Efficacy and Safety of Combined Bedaquiline and Delamanid Use among Patients with Multidrug-Resistant Tuberculosis in Beijing,China

Objectives The combined use of bedaquiline and delamanid(BDQ-DLM)is limited by an increased risk of prolonging the QTc interval.We retrospectively evaluated patients who received DLM/BDQcontaining regimens at a TB-specialized hospital.We aimed to present clinical efficacy and safety data for Chinese patients.Methods This case-control study included patients with multidrug-resistant tuberculosis(MDR-TB)treated with BDQ alone or BDQ plus DLM.Results A total of 96 patients were included in this analysis:64 in the BDQ group and 32 in the BDQ+DLM group.Among the 96 patients with positive sputum culture at the initiation of BDQ alone or BDQ combined with DLM,46 patients(71.9%)in the BDQ group and 29(90.6%)in the BDQ-DLM group achieved sputum culture conversion during treatment.The rate of sputum culture conversion did not differ between the two groups.The time to sputum culture conversion was significantly shorter in the BDQ-DLM group than in the BDQ group.The most frequent adverse event was QTc interval prolongation;however,the frequency of adverse events did not differ between the groups.Conclusion In conclusion,our results demonstrate that the combined use of BDQ and DLM is efficacious and tolerable in Chinese patients infected with MDR-TB.Patients in the BDQ-DLM group achieved sputum culture conversion sooner than those in the BDQ group.

基于格网尺度的新城区可持续空间形态要素测度研究——以宁波鄞州新城区为例

基于城市形态学,提出良好的街道可达性、适宜的建设强度与建筑形态、足够的功能混合度是促进城市可持续发展的空间形态基础,以宁波市鄞州新城区为例,通过空间句法、空间矩阵、混合功能指标测度其城市空间形态要素,结果表明:1)鄞州新城区街道网络整体协同能力较强,建筑形态以中层板式及围合式、低层围合式、高层板式为主,单一功能用地占主导地位,完全混合用地仅占1.73%;2)鄞州新城区空间活力中值区占比最高,通过密度-形态关联性分析,其在多层高覆盖率的形态区间被屏蔽;3)功能混合、可达性、建筑强度及形态之间重合度较高,高容积率(>2.2)单元格中有64.54%聚集在可达性高值区,双功能、多功能混合单元有50.25%、85.71%聚集在可达性高值区,混合单元有公共设施用地时混合功能-可达性关联的效应更明显。

Research on the Distribution of Incremental Benefits from the Entry of Collective Construction Land into the Market

In this paper,based on the process data of evaluating the benchmark land prices of collective construction land and agricultural land,the score of influencing factors is calculated,and a regression model between value-added benefits and influencing factors is established.According to the contribution of the government and collectives to value-added benefits,the distribution proportions of different purposes and levels are calculated.The research results show that there are significant differences in the distribution proportion of value-added income among different levels.The government distribution proportion decreases with the decrease of level,while the collective distribution proportion increases with the decrease of level.For each level of decrease in commercial service industry land and industrial and mining warehousing industry land,the government distribution proportion decreases by an average of 2.66%and 2.34%,while the collective distribution proportion increases by an average of 2.66%and 2.34%,respectively.The average distribution proportion of the government in the value-added income of commercial service industry land is 31.58%,which is much higher than the average income of 23.68%in the value-added income of industrial and mining warehousing industry land.

以通用型化工学训工场和大型化工企业为基地开展本科实习教育的探索

化工生产实习是化工类专业教学的重要环节,旨在培养和提高学生实践动手能力。面对现在校企合作实习举步维艰的境地,提出了一种高校结合化工学训工场和大型化工企业为基地开展本科实习教育的模式,并就该模式的优势和效果进行了探讨,为推动化工专业生产实习教学改革提供参考。

C-I codoped porous g-C_3N_4 for superior photocatalytic hydrogen evolution

Porous C‐I codoped carbon nitride materials were synthesized by in‐situ codoping with iodized ionic liquid followed by post‐thermal treatment in air.The effects of doping content of C‐I codoping with different amounts of ionic liquid on the structural,optical and photocatalytic properties of the samples were investigated.Characterization results show that more compact interlayer sacking can be achieved by post‐thermal treatment.Combined with C‐I codoping by insertion of ionic liquids,much enlarged surface area but optimized sp2 conjugated heterocyclic structure can be found in the catalysts.Optical and energy band analysis results evidence that the light absorptions especially in visible light region are significantly improved.Although the band gap of porous C‐I codoped samples enlarge because of the generation of porous,the negatively shifted conduction band position thermodynamically supplies stronger motivation for water reduction.Photoelectricity tests reveal that the photo‐induced electron density was increased after C‐I codoping modification.Also,the recombination rate of electron‐hole pairs is remarkably inhibited.The catalysts with moderate C‐I codoing content perform sharply enhanced photocatalytic H2 evolution activity under visible light irradiation.A H2 evolution rate of 168.2μmol/h was achieved and it was more than 9.8 times higher than pristine carbon nitride.This study demonstrates a novel non‐metal doping strategy for synthesis and optimization of polymer semiconductor with gratifying photocatalytic H2 evolution performance from water hydrolysis.

