A method for establishing a bearing residual life prediction model for process enhancement equipment based on rotor imbalance response analysis

A rotating packed bed is a typical chemical process enhancement equipment that can strengthen micromixing and mass transfer.During the operation of the rotating packed bed,the nonreactants and products irregularly adhere to the wire mesh packing in the rotor,thus resulting in an imbalance in the vibration of the rotor,which may cause serious damage to the bearing and material leakage.This study proposes a model prediction for estimating the bearing residual life of a rotating packed bed based on rotor imbalance response analysis.This method is used to determine the influence of the mass on the imbalance in the vibration of the rotor on bearing damage.The major influence on rotor vibration was found to be exerted by the imbalanced mass and its distribution radius,as revealed by the results of orthogonal experiments.Through implementing finite element analysis,the imbalance response curve for the rotating packed bed rotor was obtained,and a correlation among rotor imbalance mass,distribution radius of imbalance mass,and bearing residue life was established via data fitting.The predicted value of the bearing life can be used as the reference basis for an early safety warning of a rotating packed bed to effectively avoid accidents.

Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

There is uncertain result with regard to the use of inhalation or instillation steroids to prevent bronchopulmonary dysplasia in preterm infants. This meta-analysis was designed to evaluate the efficacy and safety of early airway administration (within 2 days after birth) of corticosteroids and pulmonary surfactant (PS) for preventing bronchopulmonary dysplasia (BPD) in premature infants with neonatal respiratory distress syndrome (NRDS). The related studies were retrieved in PubMed, EMBASE, the Cochrane Library, Clinical Trial, CNKI, Wanfang and VIP Database from inception to August 2018. Two reviewers independently screened the studies to ensure that all patients with diagnosis of NRDS were enrolled to studies within 1 day after birth, assessed the quality of included studies by GRADEpro system and extracted the data for review. The meta-analysis was performed by RevMan 5.2 software. A subgroup analysis about inhaled corticosteroid (ICS) delivery method was made between ICS inhalation subgroup [inhalation of ICS by nebulizer or metered dose inhaler (MDI)] and ICS intratracheal instillation subgroup (PS used as a vehicle). Eight randomized controlled trials were enrolled in the meta-analysis, 5 trials of which stated the randomized method, grouping and blinded method, and the follow-up procedures were reported. GRADEpro system showed high quality of 4 trials (5 articles), and the rest 4 trials had moderate quality. Meta-analysis showed that the incidence of BPD was decreased in ICS group, the relative risk (RR) was 0.56 (95% CI: 0.42-0.76), and similar trends were found in ICS inhalation subgroup and ICS intratracheal instillation subgroup, with the corresponding RR being 0.58 (95% CI: 0.41-0.82) and 0.47 (95% CI: 0.24-0.95) respectively. ICS could also significantly reduce the mortality risk as compared with placebo control group (RR: 0.67;95% CI: 0.45-0.99), with RR of ICS inhalation subgroup and ICS intratracheal instillation subgroup being 0.81 (95% CI: 0.34-1.94) and 0.64 (95% CI: 0.41-0.99) respectively. Moreover, the percentage of infants using PS more than one time was lower in ICS group than in the placebo control group, with the RR and 95% CI being 0.55 (95% CI: 0.45-0.67), and that in ICS intratracheal instillation subgroup lower than in ICS inhalation subgroup (RR: 0.56;95% CI: 0.45-0.69, and RR: 0.35;95% CI:0.08-1.52 respectively). There was no significant difference in the incidence of infection or retinopathy of prematurity and neuro-motor system impairment between ICS group and placebo control group, with the corresponding RR being 0.95 (95% CI:0.59-1.52), 0.92 (95% CI: 0.62-1.38) and 1.13 (95% CI: 0.92-1.39), respectively. It was concluded that early administration of ICS and PS is an effective and safe option for preterm infants with NRDS in preventing BPD and reducing mortality, decreasing the additional PS usage, especially for the ICS intratracheal instillation subgroup. Furthermore, the appropriate dose and duration of ICS, combined use of inhalation or instillation of ICS with PS and the long-term safety of airway administration of corticosteroids need to be assessed in large trials.

