to achieve better communication performance under the road conditions of intelligent transportation systems(ITS). Firstly, in traffic scenarios, based on the characteristic to predict the relative position of the mobile transceivers, a strategy is developed to cooperate on the mobile cellular network and the Dedicated Short-Range Communications(DSRC). Secondly, by adopting the general network simulator NS3, the dedicated mobile channel models that are suitable for the data interaction of ITS, is applied to confirm the feasibility and reliability of the strategy. Finally, by the simulation, comparison, and analysis of some critical performance parame-ters, we conclude that the novel strategy does not only reduce the system delay but also improve the other communication performance indicators, such as the PDR and communication capacity. 展开更多
关键词 IoV bandwidth-link RESOURCES COOPERATIVE ALLOCATION strategy system delay PDR
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Advances in MoS_2-Based Field Effect Transistors(FETs) 被引量:7
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作者 xin tong Eric Ashalley +2 位作者 Feng Lin Handong Li Zhiming M.Wang 《Nano-Micro Letters》 SCIE EI CAS 2015年第3期203-218,共16页
This paper reviews the original achievements and advances regarding the field effect transistor(FET) fabricated from one of the most studied transition metal dichalcogenides: two-dimensional Mo S2. Not like graphene, ... This paper reviews the original achievements and advances regarding the field effect transistor(FET) fabricated from one of the most studied transition metal dichalcogenides: two-dimensional Mo S2. Not like graphene, which is highlighted by a gapless Dirac cone band structure, Monolayer Mo S2 is featured with a 1.9 e V gapped direct energy band thus facilitates convenient electronic and/or optoelectronic modulation of its physical properties in FET structure. Indeed,many Mo S2 devices based on FET architecture such as phototransistors, memory devices, and sensors have been studied and extraordinary properties such as excellent mobility, ON/OFF ratio, and sensitivity of these devices have been exhibited. However, further developments in FET device applications depend a lot on if novel physics would be involved in them. In this review, an overview on advances and developments in the Mo S2-based FETs are presented. Engineering of Mo S2-based FETs will be discussed in details for understanding contact physics, formation of gate dielectric, and doping strategies. Also reported are demonstrations of device behaviors such as low-frequency noise and photoresponse in Mo S2-based FETs, which is crucial for developing electronic and optoelectronic devices. 展开更多
关键词 Mo S2FETs engineering Low-frequency noise Optical properties Mo S2sensors Mo S2memory devices
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Microstructure and mechanical properties of repair welds of low-pressure sand-cast Mg?Y?RE?Zr alloy by tungsten inert gas welding 被引量:6
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作者 xin tong Guohua Wu +3 位作者 Liang Zhang Yingxin Wang Wencai Liu Wenjiang Ding 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2022年第1期195-209,共15页
The sand castings of Mg-Y-RE-Zr series alloys are widely utilized in the large scales and complex shapes in the aerospace industry,as a result of which there are always some cast defects in the products. In this study... The sand castings of Mg-Y-RE-Zr series alloys are widely utilized in the large scales and complex shapes in the aerospace industry,as a result of which there are always some cast defects in the products. In this study, the feasibility of repair welding of sand-cast Mg-4 Y-3 RE-0.5 Zr alloy by tungsten inert gas(TIG) welding was scrutinized with different welding currents from 150 to 210 A. The results indicated that defect-free repaired joints with good appearance could be acquired at 170 and 190 A. Interestingly, the grain size of the fusion zone(FZ) was refined initially and then increased with the linear increment of welding