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浅谈创新药物研究案例在有机化学教学中的应用 被引量:1
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作者 闵真立 王婷 +1 位作者 陈亚军 杨曦亮 《大学化学》 CAS 2023年第12期45-50,共6页
有机化学是药学专业的重要基础课,与药物化学和创新药物研究联系紧密。有机化学内容庞杂,其中价键理论等与创新药物设计相关的内容抽象、难懂。将创新药物研究的案例引入有机化学课堂教学,或者结合相关软件,展示有机小分子与生物大分子... 有机化学是药学专业的重要基础课,与药物化学和创新药物研究联系紧密。有机化学内容庞杂,其中价键理论等与创新药物设计相关的内容抽象、难懂。将创新药物研究的案例引入有机化学课堂教学,或者结合相关软件,展示有机小分子与生物大分子的相互作用,能使得这些知识点的教学更加形象生动,易于接受,同时,能加深学生对有机化学与药学关系的了解,激发学生的学习兴趣和主动性,提高教学质量。 展开更多
关键词 有机化学 药学 创新药物研究 教学案例
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Secure Transmission Scheme Based on Dual-Thresholds for Simultaneous Wireless Information and Power Transfer 被引量:1
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作者 Xin Hu Kaizhi Huang +2 位作者 yajun chen Liang Jin Yunjia Xu 《China Communications》 SCIE CSCD 2017年第12期25-44,共20页
This paper studies a simultaneous wireless information and power transfer system with multiple external eavesdroppers and internal curious users.We model the random network by Poisson cluster process in consideration ... This paper studies a simultaneous wireless information and power transfer system with multiple external eavesdroppers and internal curious users.We model the random network by Poisson cluster process in consideration of the case where eavesdroppers hide around certain targets.Focusing on the users that work in harvesting-transmitting mode with time switching receivers,we establish communication model via time division multiple access.On this basis,we propose a lightweight secure transmission scheme based on dual-thresholds for physical-layer security enhancement,which consists of two protocols applied to the downlink(DL) and uplink(UL) transmission respectively.In the DL,we design a dynamic information-power switching transmission protocol based on signal-to-noise ratio threshold,which provides an opportunistic approach to reform the fixed period allocation of information and power transfer;in the UL,an energy threshold is proposed for users to control the transmission,which is called a user-led on-off transmission protocol.Furthermore,we give a comprehensive performance analysis for the proposed scheme in terms of delay,reliability,security and secrecy throughput.Based on the analysis results,we optimize the two thresholds and the DL-UL allocationcoefficient to maximize the secrecy throughput.Simulation results show the proposed scheme can bring about a substantial secrecy gain. 展开更多
关键词 physical layer security simultane-ous WIRELESS INFORMATION and power transfer OPPORTUNISTIC approach on-offtransmission
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思政教育助力游戏开发课程教学改革探索与实践 被引量:1
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作者 李维 范彩霞 +1 位作者 陈亚军 王禄川 《中国教育信息化》 2022年第5期74-80,共7页
高等教育是培养社会主义接班人的重要环节,高校思政教育是落实立德树人根本任务、培养大学生思想觉悟和道德修养的重要举措。文章从国家社会需求、行业发展需求和人才培养需求三方面为切入点,以隐性课程理论和建构主义理论为基础,探索... 高等教育是培养社会主义接班人的重要环节,高校思政教育是落实立德树人根本任务、培养大学生思想觉悟和道德修养的重要举措。文章从国家社会需求、行业发展需求和人才培养需求三方面为切入点,以隐性课程理论和建构主义理论为基础,探索思政教育下游戏开发课程的教学目标、教学内容和教学方法;通过体验式学习、实践式学习和项目式学习充分调动学生的积极性,帮助学生塑造正确的道德素养、职业素养和个人素养,促进学生的全方位发展。在此基础上,文章建议高校应根据专业人才培养方案,充分利用课程思政这一渠道,通过形式多样的教学方法来拓展思政教育的影响面积,在提升思政教育实效性、培养学生专业能力的同时,塑造学生正确的价值观和人生观。 展开更多
关键词 课程思政 立德树人 教学实践 游戏开发
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Roles of endoplasmic reticulum stress and apoptosis signaling pathways in gynecologic tumor cells:A systematic review 被引量:2
