In medical research,there are times when the introduction of a new tool can launch scientific discovery in new directions.While antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)r...In medical research,there are times when the introduction of a new tool can launch scientific discovery in new directions.While antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic development.The recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).展开更多
Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their s...Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.展开更多
[Objective] This study was conducted to investigate the quality condition of chemical components of tobacco in Yunnan. [Method] The C3F samples were collected from 76 base units in Yunnan Province and their convention...[Objective] This study was conducted to investigate the quality condition of chemical components of tobacco in Yunnan. [Method] The C3F samples were collected from 76 base units in Yunnan Province and their conventional chemical components were analyzed, and the evaluation was carded out based on the membership function and hierarchical cluster analysis of cigarette brands H1 and H2 in Yunnan. [Result] The results showed that： （1） Major chemical components of 76 base units were coordinated overall. （2） Total nitrogen of brand H1 was higher than that of the high-quality tobacco leaves by 12.08%; raw tobacco of brands H3 and H2 satisfied the quality requirements of high-quality tobacco in Yunnan; and the total sugar and reducing sugar in flue-cured tobacco of brand H4 were higher those of the high-quality tobacco leaves by 0.76% and 10.3%, respectively. （3） The total sugar, reducing sugar and potassium of tobacco leaves from bases of G1 group were higher than those of tobacco from bases of G2 group by 38.1%, 2.27% and 7.34%, respectively; and total nitrogen and chlorine were lower by 4.69% and 11.11%, respectively; and nicotine contents in tobacco of the two groups were similar. （4） H2 and H3 were not significantly different in main chemical components; H3 and H4 were significantly different in total nitrogen, while other main chemical components were not significant different; and there were no significant differences between H4 and H2. [Conclusion] The quality of tobacco leaves from tobacco base units of G1 and G2 groups was better. Therefore, the evaluation provides theoretical reference for construction of tobacco base units.展开更多
Purpose:To observe the clinical efficacy of sodium cromoglicate eye drops combined with Yupingfeng granules in the treatment of allergic conjunctivitis.Methods:.A total of 118 patients with allergic conjunctivitis wer...Purpose:To observe the clinical efficacy of sodium cromoglicate eye drops combined with Yupingfeng granules in the treatment of allergic conjunctivitis.Methods:.A total of 118 patients with allergic conjunctivitis were randomly divided into a combined sodium cromoglicate and Yupingfeng Granule (treatment)group(n=74) and a sodium cromoglicate (control) group (n=44).Clinical efficacy of the two treatments was evaluated by observing the changes in patients'symptoms and physical signs before and after their respective treatments.Results:.Following treatment,.the symptoms and physical signs related to allergic conjunctivitis were significantly alleviated in all 118 cases.The total efficacy of the combined sodium cromoglicate and Yupingfeng granule treatment was91.9%,.which was significantly higher than the value of 75.0%obtained with sodium cromoglicate alone(P<0.05).Conclusion:.Combined therapy of sodium cromoglicate eye drops and Yupingfeng granules had a high efficacy and no significant adverse reactions..Therefore,.this treatment deserves to be considered for wide application in clinical settings.展开更多
目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生...目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生体重低于同胎龄同性别婴儿的第3百分位数)、轻度SGA组(出生体重≥第3百分位数且<第10百分位数)和非SGA组(出生体重≥第10百分位数)。采用有序多分类logistic回归模型分析不同程度SGA发生的影响因素。结果共纳入14821例新生儿,其中重度SGA组258例(1.74%),轻度SGA组902例(6.09%),非SGA组13661例(92.17%)。早产儿比例和死产比例均为重度SGA组>轻度SGA组>非SGA组(P<0.0125);重度SGA组与轻度SGA组新生儿窒息比例均大于非SGA组(P<0.0125)。有序多分类logistic回归分析显示:母孕前消瘦(OR=1.838)、母孕前肥胖(OR=3.024)、体外受精-胚胎移植(OR=2.649)、妊娠合并子痫前期(OR=1.743)、妊娠合并结缔组织病(OR=1.795)、脐带绕颈(OR=1.213)、羊水少(OR=1.848)、宫内生长受限(OR=27.691)等均与发生更严重的SGA有关(P<0.05);孕母为经产妇(OR=0.457)更倾向于不发生严重的SGA(P<0.05)。结论母孕前消瘦、母孕前肥胖、体外受精-胚胎移植、妊娠合并子痫前期、妊娠合并结缔组织病、羊水少、脐带绕颈、宫内生长受限与更严重的SGA发生密切相关;孕母为经产妇是发生严重SGA的保护因素。展开更多
文摘In medical research,there are times when the introduction of a new tool can launch scientific discovery in new directions.While antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic development.The recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).
