Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this genus.In this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate analyses.Molecular dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle Miocene.Cymbidium spp.migration to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene period.Our analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon intensity.Favorable hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle Miocene.The transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification rates.This study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

三维重建应用于肾脏肿瘤外科手术专家共识

肾脏肿瘤的手术治疗一直是泌尿科领域的重点和难点。传统的二维影像学检查虽然能够提供一定的解剖信息,但在肿瘤的精确定位、手术规划和风险评估方面存在局限性。三维重建技术通过展示更为直观和详细的解剖结构,使得外科医师能够更好地理解肿瘤与周围组织的关系,从而制定更为精确和个性化的手术方案。基于相关循证医学证据和专家共识,中国抗癌协会泌尿肿瘤专业委员会联合中国临床肿瘤学会肾癌专家委员会从三维重建的临床应用角度制定了《三维重建应用于肾脏肿瘤外科手术专家共识》,旨在规范三维重建技术在肾脏肿瘤外科领域内的应用,更好地服务于临床诊治,使患者受益。

Spatial and Temporal Distribution Characteristics of Solar Energy Resources in Tibet

The Tibet Plateau is one of the regions with the richest solar energy resources in the world.In the process of achieving carbon neutrality in China,the development and utilization of solar energy resources in the region will play an important role.In this study,the gridded solar resource data with 1km resolution in Tibet were obtained by spatial correction and downscaling of SMARTS model.On this basis,the spatial and temporal distribution characteristics of solar energy resources in the region in the past 30 years(1991–2020)are finely evaluated,and the annual global horizontal radiation resource is calculated.The results show that:1)The average annual global horizontal radiation amount in Tibet is 1816 kWh/m^(2).More than 60%of the area belongs to the“Most abundant”(GHI≥1750 kWh/m^(2))area of China’s solar energy resources category A,and nearly 40%belongs to the“Quite abundant”(1400≤GHI<1750)area of China’s solar energy resource category B.2)In space,the solar energy resources in Tibet increased gradually from north to south and from east to west.Lhasa,Central and Eastern Shigatse,Shannan,and Southwestern Ali are the most abundant cities,with a maximum annual radiation level of 2189 kWh/m2.3)In terms of time,the total horizontal radiation in Tibet was the highest in May and the lowest in December.74%of the total area belongs to the“Very stable”(R_(w)≥0.47)area of solar resource stability category A,and 26%belongs to the“stable”(0.36≤R_(w)<0.47)area of solar resource stability category B.Solar energy resources in the region show the characteristics of both strong and stable.Average solar energy resources in the region have shown a fluctuating downward trend over the past 30 years,with an average decline of about 12.86(kWh/m2)per decade.4)In terms of solar radiation resources reaching the earth’s surface,the theoretical total amount of annual horizontal radiation in Tibet is about 240.07 billion tons of standard coal or 222.91 billion kilowatts on average.

In Situ Directional Polymerization of Poly(1,3-dioxolane)Solid Electrolyte Induced by Cellulose Paper-Based Composite Separator for Lithium Metal Batteries

In traditional in situ polymerization preparation for solid-state electrolytes,initiators are directly added to the liquid precursor.In this article,a novel cellulose paper-based composite separator is fabricated,which employs alumina as the inorganic reinforcing material and is loaded with polymerization initiator aluminum trifluoromethanesulfonate.Based upon this,a separator-induced in situ directional polymerization technique is demonstrated,and the extra addition of initiators into liquid precursors is no longer required.The polymerization starts from the surface and interior of the separator and extends outward with the gradually dissolving of initiators into the precursor.Compared with its traditional counterpart,the separator-induced poly(1,3-dioxolane)electrolyte shows improved interfacial contact as well as appropriately mitigated polymerization rate,which are conducive to practical applications.Electrochemical measurement results show that the prepared poly(1,3-dioxolane)solid electrolyte possesses an oxidation potential up to 4.4 V and a high Li+transference number of 0.72.After 1000 cycles at 2 C rate(340 mA g^(−1)),the assembled Li||LiFePO_(4)solid battery possesses a 106.8 mAh g^(−1)discharge capacity retention and 83.5%capacity retention ratio,with high average Coulombic efficiency of 99.5%achieved.Our work may provide new ideas for the design and application of in situ polymerization technique for solid electrolytes and solid batteries.

