Study on Characteristics of a High-Precision Cold Gas Micro Thruster

In order to improve the reliability of the spacecraft micro cold gas propulsion system and realize the precise control of the spacecraft attitude and orbit, a micro-thrust, high-precision cold gas thruster is carried out, at the same time due to the design requirements of the spacecraft, this micro-thrust should be continuous working more than 60 minutes, the traditional solenoid valve used for the thrusts can’t complete the mission, so a long-life micro latching valve is developed as the control valve for this micro thruster, because the micro latching valve can keep its position when it cuts off the outage. Firstly, the authors introduced the design scheme and idea of the thruster. Secondly, the performance of the latching valve and the flow characteristics of the nozzle were simulated. Finally, from the experimental results and compared with the numerical study, it shows that the long-life micro cold gas thruster developed in this paper meets the mission requirements.

COL4A2 enhances thyroid cancer cell proliferation through the AKT pathway

Objectives:Thyroid cancer(THCA)is the most common malignant tumor in endocrine system and the incidence has been increasing worldwide.And the number of patients dying from THCA has also gradually risen because the incidence continues to increase,so the mechanisms related to effective targets is necessary to improve the survival.This study was to preliminarily investigate the effects of the COL4A2 gene on the regulation of thyroid cancer(THCA)cell proliferation and the associated pathways.Methods:Bioinformatics analysis revealed that COL4A2 was closely associated with cancer development.COL4A2 expression in THCA tissues was analyzed using immunohistochemistry,and survival information was determined via Kaplan-Meier curves.The expression of COL4A2 and AKT pathway-related genes were analyzed using qPCR and western blot analyses.Colony formation as well as CCK-8 assays exhibited the cell proliferation level and cell activity,respectively.Downstream of COL4A2 was identified by Gene set enrichment analysis(GSEA).The effects of the COL4A2 and AKT pathways on THCA tumor growth in vivo were determined using a mouse model.Results:Bioinformatics analysis exhibited that COL4A2 plays a significant role in cancer and that the AKT pathway is downstream of COL4A2.THCA patients with high COL4A2 expression had shorter recurrence-free survival.Upregulation of COL4A2 gene expression in 2 THCA cell lines promoted tumor cell growth and activity.The use of AKT pathway blockers also restrained the growth and activity of the 2 THCA cell lines.The use of AKT pathway blockers reduced tumor volume and mass and prolonged mouse survival.Conclusions:COL4A2 can promote the growth as well as development of THCA through the AKT pathway and COL4A2 could be used as a target for THCA.

Economic Analysis and Research of New Energy Vehicle Promotion Model

New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating excessive exploitation of oil resources,a stance strongly supported by governments.However,new energy vehicles possess certain drawbacks in terms of price and usability compared to traditional counterparts.Therefore,external support is imperative for their development.This paper delineates four main sections:the background of new energy vehicle promotion and application,a comparative analysis of domestic and foreign promotion models,specific promotion suggestions,and future development prospects.By leveraging insights from economic analysis,the optimal promotion model for new energy vehicles is elucidated.

Corrosion resistance and electrical conductivity of V/Ce conversion coating on magnesium alloy AZ31B

A V/Ce conversion coating was deposited in the surface of AZ31B magnesium alloy in a solution containing vanadate and cerium nitrate.The coating composition and morphology were examined.The conversion coating appears to consist of a thin and cracked coating with a scattering of spherical particles.The corrosion behavior of the substrate and conversion coating was studied by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS).Compared with AZ31B magnesium alloy,the corrosion current density of the conversion coating is decreased by two orders of magnitude.The total impedance of the V/Ce conversion coating rise to 1.6×10^(3)Ω·cm^(2)in contrast with2.2×10^(2)Ω·cm^(2)of the bare AZ31B.In addition,the electrical conductivity of the coating was assessed by conductivity meter and Mott-Schottky measurement.The results reveal a high dependence of the conductivity of the coating on the semiconductor properties of the phase compositions.

