基于智能物联网技术的高校实验室信息管理系统研究

本论文旨在探讨智能物联网技术在提升高校实验室信息管理系统(LIMS)方面的可用性问题。论文分析了现行LIMS的局限性,提出了物联网技术在提高管理效率和安全性方面可能出现的应用模式。此外,研究还通过对国内外LIMS发展过程进行比较,提出了云计算、人工智能等技术的集成解决方案和建议,并总结了物联网技术对于促进高校科研和教学创新的重要作用。

尾矿库溃坝泥石流多级拦截坝防护效果研究

为了减轻山谷型尾矿库溃坝形成的高流速、强冲击力的尾砂泥石流对下游生命财产造成的损伤,设计以拱型为基础坝型的多级拦截坝,在此基础上构建三维数值模型,对尾矿库多级拦截坝滞留尾砂泥石流效果和对下游敏感目标防护作用开展深入研究。研究结果表明:尾矿库溃坝后形成的尾砂泥石流经多级拦截坝拦挡缓冲后,尾砂在拦截坝处滞留历程分为“爬升、回淤、攀越”3个阶段,最大流动速度减少约8.86 m/s、砂流到达村庄的最大水位高程时间推迟约210 s,下游村庄最大淹没水深降低约3.47 m,平均淤砂深度减小近1.87 m,设计的多级拦截坝滞砂防护效果显著。研究结果可为溃坝泥石流多级拦截坝安全防护问题提供借鉴。

考虑低碳需求响应及主从博弈的综合能源系统低碳优化调度

随着能源绿色转型要求的不断提高,为实现综合能源系统低碳经济调度,除考虑源侧减碳策略外,需求侧减碳潜力也值得挖掘。兼顾源荷,提出一种考虑低碳需求响应及供需主从博弈的综合能源系统优化调度模型。首先,在供能侧考虑碳交易机制,采用碳排放流模型将供能侧的碳排放折算到用户侧;然后,从用户侧角度考虑碳排放问题,提出激励型低碳需求响应模型,以引导供能侧的低碳调度;其次,采用主从博弈模型形成供能侧与用户侧间的互动,得到合理、有效的激励方案,进一步挖掘用户侧减碳潜力;最后,通过算例仿真结果验证所提方法的有效性,在保证经济性的同时减少了系统碳排放量。

Incidence and Risk Factors of Sub-syndromal Delirium in Patients after Cardiac Surgery

[Objectives]This study aimed to investigate the incidence and risk factors associated with SSD in patients following cardiac surgery.[Methods]A total of 378 patients who underwent cardiac surgery in Taihe Hospital were recruited and screened.Diagnosis of delirium was made using evaluation methods and DSM-5 criteria.SSD was defined as the presence of one or more core features of delirium without meeting the full diagnostic criteria.Statistical analysis included independent samples t-test for group comparisons and binary logistic regression analysis to identify independent risk factors for SSD after cardiac surgery.[Results]Among the 378 subjects,112(29.63%)had SSD,28(7.41%)had delirium,and the remaining 238 patients(62.96%)did not present with delirium.Univariate analysis revealed that age,APACHE II score,duration of aortic clamping,length of ICU stay,duration of sedation use,and daily sleep time were significant risk factors for the occurrence of SSD(P<0.05).Logistic regression analysis identified age>70 years old,APACHE II score>20 points,length of ICU stay>5 d,and duration of sedation use>24 h as independent risk factors for SSD after cardiac surgery(P<0.05).A functional model was fitted based on the analysis results of the binary logistic regression model,yielding the equation logit P=1.472X_(1)+2.213X_(2)+3.028X_(3)+1.306X_(4).[Conclusions]Comprehensive clinical assessment is crucial for patients undergoing cardiac surgery,and appropriate preventive measures should be taken for patients with identified risk factors.Close monitoring of the patient s consciousness should be implemented postoperatively,and timely interventions should be conducted.Further research should focus on model validation and optimization.

