BACKGROUND Intramural pregnancy is a rare type of ectopic pregnancy,which is diagnosed by transvaginal ultrasound and magnetic resonance imaging.Management strategies vary depending on the site of the pregnancy,the ge...BACKGROUND Intramural pregnancy is a rare type of ectopic pregnancy,which is diagnosed by transvaginal ultrasound and magnetic resonance imaging.Management strategies vary depending on the site of the pregnancy,the gestational age and the desire to maintain fertility.The incidence of intramural pregnancy in assisted reproductive technology is higher than that in natural pregnancy.CASE SUMMARY We present a case of intramural pregnancy after in vitro fertilization and elective single embryo transfer following salpingectomy.The patient was completely asymptomatic and her serumβ-human chorionic gonadotropin level increased from 290 m IU/m L to 1759 m IU/m L.Three-dimensional transvaginal ultrasound indicated a heterogeneous echogenic mass arising from the uterine fundus which was surrounded by myometrium and a slender and extremely hypoechoic area stretching to the uterine cavity which was thought to be a fistulous tract.Therefore,we considered a diagnosis of intramural pregnancy and laparoscopic surgery was conducted at 7 wk gestation.CONCLUSION Early diagnosis and treatment of intramural pregnancy is significant for maintaining fertility.展开更多
Long noncoding RNAs(lncRNAs)are transcribed by RNA molecules,which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.Studies have show...Long noncoding RNAs(lncRNAs)are transcribed by RNA molecules,which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.Studies have shown that lncRNAs participate in many physiological processes such as gene imprinting and X chromosome inactivation.They regulate gene expression mainly through DNA methylation,histone modification,and chromatin remodeling.LncRNAs can also affect the development of diseases,and they can be useful to diagnose and treat diseases.With the development of new sequencing and microarray techniques,hundreds of lncRNAs involved in spermatogenesis have been identified,but their functions in the testis are undefined.Herein,we will discuss the biology and regulation of lncRNAs,as well as the bioinformatics tools and searchable databases used to study them in the testis.We hope that this information will provide new insights in treating male reproductive diseases.展开更多
基金Supported by National Natural Science Foundation of China,No. 81971386 and No. 81871210
文摘BACKGROUND Intramural pregnancy is a rare type of ectopic pregnancy,which is diagnosed by transvaginal ultrasound and magnetic resonance imaging.Management strategies vary depending on the site of the pregnancy,the gestational age and the desire to maintain fertility.The incidence of intramural pregnancy in assisted reproductive technology is higher than that in natural pregnancy.CASE SUMMARY We present a case of intramural pregnancy after in vitro fertilization and elective single embryo transfer following salpingectomy.The patient was completely asymptomatic and her serumβ-human chorionic gonadotropin level increased from 290 m IU/m L to 1759 m IU/m L.Three-dimensional transvaginal ultrasound indicated a heterogeneous echogenic mass arising from the uterine fundus which was surrounded by myometrium and a slender and extremely hypoechoic area stretching to the uterine cavity which was thought to be a fistulous tract.Therefore,we considered a diagnosis of intramural pregnancy and laparoscopic surgery was conducted at 7 wk gestation.CONCLUSION Early diagnosis and treatment of intramural pregnancy is significant for maintaining fertility.
文摘Long noncoding RNAs(lncRNAs)are transcribed by RNA molecules,which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.Studies have shown that lncRNAs participate in many physiological processes such as gene imprinting and X chromosome inactivation.They regulate gene expression mainly through DNA methylation,histone modification,and chromatin remodeling.LncRNAs can also affect the development of diseases,and they can be useful to diagnose and treat diseases.With the development of new sequencing and microarray techniques,hundreds of lncRNAs involved in spermatogenesis have been identified,but their functions in the testis are undefined.Herein,we will discuss the biology and regulation of lncRNAs,as well as the bioinformatics tools and searchable databases used to study them in the testis.We hope that this information will provide new insights in treating male reproductive diseases.
