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Implementation and evaluation of a pain management core competency education program for surgical nurses 被引量:3
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作者 xuelian liu Li Li +2 位作者 Lingxiao Wang Keela Herr Qiuchan Chen 《International Journal of Nursing Sciences》 CSCD 2021年第1期51-57,I0004,共8页
Objective:To investigate the effect of a pain management core competency education program on surgical nurses’pain knowledge and pain management nursing practice behaviors.Methods:An 8-h education program focused on ... Objective:To investigate the effect of a pain management core competency education program on surgical nurses’pain knowledge and pain management nursing practice behaviors.Methods:An 8-h education program focused on pain management core competency was provided twice in two weeks including the multidimensional nature of pain,pain assessment,pharmacological and nonpharmacological management,and knowledge application was developed and implemented for surgical nurses by a multidisciplinary team.Multimodal teaching approaches such as didactic teaching and vignettes of cases for nurses to discuss were used.The Clinical Pain Knowledge Test(CPKT)was completed by 135 and 107 nurses from 17 surgical wards pre and post-program,respectively.Two hundred and three patients’medical records were randomly sampled according to the number of operations in each ward one week before and in the fifth week after the intervention,respectively.Documentation of patients’postoperative pain management nursing practice behaviors and pain intensity scores were collected.Results:After the intervention,the CPKT scores of nurses significantly increased from 45.6%±12.3%to 54.2%±10.2%(t=5.786,P<0.001).Nurses’postoperative pain management nursing practice improved,with proportion of pain assessment documentation increased from 59.6%(121/203)to 74.9%(152/203)(χ^(2)=10.746,P=0.001),those using pain intensity assessment tools increased from 81.8%(99/121)to 95.4%(145/152)(χ^(2)=13.079,P<0.001),and intramuscular injection of nonopioids decreased from 12.6%(13/103)to 2.7%(3/111)(χ^(2)=7.598,P=0.006).Patients’average worst pain score on the operation day significantly decreased(Z=-2.486,P=0.013),and scores from the first to the third postoperative day also decreased(Z=-2.172,P=0.030).Conclusions:Implementation of a pain management core competency education program for surgical nurses can increase their knowledge of core competencies of pain management,improve selected pain management practices,and decrease patients’postoperative pain intensity. 展开更多
关键词 EDUCATION Nurses Pain management Surgery department
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A Pharmacological Study on Action Mechanism of Zhizi Ganjiang Decoction from Treatise on Cold Damage Diseases in Treating Sleep Disorders
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作者 Xiaowei XIN Xuemei liu +6 位作者 xuelian liu Zhiwei YANG Fangang MENG Wenxiao WANG Xinxin WEI Daiming ZHANG Mingchen CAO 《Medicinal Plant》 CAS 2022年第6期7-13,共7页
[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of... [Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD. 展开更多
关键词 Zhizi Ganjiang Decoction(ZZGJD) BATMAN-TCM GO KEGG Network pharmacology
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A High-Linear Radio Frequency Quadrature Modulator with Improved Sideband Suppression and Carrier Leakage Performance
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作者 Yingdan Jiang Zongguang Yu +2 位作者 Shutong Wu Li Li xuelian liu 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2024年第3期635-643,共9页
