Flexible,breathable,and highly sensitive pressure sensors have increasingly become a focal point of interest due to their pivotal role in healthcare monitoring,advanced electronic skin applications,and disease diagnos...Flexible,breathable,and highly sensitive pressure sensors have increasingly become a focal point of interest due to their pivotal role in healthcare monitoring,advanced electronic skin applications,and disease diagnosis.However,traditional methods,involving elastomer film-based substrates or encapsulation techniques,often fall short due to mechanical mismatches,discomfort,lack of breathability,and limitations in sensing abilities.Consequently,there is a pressing need,yet it remains a significant challenge to create pressure sensors that are not only highly breathable,flexible,and comfortable but also sensitive,durable,and biocompatible.Herein,we present a biocompatible and breathable fabric-based pressure sensor,using nonwoven fabrics as both the sensing electrode(coated with MXene/poly(3,4-ethylenedioxythiophene):polystyrene sulfonate[PEDOT:PSS])and the interdigitated electrode(printed with MXene pattern)via a scalable spray-coating and screen-coating technique.The resultant device exhibits commendable air permeability,biocompatibility,and pressure sensing performance,including a remarkable sensitivity(754.5 kPa^(−1)),rapid response/recovery time(180/110 ms),and robust cycling stability.Furthermore,the integration of PEDOT:PSS plays a crucial role in protecting the MXene nanosheets from oxidation,significantly enhancing the device's long-term durability.These outstanding features make this sensor highly suitable for applications in fullrange human activities detection and disease diagnosis.Our study underscores the promising future of flexible pressure sensors in the realm of intelligent wearable electronics,setting a new benchmark for the industry.展开更多
Zhejiang Province firmly seized the opportunity of worldwide economy integration and manufacture industry strategically transfer to renew the ideas, execute the measures and forge ahead innovation so that it practical...Zhejiang Province firmly seized the opportunity of worldwide economy integration and manufacture industry strategically transfer to renew the ideas, execute the measures and forge ahead innovation so that it practically .developed the superiority of private enterprise system, government service, industry zone, enterprise competition, commodity brand, and culture and ideas and soon formed six manufacture development modes: grass root economy mode, block economy mode, demi-wolf economy mode, scaled economy mode, marketing economy mode and extroverted economy mode, which help Zhejiang province be a big manufacture province and economic prosperous province in China.展开更多
Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents.In this work,silver nanoparticles(AgNPs)and cisplatin(DDP)were combined in a synergistic modification...Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents.In this work,silver nanoparticles(AgNPs)and cisplatin(DDP)were combined in a synergistic modification strategy to improve the surface function of airway stents.Using polycaprolactone(PCL)as a drug carrier,a dual-functional PCL-AgNPs-DDP fiber film-coated airway stent was fabricated by electrospinning.The physicochemical and biological properties of the obtained fiber films were examined.The ATR-FTIR,XPS,SEM-EDS and TEM results suggested that AgNPs and DDP could be successfully immobilized onto the airway stent surface.The drug release and surface degradation results revealed that AgNPs and DDP can undergo sustained release from films for 30 d,and the weight loss was approximately 50%after 35 d.In addition,the dual-functional fiber film suppressed human embryonic lung fibroblast growth and exhibited excellent antibacterial activity against Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans.Furthermore,the effectiveness of the dual-functional fiber film-coated airway stent was evaluated by application to the trachea of New Zealand rabbits.The in vivo results indicated that PCL-AgNPs-DDP fiber film-coated airway stent can significantly inhibit granulation tissue formation and collagen deposition,reduced the expression of IL-8,TNF-α,IL-1α,PCNA,α-SMA and CD68,and ultimately achieved anti-inflammatory and antihyperplasia effects.Hence,this study provides a dual-functional surface-coated airway stent to address the clinical complications associated with respiratory tract inflammation and granulation tissue hyperplasia,thus inhibiting tracheal stenosis.展开更多
