Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s disease.SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport ...Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s disease.SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport and metabolism of intracellularβ-amyloid precursor protein.To better understand the underlying mechanisms of SORL1 in the pathogenesis of late-onset Alzheimer s disease,in this study,we established a mouse model of SorI1 gene knockout using cluste red regularly inters paced short palindro mic repeats-associated protein 9 technology.We found that Sorl1-knocko ut mice displayed deficits in learning and memory.Furthermore,the expression of brain-derived neurotrophic factor was significantly downregulated in the hippocampus and co rtex,and amyloidβ-protein deposits were observed in the brains of 5orl1-knockout mice.In vitro,hippocampal neuronal cell synapses from homozygous Sorl1-knockout mice were impaired.The expression of synaptic proteins,including Drebrin and NR2B,was significantly reduced,and also their colocalization.Additionally,by knocking out the Sorl1 gene in N2a cells,we found that expression of the N-methyl-D-aspartate receptor,NR2B,and cyclic adenosine monophosphate-response element binding protein was also inhibited.These findings suggest that SORL1 participates in the pathogenesis of late-onset Alzheimer s disease by regulating the N-methyl-D-aspartate receptor NR2B/cyclic adenosine monophosphate-response element binding protein signaling axis.展开更多
3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting...3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among others.In this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing platform.The 3D model fabrication is accomplished through line projection.The rotation and translation of the rod are synchronized to project and illuminate the photosensitive material volume.By controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 micrometers.By controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 micrometers.Our process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 s.Additionally,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical strength.This method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.展开更多
The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 ...The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 MeV are expected to be generated for tumor therapy.During high-repetition operation,both prompt radiation and residual radiation may cause safety problems.Therefore,human radiological safety assessment before commissioning is essential.In this paper,we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam parameters.We find that the prompt radiation can be shielded well by the concrete wall of the experimental hall,but the risk from residual radiation is nonnegligible and necessitates adequate radiation cooling.On the basis of the simulation results,we discuss the constraints imposed by radiation safety considerations on the annual working time,and we propose radiation cooling strategies for different shooting modes.展开更多
目的比较晚期肝细胞癌一线系统治疗药物的有效性和安全性,供临床实践作参考。方法网络检索PubMed、Cochrane Library、Embase和Web of Science等文献数据库,检索时限均为建库至2021年6月,根据预设的纳入标准筛选文献进行网络荟萃分析。...目的比较晚期肝细胞癌一线系统治疗药物的有效性和安全性,供临床实践作参考。方法网络检索PubMed、Cochrane Library、Embase和Web of Science等文献数据库,检索时限均为建库至2021年6月,根据预设的纳入标准筛选文献进行网络荟萃分析。结果共纳入12项随机对照研究,合计8058例患者。网络荟萃分析结果显示,相较于索拉非尼,信迪利单抗联合贝伐珠单抗生物类似物(IBI305)、阿替利珠单抗联合贝伐珠单抗和多纳非尼均降低了患者的死亡风险(HR=0.57,95%CI:0.43~0.75;HR=0.58,95%CI:0.42~0.80;HR=0.83,95%CI:0.70~0.99),该3种治疗方式有最高的P-score值,分别为0.956、0.948和0.764;在有或无“大血管侵犯/肝外转移”的两组患者亚组中,3种治疗方案的排名类似;安全性方面,除安慰剂之外,多纳非尼因不良事件终止研究治疗、减量研究药物和暂停研究治疗的P-score值均位居首位。结论晚期肝细胞癌一线系统治疗药物中,信迪利单抗联合贝伐珠单抗生物类似物、阿替利珠单抗联合贝伐珠单抗和多纳非尼单药治疗均可显著改善晚期肝细胞癌患者的总生存时间;而多纳非尼的安全性和耐受性更佳。展开更多
Compared with the traditional pyrometallurgical process, copper bioleaching has distinctive advantages of high efficiency and lower cost, enabling efficiently extracts of valuable metal resources from copper sulfides....Compared with the traditional pyrometallurgical process, copper bioleaching has distinctive advantages of high efficiency and lower cost, enabling efficiently extracts of valuable metal resources from copper sulfides. Moreover, during long-term industrial applications of bioleaching, many regulatory enhancements and technological methods are used to accelerate the interfacial reactions. With advances in microbial genetic and sequencing technologies, bacterial communities and their mechanisms in bioleaching systems have been revealed gradually. The bacterial proliferation and dissolution of sulfide ores by a bacterial community depends on the pH, temperature, oxygen, reaction product regulation, additives, and passivation substances, among other factors. The internal relationship among the influencing factors and the succession of microorganism diversity are discussed and reviewed in this paper. This paper is intended to provide a good reference for studies related to enhanced bioleaching.展开更多
