Mechanism of Gegen Qinlian Decoction in Treating Type 2 Diabetes Mellitus Complicated with NAFLD Based on Network Pharmacology

[Objectives]To explore the mechanism of Gegen Qinlian Decoction in treating type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD)by analyzing the effective components of Gegen Qinlian Decoction.[Methods]TCMSP database was used to analyze the active components of Gegen Qinlian Decoction,and pubchem and Swiss ADME databases were also used to predict drug targets,extract T2DM complicated with NAFLD targets from OMIM and Genecards databases.Venny plot was drawn to obtain intersection targets,and finally Cytoscape was used to make core target maps and drug-target-disease network maps.Using DAVID and Metascape database to analyze the intersection targets,the gene ontology information of Go and KEGG was obtained.Microbial informatics technology was used to visualize GO,and Cytoscape was used to make drug-target-disease network map-enrichment pathway map.[Results]The network pharmacological analysis showed that Gegen Qinlian Decoction acted on the key targets of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease,such as ALB and ALT1,through many components,and achieved the purpose of treating this disease.The chemical constituents of the drug include formononetin,5-hydroxyisomucronulatol-2,5-2-O-glucoside,cholesteryl laurate,isoliquiritigenin,etc.[Conclusions]This study provides a new idea and theoretical support for future drug research and clinical practice.

A High-Resolution Earth’s Gravity Field Model SGG-UGM-2 from GOCE,GRACE,Satellite Altimetry,and EGM2008

This paper focuses on estimating a new high-resolution Earth’s gravity field model named SGG-UGM-2 from satellite gravimetry,satellite altimetry,and Earth Gravitational Model 2008(EGM2008)-derived gravity data based on the theory of the ellipsoidal harmonic analysis and coefficient transformation(EHA-CT).We first derive the related formulas of the EHA-CT method,which is used for computing the spherical harmonic coefficients from grid area-mean and point gravity anomalies on the ellipsoid.The derived formulas are successfully evaluated based on numerical experiments.Then,based on the derived least-squares formulas of the EHA-CT method,we develop the new model SGG-UGM-2 up to degree 2190 and order 2159 by combining the observations of the Gravity Field and Steady-State Ocean Circulation Explorer(GOCE),the normal equation of the Gravity Recovery and Climate Experiment(GRACE),marine gravity data derived from satellite altimetry data,and EGM2008-derived continental gravity data.The coefficients of degrees 251–2159 are estimated by solving the block-diagonal form normal equations of surface gravity anomalies(including the marine gravity data).The coefficients of degrees 2–250 are determined by combining the normal equations of satellite observations and surface gravity anomalies.The variance component estimation technique is used to estimate the relative weights of different observations.Finally,global positioning system(GPS)/leveling data in the mainland of China and the United States are used to validate SGG-UGM-2 together with other models,such as European improved gravity model of the earth by new techniques(EIGEN)-6C4,GECO,EGM2008,and SGG-UGM-1(the predecessor of SGG-UGM-2).Compared to other models,the model SGG-UGM-2 shows a promising performance in the GPS/leveling validation.All GOCE-related models have similar performances both in the mainland of China and the United States,and better performances than that of EGM2008 in the mainland of China.Due to the contribution of GRACE data and the new marine gravity anomalies,SGG-UGM-2 is slightly better than SGG-UGM-1 both in the mainland of China and the United States.

Association of serum lipids and severity of epithelial ovarian cancer：an observational cohort study of 349 Chinese patients

While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who received treatment at Jiangsu Cancer Hospital, China between 2011 and 2017. We analyzed age at diagnosis, blood pressure, plasma glucose content, body mass index（BMI）, lipid levels and clinical parameters. Severity of epithelial ovarian cancer was classified according to the International Federation of Gynecology and Obstetrics（FIGO） grading system. Univariate analysis of the clinical factors according to the severity of epithelial ovarian cancer was followed by logistic regression analysis to identify clinical factors significantly associated with epithelial ovarian cancer severity. Univariate analysis indicated that age,BMI, triglyceride（TG）, and high density lipoproteins（HDL） differed significantly among different stages of epithelial ovarian cancer（P〈0.05）. In the logistic regression model, elevated TG（OR： 1.883; 95% CI= 1.207-2.937）, and low HDL（OR： 0.497; 95% CI = 0.298-0.829） levels were significantly associated with the high severity epithelial ovarian cancer. Our data indicate that high TG and low HDL levels correlate with a high severity of epithelial ovarian cancer. These data provide important insight into the potential relationship between the lipid pathway and epithelial ovarian cancer phenotype and development.