Constructed wetlands are commonly utilized to treat industrial wastewater due to their effectiveness,affordability,and environmental benefits.Many phosphorus chemical enterprises in the middle Yangtze River basin are ...Constructed wetlands are commonly utilized to treat industrial wastewater due to their effectiveness,affordability,and environmental benefits.Many phosphorus chemical enterprises in the middle Yangtze River basin are facing high pollution load challenges and efforts are needed to improve removal efficiency of pollutants.This work was the first to use constructed wetlands for phosphorus chemical industry tailwater(PCITW)treatment.The new hybrid constructed wetlands(CWs)proposed were the aeration horizontal subsurface flow constructed wetland(AHSCW)and the integrated vertical flow constructed wetland(IVCW),which were constructed on a pilot scale.Here,the effectiveness of pollutant removal along hybrid CWs,wetland plant growth,and rootassociated microbial community responses to the PCITW were investigated.The results showed that there was spatial variation in removal of carbon,nitrogen,and phosphorus in the hybrid CWs,and that the AHSCW and the IVCW played synergistic roles in the removal of pollutants.Compared with influent,the toxic effect of effluent to embryos of a rare minnow(Gobiocypris rarus)was alleviated.Exposure to the effluent resulted in no malformation or death for embryos.Plants and microorganisms in the wetland system of the phosphate chemical tailwater were then compared with the control system of municipal tailwater.Plants in the former system had lower root density,and higher average root diameter,root shoot ratio,specific root length,and specific surface area.Plant roots also had decreased NH_(4)^(+)uptake ability but increased Ca^(2+)uptake to adapt to the high load and complex pollution stress.Unlike the control system,stochastic mechanisms had a more important role than deterministic processes in shaping the microbial community assembly associated with the PCITW.Meanwhile,analysis of microbial network-level topological characteristics demonstrated substantial reduction in network interactions complexity and microbiome stability in the treatment system.Findings from this study suggest wetlands will be helpful for efficient purification of phosphorus chemical industry wastewater in the Yangtze River basin.展开更多
基金supported by the National Natural Science Foundation of China(52303051,52202108,52003002)Anhui Provincial Natural Science Foundation(2308085ME146,2008085QE213)+3 种基金Educational Commission of Anhui Province of China(2022AH040137)Key Laboratory of Intelligent Textile and Flexible Interconnection of Zhejiang Province(ZD04)Opening Fund of China National Textile and Apparel Council Key Laboratory of Flexible Devices for Intelligent Textile and Apparel,Soochow University(SDHY2227)research funding from Anhui Polytechnic University(2020YQQ002,Xjky2022070,FFBK202218,FFBK202363,FFBK202364,2020ffky01).
文摘Flexible,breathable,and highly sensitive pressure sensors have increasingly become a focal point of interest due to their pivotal role in healthcare monitoring,advanced electronic skin applications,and disease diagnosis.However,traditional methods,involving elastomer film-based substrates or encapsulation techniques,often fall short due to mechanical mismatches,discomfort,lack of breathability,and limitations in sensing abilities.Consequently,there is a pressing need,yet it remains a significant challenge to create pressure sensors that are not only highly breathable,flexible,and comfortable but also sensitive,durable,and biocompatible.Herein,we present a biocompatible and breathable fabric-based pressure sensor,using nonwoven fabrics as both the sensing electrode(coated with MXene/poly(3,4-ethylenedioxythiophene):polystyrene sulfonate[PEDOT:PSS])and the interdigitated electrode(printed with MXene pattern)via a scalable spray-coating and screen-coating technique.The resultant device exhibits commendable air permeability,biocompatibility,and pressure sensing performance,including a remarkable sensitivity(754.5 kPa^(−1)),rapid response/recovery time(180/110 ms),and robust cycling stability.Furthermore,the integration of PEDOT:PSS plays a crucial role in protecting the MXene nanosheets from oxidation,significantly enhancing the device's long-term durability.These outstanding features make this sensor highly suitable for applications in fullrange human activities detection and disease diagnosis.Our study underscores the promising future of flexible pressure sensors in the realm of intelligent wearable electronics,setting a new benchmark for the industry.
