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Increase of CD4^+CD25^+ T cells in Smad3^(-/-) mice 被引量:3
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作者 Zi-Bing Wang Yu-Fang Cui +7 位作者 Yu-Qing Liu Wei Jin Han Xu Zhu-Jun Jiang ya-xin lu Ying Zhang Xiao-Lan Liu Bo Dong 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第15期2455-2458,共4页
AIM: To investigate the changes of lymphocyte subpopulations, especially CD4^+CD25^ T regulatory cells in Smad3^-/- mice. METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Sm... AIM: To investigate the changes of lymphocyte subpopulations, especially CD4^+CD25^ T regulatory cells in Smad3^-/- mice. METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3"/- mice using cell counter and flow cytometry, respectively, and compared to their littermate controls. RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3^-/- mice compared to littermate controls. CD19^+ expressing cells in blood and spleen, and CD8^+ T cells in thymus were all markedly decreased in Smad3^-/- mice. More important, Smad3^-/- mice had an increased population of CD4^+CD25^+ T cells in peripheral lymphoid tissues, including thymus, spleen, and lymph nodes. CONCLUSION: These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3^-/- mice. 展开更多
关键词 CD4^+CD25^+ T cells Lymphocyte subpopulation SMAD3 TGF-β signaling
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