“双碳”目标下电力供应链运营的影响因素分析

随着时代的发展,电力行业体制改革也已经进行到了第四阶段,政策不断跟进、推陈出新,电力行业市场化持续推进,电力行业逐步向清洁化转型。文中基于战略三脚架模型,结合“双碳”目标,从国家电改制度、电力行业竞合关系、“双碳”投入三个维度对电力供应链运营的影响因素进行了分析,通过分析得出结论:国家电改制度为电力供应链的发展指明了方向;电力行业竞合关系的演变促进了电力供应链整体不断优化;管理费用与清洁能源占比成为电力供应链运营过程中的主要目标。

Application of Medical Failure Mode and Effect Analysis in Preoperative Preparation for Coronary Intervention

[Objectives]To explore application effect of healthcare failure mode and effect analysis(HFMEA)in preoperative management of coronary intervention.[Methods]The preoperative management process of 455 patients who underwent coronary intervention surgery from January to March in 2022 was sorted out,and the failure modes and causes in the preoperative management were analyzed.The priority risk value was calculated,and the top 6 failure modes were found out.Improvement measures were formulated according to the causes of failure modes.Two months after the implementation of the procedure,470 patients who underwent coronary intervention surgery from May to July in 2022 were selected as the intervention group,and the optimized preoperative preparation procedure by HFMEA was adopted.The decrease of risk priority number(RPN)and RPN value of two high-risk failure modes,as well as changes in the rate of the time of taking dual-antiplatelet drugs reaching the standard,the rate of passing the dress code,the rate of timely signing of informed consent,and the rate of filling in the handover form of preoperative preparation were analyzed.[Results]The rate of the time of taking dual-antiplatelet drugs reaching the standard,the rate of passing the dress code,the rate of timely signing of informed consent,and the rate of filling in the handover form of preoperative preparation in experimental groups were higher than those of the control group,and the difference was statistically significant(P<0.05).[Conclusions]Applying HFMEA to the management of preoperative preparation process for coronary intervention can effectively improve the timeliness and qualification rate of preoperative preparation for coronary intervention,and provide guarantee for the safe and smooth implementation of coronary intervention.

冰冻圈变化的可预测性、不可逆性和深度不确定性

IPCC第六次评估报告(AR6)第一工作组报告对气候系统各要素的可预测性(predictability)、不可逆性(irreversibility)和深度不确定性(deep uncertainty)给出了新认识。文中基于此对全球冰冻圈变化的上述三方面加以总结和归纳。总体来看,无论何种排放情景,半球和全球尺度上冰冻圈各要素于21世纪均具有一定的可预测性,即均向融化或退化方向变化,且具有不可逆性;但在区域尺度、短时间尺度和百年以上时间尺度上,不同冰冻圈要素或因内部变率大、或因响应机制复杂而存在可逆、可预测性差乃至深度不确定性难题。

Effects of cotransplantated Schwann cells and neural stem cells in a rat model of Alzheimer's disease

Schwann cells （SCs） are significantly better at promoting neural stem cell （NSCs） proliferation, differentiation and synaptic formation when cocultured with NSCs in vitro, compared with cultured in a single nerve growth factor. The present study transplanted NSCs and SCs into the brain of a rat model of Alzheimer＇s disease to investigate the effect of cotransplantation. Results show transplantation of both NSCs alone and NSCs ＋ SCs significantly promoted learning and memory functions in Alzheimer＇s disease rats, decreased glial fibrillary acidic protein and calcium binding protein S100β expression, but increased expression of the cholinergic neuron marker choline acetyl transferase mRNA. The effect of NSCs ＋ SCs cotransplantation was, however, more significant. NSCs and SCs cotransplantation significantly reduced the number of astrocytes and increased cholinergic neurons, facilitating the recovery of learning and memory function, compared with NSCs transplantation alone.