To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories ...To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories of physical chemistry and seepage flow mechanics, the mechanism by which seepage is enhanced under the effects of the surfactant was analyzed. The results show that the action modes of the surfactant were divided into four aspects: changing the wettability of the ore, reducing the viscosity of the leaching solution, adsorbing onto the surface of ore, and enhancing the permeability effect. The findings of column leaching tests demonstrated that permeability was substantially improved by the surfactant. In the later period of leaching, the permeability coefficient was two times higher than that of the control group. Meanwhile, the ore extraction rate increased by approximately 10%. During the leaching process, the surface tension of the solution did not substantially change, and that of the solution with surfactant increased slightly. The kinetics analysis of ore column leaching illustrated that the leaching processes were controlled by both internal diffusion(principal factor) and chemical reaction.展开更多
AIM：To assess the safety,efficacy,predictability and stability of implantable collamer lens（ICL） for residual refractive error after corneal refractive surgery.METHODS： This study evaluated 19 eyes of 12 patients ...AIM：To assess the safety,efficacy,predictability and stability of implantable collamer lens（ICL） for residual refractive error after corneal refractive surgery.METHODS： This study evaluated 19 eyes of 12 patients who underwent ICL implantation after corneal refractive surgeries.They were followed up for 1y to 5y of uncorrected distance visual acuity（UDVA）,corrected distance visual acuity（CDVA）,manifest refractive error,flat and steep K value,axial length,intraocular pressure,corneal endothelial cell density,adverse events after ICL surgery.RESULTS： The mean follow-up period was 39.05 ±19.22 mo（range,1-5y）.Spherical equivalent refractive error changed from-7.45±3.02 D preoperatively to-0.85±1.10 D 1wk to 1mo after ICL implantation,with the safety and efficacy indices being 1.12 and 1.15,respectively.A total of 52.63% of eyes were within ±0.5 D of the predicted spherical equivalents,73.68% were within ±1.0 D.A trend of mild regression towards myopia with axial elongation after 5y was observed.One eye with mild anterior capsule opacity and retinal detachment 1y after surgery were observed.CONCLUSION： ICL implantation is safe and effective for the correction of residual refractive error after corneal refractive surgeries,especially in moderate to high residual myopia.展开更多
The chemical binder is one of the critical factors affecting ore agglomeration behavior and leaching efficiency.In this study,we in-vestigated the effect of the type of binder and mass fraction of the H_(2)SO_(4)solut...The chemical binder is one of the critical factors affecting ore agglomeration behavior and leaching efficiency.In this study,we in-vestigated the effect of the type of binder and mass fraction of the H_(2)SO_(4)solution used on the curing,soaking,and leaching behavior of ag-glomerations.The results revealed that Portland cement(3CaO·SiO_(2),2CaO·SiO_(2),and 3CaO·Al_(2)O_(3))was the optimal binder for obtaining a well-shaped,stable agglomeration structure.A higher extraction rate was achieved when using Portland cement than that obtained using sodi-um silicate,gypsum,or acid-proof cement.An excessive geometric mean size is not conducive to obtaining well-shaped agglomerations and desirable porosity.Using computed tomography(CT)and MATLAB,the porosity of two-dimensional CT images in sample concentrations L1-L3 was observed to increase at least 4.5vol%after acid leaching.Ore agglomerations began to be heavily destroyed and even to disinteg-rate when the sulfuric acid solution concentration was higher than 30 g/L,which was caused by the excessive accumulation of reaction products and residuals.展开更多