Cognitive Granular-Based Path Planning and Tracking for Intelligent Vehicle with Multi-Segment Bezier Curve Stitching

Unmanned vehicles are currently facing many difficulties and challenges in improving safety performance when running in complex urban road traffic environments,such as low intelligence and poor comfort perfor-mance in the driving process.The real-time performance of vehicles and the comfort requirements of passengers in path planning and tracking control of unmanned vehicles have attracted more and more attentions.In this paper,in order to improve the real-time performance of the autonomous vehicle planning module and the comfort requirements of passengers that a local granular-based path planning method and tracking control based on multi-segment Bezier curve splicing and model predictive control theory are pro-posed.Especially,the maximum trajectory curvature satisfying ride comfort is regarded as an important constraint condition,and the corresponding curvature threshold is utilized to calculate the control points of Bezier curve.By using low-order interpolation curve splicing,the planning computation is reduced,and the real-time performance of planning is improved,com-pared with one-segment curve fitting method.Furthermore,the comfort performance of the planned path is reflected intuitively by the curvature information of the path.Finally,the effectiveness of the proposed control method is verified by the co-simulation platform built by MATLAB/Simulink and Carsim.The simulation results show that the path tracking effect of multi-segment Bezier curve fitting is better than that of high-order curve planning in terms of real-time performance and comfort.

Sodium dodecyl sulfate (SDS) as an effective corrosion inhibitor for Mg-8Li-3Al alloy in aqueous NaCl: A combined experimental and theoretical investigation

The corrosion inhibition behavior of Mg-8Li-3Al alloy in NaCl solution with sodium dodecyl sulfate(SDS)was investigated by hydrogen analysis,scanning electron microscopy(SEM),electrochemical test,scanning Kelvin probe force microscopy(SKPFM)and computational methods.Results showed that the corrosion resistance of Mg-8Li-3Al alloy in NaCl solution was effectively improved with SDS.The SEM and SKPFM results confirmed a dense,200 nm-thick SDS-adsorbed layer had formed on the alloy surface.The separation energy ΔE_(gap) and adsorption energy E_(ads) of SDS on the Mg surface were calculated by density functional theory and molecular dynamics simulations,respectively.And the corrosion inhibition mechanism was hypothesized and described.

Controlling factors on the charging process of oil and gas in the eastern main sub-sag of the Baiyun Sag,Zhujiang River(Pearl River)Mouth Basin

The eastern main sub-sag(E-MSS)of the Baiyun Sag was the main zone for gas exploration in the deep-water area of the Zhujiang River(Pearl River)Mouth Basin at its early exploration stage,but the main goal of searching gas in this area was broken through by the successful exploration of the W3-2 and H34B volatile oil reservoirs,which provides a new insight for exploration of the Paleogene oil reservoirs in the E-MSS.Nevertheless,it is not clear on the distribution of“gas accumulated in the upper layer,oil accumulated in the lower layer”(Gas_(upper)-Oil_(lower))under the high heat flow,different source-rock beds,multi-stages of oil and gas charge,and multi-fluid phases,and not yet a definite understanding of the genetic relationship and formation mechanism among volatile oil,light oil and condensate gas reservoirs,and the migration and sequential charge model of oil and gas.These puzzles directly lead to the lack of a clear direction for oil exploration and drilling zone in this area.In this work,the PVT fluid phase,the origin of crude oil and condensate,the secondary alteration of oil and gas reservoirs,the evolution sequence of oil and gas formation,the phase state of oil and gas migration,and the configuration of fault activity were analyzed,which established the migration and accumulation model of Gas_(upper)-Oil_(lower)cocontrolled by source and heat,and fractionation controlled by facies in the E-MSS.Meanwhile,the fractionation evolution model among common black reservoirs,volatile reservoirs,condensate reservoirs and gas reservoirs is discussed,which proposed that the distribution pattern of Gas_(upper)-Oil_(lower)in the E-MSS is controlled by the generation attribute of oil and gas from source rocks,the difference of thermal evolution,and the fractionation controlled by phases after mixing the oil and gas.Overall,we suggest that residual oil reservoirs should be found in the lower strata of the discovered gas reservoirs in the oil-source fault and diapir-developed areas,while volatile oil reservoirs should be found in the deeper strata near the sag with no oil-source fault area.

The Chemical Mechanism of Pestilences or Coronavirus Disease 2019 (COVID-19)

In this paper, the chemical mechanism of the coronavirus disease 2019 (COVID-19) has been explored and clearly revealed.

