With the development of traditional Chinese medicine(TCM)acupuncture and moxibustion,research on acupuncture and moxibustion in the Western world is deepening.The concept of acupuncture and moxibustion popular in the ...With the development of traditional Chinese medicine(TCM)acupuncture and moxibustion,research on acupuncture and moxibustion in the Western world is deepening.The concept of acupuncture and moxibustion popular in the West is formed.By investigating the localization of acupuncture and moxibustion in the Western world,this paper introduces several kinds of acupuncture and moxibustion popular in the West and concludes the spread of acupuncture and moxibustion popular in the West through hospitals and clinics,academic works,social organizations,education,and training.This paper provides a global vision developing domestic acupuncture and moxibustion and promoting academic prosperity and technical progress of world acupuncture and moxibustion system.展开更多
目的采用生物信息学方法,构建膀胱癌患者免疫基因预后评估模型,筛选影响膀胱癌发生及预后的生物标志物。方法下载癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中膀胱癌及癌旁正常组织转录组数据及临床病理资料,下载免疫信息学...目的采用生物信息学方法,构建膀胱癌患者免疫基因预后评估模型,筛选影响膀胱癌发生及预后的生物标志物。方法下载癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中膀胱癌及癌旁正常组织转录组数据及临床病理资料,下载免疫信息学数据库(Immunomes Project,ImmPort)中免疫基因数据,筛选差异表达免疫基因;采用单因素、多因素Cox风险回归模型分析并构建差异表达免疫基因预后评估模型。进一步分析免疫基因预后评估模型风险评分、临床病理特征与膀胱癌预后的相关性。结果基于R语言中"wilcox.test"共筛选出260个与膀胱肿瘤相关的差异表达免疫基因;纳入Cox单因素分析,结果显示25个差异表达免疫基因与膀胱肿瘤预后相关(P<0.01),取P<0.01的25个差异表达免疫基因纳入Cox多因素分析,得到包含11个(TAP1、MMP9、ADIPOQ、PDGFRA、AHNAK、KCNH2、OLR1、RAC3、NAMPT、PPY、SH3BP2)差异表达免疫基因的膀胱癌免疫基因预后评估模型;基于模型风险评分将样本分为高、低风险组,Kaplan-Meier生存曲线结果显示高风险组5年总生存率为28.6%,低风险组5年总生存率为59.7%。ROC模型曲线证实该预测模型有一定的准确性(AUC=0.732)。将临床病理特征纳入Cox回归分析,结果显示免疫基因预后评估模型评分为高风险是影响膀胱癌患者预后的独立预测因子。结论基于生物信息学方法构建的膀胱癌免疫基因预后评估模型可用于计算膀胱癌患者预后风险评分,期望为临床判断膀胱癌患者的预后提供帮助。展开更多
Founded in November 1987,the World Federation of Acupuncture-Moxibustion Societies(WFAS)is headquartered in Beijing,China.It is an NGO which has official working relations with the World Health Organization,and has re...Founded in November 1987,the World Federation of Acupuncture-Moxibustion Societies(WFAS)is headquartered in Beijing,China.It is an NGO which has official working relations with the World Health Organization,and has renewed the working relations 7 times consecutively since 1998.In 2010,WFAS was admitted as an A-liaison organization by ISO/TC249.In 2017,it展开更多
On November 15th,2018,"Special Events of World Acupuncture-Moxibustion Day into UNESCO"were held at the UNESCO headquarters in Paris,France,to celebrate the 8th anniversary of traditional Chinese medicine (T...On November 15th,2018,"Special Events of World Acupuncture-Moxibustion Day into UNESCO"were held at the UNESCO headquarters in Paris,France,to celebrate the 8th anniversary of traditional Chinese medicine (TCM) acupuncturemoxibustion being inscribed on the"Representative List of the Intangible Cultural Heritage of Humanity".展开更多
基金This research was financed by the grant from Special Project for International Cooperation of Department of International Cooperation,National Administration of Traditional Chinese Medicine(No.0610-2140NF020631).
文摘With the development of traditional Chinese medicine(TCM)acupuncture and moxibustion,research on acupuncture and moxibustion in the Western world is deepening.The concept of acupuncture and moxibustion popular in the West is formed.By investigating the localization of acupuncture and moxibustion in the Western world,this paper introduces several kinds of acupuncture and moxibustion popular in the West and concludes the spread of acupuncture and moxibustion popular in the West through hospitals and clinics,academic works,social organizations,education,and training.This paper provides a global vision developing domestic acupuncture and moxibustion and promoting academic prosperity and technical progress of world acupuncture and moxibustion system.
文摘目的采用生物信息学方法,构建膀胱癌患者免疫基因预后评估模型,筛选影响膀胱癌发生及预后的生物标志物。方法下载癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中膀胱癌及癌旁正常组织转录组数据及临床病理资料,下载免疫信息学数据库(Immunomes Project,ImmPort)中免疫基因数据,筛选差异表达免疫基因;采用单因素、多因素Cox风险回归模型分析并构建差异表达免疫基因预后评估模型。进一步分析免疫基因预后评估模型风险评分、临床病理特征与膀胱癌预后的相关性。结果基于R语言中"wilcox.test"共筛选出260个与膀胱肿瘤相关的差异表达免疫基因;纳入Cox单因素分析,结果显示25个差异表达免疫基因与膀胱肿瘤预后相关(P<0.01),取P<0.01的25个差异表达免疫基因纳入Cox多因素分析,得到包含11个(TAP1、MMP9、ADIPOQ、PDGFRA、AHNAK、KCNH2、OLR1、RAC3、NAMPT、PPY、SH3BP2)差异表达免疫基因的膀胱癌免疫基因预后评估模型;基于模型风险评分将样本分为高、低风险组,Kaplan-Meier生存曲线结果显示高风险组5年总生存率为28.6%,低风险组5年总生存率为59.7%。ROC模型曲线证实该预测模型有一定的准确性(AUC=0.732)。将临床病理特征纳入Cox回归分析,结果显示免疫基因预后评估模型评分为高风险是影响膀胱癌患者预后的独立预测因子。结论基于生物信息学方法构建的膀胱癌免疫基因预后评估模型可用于计算膀胱癌患者预后风险评分,期望为临床判断膀胱癌患者的预后提供帮助。
文摘Founded in November 1987,the World Federation of Acupuncture-Moxibustion Societies(WFAS)is headquartered in Beijing,China.It is an NGO which has official working relations with the World Health Organization,and has renewed the working relations 7 times consecutively since 1998.In 2010,WFAS was admitted as an A-liaison organization by ISO/TC249.In 2017,it
文摘On November 15th,2018,"Special Events of World Acupuncture-Moxibustion Day into UNESCO"were held at the UNESCO headquarters in Paris,France,to celebrate the 8th anniversary of traditional Chinese medicine (TCM) acupuncturemoxibustion being inscribed on the"Representative List of the Intangible Cultural Heritage of Humanity".
