A mussel-inspired,antibacterial,antioxidant,injectable composite hydrogel for the sustain delivery of salvianolic acid B for the treatment of frozen shoulder

Frozen shoulder(FS)manifests as progressively worsening pain and a reduction in shoulder range of motion(ROM).Salvianolic acid B(SaB)is recently expected to be used in the treatment of fibrosis diseases including FS.We firstly demonstrate that SaB can effectively hinder the progression of oxidative stress,inflammation,and pathological fibrosis within the synovial tissue in FS,potentially leading to the reduction or reversal of capsule fibrosis and joint stiffness.For further clinical application,we design and synthesize a novel,superior,antioxidant and antibacterial CSMA-PBA/OD-DA(CPDA)hydrogel for the delivery of SaB.In vitro experiments demonstrate that the CPDA hydrogel exhibits excellent biocompatibility and rheological properties,rendering it suitable for intra-articular injections.Upon injection into the contracted joint cavity of FS model rat,the SaBCPDA hydrogel accelerate the recovery of ROM and exhibit superior anti-fibrosis effect,presenting the promise for the treatment of FS in vivo.

Distinction of self-synchronous scrambled linear blockcodes based on multi-fractal spectrum

This study proposes a novel multi-fractal spectrumbasedapproach to distinguish linear block codes from its selfsynchronousscrambled codes. Given that the linear block codeand self-synchronous scrambled linear block code share the propertyof linear correlation, the existing linear correlation-basedidentification method is invalid for this case. This drawback can becircumvented by introducing a novel multi-fractal spectrum-basedmethod. Simulation results show that the new method has highrobustness and under the same conditions of bit error, the lowerthe code rate, the higher the recognition rate. Thus, the methodhas significant potential for future application in engineering.

Investigation of energy-efficient heat pump assisted heterogeneous azeotropic distillation for separating of acetonitrile/ethyl acetate/n-hexane mixture

The conventional distillation is hard to accomplish the separation of acetonitrile/ethyl acetate/n-hexane mixture. Herein, a heterogeneous azeotropic distillation(HAD) without adding entrainer is proposed to separate ternary mixture. The proposed scheme is optimized via the simulated annealing algorithm and minimum total annual cost(TAC) is used as objective functions. To minimize energy consumption,heat pump is added on the basis of optimal heterogeneous azeotropic distillation and heat integration technology is used to further improve the energy recovery. The TAC, gas emission, energy consumption and exergy destruction are used to discuss the economy and environmental protection of processes.Among all the processes, the heat pump with higher preheating temperature(HPT) assisted HAD process by combining with heat integration(HAD-HPT-HI) has best performances on economic, environment,energy and exergy. Compared with conventional HAD process, the HAD-HPT-HI achieves the reductions of 52.17%, 68.86%, 65.87% and 65.46% on TAC, total energy consumption, gas emissions and exergy destruction, respectively.

Rapidly and mildly transferring anatase phase of graphene-activated TiO2 to rutile with elevated Schottky barrier:Facilitating interfacial hot electron injection for Vis-NIR driven photocatalysis

Visible and even infrared(IR)light-initiated hot electrons of graphene(Gr)catalysts are a promising driven power for green,safe,and sustainable H2O2 synthesis and organic synthesis without the limitation of bandgap-dominated narrow light absorption to visible light confronted by conventional photocatalyst.However,the life time of photogenerated hot electrons is too short to be efficiently used for various photocatalytic reactions.Here,we proposed a straightforward method to prolong the lifetime of photogenerated hot electrons from graphene by tuning the Schottky barrier at Gr/rutile interface to facilitate the hot electron injection.The rational design of Gr-coated TiO2 heterojunctions with interface synergy-induced decrease in the formation energy of the rutile phase makes the phase transfer of TiO2 support proceed smoothly and rapidly via ball milling.The optimized Gr/rutile dyad could provide a H2O2 yield of 1.05 mM·g-1·h-1 under visible light irradiation(λ≥400 nm),which is 30 times of the state-of-the-art noble-metal-free titanium oxide-based photocatalyst,and even achieves a H2O2 yield of 0.39 mM·g-1·h-1 on photoexcitation by near-infrared-region light(~800 nm).