Collagen type Ⅱ suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction

Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.Collagen type II(COL2A1)was previously considered to be only a structural component of the cartilage matrix,but recently,it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy.However,the mechanisms by which COL2A1 regulates hypertrophic differentiation remain unclear.In our study,a Col2a1 p.Gly1170Ser mutant mouse model was constructed,and Col2a1 loss was demonstrated in homozygotes.Loss of Col2a1 was found to accelerate chondrocyte hypertrophy through the bone morphogenetic protein(BMP)-SMAD1 pathway.Upon interacting with COL2A1,integrinβ1(ITGB1),the major receptor for COL2A1,competed with BMP receptors for binding to SMAD1 and then inhibited SMAD1 activation and nuclear import.COL2A1 could also activate ITGB1-induced ERK1/2 phosphorylation and,through ERK1/2-SMAD1 interaction,it further repressed SMAD1 activation,thus inhibiting BMP-SMAD1-mediated chondrocyte hypertrophy.Moreover,COL2A1 expression was downregulated,while chondrocyte hypertrophic markers and BMP-SMAD1 signaling activity were upregulated in degenerative human articular cartilage.Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression.

甲状腺乳头状癌颈部淋巴结转移的危险因素

目的:探讨甲状腺乳头状癌中央区淋巴结和侧颈淋巴结转移的危险因素。方法:回顾性分析2016年1月至2016年12月于天津医科大学肿瘤医院行甲状腺切除术的1835例术后病理诊断为甲状腺乳头状癌患者的临床病例资料,对可能影响甲状腺乳头状癌淋巴结转移的相关因素进行单因素分析与多因素分析。结果:1835例患者中央区淋巴结转移率为54.88%(1007例),侧颈淋巴结转移率为20.22%(371例)。单因素分析结果提示,男性、年龄<45岁、肿瘤直径>10mm、多灶性、抗甲状腺球蛋白抗体(anti-Tg)>100.00 IU/mL、甲状腺球蛋白抗体(Tg)>130.70μg/L者中央区淋巴结转移率及侧颈淋巴结转移率较高(P<0.05)。抗甲状腺过氧化物酶抗体(anti-TPO)>100.00 IU/mL者中央区淋巴结转移率较低(P<0.05)。此外,中央区淋巴结转移者侧颈淋巴结转移率较高(P<0.05)。多因素分析结果提示,男性、年龄<45岁、肿瘤直径>10mm、多灶性、anti-Tg>100.00IU/mL是中央区淋巴结转移的独立危险因素。anti-TPO>100.00IU/mL是中央区淋巴结转移的保护性因素。男性、年龄<45岁、肿瘤直径>10mm、多灶性、anti-Tg>100.00 IU/mL、Tg>130.70μg/L、中央区淋结转移者是侧颈淋巴结转移的独立危险因素。结论:男性、年龄<45岁、肿瘤直径>10 mm、多灶性、anti-Tg>100.00 IU/mL是中央区淋巴结转移及侧颈淋巴结转移的高危因素;中央区淋巴结转移是侧颈淋巴结转移的危险因素;anti-TPO>100.00 IU/mL是中央区淋巴结转移的保护性因素。

Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp

Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation,and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues.The aim of this study was to investigate the role and the underlying molecular mechanisms of Dlx2 in osteogenic differentiation of mouse bone marrow stromal cells (BMSCs) and pre-osteoblast MC3T3-E1 cells.Initially,we observed upregulation of Dlx2 during the early osteogenesis in BMSCs and MC3T3-E1 cells.Moreover,Dlx2 overexpression enhanced alkaline phosphatase (ALP) activity and extracellular matrix mineralization in BMSCs and MC3T3-E1 cell line.In addition,micro-CT of implanted tissues in nude mice confirmed that Dlx2 overexpression in BMSCs promoted bone formation in vivo.Unexpectedly,Dlx2 overexpression had little impact on the expression level of the pivotal osteogenic transcription factors Runx2,Dlx5,Msx2,and Osterix,but led to upregulation of Alp and Osteocalcin (OCN),both of which play critical roles in promoting osteoblast maturation.Importantly,luciferase analysis showed that Dlx2 overexpression stimulated both OCN and Alp promoter activity.Through chromatin-immunoprecipitation assay and site-directed mutagenesis analysis,we provide molecular evidence that Dlx2 transactivates OCN and Alp expression by directly binding to the Dlx2-response cis-acting elements in the promoter of the two genes.Based on these findings,we demonstrate that Dlx2 overexpression enhances osteogenic differentiation in vitro and accelerates bone formation in vivo via direct upregulation of the OCN and Alp gene,suggesting that Dlx2 plays a crucial role in osteogenic differentiation and bone formation.

