A thermal stress loading technique for large-sized hot dry rock mechanical tests

Testing of large-sized specimens is becoming increasingly important in deep underground rock mechanics and engineering.In traditional mechanical loading,stresses on large-sized specimens are achieved by large host frames and hydraulic pumps,which could lead to great investment.Low-cost testing machines clearly always have great appeal.In this study,a new approach is proposed using thermal expansion stress to load rock specimens,which may be particularly suitable for tests of deep hot dry rock with high temperatures.This is a different technical route from traditional mechanical loading through hydraulic pressure.For the rock mechanics test system of hot dry rock that already has an investment in heating systems,this technology may reduce the cost of the loading subsystem by fully utilizing the temperature changes.This paper presents the basic principle and a typical design of this technical solution.Preliminary feasibility analysis is then conducted based on numerical simulations.Although some technical details still need to be resolved,the feasibility of this loading approach has been preliminarily confirmed.

Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases

The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNAP1 （Casprl）, CNTNAP2 （Caspr2）, CNTNAP3 （Caspr3）, CNTNAP4 （Caspr4） and CNTNAP5 （Caspr5）, Casprl-5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Casprl participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.

纳布啡联合右美托咪定预防性镇痛对鼻内镜手术患者血流动力学和术后疼痛的影响

目的探讨纳布啡联合右美托咪定预防性镇痛对鼻内镜手术患者血流动力学和术后疼痛的影响。方法选取择期在鼻内镜下行鼻中隔偏曲矫正术的患者60例,随机分为右美托咪定联合纳布啡组(DN组)和右美托咪定组(D组),每组30例。D组于麻醉诱导前15 min给予右美托咪定0.5μg/kg泵注;DN组于麻醉诱导前15 min给予右美托咪定0.5μg/kg泵注,同时静脉注射纳布啡0.20 mg/kg。观察麻醉前(T_(1))、插管后即刻(T_(2))、手术开始时(T_(3))、气管导管拔除即刻(T_(4))和拔管后5 min(T_(5))的平均动脉压(MAP)和心率(HR),记录术中丙泊酚、舒芬太尼和瑞芬太尼用量,以及苏醒和拔管时间,用数字分级评分(NRS)评估拔管后0.5 h(T_(6))、4.0 h(T_(7))、8.0 h(T_(8))和24.0 h(T_(9))的疼痛情况,记录补救镇痛率及不良反应发生率。结果与T_(1)时点比较,D组T_(2)~T_(5)时点MAP明显升高,HR明显加快(P<0.05),DN组T_(2)~T_(5)时点MAP和HR与T_(1)时点比较,差异无统计学意义(P>0.05)。DN组T_(2)~T_(5)时点MAP明显低于D组,HR明显慢于D组(P<0.05),T_(6)~T_(9)时点NRS明显较D组低(P<0.05),瑞芬太尼和丙泊酚用量明显较D组少(P<0.05),补救镇痛率明显较D组低(P<0.05)。结论在鼻内镜手术中使用纳布啡联合右美托咪定预防性镇痛,可稳定患者血流动力学,减少术中麻醉药物用量,减轻术后疼痛,对苏醒及拔管时间无明显影响。

Temporal alterations in pericytes at the acute phase of ischemia/reperfusion in the mouse brain

Pericytes,as the mural cells surrounding the microvasculature,play a critical role in the regulation of microcirculation;however,how these cells respond to ischemic stroke remains unclear.To determine the temporal alterations in pericytes after ischemia/reperfusion,we used the 1-hour middle cerebral artery occlusion model,which was examined at 2,12,and 24 hours after reperfusion.Our results showed that in the reperfused regions,the cerebral blood flow decreased and the infarct volume increased with time.Furthermore,the pericytes in the infarct regions contracted and acted on the vascular endothelial cells within 24 hours after reperfusion.These effects may result in incomplete microcirculation reperfusion and a gradual worsening trend with time in the acute phase.These findings provide strong evidence for explaining the“no-reflow”phenomenon that occurs after recanalization in clinical practice.

Exploring Urban Population Forecasting and Spatial Distribution Modeling with Artificial Intelligence Technology

The high precision population forecasting and spatial distribution modeling are very important for the theory and application of population sociology,city planning and Geo-Informatics.However,the two problems need to be solved for providing the high precision population information.One is how to improve the population forecasting precision of small area(e.g.,street scale);another is how to improve the spatial resolution of urban population distribution model.To solve the two problems,some new methods are proposed in this contribution.(1)To improve the precision of small area population forecasting,a new method is developed based on the fade factor and the slide window.(2)To improve the spatial resolution of urban population distribution model,a new method is proposed based on the land classification,public facility information and the artificial intelligence technology.For validation of the proposed methods,the real population data of 15 streets in Xicheng district,Beijing,China from 2010 to 2016,the remote sensing images and the public facility data are collected and used.A number of experiments are performed.The results show that the spatial resolution of proposed model reaches 30m*30m and the forecasting precision is better than 5%using the proposed method to forecast the population of 15 streets in Xicheng district in the next four years.