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作者 Kangsheng Liu Weimin Fang +1 位作者 Erhu Sun yajun chen 《Oncology and Translational Medicine》 2017年第3期131-135,共5页
Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body... Efficient functioning of the endoplasmic reticulum(ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms "endoplasmic reticulum stress/unfolded protein response/gynecologic tumor cell apoptosis" were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells. 展开更多
关键词 endoplasmic reticulum(ER) unfolded protein response(UPR) inositol-requiring-JNK(IRE1-JNK) caspase CCAAT-enhancer-binding protein homologous protein(CHOP) gynecologic tumor cell
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Shade responses of prostrate and upright turf-type bermudagrasses
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作者 Zhixin Guo Jia Jiang +4 位作者 Lili Dong Xiaoyang Sun Jingbo chen Fuchun Xie yajun chen 《Grass Research》 2022年第1期62-70,共9页
Bermudagrass(Cynodon dactylon)shade tolerance is a trait of immense importance to the turfgrass industry.However,little is known about shade tolerance of turf-type bermudagrass native to China.Additional knowledge of ... Bermudagrass(Cynodon dactylon)shade tolerance is a trait of immense importance to the turfgrass industry.However,little is known about shade tolerance of turf-type bermudagrass native to China.Additional knowledge of the mechanism of shade tolerance in bermudagrass is required to identify specific plant features that promote shade tolerance and assist breeding efforts worldwide.This study examines shade tolerance of two different bermudagrass cultivars,Yangjiang(prostrate form)and Guanzhong(upright form),which were developed in China.Each cultivar was subjected to 0,30.4,61.2,and 90.6%shade levels during growth and assessed for turf quality,turfgrass color intensity,biomass allocation,growth rate,antioxidant enzyme activity,leaf anatomy,and photochemical properties.Results generally demonstrated that turf quality and turf color intensity were lower in Guanzhong compared with Yangjiang on the 90.6%shade testing days.Yangjiang exhibited a less severe reduction of growth rate,leaf thickness,root to shoot ratio,and chlorophyll a to chlorophyll b ratio(Chla/b)under 90.6%shade compared with Guanzhong.Both cultivars exhibited a decrease in photochemical efficiency as determined by reduced qP,ETR,and Fv/Fm values.Photochemical efficiency was impacted less in Yangjian,and superoxide dismutase(SOD),peroxidase(POD),and catalase(CAT)enzymes activities were greater than in Guanzhong when exposed to severe shade.When exposed to 90.6%shade level,Yangjiang had better turf quality than Guanzhong as determined by morphological,anatomical,and physiological features.Breeding efforts focused on these shade tolerance features will lead to improved bermudagrass germplasm and aid turf management in shade environments. 展开更多
关键词 properties. CULTIVAR PHOTOCHEMICAL
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重组改构人肿瘤坏死因子用于进展期结肠癌患者术中腹腔灌注治疗的近期安全性及可行性分析
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作者 陈亚军 姜玉娟 +14 位作者 周思成 陈海鹏 王征 周海涛 毕建军 冯强 郑朝旭 姜争 刘正 梁建伟 裴炜 张海增 汤坚强 刘骞 王锡山 《中华结直肠疾病电子杂志》 2024年第2期94-100,共7页