Analysis of the impact on the gravity field determination from the data with the ununiform noise distribution using block-diagonal least squares method

The block-diagonal least squares method, which theoretically has specific requirements for the observation data and the spatial distribution of its precision, plays an important role in ultra-high degree gravity field determination. On the basis of block-diagonal least squares method, three data processing strategies are employed to determine the gravity field models using three kinds of simulated global grid data with different noise spatial distri- bution in this paper. The numerical results show that when we employed the weight matrix corresponding to the noise of the observation data, the model computed by the least squares using the full normal matrix has much higher precision than the one estimated only using the block part of the normal matrix. The model computed by the block-diagonal least squares method without the weight matrix has slightly lower precision than the model computed using the rigorous least squares with the weight matrix. The result offers valuable reference to the using of block-diagonal least squares method in ultra-high gravity model determination.

M6型射波刀立体定向放疗系统图像引导照射剂量研究

目的:分析M6型射波刀立体定向放疗(stereotactic radiotherapy,SBRT)图像引导系统产生的照射剂量及影响因素,为接受M6型射波刀治疗肿瘤患者额外照射剂量提供参考依据。方法:回顾性分析天津医科大学肿瘤医院2023年1月1日至2023年5月31日216例采用M6型射波刀SBRT的肿瘤患者,将患者按照图像引导方式和肿瘤靶区位置进行分类,分别统计患者肿瘤靶区的照射剂量、治疗分割次数、球管曝光参数、计算球管总曝光次数、累积的照射剂量,得出不同图像引导方式和治疗部位平均曝光次数、平均照射剂量,与患者肿瘤靶区的照射剂量相比较,并勾画ROC曲线取肿瘤体积及BED_(10)的cutoff值进行分层,利用多元线性逐步回归模型分析累积剂量的影响因素。结果:颅骨(6D-skull)追踪方式,椎体(x-sight)追踪方式,同步呼吸(sychrony)追踪方式,金标(fiducial)追踪方式,肺追踪(x-sight lung)肿瘤患者平均曝光次数、平均累积照射剂量(cGy)、累积照射剂量/靶区照射剂量(%)分别为131次、1.6 cGy、0.02%~0.18%;212次、8.0 cGy、0.05%~0.45%;322次、12.2 cGy、0.06%~0.62%;237次、10.1 cGy、0.07%~0.36%;411次、12 cGy、0.20%~0.21%。颅脑、胸部、腹部、盆腔肿瘤患者的平均曝光次数、累积照射剂量(c Gy)、累积照射剂量/靶区照射剂量(%)分别为131次、1.6 cGy、0.02%~0.18%;258次、9.6 cGy、0.05%~0.62%;191次、7.7 cGy、0.08%~0.44%;209次、8.5 cGy、0.07%~0.36%。ROC曲线中按照肿瘤体积(cutoff值30 mL)和BED_(10)(cutoff值60 Gy)进行分类,发现肿瘤部位、靶区体积、BED_(10)均为累积照射剂量的影响因素。当肿瘤体积≥30 mL、BED_(10)>60 Gy、肿瘤位于胸、腹、盆腔时,累积剂量增大。结论:采用颅骨(6D-skull)追踪方式颅脑肿瘤患者平均曝光次数、累积照射剂量最低,采用其余4种图像引导方式对应的胸部、腹部、盆腔肿瘤患者平均曝光次数、累积照射剂量接近。肿瘤部位、靶区体积、BED_(10)均为累积照射剂量的影响因素。M6型射波刀SBRT系统能够对患者治疗过程中进行实时位置精度验证,患者接受的辐射剂量较小。

A GOCE only gravity model GOSG01S and the validation of GOCE related satellite gravity models