Tailoring phase fractions of T'and η' phases in dual-phase strengthened Al−Zn−Mg−Cu alloy via ageing treatment

Hardness tests and transmission electron microscopy were used to investigate the strategy of tailoring the phase fraction of precipitates in an Al-Zn-Mg-Cu alloy strengthened by T’ and η’ phases. Different phase fractions of T’ and η’ phases are presented in samples subjected to either single or two stages of ageing treatments at 120 and 150 ℃.For both types of ageing, the precipitation of η’ phase is found to be promoted by ageing at lower temperature and its phase fraction increases with prolonging ageing time at 120 ℃;whereas the phase fractions of T’ and η’ phases almost remain constant during ageing at 150 ℃. Besides, the strain fields produced by T’ and η’ phases were analyzed by using the geometric phase analysis technique, and on a macroscale the contributions of T’ and η’ phases to precipitation strengthening have been quantitatively predicted by combining the size, phase fraction and number density of precipitates.

Carbon and nitrogen budget in fish-polychaete integrated aquaculture system

Integrated multi-tropic aquaculture(IMTA)systems have been used in China for many years and have achieved significant economic,social,and ecological benefits.However,there is still a lack of benthic bioremediation species that can effectively utilize the aquaculture particulate organic waste in the system.Polychaete Perinereis aibuhitensis Grube is used as an environmental remediation species for large-scale aquaculture to reduce particulate organic waste,which is of great significance to environmental protection.To improve bio-elements utilization efficiency,P.aibuhitensis was applied for IMTA indoor fish(Hexagrammos otakii)farming.Results showed that in the system,production of 1 kg of the fish discharged 2141-2338 mg of carbon and 529-532 mg of nitrogen,while in the monoculture of the fish,the figures were 3033-3390 mg and 764-794 mg,or 24.84%-35.26%and 30.35%-33.32%less,respectively.This approach promoted IMTA technology that could utilize the particulate organic waste from intensive aquaculture and reduce the adverse environmental effects.

2013年云南省会泽县鹤类及大型水禽的数量变化

会泽县地处云南东省北部,历年都有黑颈鹤(Grus nigricollis)在此越冬。2013年1月17—19日,于会泽县7个自然村采用同步统计法对鹤类和几种大型越冬水禽进行了调查。黑颈鹤为424只、灰鹤(G.grus)322只、白鹤(G.leucogeranus)1只、斑头雁(Anser indicus)610只、赤麻鸭(Tadorna ferruginea)61只,未观察到黑鹳。与2000年初相比,黑颈鹤等大型水禽栖息于会泽的种群数量相对减少。就黑颈鹤等保护提出了寻找替代生计,减缓人鸟矛盾;理顺管理体系,增加人员编制;加强人员培训和交流;加强社区共建、共管等诸项意见及建议。

Global Functional Network Connectivity Disturbances in Parkinson’s Disease with Mild Cognitive Impairment by Resting-State Functional MRI

Examining the spontaneous BOLD activity to understand the neural mechanism of Parkinson’s disease(PD)with mild cognitive impairment(MCI)is a focus in resting-state functional MRI(rs-fMRI)studies.This study aimed to investigate the alteration of brain functional connectivity in PD with MCI in a systematical way at two levels:functional connectivity analysis within resting state networks(RSNs)and functional network connectivity(FNC)analysis.Using group independent component analysis(ICA)on rs-fMRI data acquired from 30 participants(14 healthy controls and 16 PD patients with MCI),16 RSNs were identified,and functional connectivity analysis within the RSNs and FNC analysis were carried out between groups.Compared to controls,patients with PD showed decreased functional connectivity within putamen network,thalamus network,cerebellar network,attention network,and self-referential network,and increased functional connectivity within execution network.Globally disturbed,mostly increased functional connectivity of FNC was observed in PD group,and insular network and execution network were the dominant network with extensively increased functional connectivity with other RSNs.Cerebellar network showed decreased functional connectivity with caudate network,insular network,and self-referential network.In general,decreased functional connectivity within RSNs and globally disturbed,mostly increased functional connectivity of FNC may be characteristics of PD.Increased functional connectivity within execution network may be an early marker of PD.The multi-perspective study based on RSNs may be a valuable means to assess functional changes corresponding to specific RSN,contributing to the understanding of the neural mechanism of PD.