In this study,two Ru/TiO_(2)samples with different TiO_(2)facets were prepared to investigate their photo-thermal catalytic CO_(2)+H_(2)reaction behavior.Without UV irradiation,the Ru/TiO_(2)with 67%{001}facet(3 RT)di...In this study,two Ru/TiO_(2)samples with different TiO_(2)facets were prepared to investigate their photo-thermal catalytic CO_(2)+H_(2)reaction behavior.Without UV irradiation,the Ru/TiO_(2)with 67%{001}facet(3 RT)displayed improved thermal catalytic activity for CO_(2)methanation than that of Ru/TiO_(2)with 30%{001}facet(0 RT).After H_(2)pretreatment,both samples exhibited enhanced thermal catalytic activities,but the H_(2)-treated 3 RT(3 RT-H)exhibited superior activity to that of the H_(2)-treated 0 RT(0 RT-H).Under UV irradiation,3 RT-H exhibited apparent photo-promoted thermal catalytic activity and stability,but the enhanced catalytic activity was lower than that of 0 RT-H.Based on the characterization results,it is proposed that both the surface oxygen vacancies(Vos)(activating CO_(2))and the metallic Ru nanoparticles(activating H_(2))were mainly responsible for CO_(2)methanation.For 0 RT,H_(2)pretreatment and subsequent UV irradiation did not promote the formation of Vos,resulting in low catalytic activity.For 3 RT,on the one hand,H_(2)pretreatment promoted the formation of Vos,which were regenerated under UV irradiation;on the other hand,the photogenerated electrons from TiO_(2)transferred to Ru to maintain the metallic Ru nanoparticles.Both behaviors promoted the activation of CO_(2)and H_(2)and enhanced CO_(2)methanation.Moreover,the photogenerated holes favored the dissociated H at Ru migrating to TiO_(2),also promoting CO_(2)methanation.These behaviors occurring on 3 RT-H may be attributed to the suitable metal-support interaction between the Ru nanoparticles and TiO_(2){001},resulting in the easy activation of lattice oxygen in TiO_(2)to Vos.With reference to the analysis of intermediates,a photo-thermal reaction mechanism is proposed for the Ru/TiO_(2){001}facet sample.展开更多
BACKGROUND Geleophysic dysplasia(GD)presents the characterized clinical manifestations of acromelic dysplasia,including extremely short stature,short limbs,small hands and feet,stubby fingers and toes,joint stiffness ...BACKGROUND Geleophysic dysplasia(GD)presents the characterized clinical manifestations of acromelic dysplasia,including extremely short stature,short limbs,small hands and feet,stubby fingers and toes,joint stiffness and others.It is clinically distinct from the other acromelic dysplasia in terms of symptoms such as cardiac valvular abnormalities,progressive hepatomegaly and tracheal stenosis.CASE SUMMARY We report on a Chinese 9-year-old girl with GD with the c.5243G>T(p.C1748F)mutation in FBN1(fibrillin 1,OMIM 134797).She was born in Guangxi Zhuang Autonomous Region of China.The patient presented with typical clinical features of GD and recurrent respiratory tract infections over 6 years.Laboratory studies and chest computed tomography(CT)scan indicated bronchopneumonia.Her echocardiography revealed mild mitral valve thickening with regurgitation.Laryngopharyngeal CT and electronic bronchoscopy revealed severe glottic stenosis.Echocardiography examination displayed mild mitral valve thickening and regurgitation.Ophthalmic examination did not reveal myopia or lens dislocation.Treated with ceftriaxone sodium and methylprednisolone sodium succinate for injection as well as methylprednisolone orally,patient’s symptoms had improved.CONCLUSION GD is a rare genetic condition that can cause life-threatening cardiovascular and respiratory problems.This study also found that the identified genotype of GD could be related to different clinical phenotypes.展开更多
In our published letter,[1]we have identified a minor error in Figs.2 and 3.Instead,we have 2111 events in these two plots with 646,249,382,and 834 events in Run 9(20.0 ton·day),Run 10(19.4 ton·day),Run 11–...In our published letter,[1]we have identified a minor error in Figs.2 and 3.Instead,we have 2111 events in these two plots with 646,249,382,and 834 events in Run 9(20.0 ton·day),Run 10(19.4 ton·day),Run 11–1(24.2 ton·day),and Run 11–2(37.1 ton·day).The mistake is due to an incorrect application of a small energy non-linearity(known as the BLS non-linearity)in making plots,but has no impact to the final results.Figures 2 and 3 are now updated in this note.展开更多