基金This work was supported by the National Natural Science Funding of China(Grants 31170333 and 31570363).
文摘Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.
基金Supported by Raw Material Project of Tobacco Yunnan Industrial Co.,Ltd.(2014YL01-2014068)~~
文摘[Objective] This study was conducted to investigate the quality condition of chemical components of tobacco in Yunnan. [Method] The C3F samples were collected from 76 base units in Yunnan Province and their conventional chemical components were analyzed, and the evaluation was carded out based on the membership function and hierarchical cluster analysis of cigarette brands H1 and H2 in Yunnan. [Result] The results showed that： （1） Major chemical components of 76 base units were coordinated overall. （2） Total nitrogen of brand H1 was higher than that of the high-quality tobacco leaves by 12.08%; raw tobacco of brands H3 and H2 satisfied the quality requirements of high-quality tobacco in Yunnan; and the total sugar and reducing sugar in flue-cured tobacco of brand H4 were higher those of the high-quality tobacco leaves by 0.76% and 10.3%, respectively. （3） The total sugar, reducing sugar and potassium of tobacco leaves from bases of G1 group were higher than those of tobacco from bases of G2 group by 38.1%, 2.27% and 7.34%, respectively; and total nitrogen and chlorine were lower by 4.69% and 11.11%, respectively; and nicotine contents in tobacco of the two groups were similar. （4） H2 and H3 were not significantly different in main chemical components; H3 and H4 were significantly different in total nitrogen, while other main chemical components were not significant different; and there were no significant differences between H4 and H2. [Conclusion] The quality of tobacco leaves from tobacco base units of G1 and G2 groups was better. Therefore, the evaluation provides theoretical reference for construction of tobacco base units.
文摘Purpose:To observe the clinical efficacy of sodium cromoglicate eye drops combined with Yupingfeng granules in the treatment of allergic conjunctivitis.Methods:.A total of 118 patients with allergic conjunctivitis were randomly divided into a combined sodium cromoglicate and Yupingfeng Granule (treatment)group(n=74) and a sodium cromoglicate (control) group (n=44).Clinical efficacy of the two treatments was evaluated by observing the changes in patients'symptoms and physical signs before and after their respective treatments.Results:.Following treatment,.the symptoms and physical signs related to allergic conjunctivitis were significantly alleviated in all 118 cases.The total efficacy of the combined sodium cromoglicate and Yupingfeng granule treatment was91.9%,.which was significantly higher than the value of 75.0%obtained with sodium cromoglicate alone(P<0.05).Conclusion:.Combined therapy of sodium cromoglicate eye drops and Yupingfeng granules had a high efficacy and no significant adverse reactions..Therefore,.this treatment deserves to be considered for wide application in clinical settings.
文摘目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生体重低于同胎龄同性别婴儿的第3百分位数)、轻度SGA组(出生体重≥第3百分位数且<第10百分位数)和非SGA组(出生体重≥第10百分位数)。采用有序多分类logistic回归模型分析不同程度SGA发生的影响因素。结果共纳入14821例新生儿,其中重度SGA组258例(1.74%),轻度SGA组902例(6.09%),非SGA组13661例(92.17%)。早产儿比例和死产比例均为重度SGA组>轻度SGA组>非SGA组(P<0.0125);重度SGA组与轻度SGA组新生儿窒息比例均大于非SGA组(P<0.0125)。有序多分类logistic回归分析显示:母孕前消瘦(OR=1.838)、母孕前肥胖(OR=3.024)、体外受精-胚胎移植(OR=2.649)、妊娠合并子痫前期(OR=1.743)、妊娠合并结缔组织病(OR=1.795)、脐带绕颈(OR=1.213)、羊水少(OR=1.848)、宫内生长受限(OR=27.691)等均与发生更严重的SGA有关(P<0.05);孕母为经产妇(OR=0.457)更倾向于不发生严重的SGA(P<0.05)。结论母孕前消瘦、母孕前肥胖、体外受精-胚胎移植、妊娠合并子痫前期、妊娠合并结缔组织病、羊水少、脐带绕颈、宫内生长受限与更严重的SGA发生密切相关;孕母为经产妇是发生严重SGA的保护因素。