Soil Fertility,Microbial Biomass,and Microbial Functional Diversity Responses to Four Years Fertilization in an Apple Orchard in North China

Soil microbial communities play an essential role in maintaining soil fertility and are considered as ecological indicators to evaluate soil health.In the present study,we examined the influence of almost 4 years of fertilization[no fertilizer(CK),nitrogen alone(N),nitrogen,phosphorus and potassium chemical fertilizer(NPK),organicmanure(M),nitrogen plus organic manure(NM),and NPK plus organic manure(NPKM)]on soil fertility and the functional diversity of soil microbial communities in an apple orchard.Compared to CK,fertilization increased soil organic carbon,total nitrogen,and available nutrients,but reduced soil pH in N and NPK treatments.The highest microbial biomass carbon and nitrogen,most probable number of actinomycetes,bacteria,and fungi occurred in the NPKM treatment.The average well color development(AWCD)values followed the order of NPKM>M>NPK and NM>CK and N.The Shannon index in organic manure treatments were significantly higher than in control and in treatments without organic manure.The principal component analysis showed that manure treatment was significantly separated from other treatments.These results indicated that organic manure applied alone or in combination with chemical fertilizers would increase soil fertility and functional diversity of soil microbial communities.Moreover,applying balanced N,P,K fertilizer in combination with organic manure was found to be superior to the use of a single fertilizer in improving soil microbial community quality.

Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China

Since December 2019,COVID-19 has occurred unexpectedly and emerged as a health problem worldw ide.Despite the rapidly increasing number of cases in subsequent weeks,the clinical characteristics of pediatric cases are rarely described.A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province.A total of 25 confirmed pediatric cases of COVID-19 were collected.The demographic data,epidemiological history,underlying discascs,clinical mani festations,laboratory and radiological data,treatments,and outcomes were analyzcd.Of 25 hospitalized patients with COVID-19,the boy to girl ratio was 1.27:1.The median age was 3 years.COVID-19 cases in children aged<3 years,3-6 years,and≥6-years patients were 10(40%),6(24%),and 9(36%),respectively.The most common symptoms at onset of ilness were fever(13[52%]),and dry cough(11[44%]).Chest CT images showed essential normal in 8 cases(33.3%),unilateral involvement of lungs in 5 cases(20.8%),and bilateral involvement in 11 cases(45.8%).Clinical diagnoses included upper respiratory tract infection(n=8),mild pneumonia(n=15),and critical cases(n=2).Two critical cases(8%)were given invasive mechanical ventilation,corticosteroids,and immunoglobulin.The symptoms in 24(96%)of 25 patients were alleviated and one patient had been discharged.It was concluded that children were susceptible to COVID-19 like adults,while the clinical presentations and outcomes were more favorable in children.However,children less than 3 years old accounted for majority cases and critical cases lied in this age group,which demanded extra attentions during home caring and hospitalization treatment.

Comparisons of OCO-2 satellite derived XCO_(2)with in situ and modeled data over global ocean

Atmospheric CO_(2)is one of key parameters to estimate air-sea CO_(2)flux.The Orbiting Carbon Observatory-2(OCO-2)satellite has observed the column-averaged dry-air mole fractions of global atmospheric carbon dioxide(XCO_(2))since 2014.In this study,the OCO-2 XCO_(2)products were compared between in-situ data from the Total Carbon Column Network(TCCON)and Global Monitoring Division(GMD),and modeling data from CarbonTracker2019 over global ocean and land.Results showed that the OCO-2 XCO_(2)data are consistent with the TCCON and GMD in situ XCO_(2)data,with mean absolute biases of 0.25×10^(-6)and 0.67×10^(-6),respectively.Moreover,the OCO-2 XCO_(2)data are also consistent with the CarbonTracker2019 modeling XCO_(2)data,with mean absolute biases of 0.78×10^(-6)over ocean and 1.02×10^(-6)over land.The results indicated the high accuracy of the OCO-2 XCO_(2)product over global ocean which could be applied to estimate the air-sea CO_(2)flux.