目的评估重组改构人肿瘤坏死因子(rmhTNF)用于进展期结肠癌患者术中腹腔灌注治疗的近期安全性及可行性。方法前瞻性纳入2022年1月至2023年4月期间就诊于国家癌症中心/中国医学科学院肿瘤医院结直肠外科并进行手术治疗的进展期结肠癌患者... 目的评估重组改构人肿瘤坏死因子(rmhTNF)用于进展期结肠癌患者术中腹腔灌注治疗的近期安全性及可行性。方法前瞻性纳入2022年1月至2023年4月期间就诊于国家癌症中心/中国医学科学院肿瘤医院结直肠外科并进行手术治疗的进展期结肠癌患者的50例病例资料,按照腹腔是否灌注rmhTNF分为研究组和对照组,每组各入组25例,研究组在关腹后经腹腔引流管行rmhTNF腹腔灌注治疗,对照组应用蒸馏水冲洗腹腔。分析两组患者术后临床指标的差异。结果两组患者在术后胃肠道功能恢复情况、并发症发生率、血液学毒性、肝肾功能、凝血功能、炎症指标方面比较差异均无统计学意义(均P>0.05)。结论rmhTNF用于进展期结肠癌患者术中腹腔灌注治疗具有良好的安全性及耐受性,不影响术后胃肠功能恢复,未增加近期术后并发症的发生率,无血液学毒性,对肝肾功能、凝血功能、炎症指标无影响。 展开更多
关键词 结肠肿瘤 重组改构人肿瘤坏死因子 腹腔灌注治疗 安全性
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基于塔吊的林冠科学研究进展及展望 被引量:1
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作者 宋亮 吴毅 +4 位作者 胡海霞 刘文耀 中村彰宏 陈亚军 马克平 《生物多样性》 CAS CSCD 北大核心 2023年第12期147-161,共15页
林冠是生物圈中物种最为丰富的生境之一。长期以来,由于森林三维空间复杂性和林冠访问技术的限制,人们对林冠生物多样性、林冠的结构、功能和生态过程知之甚少。塔吊的应用突破了技术瓶颈,给林冠科学研究带来了深刻的变革。20世纪80年... 林冠是生物圈中物种最为丰富的生境之一。长期以来,由于森林三维空间复杂性和林冠访问技术的限制,人们对林冠生物多样性、林冠的结构、功能和生态过程知之甚少。塔吊的应用突破了技术瓶颈,给林冠科学研究带来了深刻的变革。20世纪80年代以来,基于全球的林冠塔吊,国际上先后发起了林冠与土壤节肢动物多样性调查计划、林冠生物学计划、林冠CO_(2)富集和增温实验等一系列科学研究计划,回答了林冠“有什么、在哪里、怎样变”等基本问题,极大地推动了林冠科学的发展。本综述首先介绍了林冠访问技术及发展历程。随后,较为系统地梳理了基于塔吊平台发起的林冠研究计划,并从林冠生物多样性格局、林冠生态过程和林冠对全球变化的响应与适应3方面总结了相关研究进展。最后,从林冠访问技术所驱动的重大发现、林冠科学的主要研究框架、林冠科学的地域性与局限性等方面阐述了林冠科学研究计划带来的重要启示,并提出今后的林冠研究应更多关注“林冠-地面-土壤”3个层次相互关联形成的整体结构和功能系统,通过多元异构数据融合和人工智能技术,从多尺度、全方位解析全球变化背景下,整体森林的生物多样性格局、生态过程及其服务功能的响应与维持机制。 展开更多
关键词 林冠塔吊 林冠生态学 生物多样性 生态过程 全球变化
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Pattern-reconfigurable antenna-assisted secret key generation from multipath fading channels
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作者 Zheng WAN Mengyao YAN +4 位作者 Kaizhi HUANG Zhou ZHONG Xiaoming XU yajun chen Fan WU 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2023年第12期1803-1814,共12页
Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret keys.However,multipath fading at the receiver may degrade the correlation between legitimate uplink and do... Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret keys.However,multipath fading at the receiver may degrade the correlation between legitimate uplink and downlink channels,resulting in a low key generation rate(KGR).In this paper,we propose a PKG scheme based on the pattern-reconfigurable antenna(PRA)to boost the secret key capacity.First,we propose a reconfigurable intelligent surface(RIS)based PRA architecture with the capability of flexible and reconfigurable antenna patterns.Then,we present the PRA-based PKG protocol to improve the KGR via mitigation of the effects of multipath fading.Specifically,a novel algorithm for estimation of the multipath channel parameters is proposed based on atomic norm minimization.Thereafter,a novel optimization method for the matching reception of multipath signals is formulated based on the improved binary particle swarm optimization(BPSO)algorithm.Finally,simulation results show that the proposed scheme can resist multipath fading and achieve a high KGR compared to existing schemes.Moreover,our findings indicate that the increased degree of freedom of the antenna patterns can significantly increase the secret key capacity. 展开更多
关键词 Physical layer security Secret key generation Reconfigurable intelligent surface Multipath fading Pattern-reconfigurable antenna
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Advantages of nasogastric tube feeding during neoadjuvant concurrent chemoradiotherapy for esophageal cancer:A retrospective study
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作者 Jie Dong Qingwu Du +9 位作者 Tian Zhang Xi chen Wencheng Zhang yajun chen Yaqi Zeng Chunlei Li Yueying Li Yujie Wang Kun Wang Qingsong Pang 《Radiation Medicine and Protection》 CSCD 2023年第2期98-103,共6页
