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结直肠癌术后辅助卡培他滨为基础化疗方案的临床疗效及相关药物基因组学分析 被引量:6
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作者 刘世举 张慧俭 +4 位作者 王金榜 杨会举 张新春 刘翔 刘佃温 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第17期889-893,共5页
目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周... 目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周血提取DNA用来进行胞苷脱氨酶(cytidine deaminase,CDD)多态性位点基因分型。另外,收集85例患者的化疗前外周血单核细胞(peripheral blood mononuclear cell,PBMC)提取RNA对CDD的m RNA表达水平进行测定。结果:215例患者具有良好的疗效。药物基因组学分析方面,发现CDD基因启动子区域的多态性位点-451C>A和疗效相关,该位点GA/AA和GG基因型患者的3年无疾病生存率(disease-free survival,DFS)分别为81.03%和62.42%,差异具有统计学意义(P=0.002)。两种基因型患者的5年总生存率(overall survival,OS)分别为72.41%和53.50%,差异具有统计学意义(P=0.016)。在85例患者外周血单核细胞的mRNA表达分析中发现,携带A等位基因的患者相对于GG型患者,外周血单核细胞中CDD的mRNA表达明显较高,差异具有统计学意义(P<0.001)。结论:卡培他滨为基础的化疗方案具有良好的治疗效果。CDD基因-451C>A位点可能通过影响该基因m RNA的表达使CRC患者从卡培他滨的治疗当中获益。 展开更多
关键词 结直肠癌 胞苷脱氨酶 多态性 疗效
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Opening and Sharing of Large-scale Instruments and Equipment in Agricultural Research Institutes:A Case Study of Environment and Plant Protection Institute of Chinese Academy of Tropical Agricultural Sciences
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作者 Yanmei CUI Xiaoqiang CHU +3 位作者 Huaping HUANG xinchun zhang Ye LI Shuchang WANG 《Asian Agricultural Research》 2020年第12期6-11,共6页
The article introduces the main practices and achievements of the Environment and Plant Protection Institute of Chinese Academy of Tropical Agricultural Sciences in promoting the sharing of large-scale instruments and... The article introduces the main practices and achievements of the Environment and Plant Protection Institute of Chinese Academy of Tropical Agricultural Sciences in promoting the sharing of large-scale instruments and equipment in recent years,analyzes the existing problems in the management system,management team,assessment incentives and maintenance guarantee,and proposes improvement measures and suggestions from aspects of improving the sharing management system,strengthening management team building,strengthening sharing assessment and incentives,improving maintenance capabilities and expanding external publicity,to further improve the sharing management of large-scale instruments and equipment. 展开更多
关键词 Agricultural scientific research institution Large-scale instrument and equipment Opening and sharing Existing problem SUGGESTION
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Mechanical design and analysis of bio-inspired reentrant negative Poisson’s ratio metamaterials with rigid-flexible distinction 被引量:2
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作者 xinchun zhang Junyu Wang +4 位作者 Qidong Sun Jingyang Li Sheng Zhou Junfeng Qi Ran Tao 《International Journal of Smart and Nano Materials》 SCIE EI 2024年第1期1-20,共20页
Aiming at achieving tunable reentrant structures with rigidity and uniformity,respectively,the C-shaped and S-shaped reentrant metamaterials were proposed by the bionic design of animal structures.Utilizing beam theor... Aiming at achieving tunable reentrant structures with rigidity and uniformity,respectively,the C-shaped and S-shaped reentrant metamaterials were proposed by the bionic design of animal structures.Utilizing beam theory and energy methodology,the analytical expressions of the equivalent elastic modulus of the metamaterials were derived.Differences in deformation