Prevention and treatment of hepatic encephalopathy during the perioperative period of transjugular intrahepatic portosystemic shunt

Transjugular intrahepatic portosystemic shunt(TIPS)is an established procedure for treating the complications of portal hypertension in liver cirrhosis.While the pathogenesis of postoperative TIPS-related hepatic encephalopathy(HE)has yet to be fully understood,intraoperative portosystemic shunts may provide a pathological basis for the occurrence of postope-rative HE in patients with liver cirrhosis.Studies at home and abroad have expressed mixed opinions about TIPSrelated HE.This study presents a literature review on the risk factors for and prevention and treatment of perioperative TIPS-related HE in patients with liver cirrhosis,aiming to optimize the procedure and reduce the incidence of postoperative HE.

Rare portal hypertension caused by Abernethy malformation(Type IIC):A case report

BACKGROUND Abernethy malformation is a rare congenital vascular malformation with a portosystemic shunt that may clinically manifest as cholestasis,dyspnea,or hepatic encephalopathy,among other conditions.Early diagnosis and classification are very important to further guide treatment.Typically,patients with congenital portosystemic shunts have no characteristics of portal hypertension.Herein,we report an 18-year-old female with prominent portal hypertension that manifested mainly as rupture and bleeding of esophageal varices.Imaging showed a thin main portal vein,no portal vein branches in the liver,and bleeding of the esophageal and gastric varices caused by the collateral circulation upwards from the proximal main portal vein.Patients with Abernethy malformation type I are usually treated with liver transplantation,and patients with type II are treated with shunt occlusion,surgery,or transcatheter coiling.Our patient was treated with endoscopic surgery combined with drug therapy and had no portal hypertension and good hepatic function for 24 mo of follow-up.CASE SUMMARY This case report describes our experience in the diagnosis and treatment of an 18-year-old female with Abernethy malformation type IIC and portal hypertension.This condition was initially diagnosed as cirrhosis combined with portal hypertension.The patient was ultimately diagnosed using liver histology and subsequent imaging,and the treatment was highly effective.To publish this case report,written informed consent was obtained from the patient,including the attached imaging data.CONCLUSION Abernethy malformation type IIC may develop portal hypertension,and traditional nonselective beta-blockers combined with endoscopic treatment can achieve high efficacy.

抹灰砂浆拉伸粘结强度检测准确性影响因素分析

通过试验及分析,影响抹灰砂浆拉伸粘结强度检测准确性的因素主要有成型框的种类、水泥砂浆块基材的界面粗糙程度、成型时插捣的均匀程度、钢制夹具与抹灰砂浆粘结的充分程度等。

Damage assessment of aircraft wing subjected to blast wave with finite element method and artificial neural network tool

Damage assessment of the wing under blast wave is essential to the vulnerability reduction design of aircraft. This paper introduces a critical relative distance prediction method of aircraft wing damage based on the back-propagation artificial neural network(BP-ANN), which is trained by finite element simulation results. Moreover, the finite element method(FEM) for wing blast damage simulation has been validated by ground explosion tests and further used for damage mode determination and damage characteristics analysis. The analysis results indicate that the wing is more likely to be damaged when the root is struck from vertical directions than others for a small charge. With the increase of TNT equivalent charge, the main damage mode of the wing gradually changes from the local skin tearing to overall structural deformation and the overpressure threshold of wing damage decreases rapidly. Compared to the FEM-based damage assessment, the BP-ANN-based method can predict the wing damage under a random blast wave with an average relative error of 4.78%. The proposed method and conclusions can be used as a reference for damage assessment under blast wave and low-vulnerability design of aircraft structures.