Gold/monolayer graphitic carbon nitride plasmonic photocatalyst for ultrafast electron transfer in solar-to-hydrogen energy conversion

Gold(Au)plasmonic nanoparticles were grown evenly on monolayer graphitic carbon nitride(g‐C3N4)nanosheets via a facile oil‐bath method.The photocatalytic activity of the Au/monolayer g‐C3N4 composites under visible light was evaluated by photocatalytic hydrogen evolution and environmental treatment.All of the Au/monolayer g‐C3N4 composites showed better photocatalytic performance than that of monolayer g‐C3N4 and the 1%Au/monolayer g‐C3N4 composite displayed the highest photocatalytic hydrogen evolution rate of the samples.The remarkable photocatalytic activity was attributed largely to the successful introduction of Au plasmonic nanoparticles,which led to the surface plasmon resonance(SPR)effect.The SPR effect enhanced the efficiency of light harvesting and induced an efficient hot electron transfer process.The hot electrons were injected from the Au plasmonic nanoparticles into the conduction band of monolayer g‐C3N4.Thus,the Au/monolayer g‐C3N4 composites possessed higher migration and separation efficiencies and lower recombination probability of photogenerated electron‐hole pairs than those of monolayer g‐C3N4.A photocatalytic mechanism for the composites was also proposed.

Construction of 2D/2D Z-scheme MnO_(2-x)/g-C_(3)N_(4) photocatalyst for efficient nitrogen fixation to ammonia

Reducing nitrogen to ammonia with solar energy has become a wide concern when it comes to photocatalysis research.It is considered to be one of the more promising alternate options for the conventional Haber-Bosch cycle.Herein,2D g-C_(3)N_(4)composites with modifying ultrathin sheet MnO_(2-x)were prepared and used as nitrogen fixation photocatalyst.With the assistance of the nature of MnO_(2-x),the generation rate of NH_(3)reached 225 mmol g^(-1)h^(-1),which is more than twice over the rate of pristine 2D g-C_(3)N_(4)(107 mmol g^(-1)h^(-1)).The presence of ultrathin sheet MnO_(2-x)shortens the gap of the carriers to the surface of photocatalyst.Thus the speed of electron transfer gets increased.Besides,the construction of Z-scheme heterojunction boosts the separation and migration of photogenerated carriers.As a result,the nitrogen reduction reaction(NRR)performance gets enhanced.The work may provide an example of promoting the NRR performance of non-metallic compound.

Fabrication of hierarchical ZnIn2S4@CNO nanosheets for photocatalytic hydrogen production and CO2 photoreduction

Photocatalytic H2 production and CO2 reduction have attracted considerable attention for clean energy development.In this work,we designed an efficient photocatalyst by integrating lamellar oxygen-doped carbon nitride(CNO)nanosheets into ZnIn2S4(ZIS)microflowers by a one-step hydrothermal method.A well-fitted 2D hierarchical hybrid heterostructure was fabricated.Under visible light irradiation,the ZIS@CNO composite with 40 wt%CNO(ZC 40%)showed the highest hydrogen evolution rate from water(188.4μmol·h-1),which was approximately 2.1 times higher than those of CNO and ZIS(88.6 and 90.2μmol·h-1,respectively).Furthermore,the selective CO production rates of ZC 40%(12.69μmol·h-1)were 2.2 and 14.0 times higher than those of ZIS(5.85μmol·h-1)and CNO(0.91μmol·h-1),respectively,and the CH4 production rate of ZC 40%was 1.18μmol·h-1.This enhanced photocatalytic activity of CNO@ZIS is due mainly to the formation of a heterostructure that can promote the transfer of photoinduced electrons and holes between CNO and ZIS,thereby efficiently avoiding recombination of electron-hole pairs.