An Ultra-stable Eu^(3+)Doped Yttrium Coordination Polymer with Dual-function Sensing for Cr(Ⅵ)and Fe(Ⅲ)Ions in Aqueous Solution

The exploration of a dual-functional sensor is the key to effectively detect the Cr(Ⅵ)and Fe(Ⅲ)cations in water,which is important to human health and environmental sustainability.Because of the phase stability and excellent luminescence,the rare-earth coordination polymers have great potential as dual-functional sensors.Here,we develop a Y_(0.91)Eu_(0.09)(H_(2)O)_(2){C_(6)H_(3)(CO_(2))_(3)}(MIL-92(Y):9%Eu^(3+))-based dual-function luminescent sensor on Cr(Ⅵ)and Fe(Ⅲ),which exhibits excellent phase stability and dispersibility in water.The luminescence of MIL-92(Y):9%Eu^(3+)aqueous suspension quenches on Fe^(3+)with Stern-Volmer constant K_(sv) of 1.79×10^(3)M^(-1)and limit of detection of 17μM.The MIL-92(Y):9%Eu^(3+)aqueous suspension also has turn-off sensing ability towards Cr_(2)O_(7)^(2-)and Cr O_(4)^(2-)with K_(sv) values of 3.5×10^(3)and 6.14×10^(3)M^(-1),respectively.It has detection limitations of 10 and 5μM on Cr_(2)O_(7)^(2-)and Cr_(2)O_(7)^(2-)ions,respectively.

3D direct printing of mechanical and biocompatible hydrogel meta-structures

Direct Ink Writing(DIW)has demonstrated great potential as a versatile method to 3D print multifunctional structures.In this work,we report the implementation of hydrogel meta-structures using DIW at room temperature,which seamlessly integrate large specific surface areas,interconnected porous characteristics,mechanical toughness,biocompatibility,and water absorption and retention capabilities.Robust but hydrophobic polymers and weakly crosslinked nature-origin hydrogels form a balance in the self-supporting ink,allowing us to directly print complex meta-structures without sacrificial materials and heating extrusion.Mechanically,the mixed bending or stretching of symmetrical re-entrant cellular lattices and the unique curvature patterns are combined to provide little lateral expansion and large compressive energy absorbance when external forces are applied on the printed meta-structures.In addition,we have successfully demonstrated ear,aortic valve conduits and hierarchical architectures.We anticipate that the reported 3D meta-structured hydrogel would offer a new strategy to develop functional biomaterials for tissue engineering applications in the future.

MOF adsorbents capture CO_(2) on an industrial scale

Combustion of fossil fuels in industrial settings,such as coalfired power plants,steel-smelting furnaces,and cement kilns accounts for more than 70%of CO_(2) emission.Although liquid amine scrubbing processes that are based on 30 wt%monoethanolamine aqueous solutions are feasible in capturing CO_(2)on a large scale,significant drawbacks remain concerning the energy penalty for regeneration and environmental pollution upon their disposal after degradation[1].

One-step reduction-encapsulated synthesis of Ag@polydopamine multicore-shell nanosystem for enhanced photoacoustic imaging and photothermal-chemodynamic cancer therapy

Though imaging-guided multimodal therapy has been demonstrated as an effective strategy to improve cancer diagnosis and therapy,challenge remains as to simplify the sophisticated synthesis procedure for the corresponding nanoagents.Herein,an insitu one-step reduction-encapsulated method has been reported,for the first time,to synthesize multicore-shell polydopaminecoated Ag nanoparticles(AgNPs@PDA)as a cancer theranostic agent,integrating amplified photoacoustic imaging,enhanced photothermal therapy,and photothermal promoted dual tumor microenvironment-coactivated chemodynamic therapy.The photoacoustic signal and the photothermal conversion efficiency of AgNPs@PDA nanosystem present a 6.6-and 4.2-fold enhancement compared to those of M-AgNPs-PDA(simply mixing PDA and AgNPs)derived from the increased interface heat transfer coefficient and the stronger near-infrared absorption.Importantly,AgNPs@PDA coactivated by dual tumor microenvironment(TME)enables controllable long-term release of hydroxyl radicals(·OH)and toxic Ag+,which can be further promoted by near-infrared light irradiation.Moreover,the high efficiency of AgNPs@PDA nanosystem with prominent photoacoustic imaging-guided synergistic photothermal-chemodynamic cancer treatment is also found in in vitro and in vivo studies.As a special mention,the formation mechanism of the one-step synthesized multicore-shell nanomaterials is systematically investigated.This work provides a much simplified one-step synthesis method for the construction of a versatile nanoplatform for cancer theranostics with high efficacy.