Single crystal silicon carbide(SiC)is widely used for optoelectronics applications.Due to the anisotropic characteristics of single crystal materials,the C face and Si face of single crystal SiC have different physica...Single crystal silicon carbide(SiC)is widely used for optoelectronics applications.Due to the anisotropic characteristics of single crystal materials,the C face and Si face of single crystal SiC have different physical properties,which may fit for particular application purposes.This paper presents an investigation of the material removal and associated subsurface defects in a set of scratching tests on the C face and Si face of 4H-SiC and 6H-SiC materials using molecular dynamics simulations.The investigation reveals that the sample material deformation consists of plastic,amorphous transformations and dislocation slips that may be prone to brittle split.The results showed that the material removal at the C face is more effective with less amorphous deformation than that at the Si face.Such a phenomenon in scratching relates to the dislocations on the basal plane(0001)of the SiC crystal.Subsurface defects were reduced by applying scratching cut depths equal to integer multiples of a half molecular lattice thickness,which formed a foundation for selecting machining control parameters for the best surface quality.展开更多
Dear Editor,In recent years,multi-modal medical image fusion has received widespread attention in the image processing community.However,existing works on medical image fusion methods are mostly devoted to pursuing hi...Dear Editor,In recent years,multi-modal medical image fusion has received widespread attention in the image processing community.However,existing works on medical image fusion methods are mostly devoted to pursuing high performance on visual perception and objective fusion metrics,while ignoring the specific purpose in clinical applications.展开更多
Photothermal catalysis is a widely researched field in which the reaction mechanism is usually investigated based on the photochemical behavior of the catalytic material.Considering that the adsorption of reactants is...Photothermal catalysis is a widely researched field in which the reaction mechanism is usually investigated based on the photochemical behavior of the catalytic material.Considering that the adsorption of reactants is essential for catalytic reactions to occur,in this study,the synergistic effect of photothermal catalysis is innovatively elucidated in terms of the electron transfer behavior of reactant adsorption.For the H_(2)+O2 or CO+H_(2)reaction systems over a ZnO catalyst,UV irradiation at 25°C or heat without UV irradiation did not cause H_(2)oxidation or CO reduction;only photothermal conditions(100 or 150°C+UV light)initiated the two reactions.This result is related to the electron transfer behavior associated with the adsorption of CO or H_(2)on ZnO,in which H_(2)or CO that lost an electron could be oxidized by O2 or hydroxyls.However,the electron‐accepting CO could be reduced by the electron‐donating H_(2)into CH4 under photothermal conditions.Based on the in‐situ characterization and theoretical calculation results,it was established that the synergistic effect of the photothermal conditions acted on the(002)crystal surface of ZnO to stimulate the growth of zinc vacancies,which resulted in the formation of defect energy levels,adsorption sites,and an adjusted Fermi level.As a result,the electron transfer behavior between adsorbed CO or H_(2)and the crystal surface varied,which further affected the photocatalytic behavior.The results show that the effect of photothermal synergy may not only produce the expected kinetic energy,but more importantly,produce energy that can change the activation mode of the reactant gas.This study provides a new understanding of the CO catalytic oxidation and reduction processes over semiconductor materials.展开更多
基金supported by the Community Development Office of Hunan Provincial Science and Technology DepartmentChina,Nos.2020SK53613(to DH),21JJ31006(to DH)the Fundamental Research Funds of Central South University,Nos.CX20220375(to TX),2023zzts215(to MZ)。
文摘Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s disease.SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport and metabolism of intracellularβ-amyloid precursor protein.To better understand the underlying mechanisms of SORL1 in the pathogenesis of late-onset Alzheimer s disease,in this study,we established a mouse model of SorI1 gene knockout using cluste red regularly inters paced short palindro mic repeats-associated protein 9 technology.We found that Sorl1-knocko ut mice displayed deficits in learning and memory.Furthermore,the expression of brain-derived neurotrophic factor was significantly downregulated in the hippocampus and co rtex,and amyloidβ-protein deposits were observed in the brains of 5orl1-knockout mice.In vitro,hippocampal neuronal cell synapses from homozygous Sorl1-knockout mice were impaired.The expression of synaptic proteins,including Drebrin and NR2B,was significantly reduced,and also their colocalization.Additionally,by knocking out the Sorl1 gene in N2a cells,we found that expression of the N-methyl-D-aspartate receptor,NR2B,and cyclic adenosine monophosphate-response element binding protein was also inhibited.These findings suggest that SORL1 participates in the pathogenesis of late-onset Alzheimer s disease by regulating the N-methyl-D-aspartate receptor NR2B/cyclic adenosine monophosphate-response element binding protein signaling axis.