Improvement of Evaluation Methods for Cultivated Land Quality

As the existing cultivated land quality evaluation index system is unable to accurately evaluate the quality of cultivated land after land remediation,a modified land use coefficient method was established in this study to calculate the land use coefficient of cultivated land after land remediation. An evaluation index system was first established for the land utilization level of cultivated land in the remediation areas.After that,the land utilization level index before and after the remediation was evaluated separately. The ratio of the two was used as the correction factor to correct the original land use coefficient. The corrected land use coefficient was used to evaluate the quality of cultivated land. The quality evaluation and verification of the land remediation areas in Yuzhou City were conducted. It was found that the land use coefficient corrected by the modified method was more consistent with that calculated by production method 5 years after the project acceptance. It suggests that the modified land use coefficient method reflects the impact of land remediation on the quality of cultivated land,and it is more suitable compared with the production method for the quality evaluation of cultivation land in remediation areas.

A Facile Synthesis and Photoluminescence Properties of SiO₂:Tb³⁺Spherical Nanoparticles

Controlled synthesis of functional photoluminescent materials are of particular interest due to their fascinating optical properties. Herein, highly uniform SiO2:xTb3+spherical nanoparticles are fabricated by a facile sol-gel method. The structure, morphology, compositions, and luminescence properties of As-prepared samples were well investigated using TEM, SEM, EDX, XRD, XPS and luminescence spectroscopy. The PL intensity of SiO2:xTb3+spherical nanoparticles is Tb3+ ions concentration dependent achieved a maximum at 3 mol % of Tb3+. Particularly, SiO2:xTb3+spherical nanoparticles exhibit a green emission corresponding to 5D4→7Fj transition (541 nm) of Tb3+. These results show that As-prepared phosphors may find potential application in solid-state lighting fields.

Study on Ecological Carrying Capacity of Land in Henan Province

In order to explore the technical methods to improve the ecological carrying capacity of regional land under the premise of limited land use area,an open ecological footprint model is established based on the traditional ecological footprint model.Using the two models,this paper evaluates the ecological carrying capacity of Henan Province in 2017.The results indicate that the ecological productive footprint of cultivated land in Henan Province is much larger than the ecological carrying capacity,but the ecological consumption footprint is lower than the ecological carrying capacity.The open ecological footprint model can clearly distinguish the internal and the external ecological consumption footprint after corrected by the consumption adjustment coefficient and the land-use structure adjustment coefficient.Based on the open ecological footprint model,the ecological carrying capacity evaluation results of Henan Province are more realistic.The comprehensive ecological carrying capacity in Henan Province has a surplus,but there are significant differences among different land use types.The cultivated land has the largest ecological carrying capacity surplus,while the fossil energy land has a larger ecological carrying capacity deficit.In the process of achieving sustainable development,Henan Province should focus on reducing energy consumption and improving the ecological carrying capacity of fossil energy land.The paper concludes that the open ecological footprint model can simulate the ecological carrying capacity under different land use structures and different consumption structures.According to the simulation results,the technical methods to improve the ecological carrying capacity under the premise of limited land use scale can be proposed.The research can provide reference for land use structure adjustment,land use planning and land protection in Henan Province.It can also provide scientific basis for ecological protection and high-quality development of the Yellow River basin.

Study on the Theory and Method of Real Estate Property Right Appraisal

This paper first introduces the overview of real estate appraisal theory,the basic situation of real estate appraisal,the basic principles and characteristics of real estate appraisal,and three main appraisal methods.On this basis,the specific use scope of each method,the meaning of each parameter,and the influencing factors are analyzed.Then,based on the in-depth study of various existing appraisal theories and methods,a new appraisal method is proposed:the appraisal analysis method based on fuzzy analytic hierarchy process.

Study on"Same Land,Same Right,Same Price"of Collective Commercial Construction Land and State-owned Land

Taking Changyuan City of Henan Province,a pilot city of collective commercial construction land reform,as the research object,this paper analyzes the scientific connotation of"same land,same right,same price"of collective commercial construction land and state-owned land in the unified urban-rural construction land market system,and how to realize"same land,same right,same price".The results show that in order to realize the fair entry of collective construction land into the market,it must base on scientific use control,unify the urban and rural construction land market and adhere to the guidance of market mechanism,and finally realize the sustainable development of the land market.

Research on Dynamic Change of Regional Cultivated Land Quality and Its Influence Factors

According to the reason of quality change,cultivated land is divided into four change types: decrease,increase,land construction project and gradual change. Farmland grading factor method is used to evaluate the quality of cultivated land in Zhengzhou City. The results show that(1) the quality of cultivated land in Zhengzhou City has slightly increased during the study period. Due to the decrease in the amount of cultivated land,the production capacity has declined.(2) The impact of different types of cultivated land change on the quality of regional cultivated land is in the order of gradual change> decrease > increase > land construction project.(3) Zhengzhou City is able to maintain the quality of regional cultivated land through new cultivated land and project construction,but fails to maintain the production capacity. By analyzing the mechanism of regional cultivated land quality change in different types,the relationship between quality changes in various types of areas and overall quality changes could be analyzed,and it could provide policy recommendations for managers to formulate farmland quality and capacity protection,with significant application value.

