In order to accurately predict bus travel time, a hybrid model based on combining wavelet transform technique with support vector regression(WT-SVR) model is employed. In this model, wavelet decomposition is used to e...In order to accurately predict bus travel time, a hybrid model based on combining wavelet transform technique with support vector regression(WT-SVR) model is employed. In this model, wavelet decomposition is used to extract important information of data at different levels and enhances the forecasting ability of the model. After wavelet transform different components are forecasted by their corresponding SVR predictors. The final prediction result is obtained by the summation of the predicted results for each component. The proposed hybrid model is examined by the data of bus route No.550 in Nanjing, China. The performance of WT-SVR model is evaluated by mean absolute error(MAE), mean absolute percent error(MAPE) and relative mean square error(RMSE), and also compared to regular SVR and ANN models. The results show that the prediction method based on wavelet transform and SVR has better tracking ability and dynamic behavior than regular SVR and ANN models. The forecasting performance is remarkably improved to obtain within 6% MAPE for testing section Ⅰ and 8% MAPE for testing section Ⅱ, which proves that the suggested approach is feasible and applicable in bus travel time prediction.展开更多
Metro system has experienced the global rapid rise over the past decades. However,few studies have paid attention to the evolution in system usage with the network expanding. The paper's main objectives are to ana...Metro system has experienced the global rapid rise over the past decades. However,few studies have paid attention to the evolution in system usage with the network expanding. The paper's main objectives are to analyze passenger flow characteristics and evaluate travel time reliability for the Nanjing Metro network by visualizing the smart card data of April 2014,April 2015 and April 2016. We performed visualization techniques and comparative analyses to examine the changes in system usage between before and after the system expansion. Specifically,workdays,holidays and weekends were specially segmented for analysis.Results showed that workdays had obvious morning and evening peak hours due to daily commuting,while no obvious peak hours existed in weekends and holidays and the daily traffic was evenly distributed. Besides,some metro stations had a serious directional imbalance,especially during the morning and evening peak hours of workdays. Serious unreliability occurred in morning peaks on workdays and the reliability of new lines was relatively low,meanwhile,new stations had negative effects on exiting stations in terms of reliability. Monitoring the evolution of system usage over years enables the identification of system performance and can serve as an input for improving the metro system quality.展开更多
In order to explore the travel characteristics and space-time distribution of different groups of bikeshare users,an online analytical processing(OLAP)tool called data cube was used for treating and displaying multi-d...In order to explore the travel characteristics and space-time distribution of different groups of bikeshare users,an online analytical processing(OLAP)tool called data cube was used for treating and displaying multi-dimensional data.We extended and modified the traditionally threedimensional data cube into four dimensions,which are space,date,time,and user,each with a user-specified hierarchy,and took transaction numbers and travel time as two quantitative measures.The results suggest that there are two obvious transaction peaks during the morning and afternoon rush hours on weekdays,while the volume at weekends has an approximate even distribution.Bad weather condition significantly restricts the bikeshare usage.Besides,seamless smartcard users generally take a longer trip than exclusive smartcard users;and non-native users ride faster than native users.These findings not only support the applicability and efficiency of data cube in the field of visualizing massive smartcard data,but also raise equity concerns among bikeshare users with different demographic backgrounds.展开更多
Short-term prediction of on-street parking occupancy is essential to the ITS system,which can guide drivers in finding vacant parking spaces.And the spatial dependencies and exogenous dependencies need to be considere...Short-term prediction of on-street parking occupancy is essential to the ITS system,which can guide drivers in finding vacant parking spaces.And the spatial dependencies and exogenous dependencies need to be considered simultaneously,which makes short-term prediction of on-street parking occupancy challenging.Therefore,this paper proposes a deep learning model for predicting block-level parking occupancy.First,the importance of multiple points of interest(POI)in different buffers is sorted by Boruta,used for feature selection.The results show that different types of POI data should consider different buffer radii.Then based on the real on-street parking data,long short-term memory(LSTM)that can address the time dependencies is applied to predict the parking occupancy.The results demonstrate that LSTM considering POI data after Boruta selection(LSTM(+BORUTA))outperforms other baseline methods,including LSTM,with an average testing MAPE of 11.78%.The selection process of POI data helps LSTM reduce training time and slightly improve the prediction performance,which indicates that complex correlations among the same type of POI data in different buffer zones will also affect the prediction accuracy of LSTM.When there are more restaurants on both sides of the street,the prediction performance of LSTM(+BORUTA)is significantly better than that of LSTM.展开更多
