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Acute liver failure with thrombotic microangiopathy due to sodium valproate toxicity:A case report 被引量:2
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作者 xuan mei Hai-Cong Wu +1 位作者 mei Ruan Li-Rong Cai 《World Journal of Clinical Cases》 SCIE 2021年第17期4310-4317,共8页
BACKGROUND Sodium valproate is widely used in the treatment of epilepsy in clinical practice.Most adverse reactions to sodium valproate are mild and reversible,while serious idiosyncratic side effects are becoming app... BACKGROUND Sodium valproate is widely used in the treatment of epilepsy in clinical practice.Most adverse reactions to sodium valproate are mild and reversible,while serious idiosyncratic side effects are becoming apparent,particularly hepatotoxicity.Herein,we report a case of fatal acute liver failure(ALF)with thrombotic microangiopathy(TMA)caused by treatment with sodium valproate in a patient following surgery for meningioma.CASE SUMMARY A 42-year-old man who received antiepileptic treatment with sodium valproate after surgery for meningioma exhibited extreme fatigue,severe jaundice accompanied by oliguria,soy sauce-colored urine,and ecchymosis.His postoperative laboratory values indicated a rapid decreased platelet count and hemoglobin level,severe liver and kidney dysfunction,and disturbance of the coagulation system.He was diagnosed with drug-induced liver failure combined with TMA.After plasma exchange combined with hemoperfusion,pulse therapy with high-dose methylprednisolone,and blood transfusion,his liver function deteriorated,and finally,he died.CONCLUSION ALF with TMA is a rare and fatal adverse reaction of sodium valproate which needs to be highly valued. 展开更多
关键词 Sodium valproate Drug-induced liver injury Thrombotic microangiopathy Plasma exchange Organ transplantation Case report
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An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats
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作者 Jialu Yao Junlang Li +12 位作者 Dashuai Zhu Yuan Li Panagiotis Tasoudis Shuo Liu xuan mei Kristen Popowski Thomas G.Caranasos Haipeng Wang Mingzhu Xu Tingbo Jiang Kan Shen Hongxia Li Ke Huang 《Bioactive Materials》 SCIE CSCD 2024年第10期571-581,共11页
Chemotherapy-induced cardiotoxicity with subsequent heart failure(HF)is a major cause of morbidity and mortality in cancer survivors worldwide.Chemotherapy-induced HF is exceptionally challenging as it generally manif... Chemotherapy-induced cardiotoxicity with subsequent heart failure(HF)is a major cause of morbidity and mortality in cancer survivors worldwide.Chemotherapy-induced HF is exceptionally challenging as it generally manifests in patients who are typically not eligible for left ventricular device implantation or heart transplantation.To explore alternative treatment strategies for cancer survivors suffering from chemotherapy-induced HF,we developed a minimally invasive infusible cardiac stromal cell secretomes adhesive(MISA)that could be delivered locally through an endoscope-guided intrapericardial injection.To mimic the typical clinical presentation of chemotherapy-induced HF in elder patients,we established an aged rat model in which restrictive cardiomyopathy with sequential HF was induced via consecutive doxorubicin injections.In vitro,we prove that MISA not only enhanced cardiomyocytes proliferation potency and viability,but also inhibited their apoptosis.In vivo,we prove that MISA improved the ventricular contractility indexes and led to beneficial effects on histological and structural features of restrictive cardiomyopathy via promoting cardiomyocyte proliferation,angiogenesis,and mitochondrial respiration.Additionally,we also evaluated the safety and feasibility of MISA intrapericardial delivery in a healthy porcine model with an intact immune system.In general,our data indicates that MISA has a strong potential for translation into large animal models and ultimately clinical applications for chemotherapy-induced HF prior to the final option of heart transplantation. 展开更多
关键词 Secretomes Cardiac stromal cells Extracellular matrix Chemotherapy Heart failure Intrapericardial injection
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肥东地区职工职业健康体检心电图结果分析
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作者 宣梅 金声 +2 位作者 郑文劢 李亮亮 陈晓明 《华南预防医学》 2024年第6期506-510,共5页
目的 分析职工职业健康体检心电图结果并探讨心电图异常的相关因素,为开展心血管疾病预防提供依据。方法 采用方便抽样法选择2022年1—12月在肥东县1家二级医院(肥东县中医院)和1家三级医院(肥东县人民医院)进行健康体检的职工作为调查... 目的 分析职工职业健康体检心电图结果并探讨心电图异常的相关因素,为开展心血管疾病预防提供依据。方法 采用方便抽样法选择2022年1—12月在肥东县1家二级医院(肥东县中医院)和1家三级医院(肥东县人民医院)进行健康体检的职工作为调查对象,收集调查对象的心电图检查报告、体检结果、实验室指标,同时进行问卷调查,采用描述性分析方法对该人群心电图异常情况进行分析,并采用单、多因素分析方法对异常检出的相关因素进行分析。结果 参与本研究者共10 828人,其中男性5 848人,占54.01%,女性4 980人,占45.99%。共收集心电图10 828份,检出异常心电图1 458份,检出率为13.47%。单因素结果显示,年龄、医院等级、吸烟、酗酒、高血压、高血糖、高血脂、BMI、健康饮食、运动情况、工作年限、工作时间、工作应激与职工心电图异常有关(均P<0.01);多因素logistic回归分析结果显示,年龄(50~60岁OR=4.604)、吸烟(OR=4.154)、酗酒(OR=3.725)、高血压(OR=2.433)、BMI(超重/肥胖OR=3.747)、运动情况(充足OR=0.232)、工作年限(≥31年OR=6.197)、工作时间(OR=4.595)、工作应激(OR=4.513)均是职工心电图异常检出的相关因素。结论 肥东地区职工异常心电图检出率较高,与年龄、吸烟等因素相关,定期体检和针对性的健康管理对此类人群预防心血管疾病有积极作用。 展开更多
关键词 健康体检 心电图 职工 心律失常 相关因素
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Two-dimensional nanomaterials: fascinating materials in biomedical field 被引量:15
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作者 Tingting Hu xuan mei +3 位作者 Yingjie Wang Xisheng Weng Ruizheng Liang Min Wei 《Science Bulletin》 SCIE EI CAS CSCD 2019年第22期1707-1727,共21页