Performance analysis of mobile ad hoc networks under flooding attacks

Due to their characteristics of dynamic topology, wireless channels and limited resources, mobile ad hoc networks are particularly vulnerable to a denial of service （DoS） attacks launched by intruders. The effects of flooding attacks in network simulation 2 （NS2） and measured performance parameters are investigated, including packet loss ratio, average delay, throughput and average number of hops under different numbers of attack nodes, flooding frequency, network bandwidth and network size. Simulation results show that with the increase of the flooding frequency and the number of attack nodes, network performance sharply drops. But when the frequency of flooding attacks or the number of attack nodes is greater than a certain value, performance degradation tends to a stable value.

Improving Access to Quality Care in Family Planning:WHO’s Four Cornerstones of Evidence-based Guidance

The four cornerstones of guidance in technique service of family planning are established by WHO based on high quality evidences. They have been updated according to the appearing new evidences, and the consensuses were reached by the international experts in this field. The four documents include Medical Eligibility Criteria for Contraceptive Use, Selected Practice Recommendations for Contraceptive Use, Decision-making Tool for Family Planning Clients and Providers and The Global Handbook for Family Planning Providers. The first two documents mainly face to the policymakers and programme managers and were treated as the important references for creating the local guideline. The other two documents were developed for the front-line health-care and family planning providers at different levels, which include plenty of essential technical information to help providers improve their ability in service delivery and counselling. China paid great attention to the introduction and application of WHO guidelines. As soon as the newer editions of these documents were available, the Chinese version would be followed. WHO guidelines have been primarily adapted with the newly issued national guideline, The Clinical Practical Skill Guidelines-Family Planning Part, which was established by China Medical Association. At the same time, the WHO guidelines have been introduced to some of the clinicians and family planning providers at different levels. In the future, more special training courses will be introduced to the township level based on the needs of grass-root providers.

Acute diarrhea and metabolic acidosis caused by tuberculous vesico-rectal fistula

Acquired vesico-rectal fistula is an uncommon complication of pelvic malignant tumors,surgical injury,inflammatory disorders such as tuberculosis infection,radiotherapy and less commonly diverticulum of the urinary tract.The fistula is often identified by urinary tract abnormalities such as dysuria,recurrent urinary tract infection,pneumaturia,and fecaluria.Here,we report an unusual case of a patient with a vesico-rectal fistula of tuberculous origin,presenting with severe acute diarrhea,metabolic acidosis,hyperchloremia and hypokalemia while with only mild urinary tract symptoms.The patient was cured by tuberculostatic therapy.

Mesenchymal hamartoma of liver: Magnetic resonance imaging and histopathologic correlation

AIM： To describe the imaging features of hepatic mesenchymal hamartoma with emphasis on magnetic resonance imaging （MRI） compared to histopathologic results. METHODS： Spin-echo sequence（SE）,fast spin-echo sequence（FSE） were detected in 12 children （7 males,5 females） with mesenchymal hamartoma of the liver （IVlHL）, aged 1.2 months to 12 years,（ mean age, 6.3 years） by axial, saggital, coronary plain imaging with an Elscint 2.0T MR equipment. Their main symptoms were abdominal mass （5 cases）, enlarged liver （8 cases）, abdominal pain （1 case） and anemia （2 cases）, and negative alpha-fetoprotein. Dynamic enhancement examination was added in 2 cases. RESULTS： Six cases had single mass type of MHL, in which 3 cases had solid masses showing slight low- signal-intensity in TlWI, and irregular high-signal- intensity in T2WI, 1 case had a cystic-solid mixed mass showing several border-clear cysts in a solid mass, 2 cases had cystic masses with multi-septa. Five cases had diffuse and multifocal lesions type of MHL with its signal intensity being similar to that of the solid mass. One case had a combined diffuse and single cystic mass. In the early dynamic enhancement examination, the lesions were slightly circum-enhanced , and the center was enhanced in the later scan images. Inner hepatic vessels were compressed in 5 cases, vena cava and abdominal aortae were compressed in 3 cases. Pathological findings included fiber hyperplasia, hyaline degeneration, biliary duct hyperplasia, Iobule-like array. CONCLUSION： MR imaging is a better way to differentiate and diagnose MHL. MHL may be recognized by its characteristic occurrence in infancy and MR imaging features.