基金supported financially by the Fundamental Research Funds for the Central Universities (YWF-22-K-101,YWF-23-L-805 and YWF-23-YG-QB-006)the support from the National Natural Science Foundation of China (12372106)Fundamental Research Funds for the Central Universities
文摘3D printing techniques offer an effective method in fabricating complex radially multi-material structures.However,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among others.In this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing platform.The 3D model fabrication is accomplished through line projection.The rotation and translation of the rod are synchronized to project and illuminate the photosensitive material volume.By controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 micrometers.By controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 micrometers.Our process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 s.Additionally,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical strength.This method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.
基金supported by the National Natural Science Foundation of China(Grant No.12205008)the NSFC Innovation Group Project(Grant No.11921006)+1 种基金the National Grand Instrument Project(Grant Nos.2019YFF01014402 and 2019YFF01014403)the National Science Fund for Distinguished Young Scholars(Grant No.12225501).
文摘The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 MeV are expected to be generated for tumor therapy.During high-repetition operation,both prompt radiation and residual radiation may cause safety problems.Therefore,human radiological safety assessment before commissioning is essential.In this paper,we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam parameters.We find that the prompt radiation can be shielded well by the concrete wall of the experimental hall,but the risk from residual radiation is nonnegligible and necessitates adequate radiation cooling.On the basis of the simulation results,we discuss the constraints imposed by radiation safety considerations on the annual working time,and we propose radiation cooling strategies for different shooting modes.
文摘目的比较晚期肝细胞癌一线系统治疗药物的有效性和安全性,供临床实践作参考。方法网络检索PubMed、Cochrane Library、Embase和Web of Science等文献数据库,检索时限均为建库至2021年6月,根据预设的纳入标准筛选文献进行网络荟萃分析。结果共纳入12项随机对照研究,合计8058例患者。网络荟萃分析结果显示,相较于索拉非尼,信迪利单抗联合贝伐珠单抗生物类似物(IBI305)、阿替利珠单抗联合贝伐珠单抗和多纳非尼均降低了患者的死亡风险(HR=0.57,95%CI:0.43~0.75;HR=0.58,95%CI:0.42~0.80;HR=0.83,95%CI:0.70~0.99),该3种治疗方式有最高的P-score值,分别为0.956、0.948和0.764;在有或无“大血管侵犯/肝外转移”的两组患者亚组中,3种治疗方案的排名类似;安全性方面,除安慰剂之外,多纳非尼因不良事件终止研究治疗、减量研究药物和暂停研究治疗的P-score值均位居首位。结论晚期肝细胞癌一线系统治疗药物中,信迪利单抗联合贝伐珠单抗生物类似物、阿替利珠单抗联合贝伐珠单抗和多纳非尼单药治疗均可显著改善晚期肝细胞癌患者的总生存时间;而多纳非尼的安全性和耐受性更佳。
基金financially supported by the National Key Research and Development Program of China (No. 2016YFC0600704)the National Science Fund for Excellent Young Scholars of China (No. 51722401)the Key Program of National Natural Science Foundation of China (No. 51734001)
文摘Compared with the traditional pyrometallurgical process, copper bioleaching has distinctive advantages of high efficiency and lower cost, enabling efficiently extracts of valuable metal resources from copper sulfides. Moreover, during long-term industrial applications of bioleaching, many regulatory enhancements and technological methods are used to accelerate the interfacial reactions. With advances in microbial genetic and sequencing technologies, bacterial communities and their mechanisms in bioleaching systems have been revealed gradually. The bacterial proliferation and dissolution of sulfide ores by a bacterial community depends on the pH, temperature, oxygen, reaction product regulation, additives, and passivation substances, among other factors. The internal relationship among the influencing factors and the succession of microorganism diversity are discussed and reviewed in this paper. This paper is intended to provide a good reference for studies related to enhanced bioleaching.