Due to their high anisotropy and chemical functions,two-dimensional(2D)nanomaterials have attracted increasing interest and attention from various scientific fields,including functional electronics,catalysis,supercapa... Due to their high anisotropy and chemical functions,two-dimensional(2D)nanomaterials have attracted increasing interest and attention from various scientific fields,including functional electronics,catalysis,supercapacitors,batteries and energy materials.In the biomedical field,2D nanomaterials have made significant contributions to the field of nanomedicine,especially in drug/gene delivery systems,multimodal imaging,biosensing,antimicrobial agents and tissue engineering.2D nanomaterials such as graphene/graphene oxide(GO)/reduced graphene oxide(r GO),silicate clays,layered double hydroxides(LDHs),transition metal dichalcogenides(TMDs),transition metal oxides(TMOs),black phosphorus(BP),graphitic carbon nitride(g-C3N4),hexagonal boron nitride(h-BN),antimonene(AM),boron nanosheets(B NSs)and tin telluride nanosheets(Sn Te NSs)possess excellent physical,chemical,optical and biological properties due to their uniform shapes,high surface-to-volume ratios and surface charge.In this review,we first introduce the properties,structures and synthetic strategies of different configurations of 2D nanomaterials.Recent advances and paradigms of 2D nanomaterials in a variety of biomedical applications,ranging from drug delivery,cancer treatment,bioimaging and tissue engineering to biosensing are discussed afterwards.In the final part,we foresee the development prospects and challenges of 2D nanomaterials after summarizing the research status of ultrathin 2D nanomaterials. 展开更多
关键词 2D NANOMATERIALS DRUG delivery TISSUE engineering BIOSENSING
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Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy 被引量:11
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作者 Sichen Zhang Dashuai Zhu +6 位作者 xuan mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng 《Bioactive Materials》 SCIE 2021年第7期1957-1972,共16页
Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms resu... Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. 展开更多
关键词 Stem cells Primary ovarian insufficiency Cell therapy BIOMATERIALS
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Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs 被引量:2
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作者 xuan mei Simin Xu +6 位作者 Tongyang Hu Liuqi Peng Rui Gao Ruizheng Liang Min Wei David G. Evans Xue Duan 《Nano Research》 SCIE EI CAS CSCD 2018年第1期195-205,共11页
Two-dimensional (2D) nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double ... Two-dimensional (2D) nanomaterials have gained tremendous attention in the field of biomedicine because of their high specific surface areas and fascinating physicochemical properties. Herein, 2D monolayered double hydroxide (MLDH) nanosheets were employed to localize doxorubicin (DOX), an anticancer drug, with a loading capacity of as high as 3.6 mg.mg-1 (w/w). Structural characterizations and theoretical calculations indicate that the DOX molecule is uniformly arranged and oriented at the surface of the MLDHs with a binding energy of 15.90 eV, showing significant electrostatic interaction. With the assistance of the targeting agent folic acid (FA), DOX-FA/MLDHs demonstrate targeted cellular uptake and superior anticancer behavior based on in vitro tests performed with cancer cells. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy. 展开更多
关键词 TWO-DIMENSIONAL NANOMATERIALS MONOLAYER layered double hydroxide(LDH) drug loading controllable release
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A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse 被引量:2
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作者 Mengjie Xie Junlang Li +7 位作者 Sichen Zhang Dashuai Zhu xuan mei Zhenzhen Wang Xiao Cheng Zhenhua Li Shaowei Wang Ke Cheng 《Bioactive Materials》 SCIE 2021年第6期1777-1788,共12页
Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding phar... Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience,and hardbor safety and hygiene.In this study,we fabricated a carbomer-based contraceptive gel consisting of three agents:tenofovir,gossypol acetate,and nitroglycerin(TGN),with pH adjusted to 4.5(to be compatible with the vagina).In vitro,the gossypol component of the contraceptive gel proved to be an effective spermicide.When the concentration of gossypol acetate was 10 mg/ml,the spermicidal ability reached 100%after 30 s.In addition,tenofovir in the gel significantly inhibited lentiviral transfection efficiency in cell-containing media.In 6 pairs of rats,the gel successfully prevented all females from conceiving after successful mating.Moreover,increased sexual frequency and enhanced erection,which were promoted by the nitroglycerin in the components,were observed in male rats that had the gel applied to their penises.This novel TGN contraceptive gel yielded a higher contraceptive success rate than that of the commercial contraceptive gel(Contragel®).In addition,it has the added benefits to prevent sexually transmitted diseases and improve male libido and erectile function during sexual intercourse.Combining three FDA-approved and marketed agents together,our trifunctional TGN gel has a great potential for further translation and commercialization. 展开更多
关键词 CONTRACEPTIVE HYDROGEL ANTI-VIRAL LIBIDO Erectile function
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