单核苷酸多态性对原发性中枢神经系统淋巴瘤患者甲氨蝶呤化疗所致骨髓抑制的影响

目的 探讨甲氨蝶呤作用通路上6个相关基因SLCO1B1、SLC19A1、ABCC2、ABCB1、FPGS、GGH的单核苷酸多态性对原发性中枢神经系统淋巴瘤患者使用甲氨蝶呤化疗所致骨髓抑制不良反应的影响。方法 采用基质辅助激光解吸电离飞行时间质谱法对121例原发性中枢神经系统淋巴瘤患者的DNA样本进行基因分型。从电子病历系统获取患者的人口学及相应的临床资料,采用χ^(2)检验及多因素Logistic回归分析探讨单核苷酸多态性对患者化疗后骨髓抑制的影响。结果 121例患者共经历了508个疗程,其中186个疗程(36.6%)发生了骨髓抑制不良反应。单因素分析结果显示,SLCO1B1 rs2306283及GGH rs2305558位点的单核苷酸多态性对甲氨蝶呤所致骨髓抑制的发生率均有影响(P <0.05)。Logistic回归分析显示,SLCO1B1 rs2306283位点单核苷酸多态性仍然对甲氨蝶呤所致骨髓抑制的发生率有影响[OR=1.542,95%CI(1.040,2.287),P=0.031]。结论 SLCO1B1 rs2306283 GG基因型可作为甲氨蝶呤所致骨髓抑制的独立危险因素,为甲氨蝶呤的个体化给药提供依据。

Clinical effects and complications of TIPS for portal hypertension due to cirrhosis:A single center

AIM:To determine the clinical effects and complications of transjugular intrahepatic portosystemic shunt(TIPS)for portal hypertension due to cirrhosis.METHODS:Two hundred and eighty patients with portal hypertension due to cirrhosis who underwent TIPS were retrospectively evaluated.Portal trunk pressure was measured before and after surgery.The changes in hemodynamics and the condition of the stent were assessed by ultrasound and the esophageal and fundic veins observed endoscopically.RESULTS:The success rate of TIPS was 99.3%.The portal trunk pressure was 26.8±3.6 cmH2O after surgery and 46.5±3.4 cmH2O before surgery(P<0.01).The velocity of blood flow in the portal vein increased.The internal diameters of the portal and splenic veins were reduced.The short-term hemostasis rate was100%.Esophageal varices disappeared completely in68%of patients and were obviously reduced in 32%.Varices of the stomach fundus disappeared completely in 80%and were obviously reduced in 20%of patients.Ascites disappeared in 62%,were markedly reduced in 24%,but were still apparent in 14%of patients.The total effective rate of ascites reduction was 86%.Hydrothorax completely disappeared in 100%of patients.The incidence of post-operative stent stenosis was 24%at 12 mo and 34%at 24 mo.The incidence of post-operative hepatic encephalopathy was 12%at3 mo,17%at 6 mo and 19%at 12 mo.The incidence of post-operative recurrent hemorrhage was 9%at 12mo,19%at 24 mo and 35%at 36 mo.The cumulative survival rate was 86%at 12 mo,81%at 24 mo,75%at 36 mo,57%at 48 mo and 45%at 60 mo.CONCLUSION:TIPS can effectively lower portal hypertension due to cirrhosis.It is significantly effective for hemorrhage of the digestive tract due to rupture of esophageal and fundic veins and for ascites and hydrothorax caused by portal hypertension.

contrast enhanced computed tomography and reconstruction of hepatic vascular system for transjugular intrahepatic portal systemic shunt puncture path planning

AIM: To describe a method for the transjugular intrahepatic portal systemic shunt(TIPS) placement performed with the aid of contrast-enhanced computed tomography(CECT) and three-dimensional reconstructed vascular images(3D RVIs), and to assess its safety and effectiveness. METHODS: Four hundred and ninety patients were treated with TIPS between January 2005 and December 2012. All patients underwent liver CECT and reconstruction of 3D RVIs of the right hepatic vein to portal vein(PV) prior to the operation. The 3D RVIs were carefully reviewed to plan the puncture path fromthe start to target points for needle pass through the PV in the TIPS procedure. R E S U LTS :The improved TIPS procedure was successful in 483(98.6%) of the 490 patients. The number of punctures attempted was one in 294(60%) patients, 2 to 3 in 147(30%) patients, 4 to 6 in 25(5.1%) patients and more than 6 in 17(3.5%) patients. Seven patients failed. Of the 490 patients, 12 had punctures into the artery, 15 into the bile duct, eight into the gallbladder, and 18 through the liver capsule. Analysis of the portograms from the 483 successful cases indicated that the puncture points were all located distally to the PV bifurcation on anteroposterior images, while the points were located proximally to the bifurcation in the three cases with intraabdominal bleeding. The complications included three cases of bleeding, of whom one died and two needed surgery. CONCLUSION: Use of CECT and 3D RVIs to plan the puncture path for TIPS procedure is safe, simple and effective for clinical use.

Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure

AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a"tonifying qi and detoxification"("TQD")group(72 patients);and(3)a"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the"TQD"group were given a TCM formula"tonifying qi and detoxification"and general internal medicine treatment;patients in the"TTK"group were given a TCM formula of"TTK"and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,"TQD",and"TTK"groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the"TTK"group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the"TQD"group and"TTK"group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the"TQD"group and one case of gastrointestinal side effect in the"TTK"group.CONCLUSION:Treatment with"TTK"improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored.

秋石斛‘三亚阳光’Actin的克隆与表达模式分析

本研究克隆了秋石斛‘三亚阳光’(Dendrobium ‘Sonia Hiasakul’)肌动蛋白基因(DenActin)cDNA全长序列,并进行了DenActin进化地位和表达模式的分析。通过克隆获得的DenActin cDNA序列的全长为1 596 bp,其中开放阅读框为1 134 bp,编码377个氨基酸,同时通过gDNA克隆获得了DenActin 3′端的一段包含一个内含子的403 bp的片段。序列同源性分析发现该基因序列与GenBank中注册的其他植物Actin核苷酸序列的同源性均在85%以上,氨基酸序列的同源性高达97%以上。通过最大似然法构建其系统进化树,分析发现DenActin与黄石斛Actin的亲缘关系最为密切,并与其他兰科植物归为一大类。半定量PCR分析表明,DenActin在幼苗叶片和中苗茎尖、根、叶片以及成熟植株的茎、根、叶片、花柄、1 mm花苞、3 mm花苞、5 mm花苞、9 mm花苞中均稳定表达。秋石斛DenActin的克隆和表达模式分析为秋石斛功能基因的表达分析提供了候选的内参基因,而3′端包含内含子的gDNA片段的克隆为避免实时定量分析中的gDNA污染提供了引物设计的便利。

Hydrogen production via steam reforming of bio-oil model compounds over supported nickel catalysts

The steam reforming of four bio-oil model compounds（acetic acid,ethanol,acetone and phenol） was investigated over Ni-based catalysts supported on Al2O3 modified by Mg,Ce or Co in this paper.The activation process can improve the catalytic activity with the change of high-valence Ni（Ni2O3,NiO） to low-valence Ni（Ni,NiO）.Among these catalysts after activation,the Ce-Ni/Co catalyst showed the best catalytic activity for the steam reforming of all the four model compounds.After long-term experiment at 700°C and the S/C ratio of 9,the Ce-Ni/Co catalyst still maintained excellent stability for the steam reforming of the simulated bio-oil（mixed by the four compounds with the equal masses）.With CaO calcinated from calcium acetate as CO2 sorbent,the catalytic steam reforming experiment combined with continuous in situ CO2 adsorption was performed.With the comparison of the case without the adding of CO2 sorbent,the hydrogen concentration was dramatically improved from 74.8% to 92.3%,with the CO2 concentration obviously decreased from 19.90% to 1.88%.

Clinical efficacy of antiviral therapy in patients with hepatitis Brelated cirrhosis after transjugular intrahepatic portosystemic shunt

BACKGROUND As a country with a high burden of hepatitis B,China has about 86 million cases of hepatitis B virus infection,ranking the first in the world.Currently,there are about 390000 deaths due to hepatitis B-related complications such as liver cirrhosis and liver cancer every year.Consequently,how to control portal hypertension,improve liver functional reserve,and reduce the incidence of hepatic failure and liver cancer in such patients is the focus of current clinical attention.Previous clinical study in our center suggested that at 24 mo after transjugular intrahepatic portosystemic shunt(TIPS),the liver functional reserve of patients with hepatitis B cirrhosis was better than that of patients with alcoholinduced and immune cirrhosis,which may be related to the effective etiological treatment.AIM To investigate the clinical efficacy of three first-line antiviral drugs recommended by the guidelines of prevention and treatment for chronic hepatitis B in China(2019)in the treatment of patients with hepatitis B-related cirrhosis who had received a TIPS.METHODS The clinical data of 137 patients with hepatitis B-related cirrhosis with portal hypertension after receiving TIPS at our centre between March 2016 and December 2020 were analysed retrospectively.According to different anti-viral drugs,the patients were divided into entecavir(ETV)(n=70),tenofovir alafenamide fumarate(TAF)(n=32),and tenofovir disoproxil fumarate(TDF)(n=35)groups.The cumulative incidence of hepatic encephalopathy and hepatocellular carcinoma,survival,and changes in hepatic reserve function and glomerular filtration rate in patients treated with different antiviral drugs within 24 mo after surgery were investigated.RESULTS At 24 mo after surgery,the Child-Pugh score in the TAF group(6.97±0.86)was lower than that in the TDF(7.49±0.82;t=-2.52,P=0.014)and ETV groups(7.64±1.17;t=-2.92,P=0.004).The model for end-stage liver disease score in the TAF group at 24 mo after surgery was 9.72±1.5,which was lower than that in the TDF(10.74±2.33;t=-2.09,P=0.040)and ETV groups(10.97±2.17;t=-2.93,P=0.004).At 24 mo after surgery,the estimated glomerular filtration rate(eGFR)in the TAF group(104.41±12.54)was higher than that in the TDF(93.54±8.97)and ETV groups(89.96±9.86)(F=21.57,P<0.001).CONCLUSION At 24 mo after surgery,compared with TDF and ETV,TAF has significant advantages in the improvement of liver functional reserve and eGFR.

