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Expert consensus on endodontic therapy for patients withsystemic conditions 被引量:1
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作者 Xin Xu Xin Zheng +21 位作者 Fei Lin Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Jiyao Li Lili Chen Zuomin Wang Hongkun Wu Zhiyue Lu Jizhi Zhao Yuhong Liang Jin Zhao Yihuai Pan Shuang Pan Xiaoyan Wang Deqin Yang Yanfang Ren Lin Yue xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第3期390-397,共8页
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds ... The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health. 展开更多
关键词 PATIENTS DIAGNOSIS PROGNOSIS
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Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment 被引量:1
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作者 Jiang Lin Chengshuo Wang +18 位作者 Xiangdong Wang Faming Chen Wei Zhang Hongchen Sun Fuhua Yan Yaping Pan Dongdong Zhu Qintai Yang Shaohua Ge Yao Sun Kuiji Wang Yuan Zhang Mu Xian Ming Zheng Anchun Mo Xin Xu Hanguo Wang xuedong zhou Luo Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第1期1-14,共14页
Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of uniq... Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multidisciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management. 展开更多
关键词 DIAGNOSIS SINUSITIS MAXILLARY
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Expert consensus on difficulty assessment of endodontic therapy 被引量:1
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作者 Dingming Huang Xiaoyan Wang +33 位作者 Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei Chen Jiyao Li Ling Ye Lei Cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi Chen Lihong Qiu Wenxia Chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第1期15-25,共11页
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is ... Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics. 展开更多
关键词 ANATOMY DIFFICULTY TREATMENT
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Expert consensus on the diagnosis and therapy of endo-periodontal lesions
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作者 Bin Chen Yanan Zhu +19 位作者 Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song Ge Jiang Lin Yaping Pan Yan Xu Yi Ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue xuedong zhou Fuhua Yan 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第3期381-389,共9页
Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple cont... Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing factors.This etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical practice.Furthermore,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal therapy.By compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence. 展开更多
关键词 DIAGNOSIS PERIODONTAL LESIONS
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Expert consensus on irrigation and intracanal medication in root canal therapy
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作者 Xiaoying Zou Xin Zheng +25 位作者 Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen xuedong zhou Lin Yue 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第1期26-35,共10页
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical regi... Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. 展开更多
关键词 TREATMENT IRRIGATION EXPERT
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The role of TGF-beta3 in cartilage development and osteoarthritis 被引量:8
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作者 Xinmei Du Linyi Cai +1 位作者 Jing Xie xuedong zhou 《Bone Research》 SCIE CAS CSCD 2023年第1期108-123,共16页
Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member... Articular cartilage serves as a low-friction,load-bearing tissue without the support with blood vessels,lymphatics and nerves,making its repair a big challenge.Transforming growth factor-beta 3(TGF-β3),a vital member of the highly conserved TGF-βsuperfamily,plays a versatile role in cartilage physiology and pathology.TGF-β3 influences the whole life cycle of chondrocytes and mediates a series of cellular responses,including cell survival,proliferation,migration,and differentiation.Since TGF-β3 is involved in maintaining the balance between chondrogenic differentiation and chondrocyte hypertrophy,its regulatory role is especially important to cartilage development.Increased TGF-β3 plays a dual role:in healthy tissues,it can facilitate chondrocyte viability,but in osteoarthritic chondrocytes,it can accelerate the progression of disease.Recently,TGF-β3 has been recognized as a potential therapeutic target for osteoarthritis(OA)owing to its protective effect,which it confers by enhancing the recruitment of autologous mesenchymal stem cells(MSCs)to damaged cartilage.However,the biological mechanism of TGF-β3 action in cartilage development and OA is not well understood.In this review,we systematically summarize recent progress in the research on TGF-β3 in cartilage physiology and pathology,providing up-to-date strategies for cartilage repair and preventive treatment. 展开更多
