AIM:To evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF),photodynamic therapy(PDT),and laser treatment(LT)for anatomical and functional improvement in myopic choroid...AIM:To evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF),photodynamic therapy(PDT),and laser treatment(LT)for anatomical and functional improvement in myopic choroidal neovascularization(mCNV)patients.METHODS:Two researchers independently searched PubMed,Cochrane Library,Web of Science,and other databases to screen studies comparing best-corrected vision acuity(BCVA)and foveal center thickness(FCT)changes after mCNV treatment.Post-treatment chorioretinal atrophy(CRA)is a secondary outcome indicator.The retrieval time limit is from the database construction to January 30,2023.RESULTS:A total of 1072 eyes in 16 articles were included.In the RCTs,intravitreal bevacizumab(IVB)and intravitreal ranibizumab(IVR)were superior to PDT(MD=0.18,95%CI:0.02,0.40,MD=0.18,95%CI:0.01,0.42)in improving BCVA of mCNV patients(P<0.05).The relative effectiveness in improving BCVA,from high to low,appeared to be IVR,intravitreal aflibercept(IVA),IVB,LT,PDT,and sham first followed by IVA(Sham/IVA).While improving the FCT from high to low was IVA,IVR,IVB,PDT.In retrospective studies,the results of BCVA after long-term treatment showed that all the therapeutic effects from high to low was IVA,intravitreal conbercept(IVC),IVR,IVB,IVB/IVR,PDT with IVB/IVR,PDT.The effect of improving FCT was IVA,IVR,IVC,PDT,and IVB from high to low.And in the effects of improving CRA,the IVB appeared to be higher than IVR,while the PDT was the smallest,but none of the differences in the results were statistically significant.CONCLUSION:Anti-VEGF has the best effect on longterm vision improvement in mCNV patients,using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with PDT.There is no significant difference in the improvement of visual acuity,macular edema,and CRA in mCNV patients treated with any different anti-VEGF drugs.展开更多
AIM: To compare the anatomic and functional outcomes between vitrectomy with internal limiting membrane(ILM) peeling and internal ILM flap insertion technique for high myopia macular hole(MH).METHODS: Pub Med, Cochran...AIM: To compare the anatomic and functional outcomes between vitrectomy with internal limiting membrane(ILM) peeling and internal ILM flap insertion technique for high myopia macular hole(MH).METHODS: Pub Med, Cochrane Library, EMBASE, and CNKI were systematically searched, and all studies involved MH were included. The closure rate of MH and the postoperative best-corrected visual acuity(BCVA) at 6 mo after the initial surgery were the primary measures. All statistical tests were performed in Review Manager 5.3.RESULTS: Five studies that included 151 eyes of 151 patients were finally included, all of which were retrospectively comparative studies. Between the pars plana vitrectomy(PPV) with ILM peeling surgery and the ILM insertion technique, the latter had significantly better efficacy with respect to the closure rate of MH(OR=21.32, 95%CI=7.25-62.67, P<0.001);However, regarding BCVA at 6 mo after the initial surgery in MH, there was no statistical significance between the groups(OR=-0.04, 95%CI=-0.22-0.14, P=0.66). In addition, regarding the rate of retinal reattachment after the initial surgery, the two different methods were not significantly different(OR=2.22, 95%CI=0.34-14.32, P=0.4).CONCLUSION: Both ILM peeling and ILM insertion technique could significantly improve anatomic outcomes of MH in high myopia with or without retinal detachment(RD), and anatomic outcomes are more effective. However, there is no statistical significance in BCVA at 6 mo after the initial surgery in MH, or in the rate of retinal reattachment after the first surgery, between the two methods.展开更多
In deep space exploration,many engineering and scientific requirements require the accuracy of the measured Doppler frequency to be as high as possible.In our paper,we analyze the possible frequency measurement points...In deep space exploration,many engineering and scientific requirements require the accuracy of the measured Doppler frequency to be as high as possible.In our paper,we analyze the possible frequency measurement points of the third-order phase-locked loop(PLL)and find a new Doppler measurement strategy.Based on this finding,a Doppler frequency measurement algorithm with significantly higher measurement accuracy is obtained.In the actual data processing,compared with the existing engineering software,the accuracy of frequency of 1 second integration is about 5.5 times higher when using the new algorithm.The improved algorithm is simple and easy to implement.This improvement can be easily combined with other improvement methods of PLL,so that the performance of PLL can be further improved.展开更多