Conservation of Jiaohe ancient earthen site in China

Earthen sites, which are mainly made of earth, are cultural heritages with historical, artistic and scientific values. Many extremely valuable earthen sites have been preserved in the arid areas in China. The earthen site of Jiaohe Ancient City is one of the earliest National Protected Important Cultural Heritage Sites. The Jiaohe Ancient City site exhibits all kinds of deteriorations, which can be found in the earthen sites in arid environments in China. Through a case study of the Jiaohe ancient earthen site, we present in this paper the comprehensive conservation technologies, including the mud bricklaying and reparation, wooden rod anchorage, crack grouting, surface potassium silicate （PS） penetration consolidation, and suspended steel beam ceiling, etc. Results of this case study showed that better conservation effects could be achieved by selecting proper PS penetration and crack grouting processes based on the deterioration characteristics of the earthen sites. The technology of mud bricklaying and reparation was also an effective method for preventing the earthen body from collapsing. Compared with traditional conservation technologies, the suspended steel beam ceiling technology could effectively reduce the negative impacts to the original state of the earthen site. As for unstable cliffs, a new method using composite anchor rod of bamboo and steel with massive loose earth was applied. Deformation monitoring and temporary supports were critical and indispensable measures for the safe of site conservation projects. Through years of monitoring and practical operation at the Jiaohe ancient earthen site, deterioration at the site has been effectively controlled.

甲状腺超声智能诊断的现状及研究进展

近几十年在全球范围内甲状腺癌发病率增长迅速。超声检查是甲状腺结节诊断的首选检查手段。作为一项经济、便利且易于推广的检查项目,其对影像学医师的要求较高,需要有丰富的经验。超声检查对甲状腺癌的诊断标准也在不断完善,统一化标准的推广、普及和成熟利用在实施过程中需要大量的人力和财力,目前较难实现。近些年中国医疗卫生资源需求巨大,医疗资源分布欠均衡,临床诊疗中需要全面评估甲状腺结节的恶性风险和颈部淋巴结的性质以进行临床决策,诊断工作繁重复杂。人工智能领域的深度学习算法飞速发展,其在医学图像诊断领域展示出强大的性能,大数据结合深度学习可有效地解决临床诊疗中的问题,深度学习在医疗图像诊断领域、甲状腺结节超声诊断方向显示出较大的优势和应用前景。利用深度学习算法分析超声图像构建超声自动诊断系统,可辅助甲状腺肿瘤超声诊断,简化超声医生的工作流程,有助于提高临床实践效率。本文对近年来深度学习在甲状腺肿瘤及颈部淋巴结超声诊断领域的研究现状和研究进展予以概述。

Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration

Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem,researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous disease microenvironments or involving multiple integrated strategies. Typical external physical triggers include light irradiation, electric and magnetic fields, ultrasound, and mechanical stimuli. These stimuli can transform the internal atomic packing arrangements of materials and affect cell fate, thus enhancing bone tissue therapy and regeneration. In addition to the external stimuli-responsive strategy, some specific pathological microenvironments, such as excess reactive oxygen species and mild acidity in tumors, specific p H reduction and enzymes secreted by bacteria in severe infection, and electronegative potential in bone defect sites, could be used as biochemical triggers to activate bone disease therapy and bone regeneration.Herein, we summarize and discuss the rational construction of versatile biomaterials with bone therapeutic and regenerative functions. The specific mechanisms, clinical applications, and existing limitations of the newly designed biomaterials are also clarified.