The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator frequencies.In this paper,non-ideal factors thatinfluence t... The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator frequencies.In this paper,non-ideal factors thatinfluence the performance of the quadrature modulator are considered,and solutions are accordingly taken inthe quadrature modulator design.A high-linear RF quadrature modulator with improved sideband suppressionand carrier leakage performance is presented in this work.The quadrature modulator implemented in the0.18-μm SiGe process uses the current bleeding technique to improve the general performance of the doublebalanced active Gilbert mixers.An on-chip prescaler followed by two cascaded limiting amplifiers is designed toprovide accurate quadrature local oscillator signals.Predrivers at quadrature baseband signal input ports areproposed to eliminate DC offsets.The measured sideband suppression achieves a performance of better than−43 dBc and carrier leakage is less than−38 dBm over the output RF frequency range of 30 MHz to 2.15 GHz.The output 1 dB compression point equals 11.4 dBm at 800 MHz. 展开更多
关键词 Radio Frequency(RF) quadrature modulator sideband suppression carrier leakage LINEARITY
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Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos 被引量:15
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作者 Chuan Chen Wenqiang liu +16 位作者 Jiayin Guo Yuanyuan liu xuelian liu Jun liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao 《Protein & Cell》 SCIE CSCD 2021年第6期455-474,共20页
N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.He... N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. 展开更多
关键词 YTHDC1 LINE1-scaffold complex 2-cell RETROTRANSPOSONS H3K9me3
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Dendritic BiVO4 decorated with MnOx co-catalyst as an efficient hierarchical catalyst for photocatalytic ozonation 被引量:6
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作者 Jin Yang xuelian liu +3 位作者 Hongbin Cao Yanchun Shi Yongbing Xie Jiadong Xiao 《Frontiers of Chemical Science and Engineering》 SCIE EI CAS CSCD 2019年第1期185-191,共7页
An appropriate co-catalyst can significantly promote the photocatalytic efficacy, but this has been seldom studied in the visible-light photocatalysis combined with ozone, namely photocatalytic ozonation. In this work... An appropriate co-catalyst can significantly promote the photocatalytic efficacy, but this has been seldom studied in the visible-light photocatalysis combined with ozone, namely photocatalytic ozonation. In this work, a dendritic bismuth vanadium tetraoxide (BiVO4) material composited with highly dispersed MnOv nanoparticles was synthesized, and its catalytic activity is 86.6% higher than bare BiVO4 in a visible light and ozone combined process. Catalytic ozonation experiments, ultraviolet- visible (UV-Vis) diffuse reflectance spectra and photoluminescence spectra jointly indicate that MnOA plays a triple role in this process. MnOv strengthens the light adsorption and promotes the charge separation on the composite material, and it also shows good activity in catalytic ozonation. The key reactive species in this process is OH, and various pathways for its generation in this process is proposed. This work provides a new direction of catalyst preparation and pushes forward the application of photocatalytic ozonation in water treatment. 展开更多
关键词 manganese oxide bismuth vanadium tetraoxide photocatalytic OZONATION HYDROXYL radical COCATALYST
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Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia 被引量:5
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作者 Rui Wu Ping-An Zhang +5 位作者 xuelian liu Yuan Zhou Meijie Xu Xinghong Jiang Jun Yan Guang-Yin Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第5期791-801,共11页
Chronic visceral hypersensitivity is an important type of chronic pain with unknown etiology and pathophysiology. Recent studies have shown that epigenetic regulation plays an important role in the development of chro... Chronic visceral hypersensitivity is an important type of chronic pain with unknown etiology and pathophysiology. Recent studies have shown that epigenetic regulation plays an important role in the development of chronic pain conditions. However, the role of mi RNA-325-5 p in chronic visceral pain remains unknown. The present study was designed to determine the roles and mechanism of mi RNA-325-5 p in a rat model of chronic visceral pain.This model was induced by neonatal colonic inflammation(NCI). In