Flavonol synthase gene MsFLS13 regulates saline-alkali stress tolerance in alfalfa

Alfalfa(Medicago sativa L.) is one of the most extensively grown leguminous forage worldwide.Environmental saline-alkali stress significantly influences the growth,development,and yield of alfalfa,posing a threat to its agricultural production.However,little is known about the potential mechanisms by which alfalfa responds to saline-alkali stress.Here,we investigated these mechanisms by cloning a saline-alkali-induced flavonol synthase gene(Ms FLS13) from alfalfa,which was previously reported to be significantly upregulated under saline-alkali stress,and examining its function in the saline-alkali response.Overexpression of Ms FLS13 in alfalfa promoted plant tolerance to saline-alkali stress by enhancing flavonol accumulation,antioxidant capacity,osmotic balance,and photosynthetic efficiency.Conversely,Ms FLS13 inhibition using RNA interference reduced flavonol synthase activity and inhibited hairy root growth under saline-alkali stress.Yeast one-hybrid and dual-luciferase reporter assays indicated that the R2R3-MYB Ms MYB12 transcription factor activates Ms FLS13 expression by binding to the MBS motif in the Ms FLS13 promoter.Further analysis revealed that abscisic acid mediates the salinealkali stress response partially by inducing Ms MYB12 and Ms FLS13 expression,which consequently increases flavonol levels and maintains antioxidant homeostasis in alfalfa.Collectively,our findings highlight the crucial role of Ms FLS13 in alfalfa in response to saline-alkali stress and provide a novel genetic resource for creating saline-alkali-resistant alfalfa through genetic engineering.

云南西盟蔗区土壤大量元素养分状况分析与评价

土壤pH值、有机质和养分含量是影响甘蔗产量和糖分的重要因素,通过分析研究西盟蔗区土壤pH值、有机质和养分含量及聚类状况,提出甘蔗科学种植的养分管理建议。2020年11月采集西盟昌裕糖业有限责任公司蔗区3400 hm^(2)有代表性的土壤类型、海拔、品种分布的蔗区土壤混合样品104份,对土壤的pH值、有机质、碱解氮、有效磷、速效钾等进行检测分析。结果表明:蔗区土壤pH变化范围在4.3~7.1,平均值为5.4,有机质变化范围为8.3~65.6 g/kg,平均值为31.6 g/kg,碱解氮变化范围为53.8~227.6 mg/kg,平均值为128.3 mg/kg,有效磷变化范围为1.2~80.8 mg/kg,平均值为13.92 mg/kg,速效钾变化范围为20~811 mg/kg,平均值为134.5 mg/kg。蔗区土壤呈酸性,有机质属于较高水平,碱解氮为较高水平,有效磷和速效钾为一般水平;聚类分析结果表明,勐卡镇、新厂镇、力所乡和澜沧县竹塘乡的土壤有机质、碱解氮、有效磷、速效钾等性质具有相似性;勐梭镇、翁嘎科乡、中课镇和澜沧县拉巴乡土壤性质具有相似性。通过分析研究蔗区土壤状况,提出甘蔗科学种植的养分管理建议,促进蔗农持续增产增收,对稳定和发展甘蔗种植面积具有重要的实际意义。

Competition between(18,18)and(18,16)Configurations in Ni2(CO)5:An Isomerization Energy Decomposition Analysis

The potential energy landscape of the neutral Ni_(2)(CO)_(5) complex was re-examined.A new C_(2v) structure with double bridging carbonyls is found to compete with the previously proposed triply carbonyl-bridged D_(3h) isomer for the global minimum of Ni_(2)(CO)_(5).Despite that the tri-bridged isomer possesses the more favored(18,18)configuration,where both metal centers satisfy the 18-electron rule,the neutral Ni_(2)(CO)_(5) complex prefers the di-bridged geometry with(18,16)configuration.The isomerization energy decomposition analysis reveals that the structural preference is a consequence of the maximization of electrostatic and orbital interactions.