We compile the GOCE-only satellite model GOSG01S complete to spherical harmonic degree of 220 using Satellite Gravity Gradiometry （SGG） data and the Satellite-to-Satellite Tracking （SST） observations along the GOCE orbit based on applying a least-squares analysis. The diagonal components （Vxx, Vyy, Vzz） of the gravitational gradient tensor are used to form the system of observation equations with the band-pass ARMA filter. The point-wise acceleration observations （ax, ay, az） along the orbit are used to form the system of observation equations up to the maximum spherical harmonic degree/order 130. The analysis of spectral accuracy characteristics of the newly derived gravitational model GOSG01S and the existing models GOTIM04S, GODIR04S, GOSPW04S and JYY_GOCE02S based on their comparison with the ultrahigh degree model EIGEN-6C2 reveals a significant consistency at the spectral window approximately between 80 and 190 due to the same period SGG data used to compile these models. The GOCE related satellite gravity models GOSG01S, GOTIM05S, GODIR05S, GOTIM04S, GODIR04S, GOSPW04S, JYY_- GOCE02S, EIGEN-6C2 and EGM2008 are also validated by using GPS-leveling data in China and USA. According to the truncation at degree 200, the statistic results show that all GGMs have very similar differences at GPS-leveling points in USA, and all GOCE related gravity models have better performance than EGM2008 in China. This suggests that all these models provide much more information on the gravity field than EGM2008 in areas with low terrestrial gravity coverage. And STDs of height anomaly differences in China for the selected truncation degrees show that GOCE has improved the accuracy of the global models beyond degree 90 and the accuracies of the models improve from 24 cm to 16 cm. STDs of geoid height differences in USA show that GOSG01S model has best consistency comparing with GPSleveling data for the frequency band of the degree between 20 and 160.

Review of the Research Progress on Static Earth Gravity Field and Vertical Datum in China during 2019—2023

The contribution presents the representative research progress on global static gravity field modeling,regional geoid/quasigeoid determination,vertical datum study,as well as the theory,algorithm and software for gravity field study in China from 2019 to 2023,which are the highlights of the chapter 6“Progress in Earth Gravity Model and Vertical Datum”in the“2019—2023 China National Report on Geodesy”that submitted to the International Association of Geodesy(IAG).In addition,suggestions are proposed to promote the research in the fields of earth gravity field,geoid/quasigeoid and vertical datumin China according to trends of international geodesy and related disciplines.

Hawk‐eye‐inspired perception algorithm of stereo vision for obtaining orchard 3D point cloud navigation map

The binocular stereo vision is the lowest cost sensor for obtaining 3D information.Considering the weakness of long‐distance measurement and stability,the improvement of accuracy and stability of stereo vision is urgently required for application of precision agriculture.To address the challenges of stereo vision long‐distance measurement and stable perception without hardware upgrade,inspired by hawk eyes,higher resolution perception and the adaptive HDR(High Dynamic Range)were introduced in this paper.Simulating the function from physiological structure of‘deep fovea’and‘shallow fovea’of hawk eye,the higher resolution reconstruction method in this paper was aimed at ac-curacy improving.Inspired by adjustment of pupils,the adaptive HDR method was proposed for high dynamic range optimisation and stable perception.In various light conditions,compared with default stereo vision,the accuracy of proposed algorithm was improved by 28.0%evaluated by error ratio,and the stability was improved by 26.56%by disparity accuracy.For fixed distance measurement,the maximum improvement was 78.6%by standard deviation.Based on the hawk‐eye‐inspired perception algorithm,the point cloud of orchard was improved both in quality and quantity.The hawk‐eye‐inspired perception algorithm contributed great advance in binocular 3D point cloud recon-struction in orchard navigation map.

Simulation of earth gravity field using satellite constellation with variable inclination configuration

Based on a satellite constellation composed of two GRACE-type satellite formations with different inclinations(near polar orbit + low inclination) and the theory of repeat orbit cycle, we discuss the methods for selecting medium-low inclinations for global and local gravity fields. The effects of this constellation configuration on gravity field inversion are comparatively analyzed using a whole-course dynamics simulation. The results show that compared with the single GRACE-type satellite formation,the use of satellite constellations with different inclination configurations improves the gravity solution precision by 34%. The inclusion of multi-directional observations can improve the spatio-temporal resolution of the satellite missions, and yield gravity field solutions with higher isotropic sensitivity.Furthermore, it is necessary to select the optimal low inclination according to the study area, which will have a significant influence on the gravity field solution.