关键词 CARTILAGE protective VERSATILE
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Promising applications of human-derived saliva biomarker testing in clinical diagnostics 被引量:4
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作者 Mengyuan Song Hao Bai +2 位作者 Ping Zhang xuedong zhou Binwu Ying 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第1期16-32,共17页
Saliva testing is a vital method for clinical applications,for its noninvasive features,richness in substances,and the huge amount.Due to its direct anatomical connection with oral,digestive,and endocrine systems,clin... Saliva testing is a vital method for clinical applications,for its noninvasive features,richness in substances,and the huge amount.Due to its direct anatomical connection with oral,digestive,and endocrine systems,clinical usage of saliva testing for these diseases is promising.Furthermore,for other diseases that seeming to have no correlations with saliva,such as neurodegenerative diseases and psychological diseases,researchers also reckon saliva informative.Tremendous papers are being produced in this field.Updated summaries of recent literature give newcomers a shortcut to have a grasp of this topic.Here,we focused on recent research about saliva biomarkers that are derived from humans,not from other organisms.The review mostly addresses the proceedings from 2016 to 2022,to shed light on the promising usage of saliva testing in clinical diagnostics.We recap the recent advances following the category of different types of biomarkers,such as intracellular DNA,RNA,proteins and intercellular exosomes,cell-free DNA,to give a comprehensive impression of saliva biomarker testing. 展开更多
关键词 CLINICAL TESTING mostly
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Expert consensus on digital guided therapy for endodontic diseases 被引量:3
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作者 Xi Wei Yu Du +19 位作者 xuedong zhou Lin Yue Qing Yu Benxiang Hou Zhi Chen Jingping Liang Wenxia Chen Lihong Qiu Xiangya Huang Liuyan Meng Dingming Huang Xiaoyan Wang Yu Tian Zisheng Tang Qi Zhang Leiying Miao Jin Zhao Deqin Yang Jian Yang Junqi Ling 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第4期540-551,共12页
Digital guided therapy(DGT)has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades.The concept of DGT for endodontic diseases is categorized into static guided ... Digital guided therapy(DGT)has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades.The concept of DGT for endodontic diseases is categorized into static guided endodontics(SGE),necessitating a meticulously designed template,and dynamic guided endodontics(DGE),which utilizes an optical triangulation tracking system.Based on cone-beam computed tomography(CBCT)images superimposed with or without oral scan(OS)data,a virtual template is crafted through software and subsequently translated into a 3-dimensional(3D)printing for SGE,while the system guides the drilling path with a real-time navigation in DGE.DGT was reported to resolve a series of challenging endodontic cases,including teeth with pulp obliteration,teeth with anatomical abnormalities,teeth requiring retreatment,posterior teeth needing endodontic microsurgery,and tooth autotransplantation.Case reports and basic researches all demonstrate that DGT stand as a precise,time-saving,and minimally invasive approach in contrast to conventional freehand method.This expert consensus mainly introduces the case selection,general workflow,evaluation,and impact factor of DGT,which could provide an alternative working strategy in endodontic treatment. 展开更多
关键词 TEMPLATE utilize PRECISE
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Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry 被引量:1
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作者 Bin Liu xuedong zhou +27 位作者 Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第3期371-376,共6页
The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,e... The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience. 展开更多
关键词 OPERATIVE SURGERY primarily
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Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development
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作者 Xiaoyue Liang Ding Chen +10 位作者 Jiannan Wang Binyou Liao Jiawei Shen Xingchen Ye Zheng Wang Chengguang Zhu Lichen Gou Xinxuan zhou Lei Cheng Biao Ren xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第4期613-625,共13页
Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence byswitching its forms from yeasts to hyphae and becomes the major pathogenic agent for... Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence byswitching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis. However, the overuse ofcurrent clinical antifungals and lack of new types of drugs highlight the challenges in the antifungal treatments because of the drugresistance and side effects. Anti-virulence strategy is proved as a practical way to develop new types of anti-infective drugs. Here,seven artemisinins, including artemisinin, dihydroartemisinin, artemisinic acid, dihydroartemisinic acid, artesunate, artemether andarteether, were employed to target at the hyphal development, the most important virulence factor of C. albicans. Artemisininsfailed to affect the growth, but significantly inhibited the hyphal development of C. albicans, including the clinical azole resistantisolates, and reduced their damage to oral epithelial cells, while arteether showed the strongest activities. The transcriptomesuggested that arteether could affect the energy metabolism of C. albicans. Seven artemisinins were then proved to significantlyinhibit the productions of ATP and cAMP, while reduced the hyphal inhibition on RAS1 overexpression strain indicating thatartemisinins regulated the Ras1-cAMP-Efg1 pathway to inhibit the hyphal development. Importantly, arteether significantlyinhibited the fungal burden and infections with no systemic toxicity in the murine oropharyngeal candidiasis models in vivo causedby both fluconazole sensitive and resistant strains. Our results for the first time indicated that artemisinins can be potentialantifungal compounds against C. albicans infections by targeting at its hyphal development. 展开更多
关键词 INS DRUGS inhibited
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钛种植体表面改性方法 被引量:24
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作者 杨帮成 周学东 +5 位作者 于海洋 吴尧 包崇云 满毅 程磊 孙瑶 《华西口腔医学杂志》 CAS CSCD 北大核心 2019年第2期124-129,共6页
钛种植体具有美观舒适、不损伤邻牙、临床效果显著等优点,广泛应用于口腔种植修复领域;但应用中存在骨结合失败、种植体周围骨吸收、种植体周围炎等问题,使其应用受到一定的限制。对钛种植体进行表面改性,在其表面制备不同的理化涂层和... 钛种植体具有美观舒适、不损伤邻牙、临床效果显著等优点,广泛应用于口腔种植修复领域;但应用中存在骨结合失败、种植体周围骨吸收、种植体周围炎等问题,使其应用受到一定的限制。对钛种植体进行表面改性,在其表面制备不同的理化涂层和生物活性涂层,可以提高种植体的种植成功率,满足临床应用需求。本文从物理、化学、生物三方面对各种钛种植体表面改性方法的特点进行总结,为牙种植材料的研究和临床应用提供参考。 展开更多
关键词 种植体 表面改性 表面涂层
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白细胞介素-1α信号通路在牙萌出中的研究 被引量:2
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作者 蒙明梅 郭维华 +1 位作者 周学东 邹静 《国际口腔医学杂志》 CAS CSCD 2019年第3期259-263,共5页
牙萌出是发育中的牙齿穿过牙槽骨和口腔黏膜到达功能位置的复杂生理过程,其间牙槽骨、牙囊、破骨细胞、成骨细胞及多种细胞因子等共同参与该过程。白细胞介素(IL)-1α是具有特殊生理意义的双重功能细胞因子。本文就IL-1α信号通路在牙... 牙萌出是发育中的牙齿穿过牙槽骨和口腔黏膜到达功能位置的复杂生理过程,其间牙槽骨、牙囊、破骨细胞、成骨细胞及多种细胞因子等共同参与该过程。白细胞介素(IL)-1α是具有特殊生理意义的双重功能细胞因子。本文就IL-1α信号通路在牙萌出中的研究进行综述。 展开更多
关键词 牙萌出 白细胞介素-1Α 牙囊
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Transforming growth factor-β in stem cells and tissue homeostasis 被引量:30
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作者 Xin Xu Liwei Zheng +4 位作者 Quan Yuan Gehua Zhen Janet L.Crane xuedong zhou Xu Cao 《Bone Research》 CAS CSCD 2018年第1期1-31,共31页
TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adu... TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β. 展开更多
关键词 CELLS METASTASIS TGF-Β1 LIGAND human LEAD CAN not
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Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus 被引量:28
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作者 Haiyang Yu Yuwei Zhao +17 位作者 Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2019年第4期241-251,共11页
By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the opti... By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. 展开更多
关键词 PREPARATION BREAKTHROUGH removing
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Transmission routes of 2019-nCoV and controlsin dental practice 被引量:32
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作者 Xian Peng Xin Xu +3 位作者 Yuqing Li Lei Cheng xuedong zhou Biao Ren 《International Journal of Oral Science》 SCIE CAS CSCD 2020年第1期25-30,共6页