adulthood, NCI led to a significant reduction in the expression of mi RNA-325-5 p in colon-related dorsal root ganglia(DRGs), starting to decrease at the age of4 weeks and being maintained to 8 weeks. Intrathecal administration of mi RNA-325-5 p agomir significantly enhanced the colorectal distention(CRD) threshold in a time-dependent manner. NCI also markedly increased the expression of CCL2(C-C motif chemokine ligand 2) in colon-related DRGs at the m RNA and protein levels relative to age-matched control rats. The expression of CXCL12, IL33, SFRS7, and LGI1 was not significantlyaltered in NCI rats. CCL2 was co-expressed in Neu Npositive DRG neurons but not in glutamine synthetasepositive glial cells. Furthermore, CCL2 was mainly expressed in isolectin B4-binding-and calcitonin generelated peptide-positive DRG neurons but in few NF-200-positive cells. More importantly, CCL2 was expressed in mi R-325-5 p-positive DRG neurons. Intrathecal injection of mi RNA-325-5 p agomir remarkably reduced the upregulation of CCL2 in NCI rats. Administration of Bindarit, an inhibitor of CCL2, markedly raised the CRD threshold in NCI rats in a dose-and time-dependent manner. These data suggest that NCI suppresses mi RNA-325-5 p expression and enhances CCL2 expression, thus contributing to visceral hypersensitivity in adult rats. 展开更多
关键词 VISCERAL pain DORSAL root GANGLIA miRNA-325-5p CCL2 EPIGENETIC regulation
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Earthworm regulation of nitrogen pools and dynamics and marker genes of nitrogen cycling: A meta-analysis 被引量:2
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作者 Rui XUE Chong WANG +1 位作者 xuelian liu Mengli liu 《Pedosphere》 SCIE CAS CSCD 2022年第1期131-139,共9页
Earthworms, as the ecosystem engineers, both directly and indirectly affect the nitrogen(N) cycle. We aimed to provide a quantitative assessment of the contribution of earthworms to the terrestrial ecosystem N cycle u... Earthworms, as the ecosystem engineers, both directly and indirectly affect the nitrogen(N) cycle. We aimed to provide a quantitative assessment of the contribution of earthworms to the terrestrial ecosystem N cycle using meta-analysis of 130 publications selected. The natural logarithm of the response ratio(lnRR) was used to indicate the effect size of earthworms on N dynamic variables. The results showed that earthworms significantly affected soil N-cycling microorganisms, including the amoA gene abundance of soil ammonia-oxidizing bacteria(AOB), and significantly promoted soil N cycle processes,including denitrification, mineralization, and plant assimilation. The effects of earthworms on the N cycle were experimental design dependent and affected by factors such as the functional group of earthworm and residue input. The presence of the anecic earthworms decreased the rates of mineralization and nitrification, and increased nitrification and denitrification responses were more pronounced in the presence of the endogeic earthworms than that of the other two functional groups of earthworms. In addition, residue input enhanced the effects of earthworms on the N cycle. The effects of earthworms on nitrous oxide(N_(2) O) emission increased when residues were added. These findings indicate that residue input and introducing suitable functional groups of earthworms into the field can lead to N sustainability without increasing N2 O emission. This meta-analysis also provides systematic evidence for the positive effects of earthworms on the plant N pool, N availability(soil ammonium(NH_(4)^(+)) content), and soil microbial biomass N content, showing the potential to alter ecosystem functions and services in relation to N cycling. 展开更多
关键词 ammonia-oxidizing bacteria DENITRIFICATION earthworm functional group MINERALIZATION NITRIFICATION residue input
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凶险性前置胎盘合并胎盘植入"一站式"杂交手术配合
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作者 杨挺岸 李秋阳 +3 位作者 刘雪莲 高倩 傅娴 贺海朋 《中华介入放射学电子杂志》 2022年第3期320-324,共5页
