Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives

A one-pot sequential reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]quinoline derivatives has been developed.The reaction included firstly the Cu-catalyzed three-component reaction of isoquinoline（quinoline）,acetylenedicarboxylate and alkynylbenzene and then Cs 2 CO 3-promoted intramolecular cyclization reaction of initially formed 1-alkenyl-2-alkynyl-1,2-dihydroisoquinoline（1,2-dihydroquinoline）.

Efficient Synthesis of Complex Bridged 1,3-Oxazabicycles via Reactions of N-Alkyl-1,10-phenanthrolinium Halides with Cyclic 1,3-Diketones

Complex bridged 1,3-oxazabicycles and 1,4-disubstituted 1,10-phenanthroline derivatives were efficiently prepared by the reactions of N-methyl or N-benzylphenanthrolinium halides with cyclic 1,3-dicarbonyl compounds in a K2CO3/CH3CN system.

Synthesis of Polysubstituted 1,4-Dihydropyridines via Four-component Reactions of Arylamine,Acetylenedicarboxylate, Aromatic Aldehyde and Ethyl Acetoacetate

An efficient synthetic protocol for the 1,4-diaryl-1,4-dihydropyridines was developed via the domino four-component reaction of arylamine,acetylenedicarboxylate,aromatic aldehyde and ethyl acetoacetate.The reaction mechanism involves the formation of β-enamino ester and its sequential Michael addition to arylidene acetoacetate.

Microwave Assisted Synthesis of 3,3',3″,3'″-o-,p-Phenylenedi-methylidinetetrakis-(4-hydroxy-2H-1-benzopyran-2-one)

Under microwave irradiation,2,2＇-alkoxy-bridging or 4,4＇-alkoxy-bridging dibenzaldehydes reacted with 4-hydroxycoumarin in DMF to give a series of 3,3＇,3″,3＇″-o-and 3,3＇,3″,3＇″-p-phenylenedimethylidinetetrakis-（4-hydroxy-2H-1-benzopyran-2-ones） in moderate yields.The structures of the synthetic coumarin derivatives were characterized with IR,1H NMR and MS spectroscopy as well as X-ray single crystallography.

Synthesis, Structure and Electrochemistry of Macrocyclic 1,1'-Bis(1,3-phenyleneoxyacetylpyrazoyl)ferrocene

1,1＇-Diacetoacetylferrocene 1 reacted with phenylene-1,3-dioxyactyl hydrazine 2 in absolute ethanol to give the macrocyclic ferrocenyl dipyrazole compound in moderate yield. Determined by X-ray structure analysis, it crystallizes in monoclinic system, space group P21/c with a = 13.7509（4）, b = 8.1277（2）, c = 21.7472（6） A, β = 103.1030（10）°, V = 2367.25（11） A^3, Z = 4, Dc = 1.505 g/cm^3, R = 0.0353 and wR = 0.0811. The electrochemical studies reveal that redox of Fe^＋/Fe in ferrocene is a reversible one-electron process.

Synthesis, Crystal Structure of Bis-terpyridinyl-calix[4]arene Derivatives and Fluorescent Sensor for Zn2＋

The calix[4]arene-based podands which incorporates two terpyridinyl functional groups derived from the alkylatiorl reactions of 4-（co-chloroalkoxyphenyl）-2,2＇：6＇,2＂-terpyridine in 1,3-alternate position at lower rim have been prepared in moderate yields. The structures of four pyridyl compounds were determined by X-ray single crystal diffraction method. The complexing properties of bis-terpyridinyl-calix[4]arenes for transition metal ions were inves- tigated by fluorescence spectra. Bis-terpyridinyl-calix[4]arenes gave a more efficient fluorescent sensing ability to Zn2＋.

Diastereoselective Synthesis of 1,10-Dihydropyrrolo [ 1,2-a] [1,10]phenanthroline Derivatives via 1,3-Dipolar Cycloaddition Reaction

The functionalized 1,10-dihydropyrrolo[1,2-a][1,10]phenanthroline derivatives were synthesized in good yields and with high diastereoselectivity by 1,3-dipolar cycloaddition reactions of N-phenacylphenanthrolinium bromides or N-ethoxycarbonylmethylene phenanthrolinium bromide with various nitrostyrenes in acetonitrile at room temperature in the presence of triethvlamine,