基金financially supported by the National Natural Science Foundation of China (No. 51604138)the Open Fund of the Key Laboratory of Ministry of Education of China for Efficient Mining and Safety of Metal Mines (No. ustbmslab201806)
文摘To solve the problem of low permeability and lower extraction rates of high-mud ores, a surfactant was added as a penetrant to the pregnant leaching solution during column leaching tests. On the basis of the theories of physical chemistry and seepage flow mechanics, the mechanism by which seepage is enhanced under the effects of the surfactant was analyzed. The results show that the action modes of the surfactant were divided into four aspects: changing the wettability of the ore, reducing the viscosity of the leaching solution, adsorbing onto the surface of ore, and enhancing the permeability effect. The findings of column leaching tests demonstrated that permeability was substantially improved by the surfactant. In the later period of leaching, the permeability coefficient was two times higher than that of the control group. Meanwhile, the ore extraction rate increased by approximately 10%. During the leaching process, the surface tension of the solution did not substantially change, and that of the solution with surfactant increased slightly. The kinetics analysis of ore column leaching illustrated that the leaching processes were controlled by both internal diffusion(principal factor) and chemical reaction.
基金Supported by the Committee of Science and Technology of Shanghai,China(No.09411962100)the Health and Family Planning Committee of Pudong New District of Shanghai,China(No.PW2014D-1)
文摘AIM：To assess the safety,efficacy,predictability and stability of implantable collamer lens（ICL） for residual refractive error after corneal refractive surgery.METHODS： This study evaluated 19 eyes of 12 patients who underwent ICL implantation after corneal refractive surgeries.They were followed up for 1y to 5y of uncorrected distance visual acuity（UDVA）,corrected distance visual acuity（CDVA）,manifest refractive error,flat and steep K value,axial length,intraocular pressure,corneal endothelial cell density,adverse events after ICL surgery.RESULTS： The mean follow-up period was 39.05 ±19.22 mo（range,1-5y）.Spherical equivalent refractive error changed from-7.45±3.02 D preoperatively to-0.85±1.10 D 1wk to 1mo after ICL implantation,with the safety and efficacy indices being 1.12 and 1.15,respectively.A total of 52.63% of eyes were within ±0.5 D of the predicted spherical equivalents,73.68% were within ±1.0 D.A trend of mild regression towards myopia with axial elongation after 5y was observed.One eye with mild anterior capsule opacity and retinal detachment 1y after surgery were observed.CONCLUSION： ICL implantation is safe and effective for the correction of residual refractive error after corneal refractive surgeries,especially in moderate to high residual myopia.
基金This work was financially supported by the National Nat-ural Science Foundation for Excellent Youth of China(No.51722401)the State Key Research Development Program of China(No.2016YFC0600704)the Key Program of Na-tional Natural Science Foundation of China(No.51734001).