Protective effects of transplanted neural stem cells on the brain of Alzheimer’s disease rats

BACKGROUND： To date, no drugs are able to halt the progression of Alzheimer＇s disease （AD）. Neural stem cells （NSCs） transplantation has been widely used to treat AD, but the mechanism of AD treatment remains unclear. OBJECTIVE： To observe changes in protein and factors in the hippocampus and frontal lobe of AD rats following NSCs transplantation, and to understand mechanism of action of NSCs transplantation in AD treatment. DESIGN, TIME AND SETTING： A randomized, controlled animal study was conducted at the First Clinical Hospital, Jilin University, China from July 2007 to March 2009. MATERIALS： NSCs were harvested from the hippocampus of 10 E16 Wistar rats. METHODS： A total of 57 male adult Wistar rats were equally and randomly divided into normal control, AD model and NSCs groups. AD models were established in the AD model and NSCs groups by bilateral removal of hippocampus. At 2 weeks postsurgery, NSCs were transplanted into the hippocampus of rats from the NSCs group. MAIN OUTCOME MEASURES： Protein levels were measured in the hippocampus of rats from normal control, NSCs and AD model groups using proteomics. Expression of choline acetyl transferase mRNA, glial fibrillary acidic protein and S100β was measured in the hippocampus and frontal lobe of rats using in situ hybridization and immunohistochemistry. RESULTS： Expression of choline acetyl transferase mRNA, heat shock protein 70, heat shock protein 90, F-actin and actin was significantly higher in the NSCs group compared with AD model group. Glial fibrillary acidic protein and S100β expression was less in the NSCs group compared with AD model group. CONCLUSlOIN： NSCs implanted into the brain may generate new neural cells, which can relieve damage to the cholinergic system and resist apoptosis. NSCs transplantation plays a protective role in the cholinergic system in the AD rats to some extent.

Upper crustal velocity and seismogenic environment of the M7.0 Jiuzhaigou earthquake region in Sichuan, China

On August 8,2017,a magnitude 7.0 earthquake occurred in Jiuzhaigou County,Sichuan Province,China.The deep seismogenic environment and potential seismic risk in the eastern margin of Tibetan Plateau have once again attracted the close attention of seismologists and scholars at home and abroad.The post-earthquake scientific investigation could not identify noticeable surface rupture zones in the affected area;the complex tectonic background and the reason(s)for the frequent seismicity in the Jiuzhaigou earthquake region are unclear.In order to reveal the characteristics of the deep medium and the seismogenic environment of the M7.0 Jiuzhaigou earthquake region,and to interpret the tectonic background and genesis of the seismicity comprehensively,in this paper,we have reviewed all available observation data recorded by the regional digital seismic networks and large-scale,dense mobile seismic array(China Array)for the northern section of the North-South Seismic Belt around Jiuzhaigou earthquake region.Using double-difference seismic tomography method to invert the three-dimensional P-wave velocity structure characteristics of the upper crust around the Jiuzhaigou earthquake region,we have analyzed and discussed such scientific questions as the relationship between the velocity structure characteristics and seismicity in the Jiuzhaigou earthquake region,its deep tectonic environment,and the ongoing seismic risk in this region.We report that:the P-wave velocity structure of the upper crust around the Jiuzhaigoug earthquake region exhibits obvious lateral inhomogeneity;the distribution characteristics of the shallow P-wave velocity structure are closely related to surface geological structure and formation lithology;the M7.0 Jiuzhaigou earthquake sequence is closely related to the velocity structure of the upper crust;the mainshock of the M7.0 earthquake occurred in the upper crust;the inhomogeneous variation of the velocity structure of the Jiuzhaigou earthquake area and its surrounding medium appears to be the deep structural factor controlling the spatial distribution of the mainshock and its sequence.The 3D P-wave velocity structure also suggests that the crustal low-velocity layer of northeastern SGB(Songpan-GarzêBlock)stretches into MSM(Minshan Mountain),and migrates to the northeast,but the tendency to emerge as a shallow layer is impeded by the high-velocity zone of Nanping Nappe tectonics and the Bikou Block.Our results reveal an uneven distribution of high-and low-velocity structures around the Tazang segment of the East Kunlun fault zone.Given that the rupture caused by the Jiuzhaigou earthquake has enhanced the stress fields at both ends of the seismogenic fault,it is very important to stay vigilant to possible seismic hazards in the large seismic gap at the Maqu-Maqên segment of the East Kunlun fault zone.

Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation

Studies have shown that downregulation of nuclear-enriched autosomal transcript 1(Neat1)may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice.Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear.Therefore,the effects of Neat1 on neuronal apoptosis were observed.C57 BL/6 primary neurons were obtained from the cortices of newborn mice and cultured in vitro,and an oxygen and glucose deprivation cell model was established to simulate the secondary brain injury that occurs after traumatic brain injury in vitro.The level of Neat1 expression in neuronal cells was regulated by constructing a recombinant adenovirus to infect neurons,and the effects of Neat1 expression on neuronal apoptosis after oxygen and glucose deprivation were observed.The experiment was divided into four groups:the control group,without any treatment,received normal culture;the oxygen and glucose deprivation group were subjected to the oxygen and glucose deprivation model protocol;the Neat1 overexpression and Neat1 downregulation groups were treated with Neat1 expression intervention techniques and were subjected to the in oxygen and glucose deprivation protocol.The protein expression levels of neurons p53-induced death domain protein 1(PIDD1,a pro-apoptotic protein),caspase-2(an apoptotic priming protein),cytochrome C(a pro-apoptotic protein),and cleaved caspase-3(an apoptotic executive protein)were measured in each group using the western blot assay.To observe changes in the intracellular distribution of cytochrome C,the expression levels of cytochrome C in the cytoplasm and mitochondria of neurons from each group were detected by western blot assay.Differences in the cell viability and apoptosis rate between groups were detected by cell-counting kit 8 assay and terminal deoxynucleotidyl transferase dUTP nick-end labeling assay,respectively.The results showed that the apoptosis rate,PIDD1,caspase-2,and cleaved caspase-3 expression levels significantly decreased,and cell viability significantly improved in the Neat1 overexpression group compared with the oxygen and glucose deprivation group;however,Neat1 downregulation reversed these changes.Compared with the Neat1 downregulation group,the cytosolic cytochrome C level in the Neat1 overexpression group significantly decreased,and the mitochondrial cytochrome C level significantly increased.These data indicate that Neat1 upregulation can reduce the release of cytochrome C from the mitochondria to the cytoplasm by inhibiting the PIDD1-caspase-2 pathway,reducing the activation of caspase-3,and preventing neuronal apoptosis after oxygen and glucose deprivation,which might reduce secondary brain injury after traumatic brain injury.All experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Chongqing Medical University,China,on December 19,2020(approval No.2020-895).

Evidence-based treatment for acute spinal cord injury

OBJECTIVE： To formulate an evidence-based treatment for one patient with acute spinal cord injury and summarize evidence for evaluating acute spinal cord injury treatment. METHODS： Studies related to the treatment for acute spinal cord injury were identified via a search of National Guideline Clearinghouse （NGC, 2000 11）, the Cochrane Library （Issue 1,2011）, TRIP Database （2000 11）, and PubMed （1966-2011）. Treatment strategies were formulated according to three basic principles： best evidence, doctor＇s professional experience, and wishes of the patient. RESULTS： A total of 34 articles were selected, including 1 NGC guideline, 22 systematic reviews, and 11 randomized controlled trials. Based on our review, we arrived at the following recommendations： no clinical evidence exists definitively to recommend the use of any of neuroprotective pharmaceuticals; surgery should be undertaken early; mechanical compression devices and low-molecular weight heparin should be employed to prevent thrombosis; respiratory muscle training is beneficial for pulmonary function and quality of life; and functional electrical stimulation and acupuncture can promote functional recovery. The patient accordingly underwent surgery 6 hours after trauma without receiving any neuroprotective pharmaceuticals; low-molecular weight heparin and intermittent pneumatic compression were applied to prevent thrombosis. He also underwent respiratory muscle training daily for 8 weeks and received functional electrical stimulation for 15 minutes and acupuncture for 30 minutes every day. After follow-up for 3 months, the above therapeutic regimen was confirmed efficacious for acute spinal cord injury. CONCLUSION： Evidence-based medicine provides an individualized treatment protocol for acute spinal cord injury, which can significantly improve the therapeutic effect and prognosis.