modes,mechanical properties,and energy absorption capacities were characterized by using experiments and the finite element analysis method.The effects of ligament angle and thickness on the mechanical characteristics of two novel metamaterials were investigated by using a parametric analysis.The results show that the stiffness,deformation mode,stress-strain curve,and energy absorption effects of three metamaterials are significantly different.This design philosophy can be extended from 2D to 3D and is applicable at multiple dimensions. 展开更多
关键词 Re-entrant mechanical metamaterials negative poisson’s ratio enhanced stiffness rigid-flexible distinction energy absorption
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多边共管的多模态网络标识域名生成管理解析原型系统 被引量:9
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作者 李挥 邬江兴 +34 位作者 邢凯轩 伊鹏 陈世胜 梁伟 魏进武 李卫 朱伏生 田开颜 朱江 陆以勤 徐恪 宋佳兴 刘怡俊 董永吉 韩永祥 侯韩旭 马军锋 徐睿 阙建明 杨伟豪 缪伟豪 郑泽峰 孙涛 韦国华 綦九华 刘吉 白永杰 宁崇辉 王菡 张昕淳 胡嘉伟 黄健森 吕赛 刘馨蔚 李更新 《中国科学:信息科学》 CSCD 北大核心 2019年第9期1186-1204,共19页
面对新形势下互联网蓬勃发展给现有网络体系带来的挑战,现有单边主义下的域名管理系统(DNS)在专业化服务质量和安全管控方面已力不从心.本文从分析现有网络体系问题出发,结合世界网络发展趋势,明确新型网络基本技术特征,以高安全、高鲁... 面对新形势下互联网蓬勃发展给现有网络体系带来的挑战,现有单边主义下的域名管理系统(DNS)在专业化服务质量和安全管控方面已力不从心.本文从分析现有网络体系问题出发,结合世界网络发展趋势,明确新型网络基本技术特征,以高安全、高鲁棒、高效能和高可用性为导向,提出新型多模态域名管理技术框架,实现融合多边共管的投票管理和多模态网络下标识域名互访和互隧道功能的原型系统.原型系统通过现网测试验证了理论的正确性和可行性.该系统可以方便地应用于自主多模态标识空间下的主权网及高安全专网,为全世界对网络共管共治的诉求提供了中国方案. 展开更多
关键词 多边共管 域名解析 多模态网络 联盟链共识PoV 多模标识互相隧道/互译 后IP高安全专网
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A Passive Anti-icing Strategy Based on a Superhydrophobic Mesh with Extremely Low Ice Adhesion Strength 被引量:11
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作者 Peng Wang Ziqiang Li +3 位作者 Qing Xie wei Duan xinchun zhang Huilong Han 《Journal of Bionic Engineering》 SCIE EI CSCD 2021年第1期55-64,共10页
Although superhydrophobic materials have attracted much research interest in anti-icing,some controversy still exists.In this research,we report a cost-effective method used to verify the contribution of area fraction... Although superhydrophobic materials have attracted much research interest in anti-icing,some controversy still exists.In this research,we report a cost-effective method used to verify the contribution of area fraction to ice adhesion strength.We tried to partially-embed siliea nanopnarticles into microscale fabrics of a commercial polyamide mesh.Then,the area fraction could be determined by altering the mesh size.Generally,the ice adhesion strength decreases as the area fraction decreases.An ice adhesion strength of~1.9 kPa and a delayed freezing time of~1048 s can be obtained.We attribute the low ice adhesion strength to the combination of superhydro-phobicity and stress concentration.The superhydrophobicity prohibits the water from penetrating into the voids of the meshes,and the small actual contact area leads to stress concentration which promotes interfacial crack propagation.Moreover,our superhydrophobic mesh simultaneously exhibis a micro-nano hierarchical structure and a partally-cmbedded structure.Therefore,the as-prepared superhydrophobic mesh retained the ieephobicity after 20 icingldeicing cycles,and maintained its superhydrophobicity even afier 60 sandpaper-abrasion cycles and a 220"C thermal treatment. 展开更多
关键词 BIONIC SUPERHYDROPHOBIC ANTI-ICING mechanical robustness hierarchical structure partially-embedded structure
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