A digital pulsar backend based on a Field Programmable Gate Array （FPGA） is developed. It is designed for incoherent de-dispersion of pulsar observations and has a maximum bandwidth of 512MHz. The channel bandwidth ...A digital pulsar backend based on a Field Programmable Gate Array （FPGA） is developed. It is designed for incoherent de-dispersion of pulsar observations and has a maximum bandwidth of 512MHz. The channel bandwidth is fixed to 1 MHz, and the highest time resolution is 10 p.s. Testing observations were carried out using the Urumqi 25-m telescope administered by Xinjiang Astronomical Observatory and the Kunming 40-m telescope administered by Yunnan Observatories, targeting PSR J0332＋5434 in the L band and PSR J0437-4715 in the S band, respectively. The successful observation of PSR J0437-4715 demonstrates its ability to observe millisecond pulsars.展开更多
HOCN and HNCO abundance ratio in molecular gas can tell us the information of their formation mechanism.We performed high-sensitivity mapping observations of HOCN,HNCO,and HNC^(18)O lines around Sagittarius B2(Sgr B2)...HOCN and HNCO abundance ratio in molecular gas can tell us the information of their formation mechanism.We performed high-sensitivity mapping observations of HOCN,HNCO,and HNC^(18)O lines around Sagittarius B2(Sgr B2)with the IRAM 30 m telescope at the 3 mm wavelength.HNCO 4_(04)-3_(03)and HOCN 4_(04)-3_(03)are used to obtain the abundance ratio of HNCO to HOCN.The ratio of HNCO 4_(04)-3_(03)to HNC^(18)O 4;-3;is used to calculate the optical depth of HNCO 4_(04)-3_(03).The abundance ratio of HOCN and HNCO is observed to range from 0.4%to0.7%toward most positions,which agrees well with the gas-grain model.However,the relative abundance of HOCN is observed to be enhanced toward the direction of Sgr B2(S),with HOCN to HNCO abundance ratio of~0.9%.The reason for that still needs further investigation.Based on the intensity ratio of HNCO and HNC^(18)O lines,we updated the isotopic ratio of;O/;O to be 296±54 in Sgr B2.展开更多
In deep space exploration,it is necessary to improve the accuracy of frequency measurement to meet the requirements of precise orbit determination and various scientific studies.A phase detector is one of the key modu...In deep space exploration,it is necessary to improve the accuracy of frequency measurement to meet the requirements of precise orbit determination and various scientific studies.A phase detector is one of the key modules that restricts the tracking performance of phase-locked loop(PLL).Based on the phase relationship between adjacent signals in the time domain,a novel phase detector is presented to replace the arctangent phase detector.The new PLL,which is a closed loop signal correlation algorithm,shows good performance in tracking signals with high precision and the tracking accuracy of frequency of1 second integration is close to Cramer-Rao lower bound(CRLB)when setting proper parameters.Actual data processing results further illustrate the excellent performance of the novel PLL.展开更多
基金Supported by 2023 Research Fund of Aier Ophthalmology Research Institute(No.AEI202310LC01).
文摘AIM:To evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF),photodynamic therapy(PDT),and laser treatment(LT)for anatomical and functional improvement in myopic choroidal neovascularization(mCNV)patients.METHODS:Two researchers independently searched PubMed,Cochrane Library,Web of Science,and other databases to screen studies comparing best-corrected vision acuity(BCVA)and foveal center thickness(FCT)changes after mCNV treatment.Post-treatment chorioretinal atrophy(CRA)is a secondary outcome indicator.The retrieval time limit is from the database construction to January 30,2023.RESULTS:A total of 1072 eyes in 16 articles were included.In the RCTs,intravitreal bevacizumab(IVB)and intravitreal ranibizumab(IVR)were superior to PDT(MD=0.18,95%CI:0.02,0.40,MD=0.18,95%CI:0.01,0.42)in improving BCVA of mCNV patients(P<0.05).The relative effectiveness in improving BCVA,from high to low,appeared to be IVR,intravitreal aflibercept(IVA),IVB,LT,PDT,and sham first followed by IVA(Sham/IVA).While improving the FCT from high to low was IVA,IVR,IVB,PDT.In retrospective studies,the results of BCVA after long-term treatment showed that all the therapeutic effects from high to low was IVA,intravitreal conbercept(IVC),IVR,IVB,IVB/IVR,PDT with IVB/IVR,PDT.The effect of improving FCT was IVA,IVR,IVC,PDT,and IVB from high to low.And in the effects of improving CRA,the IVB appeared to be higher than IVR,while the PDT was the smallest,but none of the differences in the results were statistically significant.CONCLUSION:Anti-VEGF has the best effect on longterm vision improvement in mCNV patients,using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with PDT.There is no significant difference in the improvement of visual acuity,macular edema,and CRA in mCNV patients treated with any different anti-VEGF drugs.
