Impact point prediction guidance of ballistic missile in high maneuver penetration condition

An impact point prediction(IPP) guidance based on supervised learning is proposed to address the problem of precise guidance for the ballistic missile in high maneuver penetration condition.An accurate ballistic trajectory model is applied to generate training samples,and ablation experiments are conducted to determine the mapping relationship between the flight state and the impact point.At the same time,the impact point coordinates are decoupled to improve the prediction accuracy,and the sigmoid activation function is improved to ameliorate the prediction efficiency.Therefore,an IPP neural network model,which solves the contradiction between the accuracy and the speed of the IPP,is established.In view of the performance deviation of the divert control system,the mapping relationship between the guidance parameters and the impact deviation is analysed based on the variational principle.In addition,a fast iterative model of guidance parameters is designed for reference to the Newton iteration method,which solves the nonlinear strong coupling problem of the guidance parameter solution.Monte Carlo simulation results show that the prediction accuracy of the impact point is high,with a 3 σ prediction error of 4.5 m,and the guidance method is robust,with a 3 σ error of 7.5 m.On the STM32F407 singlechip microcomputer,a single IPP takes about 2.374 ms,and a single guidance solution takes about9.936 ms,which has a good real-time performance and a certain engineering application value.

Clinical nursing path after endoscopic submucosal dissection reduces the risk of postoperative complications

Objective： To investigate the effect of the nursing path on postoperative complications after endoscopic submucosal dissection （ESD）. Method： Patients＇ nursing paths for ESD were established based on a systematic analysis of relevant literature, previous clinical procedures and consultation with chief physicians from a gastroenterology department. Forty patients were divided into the observation or control group and were assigned to follow the nursing path or the conventional path after an ESD, respectively. Next, the incidence of postoperative complications of these two groups was measured, primarily assessing the occurrences of bleeding, perforation, infection, and anxiety. Results： The incidence of complications after ESD in the observation group was remarkably lower than that of the control group （P 〈 0.05）. Conclusion： The nursing path for ESD has a positive role in reducing certain frequent complications that occur after ESD, particularly infection and anxiety; in addition, the nursing path optimizes nursing care in patients with gastrointestinal stromal tumor.

Reactive carbonyl compounds(RCCs) cause aggregation and dysfunction of fibrinogen

Fibrinogen is a key protein involved in coagulation and its deposition on blood vessel walls plays an important role in the pathology of atherosclerosis.Although the causes of fibrinogen(fibrin)deposition have been studied in depth,little is known about the relationship between fibrinogen deposition and reactive carbonyl compounds(RCCs),compounds which are produced and released into the blood and react with plasma protein especially under conditions of oxidative stress and inflammation.Here,we investigated the effect of glycolaldehyde on the activity and deposition of fibrinogen compared with the common RCCs acrolein,methylglyoxal,glyoxal and malondialdehyde.At the same concentration(1 mmol/L),glycolaldehyde and acrolein had a stronger suppressive effect on fibrinogen activation than the other three RCCs.Fibrinogen aggregated when it was respectively incubated with glycolaldehyde and the other RCCs,as demonstrated by SDS-PAGE,electron microscopy and intrinsic fluorescence intensity measurements.Staining with Congo Red showed that glycolaldehyde-and acrolein-fibrinogen distinctly formed amyloid-like aggregations.Furthermore,the five RCCs,particularly glycolaldehyde and acrolein,delayed human plasma coagulation.Only glycolaldehyde showed a markedly suppressive effect on fibrinogenesis,none did the other four RCCs when their physiological blood concentrations were employyed,respectively.Taken together,it is glycolaldehyde that suppresses fibrinogenesis and induces protein aggregation most effectively,suggesting a putative pathological process for fibrinogen(fibrin)deposition in the blood.

Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs(ncRNAs)involved in diverse cellular processes.NcRNAs as epigenetic mediators play key roles in neuronal development,maintenance,and dysfunction by controlling gene expression at multiple levels.NcRNAs may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group(PcG)proteins to drive orchestrated transcriptional programs.Recent significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional,post-transcriptional,and epigenetic regulation.More importantly,dysregulation of ncRNAs,PcG proteins,and interplay among them is closely associated with the pathogenesis of central nervous system(CNS)disorders.In this review,we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.