大幅面集成成像显示系统中宏透镜阵列位置误差度量与校正

在大幅面集成成像显示系统中,宏透镜阵列位置误差会严重影响成像质量。宏透镜阵列位置误差可以分为轴向位置误差和横向位置误差,理想情况下汇聚于重构点的像素在位置误差作用下将不再汇聚,这些像素将在其他点处成像。本文利用重构点到这些点的距离的平均值和方差对位置误差的大小进行了度量,并讨论了宏透镜阵列轴向位置和横向位置的测量方法,给出了宏透镜阵列轴向位置误差和横向位置误差的校正方法,从而缓解了宏透镜阵列位置误差对成像质量的影响,提高了显示效果。

借助GeoGebra的3D作图功能认识空间解析几何中的平面与曲面

为了生动展示空间平面和曲面的生成过程,利用GeoGebra的3D作图功能,对空间解析几何中的平面、圆锥面、抛物柱面进行了研究。此软件能有效突破教学难点,化抽象为具体,提高了学生的想象能力。

Earthquake Electromagnetic Precursor Anomalies Detected by a New Ground-based Observation Network

It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electromagnetic(EM)precursors were published by using techniques equipped in either satellites or on ground-based stations.But there are only a few cases that the shortterm precursor anomalies of EM field before earthquakes were observed by using alternate EM fields on ground.This paper will present a new EM observation network built in recent years and show a new finding of EM field with the variation of a one-year cycle observed using the network.As an example,the short-term precursor anomalies of apparent resistivity before the Yangbi EQ(Ms 5.1)occurred on March 27,2017 in Yunnan Province will be studied.The observed anomalous phenomena indicate that the anomaly before the EQ can be captured only if reasonable effective methods including sophisticated analytical techniques are used,and it is believed that continuously observed data on the fixed observation network for a long time is an effective means for studying anomalies that appeared before earthquakes.This network can also play an important role in studying the EM environment from space.

动态评价方法学助力建筑绿色化发展

在节能减排、经济转型发展、改善人民居住环境的驱动下,建筑亟需绿色化发展。而投融资双方信息不对称问题造成当前建筑绿色化改造在投融资阶段面临银行"惜贷"的困难。文章针对这个问题尝试设计一套基于风险补偿机制和建筑信息动态监测技术的动态评价方法学,为建筑绿色化改造提供全生命周期的数据动态监测和绿色评价服务,使金融机构能够持续及时、真实地获得此类项目的相关数据信息,优化项目风险控制和相关财务指标,疏通建筑绿色化改造投融资通道。

Prevalence and Risk Factors of Postoperative Pressure Ulcers:A Systematic Review and Meta-analysis of Diagnostic Test

[Objectives]The paper was to analyze the total prevalence of postoperative pressure ulcers in patients and to reveal the epidemic law.[Methods]By searching English databases such as PubMed,Google Academics,Scopus,Science Direct and Web of Science(WOS),a total of 2018 English articles on pressure ulcers published from January 2015 to December 2020 were selected.According to the inclusion criteria,19 high-quality literatures were selected for the study,and the extended function of meta-analysis software of Review Manager 5.1 diagnostic test was used for data statistics and meta analysis of the results.[Results]There were 19 literatures with a total of 9400 patients included in the meta-analysis.The results showed that the total prevalence estimate of postoperative pressure ulcers was 20.00%(CI 95%:15.3-24.1).The total prevalence estimate of postoperative pressure ulcers in males was 10.1%(CI 95%:7.2-13.02),and that in females was 12.8%(CI 95%:8.1-17.3).The total prevalence estimates of stage I to IV postoperative pressure ulcers were 17.02%(CI 95%:11.06-22.09),6.7%(CI 95%:3.76-9.69),0.9%(CI 95%:0.21-1.26)and 0.4%(CI 95%:-0.05-0.8),respectively.[Conclusions]The prevalence of postoperative pressure ulcers is generally high.The prevalence of postoperative pressure ulcers in females is higher than that in males,and the prevalence of stage I pressure ulcers is higher than that of other stages,which is related to age,gender and other related risk factors.