The stability of Ikaros family zinc finger protein 1(Ikaros),a critical hematopoietic transcription factor,can be regulated by cereblon(CRBN)ubiquitin ligase stimulated by immunomodulatory drugs in multiple myeloma.Ho...The stability of Ikaros family zinc finger protein 1(Ikaros),a critical hematopoietic transcription factor,can be regulated by cereblon(CRBN)ubiquitin ligase stimulated by immunomodulatory drugs in multiple myeloma.However,other stabilization mechanisms of Ikaros have yet to be elucidated.In this study,we show that the pharmacologic inhibition or knockdown of Hsp90 downregulates Ikaros in acute myeloid leukemia(AML)cells.Proteasome inhibitor MG132 but not autophagy inhibitor chloroquine could suppress the Hsp90 inhibitor STA-9090-induced reduction of Ikaros,which is accompanied with the increased ubiquitination of Ikaros.Moreover,Ikaros interacts with E3 ubiquitin-ligase C terminal Hsc70 binding protein(CHIP),which mediates the STA-9090-induced ubiquitination of Ikaros.In addition,the knockdown of Ikaros effectively inhibits the proliferation of leukemia cells,but this phenomenon could be rescued by Ikaros overexpression.Collectively,our findings indicate that the interplay between HSP90 and CHIP regulates the stability of Ikaros in AML cells,which provides a novel strategy for AML treatment through targeting the HSP90/Ikaros/CHIP axis.展开更多
基金Sponsored by the Projects of International Cooperation and Exchange of the National Natural Science Foundation of China(Grant No.51561135003)the Scientific Research Foundation of Graduated School of Southeast University(Grant No.YBJJ1842)
文摘In order to accurately predict bus travel time, a hybrid model based on combining wavelet transform technique with support vector regression(WT-SVR) model is employed. In this model, wavelet decomposition is used to extract important information of data at different levels and enhances the forecasting ability of the model. After wavelet transform different components are forecasted by their corresponding SVR predictors. The final prediction result is obtained by the summation of the predicted results for each component. The proposed hybrid model is examined by the data of bus route No.550 in Nanjing, China. The performance of WT-SVR model is evaluated by mean absolute error(MAE), mean absolute percent error(MAPE) and relative mean square error(RMSE), and also compared to regular SVR and ANN models. The results show that the prediction method based on wavelet transform and SVR has better tracking ability and dynamic behavior than regular SVR and ANN models. The forecasting performance is remarkably improved to obtain within 6% MAPE for testing section Ⅰ and 8% MAPE for testing section Ⅱ, which proves that the suggested approach is feasible and applicable in bus travel time prediction.
基金Sponsored by Projects of International Cooperation and Exchange of the National Natural Science Foundation of China(Grant No.51561135003)Key Project of National Natural Science Foundation of China(Grant No.51338003)
文摘Metro system has experienced the global rapid rise over the past decades. However,few studies have paid attention to the evolution in system usage with the network expanding. The paper's main objectives are to analyze passenger flow characteristics and evaluate travel time reliability for the Nanjing Metro network by visualizing the smart card data of April 2014,April 2015 and April 2016. We performed visualization techniques and comparative analyses to examine the changes in system usage between before and after the system expansion. Specifically,workdays,holidays and weekends were specially segmented for analysis.Results showed that workdays had obvious morning and evening peak hours due to daily commuting,while no obvious peak hours existed in weekends and holidays and the daily traffic was evenly distributed. Besides,some metro stations had a serious directional imbalance,especially during the morning and evening peak hours of workdays. Serious unreliability occurred in morning peaks on workdays and the reliability of new lines was relatively low,meanwhile,new stations had negative effects on exiting stations in terms of reliability. Monitoring the evolution of system usage over years enables the identification of system performance and can serve as an input for improving the metro system quality.