目的探讨"一站式"杂交手术救治凶险性前置胎盘患者的应用价值及重要性。方法对多学科合作行杂交手术救治凶险性前置胎盘合并胎盘植入患者的病例进行回顾性分析,总结"一站式"杂交手术多学科医护合作和护理配合要点... 目的探讨"一站式"杂交手术救治凶险性前置胎盘患者的应用价值及重要性。方法对多学科合作行杂交手术救治凶险性前置胎盘合并胎盘植入患者的病例进行回顾性分析,总结"一站式"杂交手术多学科医护合作和护理配合要点。结果经过多学科默契配合下的"一站式"杂交手术以及"L"型护理配合模式,手术顺利完成,术后无并发症发生,产妇于术后第4天出院。结论凶险性前置胎盘患者病情危重、手术难度大,通过多学科讨论会、辐射防护、安全转运、医护默契配合以及根据潜在并发症采取预见性的护理措施是"一站式"杂交手术成功的要点。 展开更多
关键词 凶险性前置胎盘 杂交手术 髂内动脉预置球囊导管 手术配合
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SiO_2@C hollow sphere anodes for lithium-ion batteries 被引量:3
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作者 xuelian liu Yuxi Chen +1 位作者 Hongbo liu Zhi-Quan liu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第3期239-245,共7页
As anode materials for lithium-ion batteries, SiO2 is of great interest because of its high capacity, low cost and environmental affinity. A facile approach has been developed to fabricate SiO2@C hollow spheres by hyd... As anode materials for lithium-ion batteries, SiO2 is of great interest because of its high capacity, low cost and environmental affinity. A facile approach has been developed to fabricate SiO2@C hollow spheres by hydrolysis of tetraethyl orthosilicate(TEOS) to form SiO2 shells on organic sphere templates followed by calcinations in air to remove the templates, and then the SiO2 shells are covered by carbon layers.Electron microscopy investigations confirm hollow structure of the SiO2@C. The SiO2@C hollow spheres with different SiO2 contents display gradual increase in specific capacity with discharge/charge cycling,among which the SiO2@C with SiO2 content of 67 wt% exhibits discharge/charge capacities of 653.4/649.6 mAh g^(-1) over 160 cycles at current density of 0.11 mA cm^(-2). The impedance fitting of the electrochemical impedance spectroscopy shows that the SiO2@C with SiO2 content of 67 wt% has the lowest charge transfer resistance, which indicates that the SiO2@C hollow spheres is promising anode candidate for lithium-ion batteries. 展开更多
关键词 Silica Hollow spheres Carbon coating Anode Lithium-ion batteries
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Correction to:Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos
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作者 Chuan Chen Wenqiang liu +16 位作者 Jiayin Guo Yuanyuan liu xuelian liu Jun liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao 《Protein & Cell》 SCIE CSCD 2022年第6期470-471,共2页
CORRECTION TO:PROTEIN CELL(2021)HTTPS://DOI.ORG/10.1007/S13238-021-00837-8 In the original publication of the article figure 1 is incorrectly published.The correct Figure 1 is provided in this correction.OPEN ACCESS T... CORRECTION TO:PROTEIN CELL(2021)HTTPS://DOI.ORG/10.1007/S13238-021-00837-8 In the original publication of the article figure 1 is incorrectly published.The correct Figure 1 is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit https://creativecommons.org/licenses/by/4.0/. 展开更多
关键词 ACCESS HTTPS FIGURE
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阿芬太尼联合丙泊酚麻醉在小儿腹腔镜疝囊高位结扎术的效果观察
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作者 张宏江 刘雪莲 郑立 《中华疝和腹壁外科杂志(电子版)》 2022年第6期711-715,共5页
目的观察阿芬太尼联合丙泊酚麻醉在小儿腹腔镜疝囊高位结扎术的效果。方法选择2017年7月至2022年6月珠海市中西医结合医院收治的150例行腹腔镜疝囊高位结扎术的患儿作为研究对象,行前瞻性研究,采用随机数字表法将患者分为3组,阿芬太尼组... 目的观察阿芬太尼联合丙泊酚麻醉在小儿腹腔镜疝囊高位结扎术的效果。方法选择2017年7月至2022年6月珠海市中西医结合医院收治的150例行腹腔镜疝囊高位结扎术的患儿作为研究对象,行前瞻性研究,采用随机数字表法将患者分为3组,阿芬太尼组(50例)采用阿芬太尼联合丙泊酚麻醉,舒芬太尼组(50例)采用舒芬太尼联合丙泊酚麻醉,芬太尼组(50例)采用芬太尼联合丙泊酚麻醉。对比3组的麻醉效果及不同时刻的心率、平均动脉压(MAP)水平,记录麻醉时间、拔管时间、苏醒时间、丙泊酚用量、呛咳及围手术期并发症发生情况,评估麻醉苏醒期躁动(PAED)及苏醒期的儿童疼痛评估量表(CHEOPS)评分。结果阿芬太尼组、舒芬太尼组与芬太尼组的麻醉总优良率分别为100.00%、98.00%、98.00%,并发症总发生率分别为8.00%、14.00%、16.00%,组间对比差异无统计学意义(P>0.05)。麻醉维持后1 min,3组的心率、MAP水平较麻醉诱导前明显降低(P<0.05),组间对比差异无统计学意义(P>0.05);麻醉维持后30 min,3组的心率、MAP水平较麻醉诱导前明显降低,而阿芬太尼组高于舒芬太尼组及芬太尼组(P<0.05),舒芬太尼组与芬太尼组差异无统计学意义(P>0.05);术毕即刻,3组的心率、MAP水平较麻醉诱导前明显降低,组间对比差异无统计学意义(P>0.05)。阿芬太尼组的麻醉时间、拔管时间、苏醒时间及丙泊酚用量明显低于舒芬太尼组及芬太尼组(P<0.05),舒芬太尼组及芬太尼组差异无统计学意义(P>0.05)。诱导期及苏醒期,阿芬太尼组的呛咳评分及呛咳发生率明显低于舒芬太尼组及芬太尼组(P<0.05),舒芬太尼组与芬太尼组差异无统计学意义(P>0.05)。阿芬太尼组的PAED评分明显低于舒芬太尼组及芬太尼组(P<0.05),CHEOPS评分稍低于舒芬太尼组及芬太尼组(P>0.05),舒芬太尼组及芬太尼组差异均无统计学意义(P>0.05)。结论阿芬太尼联合丙泊酚麻醉有利于维持小儿腹腔镜疝囊高位结扎术中的血流动力学稳定,苏醒质量良好,并有效降低术中丙泊酚用量,减少呛咳及术后躁动等并发症的发生。 展开更多
关键词 阿芬太尼 丙泊酚 麻醉 血流动力学 疝囊高位结扎术
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