Pomalidomide improves the function of CD133-or HER2-specific CAR T cells

Chimeric antigen receptor(CAR)T-cell therapy is mostly limited to hematological malignancies and has a poor effect on solid tumors.CAR T cells as a kind of immune cell may be affected by some immunomodulatory drugs such as pomalidomide,so the use of pomalidomide may improve the effect of CAR T cells on solid tumors.In this study,CD133-or HER2-specific CAR T cells were chosen to investigate whether pomalidomide can regulate the function of CAR T cells in vitro.We found that pomalidomide can significantly enhance the ability of CD133-CAR T cells and HER2-CAR T cells to kill tumor cells and increase the cytokine secretion of CD133-CAR T cells and HER2-CAR T cells.Also,pomalidomide was shown to induce down-regulation of protein levels of IL-2 transcriptional repressors Aiolos and Ikaros in CAR T cells.This study suggests that the combination of pomalidomide and CAR T cells may be a new strategy for the treatment of solid tumors.

Evaluation value of intestinal flora detection for intestinal mucosal inflammation and immune response in patients with ulcerative colitis

Objective: To study the evaluation value of intestinal flora detection for intestinal mucosal inflammatory response and immune response in patients with ulcerative colitis. Methods: The patients who were diagnosed with ulcerative colitis in Zigong Fifth People's Hospital between March 2015 and February 2017 were selected as the UC group, and those who were diagnosed with colonic polyps were selected as the control group. Fresh excreta were collected to detect the number of intestinal flora, and the diseased intestinal mucosa tissue was collected to detect the expression of inflammatory response molecules and immune cell transcription factors. Results: enterococcus contents in intestinal tract and TLR4, NF-kB, TNF-α, HMGB-1, T-bet and RORC mRNA expression levels in intestinal mucosa of UC group were significantly higher than those of control group while bifidobacteria contents in intestinal tract and SOCS2, SOCS3, Foxp3 and GATA-3 mRNA expression levels were significantly lower than those of control group;TLR4, NF-kB, TNF-α, HMGB-1, T-bet and RORC mRNA expression levels in intestinal mucosa of UC patients with grade II and grade III flora disturbance were significantly higher than those of UC patients with normal flora and grade I flora disturbance while SOCS2, SOCS3, Foxp3 and GATA-3 mRNA expression levels were significantly lower than those of UC patients with normal flora and grade I flora disturbance;TLR4, NF-kB, TNF-α, HMGB-1, T-bet and RORC mRNA expression levels in intestinal mucosa of UC patients with grade III flora disturbance were significantly higher than those of UC patients with grade II flora disturbance while SOCS2, SOCS3, Foxp3 and GATA-3 mRNA expression levels were significantly lower than those of UC patients with grade II flora disturbance. Conclusion: The intestinal flora disturbance in patients with ulcerative colitis can result in inflammatory response activation and immune response disorder.

基于业财融合的医院成本核算模型构建与应用研究——以XH医院手术麻醉科为例

业财融合在各行各业持续推进,也为新医改下医疗服务机构在管理上的改革提供了参考与引导。本文对XH医院手术麻醉科及其诊疗项目的成本核算体系进行了研究,基于业财融合的导向进行了医院成本的重分类分析,进而基于时间驱动作业成本法(TDABC)构建了以诊疗项目为对象的成本核算模型并用医院2021年6个月的实务数据和调研数据进行了运算与结果分析,发现了XH医院运营管理问题,提出了相关建议。

Tuning the membrane rejection behavior by surface wettability engineering for an effective water-in-oil emulsion separation

Membrane-based separation is a promising technology to eliminate water impurities from the oil phase.However,it remains a great challenge to separate water from highly emulsified viscous oil owing to the high stability of the water droplets in oil.Herein we report a surface wettability engineering on an alumina ceramic membrane to achieve an efficient separation of a water-in-oil(W/O)emulsion.Silanes with different carbon chain lengths and fluorinated status were introduced to endow the alumina membrane with different surface wettabilities.While all the modified membranes exhibited excellent separation of the W/O without Span 80(surfactant),the one with amphiphobic wettability and lowest surface energy failed to separate the Span 80 stabilized W/O.The presence of Span 80 reduced the interfacial tension of water droplets,making them easier to deform and penetrate the modified membrane with the lowest surface energy.It reveals that engineering proper surface wettability is the key to separating the oil and water phases.Besides,the modified membranes maintained decent separation performance and stability under long-term run separation of the emulsified W/O.