Effect of propofol on local field potential in rat prefrontal cortex during working memory task

Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat’s prefrontal cortex during working memory task was evaluated. Young (approximately 3 month) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg/Kg·min intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p 0.05). Our results suggest that propofol can impair cross-correlation coherence of LFPs in the first two days, but not long time.

Chinese High School Students' Global Competence: Development and Assessment

With the advancement of globalization and digital technology,students'ability to live in an interconnected world has become increasingly important.Global competence has gradually become an important indicator for assessing students'progress.In the study of global competence,Western countries took the lead,followed by China.China has gradually transitioned from learning from the ideas of other countries to the construction of global competence education with Chinese characteristics,demonstrating a catch-up trend.So,based on the PISA Global Competence Framework,this paper aims to interpret what global competence is,how to develop students'global competence in the context of Chinese school practices,and how to assess students'global competence using the PISA 2018 Global Competence Framework.As a result,it can substantially improve global competency research and development.

High-contrast imaging based on wavefront shaping to improve low signal-to-noise ratio photoacoustic signals using superpixel method

Photoacoustic(PA) imaging has drawn tremendous research interest for various applications in biomedicine and experienced exponential growth over the past decade. Since the scattering effect of biological tissue on ultrasound is two-to three-orders magnitude weaker than that of light, photoacoustic imaging can effectively improve the imaging depth.However, as the depth of imaging further increases, the incident light is seriously affected by scattering that the generated photoacoustic signal is very weak and the signal-to-noise ratio(SNR) is quite low. Low SNR signals can reduce imaging quality and even cause imaging failure. In this paper, we proposed a new wavefront shaping and imaging method of low SNR photoacoustic signal using digital micromirror device(DMD) based superpixel method. We combined the superpixel method with DMD to modulate the phase and amplitude of the incident light, and the genetic algorithm(GA) was used as the wavefront shaping algorithm. The enhancement of the photoacoustic signal reached 10.46. Then we performed scanning imaging by moving the absorber with the translation stage. A clear image with contrast of 8.57 was obtained while imaging with original photoacoustic signals could not be achieved. The proposed method opens new perspectives for imaging with weak photoacoustic signals.

Flutter Suppression of Long-Span Bridges Using Suboptimal Control

Based on the Theodorsen’s Theory of the aerodynamic forces on wing-aileron, the Scanlan’s Theory is expanded considering a deck-flap system. It is suggested that a new forced vibration method can acquire aerodynamic derivatives of this deck-flap system theoretically. After obtaining the wind induced forces, a deck-flap equation of motion in time domain is established to investigate its control law. Numerical simulation results indicate suboptimal control law of the deck-flap system can suppress the flutter effectively, and the flutter speed can be increased for desirable purpose.

Effects of Anesthesia on Effective Connectivity in the Brain

The brain constitutes a formidably complicated structural network. There are three main types of connectivity used to describe neuronal networks, which reflect three parallel levels of investigation: anatomical connectivity, functional connectivity and effective connectivity. Effective connectivity indicates the direct influence that a node exerts on another, and in the context of neuronal?circuits, a causal relationship between the activities of two nodes. Since its definition, effective?connectivity analysis has been used to describe causal relationship across multiple spatial scales in?PET imaging, fMRI, electroencephalography (EEG) and magnetoencephalography (MEG), single-unit, and local field potential. There are diverse literatures which probe the anesthetized state?using effective connectivity analysis over the past two decades. The examination of effective connectivity in the anesthetized state is of relevance to both anesthesiologists and neuroscientists, as it has the potential to elucidate still unclear mechanisms of anesthesia while offering insight into intrinsic functional activity in the brain. The present review attempts to examine, elucidate, and integrate the insight that effective connectivity analysis of the anesthetized state has generated thus far.