ObjectiveTo compare the effects of oral intake and nasogastric tube(NG)feeding on nutritional status,complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma(ESCC)patients... ObjectiveTo compare the effects of oral intake and nasogastric tube(NG)feeding on nutritional status,complications and survival during neoadjuvant chemoradiotherapy for esophageal squamous-cell carcinoma(ESCC)patients.MethodsA total of 61 ESCC cases treated with neoadjuvant chemoradiotherapy from December 2018 to March 2020 were enrolled,including(38 in oral intake group,and 22 in NG feeding group.Disease characteristics and baseline nutritional markers were collected in both groups.Nutritional status,complication and completion rate of chemoradiotherapy in both groups were evaluated.ResultsCompared with the oral intake group,patients in the NG feeding group had a later T stage(P=0.027)and clinical stage(P=0.014).The levels of energy intake(P=0.033),serum prealbumin(P<0.001),albumin(P=0.017)and hemoglobin(P=0.015)before treatment in NG group were significantly lower than those in oral intake group.Furthermore,patient-generated subjective global assessment(PG-SGA)score(P=0.016)and the levels of serum C-reactive protein(P=0.014)of NG feeding group were significantly higher than those of oral intake group.However,at the end of treatment,PG-SGA scores were increased in oral intake group and decreased in NG feeding group.In addition,the NG feeding group had a lower incidence of grade≥2 esophagitis(P=0.037),and higher completion rate of chemotherapy compared with oral intake group(P=0.034).Meanwhile,the proportion of parenteral nutrition(P=0.008)and anti-inflammatory(P=0.022)treatment in NG feeding group was significantly lower than that in oral intake group.Although patients in the NG feeding group had a worse prognosis,there were no statistically significant differences in overall survival(OS)and progression-free survival(PFS)between the two groups(P>0.05).ConclusionsAs a safe and effective enteral nutrition approach to improving nutrition,nasogastric tube feeding could increase treatment completion rate and reduce the incidence of≥grade 2 esophagitis reaction during neoadjuvant chemoradiotherapy. 展开更多
关键词 Nasogastric tube feeding Oral intake Nutritional status Neoadjuvant chemoradiotherapy Esophageal cancer
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儿童消化道择期手术后非计划再手术原因分析及其预后
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作者 王增萌 陈亚军 +3 位作者 彭春辉 庞文博 吴东阳 王凯 《中华普通外科杂志》 CSCD 北大核心 2022年第12期925-929,共5页
目的分析儿童消化道择期手术患儿术后发生非计划再手术的原因及其预后。方法回顾性分析2012年1月至2019年12月北京儿童医院普外科39例消化道择期手术后发生非计划再手术患儿的临床资料,分析原发疾病诊断、首次术式及手术级别、非计划再... 目的分析儿童消化道择期手术患儿术后发生非计划再手术的原因及其预后。方法回顾性分析2012年1月至2019年12月北京儿童医院普外科39例消化道择期手术后发生非计划再手术患儿的临床资料,分析原发疾病诊断、首次术式及手术级别、非计划再手术原因、非计划再手术术式以及患儿的预后。结果39例患儿的原发病包括胆道疾病、肛门和结直肠疾病及小肠疾病,其中二级手术4例(10%),三、四级手术35例(90%)。首次术式包括胆道-小肠手术19例(49%),单纯小肠手术11例(28%),肛门和结直肠手术9例(23%)。非计划再手术的直接原因包括吻合口漏(胆-肠、肠-肠)10例(26%),粘连性肠梗阻8例(20%),术后小肠套叠5例(13%),切口并发症(感染、裂开、切口疝)5例(13%),术后出血3例(8%),其他(首次手术损伤、术式选择缺陷)8例(20%)。术后24例患儿(62%)痊愈出院,9例患儿(23%)因非计划再手术导致需要进一步手术治疗,5例患儿(13%)死亡,1例(3%)发生短肠综合征。结论儿童消化道择期手术后非计划再手术大多发生于复杂手术,非计划再手术最常见的直接原因为吻合口漏、粘连性肠梗阻,非计划再手术对患儿的预后造成不良影响。 展开更多
关键词 再手术 消化系统外科手术 儿童 预后
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Discussion on a new paradigm of endogenous security towards 6G networks 被引量:3