Study of coexisting upstream solitary wave packet and downstream wakes induced by Diaoyu Dao and its affiliated islands detected by satellite sun glitter

Taking the advantage of sun glitter(SG)observed from high-resolution satellites Gaofen-1(GF-1)and Gaofen-6(GF-6),a new method named Shield and Vortex 1-2(SAV1-2)for extracting spatial texture information from sun glitter was established.Sea surface texture detail information around Diaoyu Dao and its affiliated islands was extracted using SAV1-2.Meanwhile,the dynamic characteristics of the water environment were analyzed by combining the water color,temperature and dynamic data.The results show the following information.(1)Stable westward shield effect and eastward Karman vortex streets,extracted from SG,appear upstream(westward)and downstream(eastward)of the Diaoyu Dao and its affiliated islands respectively.(2)The dominant direction of the Kuroshio Current in the Diaoyu Dao and its affiliated islands area is east,the Diaoyu Dao and its affiliated islands interacting with Kuroshio,inducing western shield and eastern shelter and wake.Furthermore,wave intervals of the shield in front of the island range from hundreds to thousands of metres,and extend wider than the island itself.(3)Combining with high-resolution sea surface temperature(SST)and chlorophyll a(Chl a)concentration,the directional changes of water color elements are mutually supported and proved with the stable shield(wave packet)effect in the west and vortex street effect in the east.The change of SST upstream of the island(western shield area)is not significant,the temperature in the downstream shelter area decreases slightly,and the SST in the downstream wake area shows a general trend of obvious decrease.The wake area is dominated by Karman vortex streets in shape,supplementing by vortices.The concentration of Chl a in the west shield of island is as low as that in downstream shelter area,while it increases significantly in the downstream wake area with shape in eddy or ribbon.(4)The SAV methods of extracting sea surface texture detail using SG can be widely used in different sea areas and water quality.This paper can provide reference for the protection and development of Diaoyu Dao and its affiliated islands and its surrounding waters.It is suggested that some kind of current buffer,such as marine wind farm,should be established in the western waters of Diaoyu Dao and its affiliated islands to protect the islands,and marine pasture should be developed in the downstream of eastern waters of Diaoyu Dao and its affiliated islands.

Perceived health-related stigma among patients with breast cancer

Breast cancer survivors face many challenges(particularly changes in body image) on their road to restoring physical and psychosocial health following diagnosis. Perceived health-related stigma(PHS)refers to the attachment of negative connotations to some types of disease diagnoses. PHS is common among patients with breast cancer and is associated with adverse emotions, attitudes and behaviors. This article summarizes the latest advances and new perspectives on PHS of breast cancer patients and approaches to block this deleterious process. Effects of PHS on patients with breast cancer, in this paper,and measures, predictors and interventions of PHS have been discussed in depth. Future studies should continue to develop more effective instruments that are specialized for measuring PHS of breast cancer patients, explore the predictors of PHS, and discuss effective interventions on the basis of the predictors.

Potato protease inhibitors,a functional food material with antioxidant and anticancer potential

Potato protease inhibitors(PPIs),as the main component of potato protein isolate,have good safety,nutrition and great market potential.The antioxidant and anticancer properties of PPIs were evaluated with cellbased biological assays.The results showed that when the concentration of PPIs was 5 mg/mL,the peroxyl radical scavenging value was(2119±204)mg VCE/100 g,and the cellular antioxidant activity values were(45.83±3.5)(no PBS wash)and(33.25±4.4)μmol QE/100 g(PBS wash).Cells pretreated with PPIs could significantly prevent the oxidative damage induced by H_(2)O_(2),inhibit the morphological changes of cells and maintain the integrity.Furthermore,PPIs had selective anti-proliferative effects on GIST882 cells(IC50=(10.53±3.87)mg/mL)and demonstrated potent inhibition of the growth,migration and invasion of cancer cells.These findings provide a scientific basis for PPIs as promising candidates for functional foods to aid in the prevention of oxidative damage and cancer.

