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更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎的系统评价 被引量:18
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作者 张琇雯 李玲 +1 位作者 卜凤娇 陈念祖 《国际眼科杂志》 CAS 北大核心 2018年第7期1206-1210,共5页
目的:评价更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎的安全性和有效性。方法:分别在中国期刊全文数据库、维普数据库和万方数据库等中文数据库和Pub Med、Cochrane Library、EMbase等外文数据库上检索所有更昔洛韦联合中药治疗单纯疱... 目的:评价更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎的安全性和有效性。方法:分别在中国期刊全文数据库、维普数据库和万方数据库等中文数据库和Pub Med、Cochrane Library、EMbase等外文数据库上检索所有更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎的随机对照试验,以临床治疗总有效率、复发率、治愈时间和不良反应发生率作为结局指标评价药物的有效性和安全性。采用改良Jadad评分量表评价纳入研究的质量;使用Rev Man5.3和Stata 12.0软件进行Meta分析。结果:共纳入15篇文献,包括1 285例单纯疱疹病毒性角膜炎患者。Meta分析结果:更昔洛韦联合中药治疗组在总有效率[患者例数:RR=1.23,95%CI(1.15~1.31);患者眼数:RR=1.18,95%CI(1.02~1.38)]、复发率[RR=0.25,95%CI(0.17~0.36)]和治愈时间[MD=-7.58,95%CI(-10.89~-4.26)]方面优于更昔洛韦组,差异有统计学意义(P<0.05)。联合治疗组不良反应发生率与对照组比较,差异无统计学意义[RR=0.53,95%CI(0.23~1.22)]。两组患者的不良反应均较轻微,且能够自行缓解。结论:更昔洛韦联合中药治疗单纯疱疹病毒性角膜炎能够提高疗效,减少复发,缩短疗程,且安全性好。 展开更多
关键词 更昔洛韦 中药 单纯疱疹病毒性角膜炎 系统评价
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Geochemical records of the sediments and their significance in Dongping Lake Area,the lower reach of Yellow River,North China 被引量:3
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作者 Lin-song Yu Hong-bo Liu +3 位作者 Fang Wan Zun-fang Hu Huai-dong Luo xiu-wen zhang 《Journal of Groundwater Science and Engineering》 2021年第2期140-151,共12页
Dongping Lake area,located in the lower reaches of Yellow River,is an ideal place to study the changes of modern river and lake sedimentary environment.The sediment samples of Dawen River,Yellow River,and Dongping Lak... Dongping Lake area,located in the lower reaches of Yellow River,is an ideal place to study the changes of modern river and lake sedimentary environment.The sediment samples of Dawen River,Yellow River,and Dongping Lake were collected,and the major elements,trace elements and organic matter geochemical composition of the samples were analyzed.Cluster analysis,characteristic element ratio method and graphic method were used to explore the geochemical characteristics of sediments and their environmental implication.The results show that the contents of SiO_(2),Na_(2)O,TiO_(2) and Zr in sediments of Dawen River and Yellow River are relatively high,and the contents of iron and manganese oxides,organic matter,CaO,P2O5 and Sr in lake sediments are relatively high.That reveals the differences of sedimentary environments between the rivers and the lake.The contents of Sr and Zr in Dawen River are affected by the rapid migration of clastic materials in the upstream carbonate source area during the flood season;the δCe,ΣREE and REE’s ratios in the sediments of the Yellow River reflect the influence of the Loess source;and the distribution of elements changes along the flow direction during the flood season.The characteristics of pH,element composition and LREE&HREE fractionation of the lake sediments indicate that the sediment source is complex,and the lake environment is affected by the flood season.The study shows that the geochemical content and its variation characteristics of sediments effectively reveal the sedimentary environment,material composition and characteristics of flood season of rivers and the lake in the study area. 展开更多
关键词 Dongping Lake Yellow River SEDIMENTS Organic matter Element geochemistry
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Characterizing the Molecular Abnormalities in Rare De Novo Ph^+ Acute Myeloid Leukemia
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作者 Hong-Ying Chao Guang-Ying Sheng +8 位作者 xiu-wen zhang Min Zhou Hong-Jie Shen Su-Ning Chen Jian-Nong Cen Yi-Wu Sun Tao Chen Xu-zhang Lu Ri zhang 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第10期1246-1248,共3页
To the Editor:The t(9;22)(q34;q 11) (Philadelphia chromosome [Ph]) balanced translocation results in fusion of the BCR gene at 22q11 with cytoplasmic tyrosine kinase gene ABL1 and plays an essential role in leu... To the Editor:The t(9;22)(q34;q 11) (Philadelphia chromosome [Ph]) balanced translocation results in fusion of the BCR gene at 22q11 with cytoplasmic tyrosine kinase gene ABL1 and plays an essential role in leukemic transformation.The Ph is an infrequent finding in de novo acute myeloid leukemia (AML),approximately 0.5-3% of newly diagnosed patients. The World Health Organization (WHO) recently released a revised version of the Classification of Hematopoietic and Lymphoid Malignancies,a new provisional category of AM L with BCR-ABL1 was added to recognize these rare Ph AML cases that could benefit from tyrosine-kinase inhibitor (TKI) therapy. It is required to enlarge the sample size and research the molecular or genomic features to increase the argument in favor ofPh AML as a real entity. 展开更多
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