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作者 Xinsheng JI Jiangxing WU +6 位作者 Liang JIN Kaizhi HUANG yajun chen Xiaoli SUN Wei YOU Shumin HUO Jing YANG 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2022年第10期1421-1450,共30页
The sixth-generation mobile communication(6G)networks will face more complex endogenous security problems,and it is urgent to propose new universal security theories and establish new practice norms to deal with the&#... The sixth-generation mobile communication(6G)networks will face more complex endogenous security problems,and it is urgent to propose new universal security theories and establish new practice norms to deal with theªunknown unknownºsecurity threats in cyberspace.This paper first expounds the new paradigm of cyberspace endogenous security and introduces the vision of 6G cyberspace security.Then,it analyzes the security problems faced by the 6G core network,wireless access network,and emerging associated technologies in detail,as well as the corresponding security technology development status and the integrated development of endogenous security and traditional security.Furthermore,this paper describes the relevant security theories and technical concepts under the guidance of the new paradigm of endogenous security. 展开更多
关键词 6G security New paradigm of endogenous security Core network Wireless access network
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How to evaluate diagnosis and management of biliary atresia in the era of liver Transplantation in China
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作者 Jianghua Zhan yajun chen Kenneth K Y Wong 《World Journal of Pediatric Surgery》 2018年第1期3-8,共6页
background Biliary atresia(BA)is one of the most challenging hepatobiliary diseases in children.Notwithstanding the reasonable outcome of liver transplantation(LT),portoenteral anastomosis(Kasai operation)is still the... background Biliary atresia(BA)is one of the most challenging hepatobiliary diseases in children.Notwithstanding the reasonable outcome of liver transplantation(LT),portoenteral anastomosis(Kasai operation)is still the first choice of treatment for patients with BA.How to improve the survival rate of the patients with BA in the era of LT is a new challenge.Data sources Based on recent original publications and the experience with the BA in China,we review many factors that influence BA survival situation,including early diagnosis and screen plan,defects of early treatment,Kasai operation,and LT and indicate present questions about BA diagnosis and treatment in China.results BA diagnosis may also be delayed due to insufficient understanding of BA and lack of jaundice monitoring methods at different levels of the hospitals in China.Further education of the physicians at smaller city hospitals about BA,neonatal jaundice and cholestasis would be helpful in improving early diagnosis of BA.Early surgical intervention is still the only guarantee to improve the survival rate of BA with native liver.Conclusions In the era of LT,especially in China,Kasai operation can provide waiting time for living donor LT and improve the success rate of LT and minimize the rapid deterioration of liver function of the children with BA and decrease the mortality in patients with BA. 展开更多
关键词 DIAGNOSIS TREATMENT GUARANTEE
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