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BRAF V600E和TERT启动子突变与甲状腺乳头状癌临床病理特征的关系 被引量:7
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作者 王旭红 彭琛 +1 位作者 李乐 秦彦超 《中国肿瘤临床》 CAS CSCD 北大核心 2020年第11期557-562,共6页
目的:探讨端粒酶逆转录酶(telomerase reverse transcriptase,TERT)启动子突变和BRAF V600E突变与甲状腺乳头状癌(papillary thyroid carcinoma,PTC)临床病理因素的关系。方法:对2014年12月至2016年12月山西省肿瘤医院728例PTC患者肿瘤... 目的:探讨端粒酶逆转录酶(telomerase reverse transcriptase,TERT)启动子突变和BRAF V600E突变与甲状腺乳头状癌(papillary thyroid carcinoma,PTC)临床病理因素的关系。方法:对2014年12月至2016年12月山西省肿瘤医院728例PTC患者肿瘤组织提取DNA,检测其BRAF V600E和TERT启动子突变情况,收集患者临床病理资料,进行统计学分析。结果:728例患者中BRAF V600E突变型308例(42.3%)。TERT C228T突变型78例(10.7%),TERT C250T突变型4例(0.5%)。TERT启动子突变与患者发病年龄(P=0.034)、腺外侵犯(P=0.026)、肿瘤直径(P=0.028)、中央区淋巴结转移(P=0.012)、远处转移(P=0.001)、TNM分期(P<0.001)、病理亚型(P=0.003)以及肿瘤复发(P=0.002)显著相关。BRAF V600E突变与PTC患者的腺外侵犯(P=0.001)、肿瘤直径(P<0.001)、桥本甲状腺炎(P<0.001)、远处转移(P=0.010)、TNM分期(P=0.009)和肿瘤复发(P=0.001)显著相关。同时伴有BRAF V600E和TERT启动子突变与发病年龄(P=0.024)、腺外侵犯(P=0.022)、合并桥本甲状腺炎(P=0.005)、中央区淋巴结转移(P=0.018)及更高临床分期(P=0.002)显著相关。结论:BRAF V600E和TERT启动子突变与高侵袭性的临床病理因素相关,BRAF V600E和TERT存在协同作用,对于指导治疗和评估预后具有积极作用。 展开更多
关键词 甲状腺乳头状癌 BRAF V600E TERT
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Quantum dot-enabled infrared hyperspectral imaging with single-pixel detection
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作者 Heyan Meng Yuan Gao +4 位作者 xuhong wang Xianye Li Lili wang Xian Zhao Baoqing Sun 《Light(Science & Applications)》 SCIE EI CSCD 2024年第6期1112-1121,共10页
Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of applications.However,... Near-infrared(NIR)hyperspectral imaging is a powerful technique that enables the capture of three-dimensional(3D)spectra-spatial information within the NIR spectral range,offering a wide array of applications.However,the high cost associated with InGaAs focal plane array(FPA)has impeded the widespread adoption of NIR hyperspectral imaging.Addressing this challenge,in this study,we adopt an alternative approach—single-pixel detection for NIR hyperspectral imaging.Our investigation reveals that single-pixel detection outperforms conventional FPA,delivering a superior signal-to-noise ratio(SNR)for both spectral and imaging reconstruction.To implement this strategy,we leverage self-assembled colloidal quantum dots(CQDs)and a digital micromirror device(DMD)for NIR spectral and spatial information multiplexing,complemented by single-pixel detection for simultaneous spectral and image reconstruction.Our experimental results demonstrate successful NIR hyperspectral imaging with a detection window about 600 nm and an average spectral resolution of 8.6 nm with a pixel resolution of 128×128.The resulting spectral and spatial data align well with reference instruments,which validates the effectiveness of our approach.By circumventing the need for expensive and bulky FPA and wavelength selection components,our solution shows promise in advancing affordable and accessible NIR hyperspectral imaging technologies,thereby expanding the range of potential applications. 展开更多
关键词 SPECTRAL QUANTUM MIRROR
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Effect of Mie resonance on photocatalytic hydrogen evolution over dye-sensitized hollow C-TiO_(2) nanoshells under visible light irradiation 被引量:1
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作者 Xiaxi Yao Xiuli Hu +4 位作者 Yingying Cui Jialei Huang Wenjun Zhang xuhong wang Dawei wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第2期750-754,共5页
Light utilization is one of the key factors for the improvement of photocatalytic perfo rmance.He rein,we design C-TiO_(2) hollow nanoshells with strong Mie resonance for enhanced photocatalytic hydrogen evolution in ... Light utilization is one of the key factors for the improvement of photocatalytic perfo rmance.He rein,we design C-TiO_(2) hollow nanoshells with strong Mie resonance for enhanced photocatalytic hydrogen evolution in a dye-sensitized system under visible light irradiation(λ≥420 nm).By tuning the inner diameters of hollow nanoshells,the Mie resonance in hollow nanoshells is adjusted for better excitation of dye molecules,which thus greatly enhances the light utilization in visible light region.This work shows the potential of Mie resonance in nanoshells can be an alternative strategy to increase the light utilization for photocatalysis. 展开更多
关键词 Mie resonance Hollow nanoshells Dye sensitization Water splitting PHOTOCATALYSIS
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