基金Supported by Projects of International Cooperation and Exchange of the National Natural Science Foundation of China(51561135003)Key Project of National Natural Science Foundation of China(51338003)Scientific Research Foundation of Graduated School of Southeast University(YBJJ1842)
文摘In order to explore the travel characteristics and space-time distribution of different groups of bikeshare users,an online analytical processing(OLAP)tool called data cube was used for treating and displaying multi-dimensional data.We extended and modified the traditionally threedimensional data cube into four dimensions,which are space,date,time,and user,each with a user-specified hierarchy,and took transaction numbers and travel time as two quantitative measures.The results suggest that there are two obvious transaction peaks during the morning and afternoon rush hours on weekdays,while the volume at weekends has an approximate even distribution.Bad weather condition significantly restricts the bikeshare usage.Besides,seamless smartcard users generally take a longer trip than exclusive smartcard users;and non-native users ride faster than native users.These findings not only support the applicability and efficiency of data cube in the field of visualizing massive smartcard data,but also raise equity concerns among bikeshare users with different demographic backgrounds.
基金supported in part by the National Key Research and Development Program of China(Project No.2018YFB1600900)the Jiangsu Province Transportation Key Project of Science(Project No.2019Z01)Zhejiang Provincial Natural Science Foundation of China(No.LTGG23E080005).
文摘Short-term prediction of on-street parking occupancy is essential to the ITS system,which can guide drivers in finding vacant parking spaces.And the spatial dependencies and exogenous dependencies need to be considered simultaneously,which makes short-term prediction of on-street parking occupancy challenging.Therefore,this paper proposes a deep learning model for predicting block-level parking occupancy.First,the importance of multiple points of interest(POI)in different buffers is sorted by Boruta,used for feature selection.The results show that different types of POI data should consider different buffer radii.Then based on the real on-street parking data,long short-term memory(LSTM)that can address the time dependencies is applied to predict the parking occupancy.The results demonstrate that LSTM considering POI data after Boruta selection(LSTM(+BORUTA))outperforms other baseline methods,including LSTM,with an average testing MAPE of 11.78%.The selection process of POI data helps LSTM reduce training time and slightly improve the prediction performance,which indicates that complex correlations among the same type of POI data in different buffer zones will also affect the prediction accuracy of LSTM.When there are more restaurants on both sides of the street,the prediction performance of LSTM(+BORUTA)is significantly better than that of LSTM.
基金supported by the National Key Research and Development Program of China(2017YFA0505200)Science and Technology Committee of Shanghai(19ZR1428700,20ZR1430600)the National Natural Science Foundation of China(81272886,81570118,81570112,81700157,81700475)。
文摘The stability of Ikaros family zinc finger protein 1(Ikaros),a critical hematopoietic transcription factor,can be regulated by cereblon(CRBN)ubiquitin ligase stimulated by immunomodulatory drugs in multiple myeloma.However,other stabilization mechanisms of Ikaros have yet to be elucidated.In this study,we show that the pharmacologic inhibition or knockdown of Hsp90 downregulates Ikaros in acute myeloid leukemia(AML)cells.Proteasome inhibitor MG132 but not autophagy inhibitor chloroquine could suppress the Hsp90 inhibitor STA-9090-induced reduction of Ikaros,which is accompanied with the increased ubiquitination of Ikaros.Moreover,Ikaros interacts with E3 ubiquitin-ligase C terminal Hsc70 binding protein(CHIP),which mediates the STA-9090-induced ubiquitination of Ikaros.In addition,the knockdown of Ikaros effectively inhibits the proliferation of leukemia cells,but this phenomenon could be rescued by Ikaros overexpression.Collectively,our findings indicate that the interplay between HSP90 and CHIP regulates the stability of Ikaros in AML cells,which provides a novel strategy for AML treatment through targeting the HSP90/Ikaros/CHIP axis.