Analysis on the Spinning Process and Properties of Tencel Yarn

Tencel fiber, as a new type of green environmental protection fiber, is drawing attention from the society and people’s favorite. In paper, the spinning process and properties of tencel yarn were studied. Also traditional cotton yarn was tested and compared to understand tencel better as they are now both widely used in apparel. Compared with cotton yarn of the same count, the weight CV of tencel quality is lower, while the twist CV is higher;breaking elongation of tencel yarn is larger, while CV of breaking elongation of tencel yarn is slightly higher;unevenness of tencel spinning yarn is lower.

Iterative physical optics model for electromagnetic scattering and Doppler analysis

An iterative physical optics（IPO） model is proposed to solve extra large scale electric electromagnetic（EM） scattering from randomly rough surfaces. In order to accelerate the convergence of the IPO model, the forward-backward methodology and its modification with underrelaxation iteration are developed to simulate the rough surface scattering; the local iteration methodology and the fast far field approximation（Fa FFA） in the matrix-vector product are proposed to reduce greatly the computational complexity. These techniques make Monte Carlo simulations possible. Thus, the average Doppler spectra of backscattered signals obtained from the simulations are compared for different incident angles and sea states. In particular, the simulations show a broadening of the Doppler spectra for a more complicated sea state at a low grazing angle（LGA）.

境外蔗区(缅甸佤邦勐波县)土壤理化状况分析与评价

境外甘蔗原料发展可以增加国内糖厂入榨甘蔗量,提高产能利用率,是境内甘蔗原料种植的有益补充。2020年12月采集缅甸佤邦勐波县4000 hm^(2)有代表性的土壤类型的蔗区土壤混合样品66份,对土壤5个理化指标进行分析。结果表明:蔗区土壤pH值变化范围为4.1~7.4,平均为5.42,有机质变化范围为0.62%~6.88%,碱解氮变化范围为14.5~225.0 mg/kg,有效磷变化范围为2.6~58.9 mg/kg,速效钾变化范围为27~459 mg/kg。蔗区土壤呈酸性,有机质属于较高水平,碱解氮为一般水平,有效磷为稍低水平,速效钾为一般水平。通过分析研究境外蔗区土壤pH值、有机质和养分状况,并进行乡镇级聚类分析,因地制宜提出境外甘蔗科学种植的测土配方施肥解决方案,有助于农务人员有针对性的指导蔗农科学合理和经济的用肥。

Mechanism of action of the bile acid receptor TGR5 in obesity

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this family.As a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose homeostasis.Recent studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and diabetes.With the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently needed.In this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

Application of CRISPR/Cas12i.3 for targeted mutagenesis in broomcorn millet(Panicum miliaceum L.)

As the global human population continues to grow and is predicted to reach 10 billion by 2050,the demand for food volume and quality raises a tremendous challenge(OECD/FAO,2017).The worldwide arable land area is decreasing,posing a major threat to crop production.To address these problems,we need to improve the endurance of major crops.

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged globally.The coronavirus disease 2019(COVID-19)has greatly influenced human society.According to data from the World Health Organization(WHO),there were over 656 million confirmed cases of COVID-19 in the world as of January 1,2023,including over 6.6 million deaths[1].

新型碳基发光纳米材料——碳点：研究进展及展望

光的应用推动着人类现代文明的进步。随着科技的发展,人们对光相关的技术成果的依赖与日俱增。传统的发光材料,如稀土、有机染料、金属配合物等,存在资源有限、价格昂贵、合成困难、稳定性差等缺点,尤其是环境与生态不相容问题束缚了其长远发展。

Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement

Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children.