目的:探究不同中医证型的高血压病患者眼底体征的差异。方法:选取符合标准的患有高血压病的患者进行研究。通过中医辨证进行分组,利用改进的U-Net网络对患者眼底图片进行预处理及血管分割,通过imageJ软件KaPPa插件计算视网膜血管曲度,an...目的:探究不同中医证型的高血压病患者眼底体征的差异。方法:选取符合标准的患有高血压病的患者进行研究。通过中医辨证进行分组,利用改进的U-Net网络对患者眼底图片进行预处理及血管分割,通过imageJ软件KaPPa插件计算视网膜血管曲度,angle tool插件测量动静脉分支夹角,使用半自动化视网膜微血管测量软件VAMPIRE(Vascular Asesment and Measuremnt Platform for Images of the Rtina)测量视网膜动静脉管径。对比分析视网膜微血管形态学指标在不同中医证型高血压病患者之间的差异。结果:共纳入相关临床资料、实验室指标、眼底照相检查完整的患者363例,通过对高血压病患者眼底图像分析发现肝火亢盛证患者视网膜病变分级多以Ⅲ级为主,而痰湿壅盛证和阴阳两虚证均以Ⅱ-Ⅲ级为主,阴虚阳亢组则以Ⅰ级为主。各组间颞上静脉、颞上动脉存在差异,其中痰湿壅盛组颞上静脉明显细于其他三组(P<0.05),肝火亢盛组颞上动脉粗于痰湿壅盛组(P<0.05)和阴虚阳亢组(P<0.05),但与阴阳两虚组无明显差异(P>0.05)。颞下动静脉各组间差异无统计学意义(P>0.05)。各证型间仅颞上静脉的血管分支夹角存在差异(P≤0.05),而其余视网膜血管组间无明显差异(P>0.05)。各证型间静脉的血管弯曲情况无明显差异(P>0.05),视网膜动脉的血管弯曲情况存在明显差异(P<0.05)。结论:不同中医证型的高血压性视网膜病变严重程度和视网膜血管形态学上存在差异,一定程度上反映中医辨证对高血压病进行中医分型的合理性,提供了眼底体征作为中医辨证分型的依据。提示或可通过高血压病的中医证型预测视网膜血管病变程度,进而预测靶器官的损伤程度。展开更多
The mesoscale eddy and internal wave both are phenomena commonly observed in oceans. It is aimed to investigate how the presence of a mesoscale eddy in the ocean affects wave form deformation of the internal solitary ...The mesoscale eddy and internal wave both are phenomena commonly observed in oceans. It is aimed to investigate how the presence of a mesoscale eddy in the ocean affects wave form deformation of the internal solitary wave propagation. An ocean eddy is produced by a quasi-geostrophic model in f-plane, and the one-dimensional nonlinear variable-coefficient extended Korteweg-de Vries （eKdV） equation is used to simulate an internal solitary wave passing through the mesoscale eddy field. The results suggest that the mode structures of the linear internal wave are modified due to the presence of the mesoscale eddy field. A cyclonic eddy and an anticyclonic eddy have different influences on the background environment of the internal solitary wave propagation. The existence of a mesoscale eddy field has almost no prominent impact on the propagation of a smallamplitude internal solitary wave only based on the first mode vertical structure, but the mesoscale eddy background field exerts a considerable influence on the solitary wave propagation if considering high-mode vertical structures. Furthermore, whether an internal solitary wave first passes through anticyclonic eddy or cyclonic eddy, the deformation of wave profiles is different. Many observations of solitary internal waves in the real oceans suggest the formation of the waves. Apart from topography effect, it is shown that the mesoscale eddy background field is also a considerable factor which influences the internal solitary wave propagation and deformation.展开更多
文摘目的:探究不同中医证型的高血压病患者眼底体征的差异。方法:选取符合标准的患有高血压病的患者进行研究。通过中医辨证进行分组,利用改进的U-Net网络对患者眼底图片进行预处理及血管分割,通过imageJ软件KaPPa插件计算视网膜血管曲度,angle tool插件测量动静脉分支夹角,使用半自动化视网膜微血管测量软件VAMPIRE(Vascular Asesment and Measuremnt Platform for Images of the Rtina)测量视网膜动静脉管径。对比分析视网膜微血管形态学指标在不同中医证型高血压病患者之间的差异。结果:共纳入相关临床资料、实验室指标、眼底照相检查完整的患者363例,通过对高血压病患者眼底图像分析发现肝火亢盛证患者视网膜病变分级多以Ⅲ级为主,而痰湿壅盛证和阴阳两虚证均以Ⅱ-Ⅲ级为主,阴虚阳亢组则以Ⅰ级为主。各组间颞上静脉、颞上动脉存在差异,其中痰湿壅盛组颞上静脉明显细于其他三组(P<0.05),肝火亢盛组颞上动脉粗于痰湿壅盛组(P<0.05)和阴虚阳亢组(P<0.05),但与阴阳两虚组无明显差异(P>0.05)。颞下动静脉各组间差异无统计学意义(P>0.05)。各证型间仅颞上静脉的血管分支夹角存在差异(P≤0.05),而其余视网膜血管组间无明显差异(P>0.05)。各证型间静脉的血管弯曲情况无明显差异(P>0.05),视网膜动脉的血管弯曲情况存在明显差异(P<0.05)。结论:不同中医证型的高血压性视网膜病变严重程度和视网膜血管形态学上存在差异,一定程度上反映中医辨证对高血压病进行中医分型的合理性,提供了眼底体征作为中医辨证分型的依据。提示或可通过高血压病的中医证型预测视网膜血管病变程度,进而预测靶器官的损伤程度。
基金The National Basic Research Program of China under contract Nos 2011CB403503 and 2012CB955601the Scientific Research Fund of the Second Institute of Oceanography, the State Oceanic Administration of China under contract Nos JG1009, JT1006 and JT0905
文摘The mesoscale eddy and internal wave both are phenomena commonly observed in oceans. It is aimed to investigate how the presence of a mesoscale eddy in the ocean affects wave form deformation of the internal solitary wave propagation. An ocean eddy is produced by a quasi-geostrophic model in f-plane, and the one-dimensional nonlinear variable-coefficient extended Korteweg-de Vries （eKdV） equation is used to simulate an internal solitary wave passing through the mesoscale eddy field. The results suggest that the mode structures of the linear internal wave are modified due to the presence of the mesoscale eddy field. A cyclonic eddy and an anticyclonic eddy have different influences on the background environment of the internal solitary wave propagation. The existence of a mesoscale eddy field has almost no prominent impact on the propagation of a smallamplitude internal solitary wave only based on the first mode vertical structure, but the mesoscale eddy background field exerts a considerable influence on the solitary wave propagation if considering high-mode vertical structures. Furthermore, whether an internal solitary wave first passes through anticyclonic eddy or cyclonic eddy, the deformation of wave profiles is different. Many observations of solitary internal waves in the real oceans suggest the formation of the waves. Apart from topography effect, it is shown that the mesoscale eddy background field is also a considerable factor which influences the internal solitary wave propagation and deformation.