Effects of transjugular intrahepatic portosystemic shunt using the Viatorr stent on hepatic reserve function in patients with cirrhosis

BACKGROUND As transjugular intrahepatic portosystemic shunt(TIPS)creation alters the hemodynamic status of the portal system,whether reduced portal blood supply affects the synthetic reserve function of the liver has been the focus of clinical attention.Since the Viatorr stent entered the Chinese market in 2015,it has not yet been widely used in clinical practice.Further,unlike other countries,the main cause of liver cirrhosis in China is viral hepatitis.Therefore,use of the Viatorr stent to establish a TIPS channel in patients with liver cirrhosis with differing etiologies is of great clinical interest.AIM To investigate factors affecting changes in liver reserve function after TIPS Viatorr stent implantation.METHODS Clinical data from 200 patients with cirrhotic portal hypertension who received TIPS treatment from March 2016 to March 2020 were analyzed retrospectively.The patients were divided into three groups(A-C),according to their disease etiology,with post-hepatitis,autoimmune,and alcoholic cirrhosis,respectively.Preoperative and postoperative liver and renal function and coagulation data,Child-Pugh grade,and model for end-stage liver disease(MELD)scores were collected.Statistical analyses were performed using the t-test or chi-square test.The incidence and of hepatic encephalopathy and patient survival were calculated using Kaplan-Meier method.RESULTS The surgical success rate was 100%,with mean portal pressure gradient(mmHg)decreasing from 25.5±5.22 to 10.04±2.76(t=45.80;P<0.001).After 24 mo,the cumulative incidence of hepatic encephalopathy in group A was significantly lower than that in group B/C,while the cumulative survival rate was significantly higher in group A than in group B/C(P<0.05 for both).The Child-Pugh score for group A was 6.96±1.21,which was significantly better than those of groups B(7.42±0.99;t=-2.44;P=0.016)and C(7.52±1.12;t=-2.67;P=0.009).Further,the MELD score for group A(9.62±2.19)was significantly better than those for groups B(10.64±1.90;t=-2.92;P=0.004)and C(10.82±2.01;t=-3.29;P=0.001).CONCLUSION Insertion of 8 mm internal diameter Viatorr stent has no significant effects on liver reserve function.Changes of liver reserve function in the medium and long term may be related to the etiology and treatment of portal hypertension.

An Adjust Duty Cycle Method for Optimized Congestion Avoidance and Reducing Delay for WSNs