文摘Zhejiang Province firmly seized the opportunity of worldwide economy integration and manufacture industry strategically transfer to renew the ideas, execute the measures and forge ahead innovation so that it practically .developed the superiority of private enterprise system, government service, industry zone, enterprise competition, commodity brand, and culture and ideas and soon formed six manufacture development modes: grass root economy mode, block economy mode, demi-wolf economy mode, scaled economy mode, marketing economy mode and extroverted economy mode, which help Zhejiang province be a big manufacture province and economic prosperous province in China.
基金This work was supported by the Young and middle-aged health science and technology innovation talent project of Henan Province(YXKC2020037),the Henan Medical Science and Technology Public Relations Program(SB201902014)and the Horizontal Research Program of Zhengzhou University(Grant No.24110005).
文摘Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents.In this work,silver nanoparticles(AgNPs)and cisplatin(DDP)were combined in a synergistic modification strategy to improve the surface function of airway stents.Using polycaprolactone(PCL)as a drug carrier,a dual-functional PCL-AgNPs-DDP fiber film-coated airway stent was fabricated by electrospinning.The physicochemical and biological properties of the obtained fiber films were examined.The ATR-FTIR,XPS,SEM-EDS and TEM results suggested that AgNPs and DDP could be successfully immobilized onto the airway stent surface.The drug release and surface degradation results revealed that AgNPs and DDP can undergo sustained release from films for 30 d,and the weight loss was approximately 50%after 35 d.In addition,the dual-functional fiber film suppressed human embryonic lung fibroblast growth and exhibited excellent antibacterial activity against Staphylococcus aureus,Pseudomonas aeruginosa and Candida albicans.Furthermore,the effectiveness of the dual-functional fiber film-coated airway stent was evaluated by application to the trachea of New Zealand rabbits.The in vivo results indicated that PCL-AgNPs-DDP fiber film-coated airway stent can significantly inhibit granulation tissue formation and collagen deposition,reduced the expression of IL-8,TNF-α,IL-1α,PCNA,α-SMA and CD68,and ultimately achieved anti-inflammatory and antihyperplasia effects.Hence,this study provides a dual-functional surface-coated airway stent to address the clinical complications associated with respiratory tract inflammation and granulation tissue hyperplasia,thus inhibiting tracheal stenosis.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Science(Grant no.XDA23040401).
文摘Constructed wetlands are commonly utilized to treat industrial wastewater due to their effectiveness,affordability,and environmental benefits.Many phosphorus chemical enterprises in the middle Yangtze River basin are facing high pollution load challenges and efforts are needed to improve removal efficiency of pollutants.This work was the first to use constructed wetlands for phosphorus chemical industry tailwater(PCITW)treatment.The new hybrid constructed wetlands(CWs)proposed were the aeration horizontal subsurface flow constructed wetland(AHSCW)and the integrated vertical flow constructed wetland(IVCW),which were constructed on a pilot scale.Here,the effectiveness of pollutant removal along hybrid CWs,wetland plant growth,and rootassociated microbial community responses to the PCITW were investigated.The results showed that there was spatial variation in removal of carbon,nitrogen,and phosphorus in the hybrid CWs,and that the AHSCW and the IVCW played synergistic roles in the removal of pollutants.Compared with influent,the toxic effect of effluent to embryos of a rare minnow(Gobiocypris rarus)was alleviated.Exposure to the effluent resulted in no malformation or death for embryos.Plants and microorganisms in the wetland system of the phosphate chemical tailwater were then compared with the control system of municipal tailwater.Plants in the former system had lower root density,and higher average root diameter,root shoot ratio,specific root length,and specific surface area.Plant roots also had decreased NH_(4)^(+)uptake ability but increased Ca^(2+)uptake to adapt to the high load and complex pollution stress.Unlike the control system,stochastic mechanisms had a more important role than deterministic processes in shaping the microbial community assembly associated with the PCITW.Meanwhile,analysis of microbial network-level topological characteristics demonstrated substantial reduction in network interactions complexity and microbiome stability in the treatment system.Findings from this study suggest wetlands will be helpful for efficient purification of phosphorus chemical industry wastewater in the Yangtze River basin.