基于简易营养评价精法评估肝癌患者出院后营养状况及其影响因素

目的探讨原发性肝癌(肝癌)患者出院后营养恢复状况及其影响因素。方法本研究对象为2019年7月1日至2021年1月31日在中山大学附属第三医院治疗并出院的70例肝癌患者。患者均签署知情同意书,符合医学伦理学规定。其中男60例,女10例;年龄28~78岁,中位年龄55岁。采用一般资料调查表、简易营养评价精法(MNA-SF)在出院当天(T1)、出院3个月(T2)、6个月(T3)对70例肝癌患者进行问卷调查。采用重复测量方差分析对3个时间点的营养状况进行比较,采用单因素方差分析和多元线性逐步回归分析营养状况影响因素。结果肝癌患者T1、T2、T3时间点平均营养状况评分分别为(9.3±1.8)、(10.2±2.0)、(11.2±2.2)分,3个时间点差异有统计学意义(F=23.891,P<0.05)。其中3个时间点营养不良发生率分别为17%(12/70)、6%(4/70)、4%(3/70),营养风险发生率分别73%(51/70)、67%(47/70)、49%(34/70)。回归分析显示,BMI、血清前白蛋白、腹腔积液、治疗方式是患者T1时间点营养状况的独立影响因素(t=3.968,2.721,-2.224,2.653;P<0.05);BMI、TB、治疗方式是患者T2时间点营养状况的独立影响因素(t=4.890,2.814,-5.346;P<0.05);BMI、治疗方式是患者T3时间点营养状况的独立影响因素(t=4.698,-5.052;P<0.05)。结论肝癌患者出院后营养状况逐步好转,但营养风险及营养不良发生率仍较高。对于BMI下降、血清前白蛋白降低、TB升高、腹腔积液和肝癌切除术后患者应在住院和居家期间进行营养干预,改善其营养状况,降低营养风险和营养不良发生率。

Investigation on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys with various Zn/Mg ratios

The effects of Zn/Mg ratios on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys aged at 150℃have been investigated by using tensile tests,optical metallography,scanning electron microscopy,transmission electron microscopy and atom probe tomography analyses.With increasing Zn/Mg ratios,the ageing process is significantly accelerated and the time to peak ageing is reduced.T’phase predominates in alloys of lower Zn/Mg ratios whileη’phase predominates in alloys with a Zn/Mg ratio over 2.86.Co-existence of T’phase andη’phase with a large number density is beneficial to the high strength of alloys.Such precipitates together with narrow precipitate free zones cause a brittle intergranular fracture.A strength model has been established to predict the co-strengthening effect of T’phase andη’phase in Al-Zn-Mg-Cu alloys,including the factors of the grain boundary,solid solution and precipitation.

烟草青枯病劳尔氏菌与拮抗菌对根系分泌物的竞争作用

[目的]研究青枯病病原菌与拮抗菌的营养特性及其对烟草根系分泌物的响应差异,对提高拮抗菌定殖能力、有效生物防控烟草青枯病具有非常重要的意义。[方法]本研究通过筛选与鉴定贵州烟区青枯病病原菌株及拮抗菌株,通过Biolog表型芯片技术分别检测病原菌与拮抗菌的特征性碳、氮源,利用气质联用(GC-MS)检测烟草主栽品种K326根系分泌物的主要物质,在此基础上进行病原菌与拮抗菌对其利用能力、利用强度以及共培养的研究。[结果]经鉴定,分离、筛选到的病原菌株和拮抗菌株分别为青枯劳尔氏菌(Ralstonia solawacearum)和枯草芽孢杆菌(Bacillus subtilis);在含量为0.01μg/mL以上的根系分泌物中,12种物质的含量从高到低排序为:果胶>葡萄糖>木糖>阿拉伯糖>半乳糖>核糖>蔗糖>苯甲酸>果糖=D-甘露醇>棕榈酸>富马酸,果胶含量最高且明显高于其他物质;拮抗菌(LX4)对碳源利用能力高于病原菌(Rs)的碳源有阿拉伯糖、木糖和核糖,分别是病原菌利用能力的1.22、1.95和2.17倍;前12 h拮抗菌利用果糖强度高于病原菌,不同碳源共培养24 h后LX4对gfp-Rs(绿色荧光蛋白标记后的青枯病病原菌)抑制率为18.34%(阿拉伯糖)、53.23%(木糖)、63.53%(核糖)和52.09%(果糖)。[结论]拮抗菌对烟草根系分泌物的利用不及病原菌,但在特定碳源条件下拮抗菌能够利用根系分泌物中的某些碳源产生某种拮抗物质抑制病原菌,拮抗菌与病原菌之间同时存在利用性竞争和干扰性竞争关系,研究结果为进一步研究烟草青枯病的生物防控提供了新的理论依据。