国家社科基金项目可视化研究报告

国家社科基金项目设置于1986年,是我国目前唯一的国家级哲学、社会科学和人文科学研究项目。作为我国层次最高的社会科学研究项目,极大地激励了各学科开展创新性研究活动,具有非常重要的示范、导向作用1。国家社科基金出版项目领域相关课题作为国家规划学科发展路径的学术性表达,其研究产出成果。

Perception of ChatGPT among Chinese Experts: A Thematic Analysis of a Semi-structured Interview

ChatGPT,as an emergent technique,has become a heat throughout the world.Currently,it was not known entirely to the public.To gain knowledge of how experts perceive and experience ChatGPT,a semi-structured interview was conducted.By doing thematic analysis of their interview reports,it found that the experts construed the chatbot not the same as some media advertised.They didn’t regard it as a threat to their occupation,but as a helper or an assistant both in life and work.Neither did they restrict its use in education or other fields.They viewed the challenges of ChatGPT in a welcomed and positive way.

免疫“分子机器”的金属干预

免疫“分子机器”的识别与调控是免疫系统有序工作的关键.金属元素作为机体必需的营养物质,具有独特的化学性质,可以通过不同机制广泛地影响和干预免疫“分子机器”.本文站在细胞内、外不同的免疫“分子机器”的角度,总结了金属对免疫“分子机器”的直接干预和间接影响,阐释了不同免疫“分子机器”中金属元素的重要作用,提出了目前相关研究的不足及其历史成因.最后,本文通过分析金属干预的化学特性,提出要结合近年来新兴的研究手段从全局性、特异性和可变性等方面进行研究,为免疫“分子机器”的金属靶向干预提供了新的见解.

Fe_(3)O_(4)@SiO_(2)-Protein A-oHSV/CD63 Ab for Capturing Virus and Exosomes

Protein A modified magnetic spheres(Fe_(3)O_(4)@SiO_(2)-Protein A)with 22.7 emu/g saturation magnetization were prepared and characterized.These spheres had a diameter of 10 nm and was stable up to 229.2℃,and can bond 19.694 mg/g of Protein A.The Fe_(3)O_(4)@SiO_(2)-Protein A was firstly combined with oHSV-BJ-2-A antibody to capture oHSV from disease venom,and the amount of binding virus was 1.92×10^(7)to 3.44×10^(7)PFU/g.Fe_(3)O_(4)@SiO_(2)-Protein A was modified with CD63 antibody,which was further fixed using dissuccinimide octylate(DSS)as a crosslinking agent.The prepared Fe_(3)O_(4)@SiO_(2)-Protein A-CD63 Ab was useful in isolating and enriching exosomes from cell supernatant.Compared with commercial kits,Fe_(3)O_(4)@SiO_(2)-Protein A-CD63 Ab demonstrated a better purification effect,which was successfully monitored using capillary electrophoresis.The total content of exosomes protein extracted using Fe_(3)O_(4)@SiO_(2)-Protein A-CD63 was 3.4 mg/g,which was obviously higher than that reported in some studies.In addition,Fe_(3)O_(4)@SiO_(2)-Protein A-CD63 Ab also showed its repeatability through bonding and elution of 5 cycles,which was effective in cost saving.These indicated Fe_(3)O_(4)@SiO_(2)-Protein A-CD63 Ab had the potential for large-scale purification of exosomes in practical applications.

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.

Enhancing strength-ductility synergy in a Mg-Gd-Y-Zr alloy at sub-zero temperatures via high dislocation density and shearable precipitates

The strength-ductility trade-offdilemma is hard to be evaded in high-strength Mg alloys at sub-zero temperatures,especially in the Mg alloys containing a high volume fraction of precipitates.In this paper,we report an enhanced strength-ductility synergy at sub-zero temperatures in an aged Mg-7.37Gd-3.1Y-0.27Zr alloy.The tensile stress-strain curves at room temperature(RT),−70℃ and−196℃ show that the strength increases monotonically with decreasing temperature,but the elongation increases first from RT to−70℃ then declines from−70℃ to−196℃.After systematic investigation of the microstructure evolutions at different deformation temperatures via synchrotron X-ray diffraction,electron backscattered diffraction(EBSD)and transmission electron microscopy(TEM),it is found that a high dislocation density with sufficient<c+a>dislocations promotes good tensile ductility at−70℃,which is attributed to the minimized critical resolved shear stress(CRSS)ratio of non-basal<c+a>to basaldislocations.In ad-dition,more shearable precipitates can further improve the ductility via lengthening the mean free path of dislocation glide.The present work demonstrates that an excellent strength-ductility synergy at sub-zero temperatures can be achieved by introducing a high dislocation density and shearable precipitates in high-strength Mg alloys.