Psychosocial Adaptation Level and Work Participation Rate of Young and Middle-aged Patients with Coronary Heart Disease after PCI

[Objectives]The research aimed to understand the psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI and their participation situation in work.[Methods]210 young and middle-aged patients aged 18-59 years with coronary heart disease treated by PCI in a tertiary hospital of Suzhou from July of 2020 to November of 2022 were selected,and general information of patients in three days after operation was registered.Self-report psychosocial adjustment to illness scale(PAIS-SR)was used to investigate the psychosocial adjustment to illness of patients in 1,3 and 6 months after operation and the participation rate of work.[Results]The psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI was different in gender,age,education level,marital status,hypertension,diabetes,postoperative cardiac color Doppler ultrasound results(left ventricular ejection fraction)and the number of stents(P<0.05).[Conclusions]The psychosocial adjustment to illness of young and middle-aged patients with coronary heart disease after PCI needs to be improved.The psychosocial adjustment to illness of men is higher than that of women.The older the age is,the lower the psychosocial adjustment to illness is.The psychosocial adjustment to illness of patients with high educational background is higher than those with low educational background,while the psychosocial adjustment to illness of married people is higher than unmarried people.The psychosocial adjustment to illness of patients with hypertension and/or diabetes is lower.

Effect of Narrative Therapy on the Psychological Status and Life Quality of Family Caregivers of Adolescents with First-episode Depression

[Objectives]The research aimed to explore the effect of narrative therapy on the negative emotion,quality of life,care burden and nursing satisfaction of family caregivers of adolescents with first-episode depression.[Methods]Using convenient sampling method,the family caregivers of the adolescents with first-episode depression hospitalized in the Children and Adolescents Psychology Department of a GradeⅢLevel A hospital in Shiyan City,Hubei Province from July 2021 to April 2022 were selected as the research objects.The coin toss method was used to determine the test group and the control group,with 60 cases in each group.The control group received routine nursing care,and the experimental group implemented narrative therapy on this basis.Self-rating anxiety scale,self-rating depression scale,health status questionnaire(SF-36),and caregiver burden inventory were used to evaluate the anxiety and depression level,quality of life,and care burden level of the caregivers before and after the intervention.The nursing satisfaction questionnaire was used to evaluate the nursing satisfaction to the caregivers after the intervention.[Results]After 8 weeks of intervention,4 cases fell off in the control group and 3 cases fell off in the intervention group.The scores of anxiety and depression in the two groups were lower than those before intervention,and the scores in the test group were significantly lower than those in the control group(P<0.05).The life quality scores of life vitality,emotional function and mental health dimensions were higher than before the intervention,and the scores in the test group were significantly higher than those in the control group(P<0.05).The total score of care burden and the scores in time dependence,development limitation and physiological dimension of the two groups were lower than those before intervention,but the difference was not statistically significant(P>0.05).[Conclusions]Narrative therapy can effectively alleviate the negative emotions of family caregivers of adolescents with first-episode depression,and improve their quality of life and nursing satisfaction,but not their care burden.

Effects of Nursing Intervention Based on Transtheoretical Model of Behavioral Change on Disposal of Home Medical Waste in Diabetic Patients

[Objectives]To explore the effects of nursing intervention on the disposal of home medical waste for diabetic patients.[Methods]A total of 118 diabetic patients with insulin injection at home who visited a community service center in Shiyan City during November 2020 and September 2021 were selected as the research objects to implement the intervention,and the medical waste knowledge,attitude scores and standardized medical waste disposal were compared before and after the intervention.[Results]After the intervention,the patient's medical waste knowledge score was significantly higher than that before the intervention,and the medical waste disposal attitude score was significantly higher than that before the intervention.[Conclusions]If the nursing intervention based on Transtheoretical Model(TTM)of Behavioral Change penetrates deep into patients'families and communities,it is helpful to improve the knowledge and attitude of diabetic patients on home medical waste disposal,and regulate their home medical waste disposal behavior.