Nanoparticle-Decorated Ultrathin La2O3 Nanosheets as an Effcient Electrocatalysis for Oxygen Evolution Reactions

Electrochemical catalysts for oxygen evolution reaction are a critical component for many renewable energy applications. To improve their catalytic kinetics and mass activity are essential for sustainable industrial applications. Here, we report a rare-earth metal-based oxide electrocatalyst comprised of ultrathin amorphous La2O3 nanosheets hybridized with uniform La2O3 nanoparticles(La2O3@NP-NS). Significantly improved OER performance is observed from the nanosheets with a nanometer-scale thickness. The as-synthesized 2.27-nm La2O3@NP-NS exhibits excellent catalytic kinetics with an overpotential of 310 mV at 10 m A cm^-2, a small Tafel slope of 43.1 mV dec^-1, and electrochemical impedance of 38 Ω. More importantly, due to the ultrasmall thickness, its mass activity, and turnover frequency reach as high as 6666.7 A g^-1 and 5.79 s^-1, respectively, at an overpotential of 310 mV. Such a high mass activity is more than three orders of magnitude higher than benchmark OER electrocatalysts, such as IrO2 and RuO2. This work presents a sustainable approach toward the development of highly e cient electrocatalysts with largely reduced mass loading of precious elements.

2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma

The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China,

2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer

In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation.

Soil Contamination with Heavy Metals and Its Impact on Food Security in China

With the rapid economic expansion, environmental degradation has become increasingly sever during the past three decades. Soil pollutions associated with toxic organic compounds and heavy metals have been identified in China. The accumulation of heavy metals in soils and its impact on food safety is of increasing concern. It has been reported that more than 20 million ha of land have been contaminated with heavy metals that can result in the potential health risks to human beings and soil ecosystems. This can potentially jeopardize the food security in China. Accumulation of heavy metals in suburb and rural soils is closely related to many anthropogenic activities, such as application of fertilizers and pesticides, irrigation of wastewater, discharge of mining, improper disposal of metal containing wastes, land application of animal manures, sewage sludge and coal combustion residues. Arable crops and vegetables in suburb and rural can take up heavy metals from contaminated soils, which is one of the main pathways of introducing heavy metals to human food chain. Events related to soil and vegetable contamination, food safety and human health risks, e.g., rice and vegetables with elevated concentrations of cadmium, are often reported in the media in recent years. The Chinese government has recently developed a number of new policies for prevention of soils from further soil contamination, and remediation of contaminated soils. This presentation will provide a comprehensive review on heavy metal pollution in soils and its impacts on food security in China, and also summarize some new technologies for remediation of soils contaminated with heavy metals.

Fatigue Performance of Orthotropic Steel Decks in Super-Wide Steel Box Girder Considering Transverse Distribution of Vehicle Load

This study presents an investigation on the fatigue analysis of four types of details on orthotropic steel decks(OSDs)for a cable-stayed super-wide steel box girder bridge based on finite-element analysis(FEA)with vehicle transverse distribution model(VTDM).A high-fidelity 3D FE model verified by the static load test is established to satisfy the fatigue analysis accuracy.The stress behavior of super-wide steel box girders under the vehicle load at different lane locations is investigated.Then,considering the effect of VTDM,the fatigue life analysis of four typical details is performed using the Miner cumulative damage rule.The results show that the vehicle transverse location has a great influence on the stress behavior of details with sharp influence surface,and the stress ranges in the outermost lane are larger than those in other lanes,indicating that the details of OSD in the outermost lane are prone to fatigue.The fatigue life analysis indicates that the diaphragm cutout is more prone to fatigue than other details,which should be carefully treated in bridge maintenance.

Modeling of fast charging station equipped with energy storage

The popularization of EVs(electric vehicles) has brought an increasingly heavy burden to the development of charging facilities. To meet the demand of rapid energy supply during the driving period, it is necessary to establish a fast charging station in public area. However, EVs arrive at the charging station randomly and connect to the distribution network for fast charging, it causes the grid power to fluctuate greatly and the peak-valley loads to alternate frequently, which is harmful to the stability of distribution network. In order to reduce the power fluctuation of random charging, the energy storage is used for fast charging stations. The queuing model is determined to demonstrate the load characteristics of fast charging station, and the state space of fast charging station system is described by Markov chain. After that the power of grid and energy storage is quantified as the number of charging pile, and each type of power is configured rationally to establish the random charging model of energy storage fast charging station. Finally, the economic benefit is analyzed according to the queuing theory to verify the feasibility of the model.