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Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application
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作者 Xianglei Fu yanbin shi +12 位作者 Zili Gu Hengchang Zang Lian Li Qingjie Wang Yongjun Wang Xiaogang Zhao Hang Wu Shengnan Qiu Yankun Zhang Jiamin Zhou Xiangqin Chen Hua Shen Guimei Lin 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2024年第3期115-130,共16页
Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usual... Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment failure.In this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during surgery.Briefly,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in SOG.Once applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like phenotype.Meanwhile,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell activation.Our data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single administration.MSL@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers. 展开更多
关键词 LIPOSOME HYDROGEL Signal transducer and activator of transcription 3 Non-small cell lung cancer MACROPHAGE
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Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting 被引量:3
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作者 Xianglei Fu yanbin shi +5 位作者 Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期279-293,共15页
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at t... Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine. 展开更多
关键词 THERAPEUTIC DRUGS PRECISE
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Anomalous enhancement oxidation of few-layer MoS_(2)and MoS_(2)/h-BN heterostructure 被引量:1
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作者 Siming Ren yanbin shi +2 位作者 Chaozhi Zhang Mingjun Cui Jibin Pu 《Nano Research》 SCIE EI CSCD 2022年第8期7081-7090,共10页
Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace... Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace at a series of increasing temperatures up to 340℃to study the oxidation behavior of continuous MoS_(2)films by either directly growing mono-and fewlayer MoS_(2)on SiO_(2)/Si substrate,or by mechanically transferring monolayer MoS_(2)or hexagonal boron nitride(h-BN)onto monolayer MoS_(2)substrate.Results show that monolayer MoS_(2)can withstand high temperature at 340℃with less oxidation while the few-layer MoS_(2)films are completely oxidized just at 280℃,resulting from the growth-induced tensile strain in few-layer MoS_(2).When the tensile strain of films is released by transfer method,the stacked few-layer MoS_(2)films exhibit superior thermal stability and typical layer-by-layer oxidation behavior at similarly high temperature.Counterintuitively,for the MoS_(2)/h-BN heterostructure,the h-BN film itself stacked on top is not damaged and forms many bubbles at 340℃,whereas the underlying monolayer MoS_(2)film is oxidized completely.By comprehensively using various experimental characterization and molecular dynamics calculations,such anomalous oxidation behavior of MoS_(2)/h-BN heterostructure is mainly due to the increased tensile strain in MoS_(2)film at elevated temperature. 展开更多
关键词 molybdenum disulfide hexagonal boron nitride HETEROSTRUCTURE enhancement oxidation tensile strain
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Research and application of leek roots in medicinal field 被引量:1
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作者 Huaijian Wang Ying Tian +5 位作者 Hao Tan Mengru Zhou Miao Li Yuchen Zhi yanbin shi Xuefeng Li 《Chinese Herbal Medicines》 CAS 2023年第3期391-397,共7页
Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical... Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical medicine of food and medicine continuum.It has a long history of medicinal applications and edible food in China.In this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were introduced.We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products. 展开更多
关键词 Allium tuberosum Rottl.ex Spreng clinical application leek roots traditional Chinese medicine PHARMACOLOGY
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