Clinical phototheranostic agents suffer from low absorption in near-infrared(NIR)region,decreasing singlet oxygen quantum yield(^(1)O_(2)QY)caused by aggregation in water,and low photothermal conversion efficiency(PCE...Clinical phototheranostic agents suffer from low absorption in near-infrared(NIR)region,decreasing singlet oxygen quantum yield(^(1)O_(2)QY)caused by aggregation in water,and low photothermal conversion efficiency(PCE),all of which are factors weakening their phototheranostic efficacy.Herein,we designed and synthesized a donor-acceptor-donor(D-A-D)structured boron-dipyrromethene derivative(B-2TPA)which exhibited NIR absorption and fluorescence.After being encapsulated in amphiphilic distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),the water-soluble B-2TPA nanoparticles(NPs)had increasing^(1)O_(2)QY(6.7%)due to the intermolecular aggregation-induced decrease in the energy gap between singlet and triplet excited states.Moreover,the quenched fluorescence and stable twisted intramolecular charge transfer in aggregates further increased the PCE of B-2TPA NPs to 60.1%.In vitro and in vivo studies confirmed that B-2TPA NPs could be used in NIR fluorescence and photoacoustic imagingguided synergistic photodynamic and photothermal therapy in tumor treatment.展开更多
Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B...Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were red-shifted.The cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,respectively.The^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,respectively.Moreover,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of cisplatin.In vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic efficacy.Together,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.展开更多
Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects...Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot(CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral response.Moreover, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.展开更多
基金supported by National Key Research and Development Program of China(No.2022YFA1207600)National Natural Science Foundation of China(Nos.62175262,62375289)+2 种基金The Science and Technology Innovation Program of Hunan Province(No.2022RC1201)The Climb Plan of Hunan Cancer Hospital(No.ZX2021005)The Hunan Provincial Natural Science Foundation of China(No.2023JJ60464)。
文摘Clinical phototheranostic agents suffer from low absorption in near-infrared(NIR)region,decreasing singlet oxygen quantum yield(^(1)O_(2)QY)caused by aggregation in water,and low photothermal conversion efficiency(PCE),all of which are factors weakening their phototheranostic efficacy.Herein,we designed and synthesized a donor-acceptor-donor(D-A-D)structured boron-dipyrromethene derivative(B-2TPA)which exhibited NIR absorption and fluorescence.After being encapsulated in amphiphilic distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),the water-soluble B-2TPA nanoparticles(NPs)had increasing^(1)O_(2)QY(6.7%)due to the intermolecular aggregation-induced decrease in the energy gap between singlet and triplet excited states.Moreover,the quenched fluorescence and stable twisted intramolecular charge transfer in aggregates further increased the PCE of B-2TPA NPs to 60.1%.In vitro and in vivo studies confirmed that B-2TPA NPs could be used in NIR fluorescence and photoacoustic imagingguided synergistic photodynamic and photothermal therapy in tumor treatment.
基金supported by National Natural Science Foundation of China(No.62175262)the Science and Technology Innovation Program of Hunan Province(No.2022RC1201)the Fundamental Research Funds for the Central Universities of Central South University(No.2019zzts849)。
文摘Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were red-shifted.The cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,respectively.The^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,respectively.Moreover,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of cisplatin.In vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic efficacy.Together,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.
基金supported by the National Natural Science Foundation of China (62175262)the Science and Technology Innovation Program of Hunan Province (2022RC1201)+2 种基金the Fundamental Research Fund for the Central South Universities (2020CX021)the Key R & D plan of Hunan Province (2022SK2101)the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University。
基金supported by National Natural Science Foundation of China (Nos. 61805287, 62175262)Natural Science Foundation of Hunan Province,China (No. 2019JJ50824)+1 种基金Fundamental Research Funds for the Central South Universities (Nos. 2020CX021,2020zzts387)Basic Research Foundation of Shenzhen Science and Technology Innovation (No. JCYJ20180307151245919)。
文摘Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot(CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral response.Moreover, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.