Electrospinning Synthesis and Photoluminescence Properties of One-Dimensional SiO₂:Tb³⁺Nanofibers and Nanobelts

Controlled synthesis of functional photoluminescent materials is of particular interest due to their fascinating optical properties. Herein, highly uniform one-dimensional (1D) SiO2:xTb3+ nanofibers and nanobelts are fabricated by electrospinning method combined with sol-gel method. The as-prepared SiO2:xTb3+ nanofibers are belt-like morphology after calcination. The formation mechanism of SiO2:xTb3+ nanofibers and nanobelts is proposed based on decomposition of polyvinylpyrrolidone (PVP) and crystallization of SiO2. The photoluminescence (PL) intensity of SiO2:xTb3+ nanofibers and nanobelts is Tb3+ ions concentration dependent with a maximum at 4 mol% of Tb3+. Particularly, SiO2:xTb3+ nanofibers and nanobelts exhibit a green emission corresponding to 5D4 → 7Fj transition (541 nm) of Tb3+.

Study on Division Method of Quality Monitoring Control Area Based on Comprehensive Cultivated Land Attribute

The quality change of cultivated land resources requires the scientific deployment of monitoring areas.In this study,Yuzhou City is taken as an example to divide the quality monitoring control areas through the study of natural quality,utilization level,income level,and utilization characteristics,etc.Compared with the traditional administrative unit division or cultivated land quality division method,the regional homogeneity of this study is stronger,and there are quality differences between regions.It provides precondition and precision guarantee for the monitoring of cultivated land quality.

Balance of Urban Benchmark Land Price in Henan Province:A Case Study of Residential Land

Benchmark land price balance is an important content of urban benchmark land price work.In this paper,by building different levels of factor layers,the balance of urban residential land in 18 cities of Henan Province is studied,and the 18 cities can be divided into five categories.It is found that the urban land price level is basically consistent with the level of economic development,and some urban land price is lower due to local policy.

Early Warning of Cultivated Land Quality Based on Multiple Indicators

At present,the quality protection and early warning of cultivated land in China are actually based on the increase and decrease of the quantity of cultivated land and the change of its quality.The early warning of cultivated land quality based on this is easy to cause the problem of missing and wrong alarm.Based on the quality and productivity change of regional cultivated land,early warning on the regional cultivated land quality is conducted in this study respectively,and the results of the two early warning are compared.Moreover,a multi-indicator cultivated land quality early warning based on the quality change,productivity change and auxiliary indicators is proposed.The results show that:early warning of cultivated land quality based on quality and productivity change of cultivated land has certain limitations.Based on multi-indicator early warning,the number of counties with heavy,medium and light warnings in Henan Province is 52,8 and 11 respectively.The multi-indicator early warning result of cultivated land quality is more accurate,which can provide a basis for cultivated land protection and management assessment,and has great application value.

Design of Trinity Framework for Cultivated Land Protection

Starting with the goals and tasks of quantity,quality and ecological protection in different scales,this paper constructs a"trinity"framework of cultivated land protection system,and puts forward the key points of cultivated land protection in different scales.Finally,a preliminary evaluation is made on the quantity,quality and ecological protection of cultivated land on a macro scale in China.

Distribution of Land Increment Income from Marketing Rural Collective Land for Development Purposes : A Case Study of Changyuan City

In order to protect the property rights and interests of farmers,promote the revitalization and development of rural areas,and provide a reference basis for the reform of marketing rural collective land for development purposes,this study explores the reasonable distribution proportion of land increment income from marketing rural collective land for development purposes through analytic hierarchy process and Delphi expert scoring method.The results show that there is a positive correlation between land increment income and land grade,that is,the higher the land grade,the higher the increment income,the larger the proportion of increment income to the transaction price.According to the calculation,when marketing rural collective land for development purposes,the reasonable distribution proportion of the land increment income of the government and the village collective is 28.6%and 71.4%,respectively,and the land increment income actually obtained by farmers has been greatly improved compared with the current situation.In practice,this distribution model has universal applicability and long-term mechanism.The reform of marketing also needs to improve the standard of marketing,explore diversified channels to protect interests,and strengthen the construction of rural collective management system.In short,the distribution of land increment income from marketing rural collective land for development purposes should proceed from the perspective of land property rights and the factors affecting the price of collective land for development purposes,in order to build a reasonable income distribution model.