帕金森病抑郁(parkinson’s disease with depression,PDD)是帕金森病(parkinson’s disease,PD)最常见的非运动症状之一,其发病机制复杂,目前尚不完全明确。PD病理学研究显示,抑郁症状可能是PD病程进展的一个临床表现。早发现、早诊断...帕金森病抑郁(parkinson’s disease with depression,PDD)是帕金森病(parkinson’s disease,PD)最常见的非运动症状之一,其发病机制复杂,目前尚不完全明确。PD病理学研究显示,抑郁症状可能是PD病程进展的一个临床表现。早发现、早诊断、早治疗有利于减缓病情的进展,提高患者的生存质量。西医治疗起效相对较快,但有一定的副作用;中医辨证论治可以达到个体化精准治疗的目的,但同时存在辨证分型复杂且证型不统一的问题,中西医结合治疗可以起到互补的优势。本文对PDD的发病率、中西医发病机制、临床诊断及近几年的临床研究现状进行了总结归纳,为临床治疗PDD提供参考。展开更多
To develop and utilize marine resources in the deep sea, the higher requirements for floating structures, which are operated in marine environment for a long term, have been put forward. Reasonable structure type and ...To develop and utilize marine resources in the deep sea, the higher requirements for floating structures, which are operated in marine environment for a long term, have been put forward. Reasonable structure type and accurate force analysis are favorable guarantees to improve the survival performance and working performance of the floating structures. Floating spheres fastened by mooring cable were widely used in floating structures. In this paper, the wave forces of the floating sphere are efficiently and accurately calculated by solving the geometric relationship between the non-submerged floating sphere and wave surface. Combined with the hydrodynamic calculation of mooring cables based on the lumped mass method, the coupled motion model of multi-floating spheres fastened by multi-mooring cable was established under wave action. Furthermore, according to the floating structures fastened by mooring cable in the actual ocean engineering, the topological method of multi-mooring cables fastening the multifloating spheres was expounded from simple to complex. Finally, the modeling method and preliminarily hydrodynamic characteristics of the fastened floating structures, including the mooring system of renewable energy devices, ocean buoy, and coral nursery, were presented and analyzed in detail. The obtained results showed that the method for calculating the wave force on the floating sphere developed in this paper can accurately describe the motion process of the floating mooring sphere and the force on the mooring cable. Also, the topological method of multiple buoys and multiple mooring cables could efficiently establish various numerical hydrodynamic models of fastened buoys in ocean engineering.展开更多
文摘帕金森病抑郁(parkinson’s disease with depression,PDD)是帕金森病(parkinson’s disease,PD)最常见的非运动症状之一,其发病机制复杂,目前尚不完全明确。PD病理学研究显示,抑郁症状可能是PD病程进展的一个临床表现。早发现、早诊断、早治疗有利于减缓病情的进展,提高患者的生存质量。西医治疗起效相对较快,但有一定的副作用;中医辨证论治可以达到个体化精准治疗的目的,但同时存在辨证分型复杂且证型不统一的问题,中西医结合治疗可以起到互补的优势。本文对PDD的发病率、中西医发病机制、临床诊断及近几年的临床研究现状进行了总结归纳,为临床治疗PDD提供参考。
基金financially supported by the National Natural Science Foundation of China (Grant No.52101330)the Basic Scientific Research Foundation of Zhejiang Provincial Universities (Grant No.2022J004)。
文摘To develop and utilize marine resources in the deep sea, the higher requirements for floating structures, which are operated in marine environment for a long term, have been put forward. Reasonable structure type and accurate force analysis are favorable guarantees to improve the survival performance and working performance of the floating structures. Floating spheres fastened by mooring cable were widely used in floating structures. In this paper, the wave forces of the floating sphere are efficiently and accurately calculated by solving the geometric relationship between the non-submerged floating sphere and wave surface. Combined with the hydrodynamic calculation of mooring cables based on the lumped mass method, the coupled motion model of multi-floating spheres fastened by multi-mooring cable was established under wave action. Furthermore, according to the floating structures fastened by mooring cable in the actual ocean engineering, the topological method of multi-mooring cables fastening the multifloating spheres was expounded from simple to complex. Finally, the modeling method and preliminarily hydrodynamic characteristics of the fastened floating structures, including the mooring system of renewable energy devices, ocean buoy, and coral nursery, were presented and analyzed in detail. The obtained results showed that the method for calculating the wave force on the floating sphere developed in this paper can accurately describe the motion process of the floating mooring sphere and the force on the mooring cable. Also, the topological method of multiple buoys and multiple mooring cables could efficiently establish various numerical hydrodynamic models of fastened buoys in ocean engineering.