A novel β-coronavirus(2019-nCoV) caused severe and even fatal pneumonia explored in a seafood market of Wuhan city, Hubei province, China, and rapidly spread to other provinces of China and other countries. The 2019-... A novel β-coronavirus(2019-nCoV) caused severe and even fatal pneumonia explored in a seafood market of Wuhan city, Hubei province, China, and rapidly spread to other provinces of China and other countries. The 2019-nCoV was different from SARS-Co V,but shared the same host receptor the human angiotensin-converting enzyme 2(ACE2). The natural host of 2019-nCoV may be the bat Rhinolophus affinis as 2019-nCoV showed 96.2% of whole-genome identity to Bat Co V Ra TG13. The person-to-person transmission routes of 2019-nCoV included direct transmission, such as cough, sneeze, droplet inhalation transmission, and contact transmission, such as the contact with oral, nasal, and eye mucous membranes. 2019-nCoV can also be transmitted through the saliva, and the fecal–oral routes may also be a potential person-to-person transmission route. The participants in dental practice expose to tremendous risk of 2019-nCoV infection due to the face-to-face communication and the exposure to saliva, blood, and other body fluids, and the handling of sharp instruments. Dental professionals play great roles in preventing the transmission of2019-nCoV. Here we recommend the infection control measures during dental practice to block the person-to-person transmission routes in dental clinics and hospitals. 展开更多
关键词 DENTAL measures SHARP
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Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging 被引量:15
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作者 Liwei Zheng Yong Cao +25 位作者 Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII xuedong zhou Jianzhong Hu Xu Cao 《Bone Research》 CAS CSCD 2018年第3期252-265,共14页
Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic a... Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. 展开更多
关键词 disc injection INTEGRIN cells IPTH effect TGF-β human
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Oral microbiota in human systematic diseases 被引量:20
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作者 Xian Peng Lei Cheng +5 位作者 Yong You Chengwei Tang Biao Ren Yuqing Li Xin Xu xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2022年第1期1-11,共11页
Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through... Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment.The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling,hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician’s understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases,and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health. 展开更多
关键词 DISEASES METABOLISM IMMUNITY
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Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis 被引量:16
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作者 Liwei Zheng Caixia Pi +9 位作者 Jun Zhang Yi Fan Chen Cui Yang zhou Jianxun Sun Quan Yuan Xin Xu Ling Ye Xu Cao xuedong zhou 《Bone Research》 CAS CSCD 2018年第4期383-392,共10页
There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transfo... There is currently no effective medical treatment for temporomandibular joint osteoarthritis(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-β(TGF-β)signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder(TMD) rat model, an ageing mouse model and a Camurati–Engelmann disease(CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by μCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen(Col X), p-Smad2/3 a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-βsignalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-β receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-β signalling could be a key player in TMJ-OA development. 展开更多
关键词 TMJ OA TMD Aberrant activation of latent transforming growth factor initiates the onset of temporomandibular joint osteoarthritis
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Calcium phosphate cements for bone engineering and their biological properties 被引量:16
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作者 Hockin HK Xu Ping Wang +7 位作者 Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao xuedong zhou Mark A Reynolds 《Bone Research》 SCIE CAS CSCD 2017年第4期286-304,共19页
Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports thei... Calcium phosphate cements (CPCs) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre- vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. 展开更多
关键词 CPC BMSCS Calcium phosphate cements for bone engineering and their biological properties
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Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus 被引量:8
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作者 Yan Li Kun Wang +12 位作者 Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong zhou Wenyuan Shi Liying Xiao Changqing Lu xuedong zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2019年第3期231-240,共10页
The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain... The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. 展开更多
关键词 IMMUNE system EROSIVE compared to
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