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Expression and significance of Musashi-1 in gastric cancer and precancerous lesions 被引量:12
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作者 Rong-Guang kuang yan kuang +3 位作者 Qing-Feng Luo Cheng-Jun Zhou Rui Ji Jian-Wen Wang 《World Journal of Gastroenterology》 SCIE CAS 2013年第39期6637-6644,共8页
AIM:To investigate expression of stem cell marker Musashi-1(Msi-1)in relationship to tumorigenesis and progression of intestinal-type gastric cancer(GC).METHODS:Endoscopic biopsy specimens and surgical specimens were ... AIM:To investigate expression of stem cell marker Musashi-1(Msi-1)in relationship to tumorigenesis and progression of intestinal-type gastric cancer(GC).METHODS:Endoscopic biopsy specimens and surgical specimens were obtained,including 54 cases of intestinal-type GC,41 high-grade intraepithelial neoplasia,57low-grade intraepithelial neoplasia,31 intestinal metaplasia,and 36 normal gastric mucosa.Specimens were fixed in 10%paraformaldehyde,conventionally dehydrated,embedded in paraffin,and sliced in 4-μm-thick serial sections.Two-step immunohistochemical staining was used to detect Msi-1 and proliferating cell nuclear antigen(PCNA)expression.Correlation analysis was conducted between Msi-1 and PCNA expression.The relationship between Msi-1 expression and clinicopathological parameters of GC was analyzed statistically.RESULTS:There were significant differences in Msi-1and PCNA expression in different pathological tissues(χ2=15.37,P<0.01;χ2=115.36,P<0.01).Msi-1and PCNA-positive cells were restricted to the isthmus of normal gastric glands.Expression levels of Msi-1and PCNA in intestinal metaplasia were significantly higher than in normal mucosa(U=392.0,P<0.05;U=40.50,P<0.01),whereas there was no significant difference compared to low or high-grade intraepithelial neoplasia.Msi-1 and PCNA expression in intestinaltype GC was higher than in high-grade intraepithelial neoplasia(U=798.0,P<0.05;U=688.0,P<0.01).There was a significantly positive correlation between Msi-1 and PCNA expression(rs=0.20,P<0.01).Msi-1expression in GC tissues was correlated with their lymph node metastasis and tumor node metastasis stage(χ2=12.62,P<0.01;χ2=11.24,P<0.05),but not with depth of invasion and the presence of distant metastasis.CONCLUSION:Msi-1-positive cells may play a key role in the early events of gastric carcinogenesis and may be involved in invasion and metastasis of GC. 展开更多
关键词 MUSASHI-1 Stem cells GASTRIC cancer PRECANCEROUS LESIONS Immunohistochemistry.
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Mathematical Model for Two-Spotted Spider Mites System: Verification and Validation
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作者 yan kuang David Ben-Arieh +3 位作者 Songnian Zhao Chih-Hang Wu David Margolies James Nechols 《Open Journal of Modelling and Simulation》 2017年第1期13-31,共19页
This paper presents and compares four mathematical models with unique spatial effects for a prey-predator system, with Tetranychus urticae as prey and Phytoseiulus persimilis as predator. Tetranychus urticae, also kno... This paper presents and compares four mathematical models with unique spatial effects for a prey-predator system, with Tetranychus urticae as prey and Phytoseiulus persimilis as predator. Tetranychus urticae, also known as two-spotted spider mite, is a harmful plant-feeding pest that causes damage to over 300 species of plants. Its predator, Phytoseiulus persimilis, a mite in the Family Phytoseiidae, effectively controls spider mite populations. In this study, we compared four mathematical models using a numerical simulation. These models include two known models: self-diffusion, and cross-diffusion, and two new models: chemotaxis effect model, and integro diffusion model, all with a Beddington-De Angelis functional response. The modeling results were validated by fitting experimental data. Results demonstrate that interaction scheme plays an important role in the prey-predator system and that the cross-diffusion model fits the real system best. The main contribution of this paper is in the two new models developed, as well as the validation of all the models using experimental data. 展开更多
关键词 Two-Spotted SPIDER MITE Phytoseiulus persimilis MATHEMATICAL Model PREY-PREDATOR SYSTEM
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Expert consensus on the management process of gynecological emergency under the regular epidemic prevention and control of COVID-19
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作者 Hongbo Wang Wei Zhang +10 位作者 Xin Du yan kuang Xiaomao Li Xiaoxin Ma Lan Xiao Xiaojun Chen Yu Zhang Donglin Li Lang Zheng yanhui Li Jianliu Wang 《Gynecology and Obstetrics Clinical Medicine》 2021年第2期100-105,共6页
At present,China is in the stage of the COVID-19 epidemic where regular prevention and control measures are required to contain the spread of disease.Reports of new sporadic cases are still widespread across China and... At present,China is in the stage of the COVID-19 epidemic where regular prevention and control measures are required to contain the spread of disease.Reports of new sporadic cases are still widespread across China and medical personnel remain at high risk of exposure to infection.This is especially the case for medical staff working within emergency departments.Most gynecological emergency cases are complex and a high proportion require emergency surgical treatment.By referring to national regulations and requirements on COVID-19 prevention and control,and by summarizing our experiences in the battle against COVID-19 within Wuhan,this consensus report provides recommendations on the triage,reception,consultation,admission and surgical management of gynecological emergency patients.We also make suggestions for the environmental layout and disinfection and the medical waste management.This consensus aims to optimize the diagnosis and treatment process of gynecological emergency patients and reduce the exposure risk of medical staff within the current context of routine COVID-19 prevention and control. 展开更多
关键词 Corona virus disease 2019 Gynecological emergency Regular epidemic prevention and control Expert consensus
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