文摘The chemical binder is one of the critical factors affecting ore agglomeration behavior and leaching efficiency.In this study,we in-vestigated the effect of the type of binder and mass fraction of the H_(2)SO_(4)solution used on the curing,soaking,and leaching behavior of ag-glomerations.The results revealed that Portland cement(3CaO·SiO_(2),2CaO·SiO_(2),and 3CaO·Al_(2)O_(3))was the optimal binder for obtaining a well-shaped,stable agglomeration structure.A higher extraction rate was achieved when using Portland cement than that obtained using sodi-um silicate,gypsum,or acid-proof cement.An excessive geometric mean size is not conducive to obtaining well-shaped agglomerations and desirable porosity.Using computed tomography(CT)and MATLAB,the porosity of two-dimensional CT images in sample concentrations L1-L3 was observed to increase at least 4.5vol%after acid leaching.Ore agglomerations began to be heavily destroyed and even to disinteg-rate when the sulfuric acid solution concentration was higher than 30 g/L,which was caused by the excessive accumulation of reaction products and residuals.
文摘In this study,two Ru/TiO_(2)samples with different TiO_(2)facets were prepared to investigate their photo-thermal catalytic CO_(2)+H_(2)reaction behavior.Without UV irradiation,the Ru/TiO_(2)with 67%{001}facet(3 RT)displayed improved thermal catalytic activity for CO_(2)methanation than that of Ru/TiO_(2)with 30%{001}facet(0 RT).After H_(2)pretreatment,both samples exhibited enhanced thermal catalytic activities,but the H_(2)-treated 3 RT(3 RT-H)exhibited superior activity to that of the H_(2)-treated 0 RT(0 RT-H).Under UV irradiation,3 RT-H exhibited apparent photo-promoted thermal catalytic activity and stability,but the enhanced catalytic activity was lower than that of 0 RT-H.Based on the characterization results,it is proposed that both the surface oxygen vacancies(Vos)(activating CO_(2))and the metallic Ru nanoparticles(activating H_(2))were mainly responsible for CO_(2)methanation.For 0 RT,H_(2)pretreatment and subsequent UV irradiation did not promote the formation of Vos,resulting in low catalytic activity.For 3 RT,on the one hand,H_(2)pretreatment promoted the formation of Vos,which were regenerated under UV irradiation;on the other hand,the photogenerated electrons from TiO_(2)transferred to Ru to maintain the metallic Ru nanoparticles.Both behaviors promoted the activation of CO_(2)and H_(2)and enhanced CO_(2)methanation.Moreover,the photogenerated holes favored the dissociated H at Ru migrating to TiO_(2),also promoting CO_(2)methanation.These behaviors occurring on 3 RT-H may be attributed to the suitable metal-support interaction between the Ru nanoparticles and TiO_(2){001},resulting in the easy activation of lattice oxygen in TiO_(2)to Vos.With reference to the analysis of intermediates,a photo-thermal reaction mechanism is proposed for the Ru/TiO_(2){001}facet sample.
文摘BACKGROUND Geleophysic dysplasia(GD)presents the characterized clinical manifestations of acromelic dysplasia,including extremely short stature,short limbs,small hands and feet,stubby fingers and toes,joint stiffness and others.It is clinically distinct from the other acromelic dysplasia in terms of symptoms such as cardiac valvular abnormalities,progressive hepatomegaly and tracheal stenosis.CASE SUMMARY We report on a Chinese 9-year-old girl with GD with the c.5243G>T(p.C1748F)mutation in FBN1(fibrillin 1,OMIM 134797).She was born in Guangxi Zhuang Autonomous Region of China.The patient presented with typical clinical features of GD and recurrent respiratory tract infections over 6 years.Laboratory studies and chest computed tomography(CT)scan indicated bronchopneumonia.Her echocardiography revealed mild mitral valve thickening with regurgitation.Laryngopharyngeal CT and electronic bronchoscopy revealed severe glottic stenosis.Echocardiography examination displayed mild mitral valve thickening and regurgitation.Ophthalmic examination did not reveal myopia or lens dislocation.Treated with ceftriaxone sodium and methylprednisolone sodium succinate for injection as well as methylprednisolone orally,patient’s symptoms had improved.CONCLUSION GD is a rare genetic condition that can cause life-threatening cardiovascular and respiratory problems.This study also found that the identified genotype of GD could be related to different clinical phenotypes.
