目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(...目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。展开更多
As an important public space in the city,street space is the second residence of people.Taking Yangmeizhu Street as the research object,this study established a street microclimate model in Beijing through microclimat...As an important public space in the city,street space is the second residence of people.Taking Yangmeizhu Street as the research object,this study established a street microclimate model in Beijing through microclimate measurement and simulation,and then calculated thermal comfort index of the street and evaluated thermal comfort of the street space and distribution model.The evaluation method used grid method to decompose and study and made several 10m×10m grids for inner space of the street,so as to compare deeply difference of microclimate environment in the street and analyze quantitatively relevance between street space elements(street pavement,street greening,building shadow coverage)and thermal comfort(physiological equivalent temperature PET)in the data.Finally,adaptive strategy of microclimate on street level was put forward to improve the environmental quality of public space in the old city by means of landscape design,aiming at creating a resilient and humanized street space and improving adaptability of microclimate and thermal comfort for living.展开更多
水资源干旱是限制灌区可持续发展的关键因素。为提高灌区的干旱防治能力,使其更好的发挥其在节水、减灾方面的作用,以淠史杭灌区为研究区,通过划分水资源配置子单元和设置调蓄节点,采用公平性最优和供水缺水率最小作为目标函数,总量控...水资源干旱是限制灌区可持续发展的关键因素。为提高灌区的干旱防治能力,使其更好的发挥其在节水、减灾方面的作用,以淠史杭灌区为研究区,通过划分水资源配置子单元和设置调蓄节点,采用公平性最优和供水缺水率最小作为目标函数,总量控制、供水能力、分质供水等作为约束条件,采用基于精英策略的非支配遗传改进算法求解,构建区域General Water Allocation and Simulation Model(GWAS)模型;以2022年为现状基准年,与2023规划年组合,分为连续干旱与不连续干旱两大类,基于灌区水资源“应急干旱三次平衡”调控思想,分析灌区水资源在不同干旱情景下缺水的基础上,展开水资源抗旱配置研究,推演分析不同抗旱方案下水资源供需平衡情况。结果表明:连续干旱年中,灌区2023规划年在情景Ⅰ(P=90%)、情景Ⅱ(P=80%)来水频率下,各乡镇配置单元均存在不同程度的缺水情况,区域总缺水率分别为35.1%、20.8%;不连续干旱年中,2023规划年在情景Ⅲ(P=50%)来水频率下,模型基准配置水量基本可以满足区域各乡镇水量需求,区域总缺水率为5.9%。经不同抗旱方案尾部泵站补水、调整作物种植结构及外调水的优化配置后,三种情景下区域总缺水率最终都降为0%,优化后各配置单元供水改善效果显著。研究成果可为淠史杭灌区未来在应对不同干旱类型情景下水资源的合理调整提供技术支撑,并且可为实现该区域水资源统一管理和水量的统一调配提供理论依据。展开更多
文摘目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。
基金Beijing Natural Science Foundation(8202017)2018 Beijing Municipal University Academic Human Resources Development-Youth Talent Support Program(PXM2018–014212–000043)National Natural Science Foundation of China(51708004).
文摘As an important public space in the city,street space is the second residence of people.Taking Yangmeizhu Street as the research object,this study established a street microclimate model in Beijing through microclimate measurement and simulation,and then calculated thermal comfort index of the street and evaluated thermal comfort of the street space and distribution model.The evaluation method used grid method to decompose and study and made several 10m×10m grids for inner space of the street,so as to compare deeply difference of microclimate environment in the street and analyze quantitatively relevance between street space elements(street pavement,street greening,building shadow coverage)and thermal comfort(physiological equivalent temperature PET)in the data.Finally,adaptive strategy of microclimate on street level was put forward to improve the environmental quality of public space in the old city by means of landscape design,aiming at creating a resilient and humanized street space and improving adaptability of microclimate and thermal comfort for living.
文摘水资源干旱是限制灌区可持续发展的关键因素。为提高灌区的干旱防治能力,使其更好的发挥其在节水、减灾方面的作用,以淠史杭灌区为研究区,通过划分水资源配置子单元和设置调蓄节点,采用公平性最优和供水缺水率最小作为目标函数,总量控制、供水能力、分质供水等作为约束条件,采用基于精英策略的非支配遗传改进算法求解,构建区域General Water Allocation and Simulation Model(GWAS)模型;以2022年为现状基准年,与2023规划年组合,分为连续干旱与不连续干旱两大类,基于灌区水资源“应急干旱三次平衡”调控思想,分析灌区水资源在不同干旱情景下缺水的基础上,展开水资源抗旱配置研究,推演分析不同抗旱方案下水资源供需平衡情况。结果表明:连续干旱年中,灌区2023规划年在情景Ⅰ(P=90%)、情景Ⅱ(P=80%)来水频率下,各乡镇配置单元均存在不同程度的缺水情况,区域总缺水率分别为35.1%、20.8%;不连续干旱年中,2023规划年在情景Ⅲ(P=50%)来水频率下,模型基准配置水量基本可以满足区域各乡镇水量需求,区域总缺水率为5.9%。经不同抗旱方案尾部泵站补水、调整作物种植结构及外调水的优化配置后,三种情景下区域总缺水率最终都降为0%,优化后各配置单元供水改善效果显著。研究成果可为淠史杭灌区未来在应对不同干旱类型情景下水资源的合理调整提供技术支撑,并且可为实现该区域水资源统一管理和水量的统一调配提供理论依据。