With the expansion of the application range and network scale of wireless sensor networks in recent years,WSNs often generate data surges and delay queues during the transmission process,causing network paralysis,even resulting in local or global congestion.In this paper,a dynamically Adjusted Duty Cycle for Optimized Congestion based on a real-time Queue Length(ADCOC)scheme is proposed.In order to improve the resource utilization rate of network nodes,we carried out optimization analysis based on the theory and applied it to the adjustment of the node’s duty cycle strategy.Using this strategy to ensure that the network lifetime remains the same,can minimize system delay and maximize energy efficiency.Firstly,the problems of the existing RED algorithm are analyzed.We introduce the improved SIG-RED algorithm into the ADCOC mechanism.As the data traffic changes,the RED protocol cannot automatically adjust the duty cycle.A scheduler is added to the buffer area manager,referring to a weighted index of network congestion,which can quickly determine the status of network congestion.The value of the weighting coefficient W is adjusted by the Bayesian method.The scheduler preferably transmits severely urgent data,alleviating the memory load.Then we combined improved data fusion technology and information gain methods to adjust the duty cycle dynamically.By simulating the algorithm,it shows that it has faster convergence speed and smaller queue jitter.Finally,we combine the adjusted congestion weight and the duty cycle growth value to adjust the data processing rate capability in the real-time network by dynamically adjusting it to adapt to bursts of data streams.Thus,the frequency of congestion is reduced to ensure that the system has higher processing efficiency and good adaptability.

Better Visual Image Super-Resolution with Laplacian Pyramid of Generative Adversarial Networks

Although there has been a great breakthrough in the accuracy and speed of super-resolution(SR)reconstruction of a single image by using a convolutional neural network,an important problem remains unresolved:how to restore finer texture details during image super-resolution reconstruction?This paper proposes an Enhanced Laplacian Pyramid Generative Adversarial Network(ELSRGAN),based on the Laplacian pyramid to capture the high-frequency details of the image.By combining Laplacian pyramids and generative adversarial networks,progressive reconstruction of super-resolution images can be made,making model applications more flexible.In order to solve the problem of gradient disappearance,we introduce the Residual-in-Residual Dense Block(RRDB)as the basic network unit.Network capacity benefits more from dense connections,is able to capture more visual features with better reconstruction effects,and removes BN layers to increase calculation speed and reduce calculation complexity.In addition,a loss of content driven by perceived similarity is used instead of content loss driven by spatial similarity,thereby enhancing the visual effect of the super-resolution image,making it more consistent with human visual perception.Extensive qualitative and quantitative evaluation of the baseline datasets shows that the proposed algorithm has higher mean-sort-score(MSS)than any state-of-the-art method and has better visual perception.

Influence of different portal vein branches on hepatic encephalopathy during intrahepatic portal shunt via jugular vein

This letter is regarding the study titled‘Targeted puncture of left branch of intrahepatic portal vein in transjugular intrahepatic portosystemic shunt(TIPS)to reduce hepatic encephalopathy’.Prior to the approval of TIPS dedicated stents(Viatorr stents)in China in October 2015,Fluency covered stents were typically used.As Fluency covered stents have a strong support force and axial elastic tension,a‘cap’may form if the stent is located too low at the end of the hepatic vein or too short at the end of the portal vein during surgery,leading to stent dysfunction.Since the blood shunted by the stent is from the main trunk of the portal vein,the correlation between the incidence of postoperative hepatic encephalopathy and the location of the puncture target(left or right portal vein branch)is worth discussion.Notably,no studies in China or foreign countries have proven the occurrence of left and right blood stratification after the accumulation of splenic vein and mesenteric blood flow in the main trunk of the portal vein in patients with cirrhotic portal hypertension.

Temporary pacemaker protected transjugular intrahepatic portosystemic shunt in a patient with acute variceal bleeding and bradyarrhythmia:A case report

BACKGROUND Esophagogastric varices are a common complication of cirrhosis with portal hypertension and endoscopic treatment has been recognized as a primary preventive and therapeutic option for such patients;however,it should be noted that bradyarrhythmia is regarded as one of the contraindications to endoscopic examination.Meanwhile,acute variceal bleeding may result in a high mortality rate in cirrhotic patients with portal hypertension accompanied by bradyarrhythmia.At present,there is an absence of reports concerning the treatment of such group of patients who underwent transjugular intrahepatic portosystemic shunt(TIPS).The present report details the case of a cirrhotic patient with acute variceal bleeding accompanied by bradyarrhythmia who underwent TIPS under temporary pacemaker protection.CASE SUMMARY We report the case of a 64-year-old male patient who was confirmed with bradyarrhythmia by ambulatory electrocardiogram 24 h before the operation.The patient was successfully treated by TIPS under temporary pacemaker protection.CONCLUSION In terms of cirrhotic patients with abnormal cardiac electrophysiological conduction,TIPS may be effective in reducing the complications of portal hypertension following the exclusion of severe pulmonary hypertension and heart failure,showing moderate feasibility in clinical applications.