文摘In our published letter,[1]we have identified a minor error in Figs.2 and 3.Instead,we have 2111 events in these two plots with 646,249,382,and 834 events in Run 9(20.0 ton·day),Run 10(19.4 ton·day),Run 11–1(24.2 ton·day),and Run 11–2(37.1 ton·day).The mistake is due to an incorrect application of a small energy non-linearity(known as the BLS non-linearity)in making plots,but has no impact to the final results.Figures 2 and 3 are now updated in this note.
基金financial support from National Natural Science Foundation of China(Grant No.51835004 and 51575197)Huaqiao University International Cultivation Program for Outstanding Postgraduates and Subsidized Projec for Postgraduates’Innovative Fund in Scientific Research of Huaqiao University(No.18011080010)。
文摘Single crystal silicon carbide(SiC)is widely used for optoelectronics applications.Due to the anisotropic characteristics of single crystal materials,the C face and Si face of single crystal SiC have different physical properties,which may fit for particular application purposes.This paper presents an investigation of the material removal and associated subsurface defects in a set of scratching tests on the C face and Si face of 4H-SiC and 6H-SiC materials using molecular dynamics simulations.The investigation reveals that the sample material deformation consists of plastic,amorphous transformations and dislocation slips that may be prone to brittle split.The results showed that the material removal at the C face is more effective with less amorphous deformation than that at the Si face.Such a phenomenon in scratching relates to the dislocations on the basal plane(0001)of the SiC crystal.Subsurface defects were reduced by applying scratching cut depths equal to integer multiples of a half molecular lattice thickness,which formed a foundation for selecting machining control parameters for the best surface quality.
基金supported by the National Natural Science Foundation of China(62176081,61922075,62171176)the Fundamental Research Funds for the Central Universities(JZ2020HGPA0111,JZ2021HGPA0061)the USTC Research Funds of the Double First-Class Initiative(KY2100000123)。
文摘Dear Editor,In recent years,multi-modal medical image fusion has received widespread attention in the image processing community.However,existing works on medical image fusion methods are mostly devoted to pursuing high performance on visual perception and objective fusion metrics,while ignoring the specific purpose in clinical applications.
文摘Photothermal catalysis is a widely researched field in which the reaction mechanism is usually investigated based on the photochemical behavior of the catalytic material.Considering that the adsorption of reactants is essential for catalytic reactions to occur,in this study,the synergistic effect of photothermal catalysis is innovatively elucidated in terms of the electron transfer behavior of reactant adsorption.For the H_(2)+O2 or CO+H_(2)reaction systems over a ZnO catalyst,UV irradiation at 25°C or heat without UV irradiation did not cause H_(2)oxidation or CO reduction;only photothermal conditions(100 or 150°C+UV light)initiated the two reactions.This result is related to the electron transfer behavior associated with the adsorption of CO or H_(2)on ZnO,in which H_(2)or CO that lost an electron could be oxidized by O2 or hydroxyls.However,the electron‐accepting CO could be reduced by the electron‐donating H_(2)into CH4 under photothermal conditions.Based on the in‐situ characterization and theoretical calculation results,it was established that the synergistic effect of the photothermal conditions acted on the(002)crystal surface of ZnO to stimulate the growth of zinc vacancies,which resulted in the formation of defect energy levels,adsorption sites,and an adjusted Fermi level.As a result,the electron transfer behavior between adsorbed CO or H_(2)and the crystal surface varied,which further affected the photocatalytic behavior.The results show that the effect of photothermal synergy may not only produce the expected kinetic energy,but more importantly,produce energy that can change the activation mode of the reactant gas.This study provides a new understanding of the CO catalytic oxidation and reduction processes over semiconductor materials.