基金Supported by National Natural Science Foundation of China(No.81760179,No.81360151)Natural Science Foundation of Jiangxi Province(No.20171BAB205046)+6 种基金Key Foundation of Education Department of Jiangxi Province(No.GJJ160033)Health Development Planning Commission Science Foundation o f Jiangxi Province(N o.20185118)Foundation of Science and Technology Supported by Jiangxi Province(No.20141BBG70027)Chinese Medicine Research Project of Jiangxi Health and Family Planning Commission(No.2017A001)Jiangxi Province Grass-Roots Health Appropriate Technology Spark Promotion Project(No.20188007)Jiangxi Provincial Health and FP General Plan(No.20141031)General Project of Jiangxi Provincial Education Department(No.GJJ13147)
文摘AIM: To compare the anatomic and functional outcomes between vitrectomy with internal limiting membrane(ILM) peeling and internal ILM flap insertion technique for high myopia macular hole(MH).METHODS: Pub Med, Cochrane Library, EMBASE, and CNKI were systematically searched, and all studies involved MH were included. The closure rate of MH and the postoperative best-corrected visual acuity(BCVA) at 6 mo after the initial surgery were the primary measures. All statistical tests were performed in Review Manager 5.3.RESULTS: Five studies that included 151 eyes of 151 patients were finally included, all of which were retrospectively comparative studies. Between the pars plana vitrectomy(PPV) with ILM peeling surgery and the ILM insertion technique, the latter had significantly better efficacy with respect to the closure rate of MH(OR=21.32, 95%CI=7.25-62.67, P<0.001);However, regarding BCVA at 6 mo after the initial surgery in MH, there was no statistical significance between the groups(OR=-0.04, 95%CI=-0.22-0.14, P=0.66). In addition, regarding the rate of retinal reattachment after the initial surgery, the two different methods were not significantly different(OR=2.22, 95%CI=0.34-14.32, P=0.4).CONCLUSION: Both ILM peeling and ILM insertion technique could significantly improve anatomic outcomes of MH in high myopia with or without retinal detachment(RD), and anatomic outcomes are more effective. However, there is no statistical significance in BCVA at 6 mo after the initial surgery in MH, or in the rate of retinal reattachment after the first surgery, between the two methods.
基金supported by the National Natural Science Foundation of China(Grant Nos.11773060,11973074,U1831137 and 11703070)National Key Basic Research and Development Program(2018YFA0404702)+1 种基金Shanghai Key Laboratory of Space Navigation and Positioning(3912DZ227330001)the Key Laboratory for Radio Astronomy of CAS。
文摘In deep space exploration,many engineering and scientific requirements require the accuracy of the measured Doppler frequency to be as high as possible.In our paper,we analyze the possible frequency measurement points of the third-order phase-locked loop(PLL)and find a new Doppler measurement strategy.Based on this finding,a Doppler frequency measurement algorithm with significantly higher measurement accuracy is obtained.In the actual data processing,compared with the existing engineering software,the accuracy of frequency of 1 second integration is about 5.5 times higher when using the new algorithm.The improved algorithm is simple and easy to implement.This improvement can be easily combined with other improvement methods of PLL,so that the performance of PLL can be further improved.
基金supported by the National Natural Science Foundation of China(Grant Nos.10821061 and10833003)
文摘A digital pulsar backend based on a Field Programmable Gate Array （FPGA） is developed. It is designed for incoherent de-dispersion of pulsar observations and has a maximum bandwidth of 512MHz. The channel bandwidth is fixed to 1 MHz, and the highest time resolution is 10 p.s. Testing observations were carried out using the Urumqi 25-m telescope administered by Xinjiang Astronomical Observatory and the Kunming 40-m telescope administered by Yunnan Observatories, targeting PSR J0332＋5434 in the L band and PSR J0437-4715 in the S band, respectively. The successful observation of PSR J0437-4715 demonstrates its ability to observe millisecond pulsars.
基金supported by the National Natural Science Foundation of China(11773054 and U1731237)supported by the international partnership program of Chinese Academy of Sciences through Grant No.114231KYSB20200009。
文摘HOCN and HNCO abundance ratio in molecular gas can tell us the information of their formation mechanism.We performed high-sensitivity mapping observations of HOCN,HNCO,and HNC^(18)O lines around Sagittarius B2(Sgr B2)with the IRAM 30 m telescope at the 3 mm wavelength.HNCO 4_(04)-3_(03)and HOCN 4_(04)-3_(03)are used to obtain the abundance ratio of HNCO to HOCN.The ratio of HNCO 4_(04)-3_(03)to HNC^(18)O 4;-3;is used to calculate the optical depth of HNCO 4_(04)-3_(03).The abundance ratio of HOCN and HNCO is observed to range from 0.4%to0.7%toward most positions,which agrees well with the gas-grain model.However,the relative abundance of HOCN is observed to be enhanced toward the direction of Sgr B2(S),with HOCN to HNCO abundance ratio of~0.9%.The reason for that still needs further investigation.Based on the intensity ratio of HNCO and HNC^(18)O lines,we updated the isotopic ratio of;O/;O to be 296±54 in Sgr B2.
基金supported by the National Natural Science Foundation of China(11773060,11973074,U1831137,11703070 and 11803069)the National Key Basic Research and Development Program(2018YFA0404702)+1 种基金Shanghai Key Laboratory of Space Navigation and Positioning(3912DZ227330001)the Key Laboratory for Radio Astronomy of CAS。
文摘In deep space exploration,it is necessary to improve the accuracy of frequency measurement to meet the requirements of precise orbit determination and various scientific studies.A phase detector is one of the key modules that restricts the tracking performance of phase-locked loop(PLL).Based on the phase relationship between adjacent signals in the time domain,a novel phase detector is presented to replace the arctangent phase detector.The new PLL,which is a closed loop signal correlation algorithm,shows good performance in tracking signals with high precision and the tracking accuracy of frequency of1 second integration is close to Cramer-Rao lower bound(CRLB)when setting proper parameters.Actual data processing results further illustrate the excellent performance of the novel PLL.