current. Because at the higher heat inputs, although the cooling rate of the molten pool was reduced, substantial constitutional supercooling for the grain refinement was attained after the Zr particles were transformed into Zr solutes. The tensile strength of the repaired joint at 170 A was 195 MPa with the maximum joint efficiency of 87.8%, and the elongation reached to 124.4% of the sand-cast base material(BM). However, serious grain coarsening and continuous eutectic structures generated in heat-affected zone(HAZ) above 190 A resulted in the weakening of the joint due to the brittle intergranular fracture. 展开更多
关键词 Sand-cast Mg-Y-RE-Zr alloy Repair welding Microstructure Tensile properties Fracture behavior
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Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy 被引量:3
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作者 Xiao-Xue Xu Rui-Xue Shi +11 位作者 Yu Fu Jia-Lu Wang xin tong Shi-Qi Zhang Na Wang Mei-Xuan Li Yu tong Wei Wang Miao He Bing-Yang Liu Gui-Lan Chen Feng Guo 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第6期1277-1285,共9页
Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity,which triggers cell death in various neuropathological diseases,including epilepsy.Studies have shown that inhibition of neuronal nitric oxide... Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity,which triggers cell death in various neuropathological diseases,including epilepsy.Studies have shown that inhibition of neuronal nitric oxide synthase activity increases the epilepsy threshold,that is,has an anticonvulsant effect.However,the exact role and potential mechanism of neuronal nitric oxide synthase in seizures are still unclear.In this study,we performed RNA sequencing,functional enrichment analysis,and weighted gene coexpression network analysis of the hippocampus of tremor rats,a rat model of genetic epilepsy.We found damaged hippocampal mitochondria and abnormal succinate dehydrogenase level and Na+-K+-ATPase activity.In addition,we used a pilocarpine-induced N2a cell model to mimic epileptic injury.After application of neuronal nitric oxide synthase inhibitor 7-nitroindazole,changes in malondialdehyde,lactate dehydrogenase and superoxide dismutase,which are associated with oxidative stress,were reversed,and the increase in reactive oxygen species level was reversed by 7-nitroindazole or reactive oxygen species inhibitor N-acetylcysteine.Application of 7-nitroindazole or N-acetylcysteine downregulated the expression of caspase-3 and cytochrome c and reversed the apoptosis of epileptic cells.Furthermore,7-nitroindazole or N-acetylcysteine downregulated the abnormally high expression of NLRP3,gasdermin-D,interleukin-1βand interleukin-18.This indicated that 7-nitroindazole and N-acetylcysteine each reversed epileptic cell death.Taken together,our findings suggest that the neuronal nitric oxide synthase/reactive oxygen species pathway is involved in pyroptosis of epileptic cells,and inhibiting neuronal nitric oxide synthase activity or its induced oxidative stress may play a neuroprotective role in epilepsy. 展开更多
关键词 APOPTOSIS bioinformatics analysis cell death EPILEPSY nitric oxide synthase oxidative stress PYROPTOSIS RNA sequencing Tremor rat weighted gene co-expression network analysis
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军队疗养健康管理信息系统的设计与实现 被引量:6
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作者 肖征 施文兴 +4 位作者 应黎鸿 辛彤 陈华 许冀 应英 《医疗卫生装备》 CAS 2021年第7期30-34,39,共6页
目的:设计一套军队疗养健康管理信息系统,利用信息化手段提升特勤人员的健康管理水平和疗养保障质量。方法:该系统采用浏览器/服务器(Browser/Server,B/S)架构,主要分为数据层、应用层和门户层。整个系统采用J2EE、可扩展标记语言(exten... 目的:设计一套军队疗养健康管理信息系统,利用信息化手段提升特勤人员的健康管理水平和疗养保障质量。方法:该系统采用浏览器/服务器(Browser/Server,B/S)架构,主要分为数据层、应用层和门户层。整个系统采用J2EE、可扩展标记语言(extensible markup language,XML)及Web Service技术设计,包括健康管理及评估子系统、健康干预子系统、健康数据离线采集及导入子系统和辅助功能子系统4个部分。结果:该系统为特勤人员提供了先进的数字化健康管理平台,可为其提供健康评估、健康干预、健康随访等全方位、全流程的健康服务。结论:该系统规范了特勤人员的健康管理流程,实现了特勤人员的精确化保障、规范化管理,同时对战斗力保持和提高起到了促进作用。 展开更多
关键词 健康管理 特勤人员 军队疗养 健康评估 健康干预
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